Notice of Participation of the National Institute on Aging (NIA) in NOT-OD-22-058, Notice of Special Interest (NOSI): Discovery of the Genetic Basis of Conditions Associated with Down Syndrome for the INCLUDE Project (X01)
Notice NOT-AG-22-017 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 8, 2022 Category: Research Source Type: funding

HEAL Initiative: Discovery and Functional Evaluation of Human Pain-associated Genes and Cells (U19 Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-22-018 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement is to support research that uses human tissue or cells to generate comprehensive datasets for the discovery and characterization of functional genetic elements, epigenetic signatures, and molecular/cellular pathways that underlie human pain transduction, transmission, and processing. This FOA will support concerted multidisciplinary team science efforts that apply large-scale high-throughput approaches on tissues involved in human pain processing as part of the NIH HEAL Initiatives Program ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 4, 2022 Category: Research Source Type: funding

HEAL Initiative: Human Pain-associated Genes and Cells Data Coordination and Integration Center (U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-22-021 from the NIH Guide for Grants and Contracts. The goal of this funding opportunity announcement is to support a Human Pain-associated Genes and Cells Data Coordination and Integration Center as part of the NIH HEAL Initiatives Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of Human Pain (PRECISION Human Pain).The Data Coordination and Integration Center will curate, harmonize, and integrate comprehensive -omics and cellular function datasets generated by companion U19 Centers for Discovery and Functional Evaluation of Human Pain-...
Source: NIH Funding Opportunities (Notices, PA, RFA) - February 4, 2022 Category: Research Source Type: funding

Notice of Special Interest (NOSI): Discovery of the Genetic Basis of Conditions Associated with Down Syndrome for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project (X01)
Notice NOT-OD-22-058 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 28, 2022 Category: Research Source Type: funding

BRAIN Initiative: Development of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in Human and Non-Human Primate Brain (UG3/UH3 Clinical Trial Optional)
Funding Opportunity RFA-MH-22-115 from the NIH Guide for Grants and Contracts. Reissue of RFA-MH-19-135 The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis and manipulation of complex circuits and provide insights into cellular interactions that underlie brain function. Critical advances in the treatment of brain disorders in human populations are hindered by our lack of ability to monitor and manipulate circuitry in safe, minimally-invasive ways. Clinical intervent...
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 25, 2022 Category: Research Source Type: funding

Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes: Assay and Data Generation Centers (RM1 Clinical Trial Not Allowed)
Funding Opportunity RFA-MH-22-111 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) supports systematic and scalable approaches to profile the biological function of genes with an excess of damaging mutations in patients with neurodevelopmental and psychiatric disorders. Current understanding of the relationship between genetic and phenotypic variation is limited and one of the main bottlenecks in translating disease-associated genes to biology lies in the lack of scalable experimental platforms that can extend the unbiased nature of gene discovery to the discovery of biological me...
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 18, 2022 Category: Research Source Type: funding

Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes: Data Resource and Administrative Coordination Center (U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-MH-22-110 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) supports systematic and scalable approaches to profile the biological function of genes with an excess of damaging mutations in patients with neurodevelopmental and psychiatric disorders. Current understanding of the relationship between genetic and phenotypic variation is limited and one of the main bottlenecks in translating disease-associated genes to biology lies in the lack of scalable experimental platforms that can extend the unbiased nature of gene discovery to the discovery of biological me...
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 18, 2022 Category: Research Source Type: funding

Webinar Available on Searches for Alternatives to Animals
The NIH Office of Laboratory Animal Welfare hosted a live webinar in December 2021 entitled, “Best Practices for Conducting a Search for Alternatives and Finding Animal Model/Model Organism Information.” The panelists included Jessie Kull from the U.S. Department of Agriculture Animal Welfare Information Center and Joelle Mornini from the NIH Library. View this recording to learn how to find: 3Rs methods (replacement, reduction, and refinement) and animal use alternative information in bibliographic databases Journal articles, patents, NIH-funded research projects, and genetic information related to animal models and ...
Source: NIH Extramural Nexus - January 6, 2022 Category: Research Authors: NIH Staff Tags: New Resources Alternatives to Animals Animal Welfare webinar Source Type: funding

Notice of Special Interest (NOSI): Genetic Underpinnings of Endosomal Trafficking as a Pathological Hub in Alzheimer's Disease and Alzheimer's Disease-Related Dementias (AD/ADRD)
Notice NOT-AG-21-034 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 28, 2021 Category: Research Source Type: funding

Notice of Special Interest (NOSI): Methods Development for Genomic Studies of Genetic Variation, Function, and Disease
Notice NOT-HG-22-007 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 9, 2021 Category: Research Source Type: funding

Refreshing NIH ’s Genomic Data Sharing Policy
Dr. Lyric Jorgenson, Acting Associate Director for Science Policy and Acting Director of the NIH Office of Science Policy Guest post by Dr. Lyric Jorgenson, Acting Associate Director for Science Policy and Acting Director of the NIH Office of Science Policy, originally released on the Under the Poliscope blog. We’ve all heard the ancient expression that “the only constant in life is change.” While this phrase was first spoken about 2500 years ago, it is a remarkably insightful way of describing the most important aspect of policymaking; being able to adapt to a changing landscape. NIH strives to ensure our policies k...
Source: NIH Extramural Nexus - December 3, 2021 Category: Research Authors: Lyric Jorgenson Tags: blog Open Mike genomic data sharing RFI Source Type: funding

Limited Competition: Research Resource for the National Swine Resource and Research Center (U42 Clinical Trial Not Allowed)
Funding Opportunity PAR-21-356 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to provide continued support for the National Swine Resource and Research Center (NSRRC). The NSRRC serves as a central resource for the creation of genetically modified swine in response to the needs of the community and the cryopreservation of genetic stocks, procurement, and distribution of those swine, reagents, and their biological materials; and as a source of information and training related to the use of these animals in biomedical research as models of human health and diseas...
Source: NIH Funding Opportunities (Notices, PA, RFA) - December 3, 2021 Category: Research Source Type: funding

Notice of Early Expiration of PAR-19-079, Molecular and Genetic Characterization of Inborn Errors of Immunity (R21 Clinical Trial Not Allowed)"
Notice NOT-AI-22-006 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 29, 2021 Category: Research Source Type: funding

Notice of Special Interest (NOSI): Molecular and Genetic Characterization of Inborn Errors of Immunity
Notice NOT-AI-21-082 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 29, 2021 Category: Research Source Type: funding

Notice of Early Expiration of PAR-19-078, Molecular and Genetic Characterization of Inborn Errors of Immunity (R01 Clinical Trial Not Allowed)"
Notice NOT-AI-22-005 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - November 29, 2021 Category: Research Source Type: funding