Amitriptyline at low-dose and titrated for irritable bowel syndrome as second-line treatment (The ATLANTIS trial): protocol for a randomised double-blind placebo-controlled trial in primary care
DiscussionDetermining the clinical and cost-effectiveness of low-dose amitriptyline as a second-line treatment for IBS in primary care will provide robust evidence to inform management decisions.Trial registrationISRCTN ISRCTN48075063
. Registered on 7th June 2019. (Source: Trials)
Source: Trials - July 8, 2022 Category: Research Source Type: clinical trials
Using text and charts to provide social norm feedback to general practices with high overall and high broad-spectrum antibiotic prescribing: a series of national randomised controlled trials
ConclusionOur broad-spectrum feedback letters had no effect on broad-spectrum prescribing; adding a bar chart to a text-only letter had no effect on overall antibiotic prescribing. Broad-spectrum and overall prescribing were both decreasing over time.Trial registrationClinicalTrials.gov NCT03862794. March 5, 2019. (Source: Trials)
Source: Trials - June 18, 2022 Category: Research Source Type: clinical trials
Behavioural intervention to promote the uptake of planned care in urgent dental care attenders: study protocol for the RETURN randomised controlled trial
DiscussionThis is a pragmatic trial, evaluating the effectiveness of the intervention under the usual condition in which it might be applied. Since dental practices work as independent contractors to the NHS, this brings implementation and fidelity challenges which will be explored and described in embedded qualitative work.Trial registrationISRCTN registry identifier ISRCTN84666712. Registered 12/04/2021. (Source: Trials)
Source: Trials - June 7, 2022 Category: Research Source Type: clinical trials
A cluster-randomized trial of a complex intervention to encourage deprescribing antidepressants in nursing home residents with dementia: a study protocol
DiscussionWe anticipate that the intervention will optimize the treatment of BPSD with antidepressants for nursing homes residents and enhance compliance with reduction of medication. The process evaluation should provide insights into the barriers and facilitators to changing the current practice of deprescribing.Trial registrationClinicaltrials.govNCT04985305. Registered on 30 July 2021. (Source: Trials)
Source: Trials - May 16, 2022 Category: Research Source Type: clinical trials
Delayed Antibiotic Therapy in General Practice
Condition: AOM - Acute Otitis Media Intervention: Sponsor: CNGE Conseil Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 4, 2022 Category: Research Source Type: clinical trials
