Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2024, 2025, and 2026 (P50 Clinical Trial Required)
Funding Opportunity PAR-23-284 from the NIH Guide for Grants and Contracts. Through this funding opportunity announcement (FOA), the National Cancer Institute (NCI) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPORE). The program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer or a highly related group of cancers. For the purpose of this FOA, a group of highly related cancers are those that are deriv...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 22, 2023 Category: Research Source Type: funding
BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)
Funding Opportunity RFA-EY-23-001 from the NIH Guide for Grants and Contracts. This FOA seeks applications for unique and innovative recording and/or modulation technologies that are in the earliest stage of development, including new and untested ideas that are in the initial stages of conceptualization. Some projects may aim to increase recording or modulation capabilities by many orders of magnitude, while others may aim to improve the precision and selectivity of recording or modulation (also referred to as stimulation, perturbation, or manipulation). A wide range of modalities are appropriate including acoustic, ch...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 19, 2023 Category: Research Source Type: funding
Research Tools for Difficult to Culture Eukaryotic Pathogens (R61/R33 Clinical Trial Not Allowed)
Funding Opportunity RFA-AI-23-055 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support high risk, milestone-driven approaches for the development of robust culture techniques, and/or genetic and molecular tools to better understand the biology of select human eukaryotic pathogens including the microsporidian Enterocytozoon bieneusi; Pneumocystis jirovecii; Plasmodium vivax; and Babesia microti. This NOFO will use a milestone-driven, biphasic award mechanism. Transition to the second phase will depend on the successful completion of milestones. (Source: NIH F...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 30, 2023 Category: Research Source Type: funding
Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes: Assay and Data Generation Centers (RM1 Clinical Trial Not Allowed)
Funding Opportunity RFA-MH-25-145 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity announcement (NOFO) supports systematic and scalable approaches to profile the biological function of genes with an excess of damaging mutations in patients with neurodevelopmental and psychiatric disorders. Current understanding of the relationship between genetic and phenotypic variation is limited and one of the main bottlenecks in translating disease-associated genes to biology lies in the lack of scalable experimental platforms that can extend the unbiased nature of gene discovery to the discovery of bi...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 30, 2023 Category: Research Source Type: funding
Notice of Change to PAR-23-021, "Avenir Award Program for Genetic or Epigenetic of Substance Use Disorders (DP1 Clinical Trial Optional)"
Notice NOT-DA-23-037 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 24, 2023 Category: Research Source Type: funding
Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01 Clinical Trial Not Allowed)
Funding Opportunity PAR-23-281 from the NIH Guide for Grants and Contracts. Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for projects to expand, improve, or transform the utility of mammalian cancer and tumor models for translational research. With this NOFO, the NCI intends to encourage submission of projects devoted to demonstrating that mammalian models or their derivatives used for translational research are robust representations of human biology, are appropriate to test questions of clinical importance, and provide reliable information for patients'...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 18, 2023 Category: Research Source Type: funding
NIH Brain Development Cohorts (NBDC) Biospecimen Access (X01 Clinical Trial Not Allowed)
Funding Opportunity PAR-23-229 from the NIH Guide for Grants and Contracts. The Adolescent Brain Cognitive Development (ABCD) Study is the largest longitudinal study of brain development and child health collecting data from more than 11,000 children across the U.S. beginning when they are 9-10 years old and continuing for a decade. In addition to behavioral assessments, youth undergo neuroimaging and provide biospecimens, including saliva for hormone analysis, urine and hair for substance use and exposure, deciduous teeth for environmental exposure, and blood for genetic analysis and metabolic and hematologic assays. T...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 11, 2023 Category: Research Source Type: funding
Limited Competition: Human Pangenome Coordinating Center (U41) Clinical Trial Not Allowed
Funding Opportunity RFA-HG-23-025 from the NIH Guide for Grants and Contracts. The National Human Genome Research Institute (NHGRI) will renew the Human Genome Reference Program (HGRP). This FOA will establish the Human Pangenome Coordinating Center (HPCC), the central component of the HGRP. The HPCC will serve as the logistic and scientific coordinating center for the HGRP and will create, improve, release, and maintain new pangenome reference versions. The overall goal of the HGRP during the renewal is to produce a human pangenome reference that optimizes both the population genetic diversity represented, along with t...
Source: NIH Funding Opportunities (Notices, PA, RFA) - June 20, 2023 Category: Research Source Type: funding
BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)
Funding Opportunity RFA-MH-24-280 from the NIH Guide for Grants and Contracts. The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - June 16, 2023 Category: Research Source Type: funding
ClinGen Genomic Curation Expert Panels (U24 Clinical Trial Not Allowed)
Funding Opportunity PAR-23-199 from the NIH Guide for Grants and Contracts. NIH established a clinical genomics infrastructure to develop an openly accessible knowledgebase that promotes data sharing and provides standardized infrastructure and tools for determining the clinical relevance of genetic variants through two initiatives: the Clinical Genomics Resource (ClinGen) and the Clinical Variant Database (ClinVar) of clinical variation. ClinGen defines the clinical relevance of genes and variants for use in precision medicine and research by standardizing clinical annotation and interpretation of variants and implemen...
Source: NIH Funding Opportunities (Notices, PA, RFA) - June 6, 2023 Category: Research Source Type: funding
Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01 Clinical Trial Not Allowed)
Funding Opportunity PAR-23-184 from the NIH Guide for Grants and Contracts. The Center for Inherited Disease Research (CIDR) high-throughput genotyping, sequencing and supporting statistical genetics services are designed to aid the identification of genes or genetic modifications that contribute to human health and disease or to enhance existing collections of well-phenotyped specimens in biorepositories by the addition of genotype or next-generation sequence data. The laboratory specializes in genomic services that cannot be efficiently carried out in individual investigator laboratories. CIDR provides the most up-to-...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 26, 2023 Category: Research Source Type: funding
Limited Competition: National Primate Research Centers (P51) (Clinical Trials Not Allowed)
Funding Opportunity PAR-23-126 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) encourages grant applications that support the activities of the National Primate Research Centers (NPRCs). Nonhuman primates (NHPs) are most closely related to humans, both physiologically and genetically. Therefore, NHPs are critical animal models for basic and translational research aimed at understanding human biology, both in normal and diseased states. Proper husbandry and management of NHPs require specialized physical and intellectual resources, which are most effectively and economically provi...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 26, 2023 Category: Research Source Type: funding
Specialized Alcohol Research Centers (P50 Clinical trial Optional)
Funding Opportunity RFA-AA-23-001 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications for specialized Alcohol Research Centers using the P50 mechanism. The overall purpose of the NIAAA Alcohol Research Center program is to provide leadership in conducting and fostering interdisciplinary, collaborative research on a wide variety of topics relevant to the Institutes mission. These topics include, but are not limited to: the nature, etiology, genetics, diagnosis, treatment, and prevention of alcohol use disorder, alcohol-related end organ diseases and their biomedical...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 24, 2023 Category: Research Source Type: funding
Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 - Clinical Trial Not Allowed)
Funding Opportunity PAR-23-212 from the NIH Guide for Grants and Contracts. This FOA would support establishing deeper mechanistic insight and causal relationships between TDP-43 pathology and phenotypic outcomes, as well as mechanistic interactions between TDP-43 and other co-pathologies, such TMEM106B. Additionally, it would include comparisons (including mechanistic, molecular, structural, cellular, genetic, -omic, anatomical, neuropathological, etc.) between TDP-43 proteinopathies, including LATE, with or without AD-NC, and FTD and/or ALS. (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 23, 2023 Category: Research Source Type: funding
Preclinical Studies to Characterize the Impact of Toxicants on Brain Aging and Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-AG-24-023 from the NIH Guide for Grants and Contracts. The central goal of this funding initiative is to evaluate the molecular, pathologic and functional consequences of major toxicants known to be associated with elevated AD/ADRD risk, in mouse models of Late Onset AD (LOAD). Projects funded through this program will examine the consequences of early and mid-life exposure on late-life brain health by conducting cross-sectional/longitudinal multi-modal phenotyping (molecular, biochemical, pathologic and behavioral) of mouse models of LOAD, and the impact of genetic diversity and sex-differences ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - May 15, 2023 Category: Research Source Type: funding
