Naja nigricincta nigricincta venom, a murine model. Evaluation of skeletal and cardio-myonecrosis, kidney injury and inflammatory response along with neutralisation efficacy by the SAIMR/SAVP - and EchiTAb-Plus-ICP polyvalent antivenoms
Toxicon. 2024 Apr 15:107719. doi: 10.1016/j.toxicon.2024.107719. Online ahead of print.ABSTRACTAfrican spitting cobra, Naja nigricincta nigricincta (Zebra snake), envenomation is an important cause of snakebite morbidity and mortality in Namibia. The snake is endemic to central and northern Namibia as well as southern Angola. The venom is mainly cytotoxic, resulting in aggressive dermo-necrosis and often accompanied by severe systemic complications. No specific antivenom exists. Rhabdomyolysis, systemic inflammatory response, haemostatic abnormalities, infective necrotising fasciitis as well as acute kidney failure have be...
Source: Toxicon - April 17, 2024 Category: Toxicology Authors: Esta L Saaiman Engelbrecht Vinny Naidoo Christo J Botha Source Type: research

Naja nigricincta nigricincta venom, a murine model. Evaluation of skeletal and cardio-myonecrosis, kidney injury and inflammatory response along with neutralisation efficacy by the SAIMR/SAVP - And EchiTAb-Plus-ICP polyvalent antivenoms
Toxicon. 2024 Apr 15;243:107719. doi: 10.1016/j.toxicon.2024.107719. Online ahead of print.ABSTRACTAfrican spitting cobra, Naja nigricincta nigricincta (Zebra snake), envenomation is an important cause of snakebite morbidity and mortality in Namibia. The snake is endemic to central and northern Namibia as well as southern Angola. The venom is mainly cytotoxic, resulting in aggressive dermo-necrosis and often accompanied by severe systemic complications. No specific antivenom exists. Rhabdomyolysis, systemic inflammatory response, haemostatic abnormalities, infective necrotising fasciitis as well as acute kidney failure hav...
Source: Toxicon - April 17, 2024 Category: Toxicology Authors: Esta L Saaiman Engelbrecht Vinny Naidoo Christo J Botha Source Type: research

A rare case of necrotizing fasciitis of the leg in an intravenous drug user caused by < em > Prevotella denticola < /em >
CONCLUSIONS: In IDUs the risk of deep skin and soft tissue infections is high and may be aggravated by contamination with oral microorganisms. The choice of empirical antibiotic treatment should include agents active against oral cavity anaerobes, such as P. denticola.PMID:38562513 | PMC:PMC10984238 | DOI:10.1080/20002297.2024.2334545 (Source: Journal of Oral Microbiology)
Source: Journal of Oral Microbiology - April 2, 2024 Category: Microbiology Authors: Andrea Bedini Filippo Medioli Altea Gallerani Irene Venturelli Giacomo Franceschi Marianna Meschiari Erica Franceschini Giacomo Maria Lima Mario Sarti Cristina Mussini Source Type: research

Catheter-related gas-forming suppurative thrombophlebitis
We present a case of catheter-related gas-forming suppurative thrombophlebitis due to Clostridium perfringens infection. Gas-forming thrombus around the catheter can be useful findings for the early diagnosis of catheter-related clostridial thrombophlebitis. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - March 4, 2024 Category: Emergency Medicine Source Type: research

IDF23-0332 Acute Limb Pain in Diabetes: Diabetic MyoNecrosis- A Rare Complication and a Rarer Differential
(Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 1, 2024 Category: Endocrinology Authors: B. Teli, J. Swain, K. Lavanya, P. Jadhao, S.L. Sravya, S.S. Vejendla, S. Panigrahi Tags: Other Complications Source Type: research

Rapidly Progressive Myonecrosis Diagnosed by Point of Care Ultrasound
Infectious Myonecrosis is a rare, rapidly progressive necrotizing infection of skeletal muscles caused by anaerobic bacterium most common in underdeveloped and tropical areas [1]. This disease requires rapid diagnosis and treatment due to its associated 20%-48% associated mortality rate. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - February 16, 2024 Category: Emergency Medicine Authors: Skyler Sloane, Rachna Subramony, Cameron Andrew Olandt, Colleen Campbell Tags: Visual Diagnosis in Emergency Medicine Source Type: research

Rapidly Progressive Myonecrosis Diagnosed by Point-of-Care Ultrasound
Infectious myonecrosis is a rare, rapidly progressive necrotizing infection of skeletal muscles caused by anaerobic bacterium, most common in underdeveloped and tropical areas (1). This disease requires rapid diagnosis and treatment due to its associated 20 –48% associated mortality rate. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - February 16, 2024 Category: Emergency Medicine Authors: Skyler Sloane, Rachna Subramony, Cameron Andrew Olandt, Colleen Campbell Tags: Visual Diagnosis in Emergency Medicine Source Type: research

Misuse of Tourniquets in Ukraine may be Costing More Lives and Limbs than they Save
Mil Med. 2024 Jan 17:usad503. doi: 10.1093/milmed/usad503. Online ahead of print.ABSTRACTHands-on training and social media sites have heavily emphasized the use of tourniquets to treat limb injuries during the Ukraine war. Tourniquet overuse or misuse can lead to significant tragedy-limb loss, physiologic complications, and even death. Casualty evacuation in Ukraine often exceeds 6 hours, and the liberal use of limb tourniquets may have unintentionally increased morbidity. Tourniquet application was appropriate in 24.6% of the wounded with tourniquets in one recent publication by a Ukrainian vascular surgeon. The longer a...
Source: Military Medicine - January 19, 2024 Category: International Medicine & Public Health Authors: Rom A Stevens Michael S Baker Ostap B Zubach Michael Samotowka Source Type: research