Gas Gangrene (Myonecrosis) Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The evaluations of the inhibition of orlistat on Clostridium perfringens sialidase (NanI) activity by in vitro and in silico approaches
Chem Biodivers. 2023 Dec 29:e202301634. doi: 10.1002/cbdv.202301634. Online ahead of print.ABSTRACTClostridium perfringens (C. perfringens) is a bacterium that causes serious problems in humans and animals such as food poisoning, gas gangrene and infections. C. perfringens has three sialidases (NanH, NanI, NanJ) and inhibition of NanI constitutes an approach in the treatment of C. perfringens since NanI provides the carbohydrate source necessary for the growth of bacteria. In our study, the inhibition effect of some drugs belonging to different drug groups on NanI activity was investigated. Among these drugs, orlistat (0.2...
Source: Chemistry and Biodiversity - December 29, 2023 Category: Biochemistry Authors: Onur Ertik Refiye Yanardag Source Type: research

Plants Causing Toxic Myopathies
Boxelder and sycamore maple contain hypoglycin A (HGA), the toxic metabolite of which, MCPA-CoA, inhibits fatty acid β-oxidation, causing seasonal pasture myopathy (SPM) or atypical myopathy (AM), respectively. White snakeroot and rayless goldenrod contain multiple benzofuran ketones (BFKs). The identity/toxicity of BFKs appear variable, possibly involving interactions between toxins/toxic metabolites, but ultima tely inhibit cellular energy metabolism. Unthrifty horses grazing sparse pastures during the fall appear predisposed to these plant-associated, frequently fatal, toxic myopathies. Toxidromes are characterized by ...
Source: Veterinary Clinics of North America: Equine Practice - December 26, 2023 Category: Veterinary Research Authors: Beatrice Sponseller, Tim Evans Source Type: research

TOXINOLOGICAL PROFILE AND HISTOPATHOLOGICAL ALTERATIONS INDUCED BY Bothrocophias campbelli VENOM FROM COLOMBIA
Acta Trop. 2023 Dec 13:107094. doi: 10.1016/j.actatropica.2023.107094. Online ahead of print.ABSTRACTSnakebite envenomings most frequently reported in Colombia are caused by snakes of the genera Bothrops, Bothriechis, Bothrocophias, and Porthidium. Their venoms induce local and systemic pathophysiological effects, sometimes leading to permanent sequelae such as reduced mobility of the limbs, amputations, besides the risk of death. The genus Bothrocophias includes nine species, among which B. campbelli has a distribution restricted to the department of Nariño in Colombia. In this work we determined the toxinological profil...
Source: Acta Tropica - December 15, 2023 Category: Infectious Diseases Authors: Mar ía-José Sevilla-Sánchez Jimmy Alexander Guerrero-Vargas Santiago Ayerbe-Gonz ález Jhon Jairo Calder ón-Leytón Bruno Lomonte Diana Mora-Obando Source Type: research

Types A and F < em > Clostridium perfringens < /em > in healthcare wastewater from Ghana
Appl Environ Microbiol. 2023 Dec 5:e0161923. doi: 10.1128/aem.01619-23. Online ahead of print.ABSTRACTClostridium perfringens causes gas gangrene and food poisoning in humans, and monitoring this bacterium is important for public health. Although whole-genome sequencing is useful to comprehensively understand the virulence, resistome, and global genetic relatedness of bacteria, limited genomic data from environmental sources and developing countries hamper our understanding of the richness of the intrinsic genomic diversity of this pathogen. Here, we successfully accumulated the genetic data on C. perfringens strains isola...
Source: Applied and Environmental Microbiology - December 5, 2023 Category: Microbiology Authors: Taira Kawamura Isaac Prah Samiratu Mahazu Anthony Ablordey Ryoichi Saito Source Type: research

Structural, biochemical and immunochemical characterization of an acidic phospholipase A2 from Lachesis acrochorda (Viperidae: Crotalinae) venom
Toxicon. 2023 Nov 25:107528. doi: 10.1016/j.toxicon.2023.107528. Online ahead of print.ABSTRACTViperids of the genus Lachesis, also known as bushmasters, are capable of injecting great amounts of venom that cause severe envenomation incidents. Since phospholipases type A2 are mainly involved in edema and myonecrosis within the snakebite sites, in this work, the isolation, amino acid sequence and biochemical characterization of the first phospholipase type A2 from the venom of Lachesis acrochorda, named Lacro_PLA2, is described. Lacro_PLA2 is an acidic aspartic 49 calcium-dependent phospholipase A2 with 93% similarity to th...
Source: Toxicon - November 28, 2023 Category: Toxicology Authors: Adri án Marcelo Franco-Vásquez Fernando Lazcano-P érez Miguel Angel Mej ía-Sánchez Gerardo Corzo Fernando Zamudio Alejandro Carbajal-Saucedo Sergio Agust ín Román-González Sa úl Gómez-Manzo Roberto Arregu ín-Espinosa Source Type: research

Rhabdomyolysis: a review of imaging features across modalities
AbstractThis review illustrates the imaging features of rhabdomyolysis across multiple modalities and in a variety of clinical scenarios. Rhabdomyolysis is the rapid breakdown of striated muscle following severe or prolonged insult resulting in the release of myocyte constituents into circulation. In turn, patients develop characteristically elevated serum creatine kinase, positive urine myoglobin, and other serum and urine laboratory derangements. While there is a spectrum of clinical symptoms, the classic presentation has been described as muscular pain, weakness, and dark urine. This triad, however, is only seen in abou...
Source: Skeletal Radiology - November 20, 2023 Category: Radiology Source Type: research

Unraveling snake venom phospholipase A < sub > 2 < /sub > : an overview of its structure, pharmacology, and inhibitors
Pharmacol Rep. 2023 Nov 6. doi: 10.1007/s43440-023-00543-8. Online ahead of print.ABSTRACTSnake bite is a neglected disease that affects millions of people worldwide. WHO reported approximately 5 million people are bitten by various species of snakes each year, resulting in nearly 1 million deaths and an additional three times cases of permanent disability. Snakes utilize the venom mainly for immobilization and digestion of their prey. Snake venom is a composition of proteins and enzymes which is responsible for its diverse pharmacological action. Snake venom phospholipase A2 (SvPLA2) is an enzyme that is present in every ...
Source: Pharmacological Reports - November 5, 2023 Category: Drugs & Pharmacology Authors: Ganesh H Sampat Kashinath Hiremath Jagadeesh Dodakallanavar Vishal S Patil Darasaguppe R Harish Prakash Biradar Rashmi K Mahadevamurthy Manish Barvaliya Subarna Roy Source Type: research

Clostridium perfringens phospholipase C, an archetypal bacterial virulence factor, induces the formation of extracellular traps by human neutrophils
Neutrophil extracellular traps (NETs) are networks of DNA and various microbicidal proteins released to kill invading microorganisms and prevent their dissemination. However, a NETs excess is detrimental to the host and involved in the pathogenesis of various inflammatory and immunothrombotic diseases. Clostridium perfringens is a widely distributed pathogen associated with several animal and human diseases, that produces many exotoxins, including the phospholipase C (CpPLC), the main virulence factor in gas gangrene. During this disease, CpPLC generates the formation of neutrophil/platelet aggregates within the vasculatur...
Source: Frontiers in cellular and infection microbiology - October 27, 2023 Category: Microbiology Source Type: research

Percutaneous decompression of primary hepatic gas gangrene caused by Clostridium perfringens
(Source: Journal of Vascular and Interventional Radiology : JVIR)
Source: Journal of Vascular and Interventional Radiology : JVIR - October 27, 2023 Category: Radiology Authors: Rachel Brader, Hyeon Yu Tags: Letter to the Editor Source Type: research

The anti-myotoxic effects and mechanisms of Sinonatrix annularis serum and a novel plasma metalloproteinase inhibitor towards Deinagkistrodon acutus envenomation
Toxicol Lett. 2023 Oct 5:S0378-4274(23)01059-7. doi: 10.1016/j.toxlet.2023.10.004. Online ahead of print.ABSTRACTNon-venomous snakes commonly evolve natural resistance to venom to escape predators. Sinonatrix annularis serum has been shown to inhibit Deinagkistrodon acutus venom-induced hemorrhage and upregulation of serum CK, CK-MB, LDH, AST and ALT levels. Using TMT-labeled proteomics analysis, 169 proteins were found to be altered significantly in the envenomed gastrocnemius muscle and categorized into pathways such as complement and coagulation cascades, leukocyte transendothelial migration, and JAK/STAT signaling. The...
Source: Toxicology Letters - October 7, 2023 Category: Toxicology Authors: Kepu Fu Liyun Cao Yitao Tang Jianqi Zhao Kejia Xiong Congjiang Hong Chunhong Huang Source Type: research

Calcific myonecrosis misdiagnosed as right leg abscess: a case report
Hong Kong Med J. 2023 Sep 27. doi: 10.12809/hkmj219898. Online ahead of print.NO ABSTRACTPMID:37752774 | DOI:10.12809/hkmj219898 (Source: Hong Kong Med J)
Source: Hong Kong Med J - September 27, 2023 Category: General Medicine Authors: C Y Lee C H Lin Source Type: research