The Role of Inflammatory Biomarkers in Mediating the Effect of Inflammatory Bowel Disease on nonmalignant Digestive System Diseases: A Multivariable Mendelian Randomized Study
CONCLUSIONS: The evidence suggests that UC is associated with an elevated risk of AP and IBS, and IL-6 may be responsible in AP. CD is associated with an increased risk of developing CeD. Implementing a proactive monitoring program for assessing the risk of gastrointestinal diseases in UC patients, particularly those with elevated IL-6 levels, may be of interest. In addition, the presence of AP and IBS may indicate the presence of UC. Preventing CeD is an essential consideration in the therapeutic management of patients with CD.PMID:38529201 | PMC:PMC10963109 | DOI:10.1155/2024/1266139 (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - March 26, 2024 Category: Gastroenterology Authors: Shu Zhou Qi Sun Ning Gao Zekai Hu Junjun Jia Jiangwei Song Guocong Xu Aiqiang Dong Weiliang Xia Jiafeng Wu Source Type: research
Depression and hepatobiliary diseases: a bidirectional Mendelian randomization study
ConclusionDepression is a susceptibility factor for non-alcoholic fatty liver disease, and the causal effect of genetic susceptibility to depression on non-alcoholic fatty liver disease is mediated by waist-hip ratio, hypertension, and daytime nap. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - March 26, 2024 Category: Psychiatry Source Type: research
Therapeutic Potential of Danyankang Capsule in High-Fat Diet-Induced Cholelithiasis and Its Impact on Liver FXR Signaling and Gut Microbiota
In conclusion, the present study demonstrates that Danyankang exerts potent therapeutic efficacy against high-fat diet-induced cholelithiasis. This beneficial outcome is potentially linked to the inhibition of the TLR4/pNF-κB and SHP/CYP7A1/CYP8B1 signaling pathways, as well as the enhancement of intestinal flora species abundance.PMID:38522942 | DOI:10.1248/bpb.b24-00052 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - March 24, 2024 Category: Drugs & Pharmacology Authors: Lin Zhou Chu-Ling Zhang Kun Jiang Hong-Yu Cheng Wen-Wen Xiong Ji-Xiao Zhu Source Type: research
Therapeutic Potential of Danyankang Capsule in High-Fat Diet-Induced Cholelithiasis and Its Impact on Liver FXR Signaling and Gut Microbiota
In conclusion, the present study demonstrates that Danyankang exerts potent therapeutic efficacy against high-fat diet-induced cholelithiasis. This beneficial outcome is potentially linked to the inhibition of the TLR4/pNF-κB and SHP/CYP7A1/CYP8B1 signaling pathways, as well as the enhancement of intestinal flora species abundance.PMID:38522942 | DOI:10.1248/bpb.b24-00052 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - March 24, 2024 Category: Drugs & Pharmacology Authors: Lin Zhou Chu-Ling Zhang Kun Jiang Hong-Yu Cheng Wen-Wen Xiong Ji-Xiao Zhu Source Type: research
Therapeutic Potential of Danyankang Capsule in High-Fat Diet-Induced Cholelithiasis and Its Impact on Liver FXR Signaling and Gut Microbiota
In conclusion, the present study demonstrates that Danyankang exerts potent therapeutic efficacy against high-fat diet-induced cholelithiasis. This beneficial outcome is potentially linked to the inhibition of the TLR4/pNF-κB and SHP/CYP7A1/CYP8B1 signaling pathways, as well as the enhancement of intestinal flora species abundance.PMID:38522942 | DOI:10.1248/bpb.b24-00052 (Source: Biological and Pharmaceutical Bulletin)
Source: Biological and Pharmaceutical Bulletin - March 24, 2024 Category: Drugs & Pharmacology Authors: Lin Zhou Chu-Ling Zhang Kun Jiang Hong-Yu Cheng Wen-Wen Xiong Ji-Xiao Zhu Source Type: research
Preoperative difficulty assessment of interval laparoscopic cholecystectomy for gallstones
In this study, we evaluated the difficulties associated with interval cholecystectomy for cholecystitis with gallstones. (Source: Surgery)
Source: Surgery - March 24, 2024 Category: Surgery Authors: Masahiro Shiihara, Yasuhiro Sudo, Norimasa Matsushita, Takeshi Kubota, Yasuhiro Hibi, Harushi Osugi, Tatsuo Inoue Source Type: research
Pathophysiology of severe gallstone pancreatitis: A new paradigm
World J Gastroenterol. 2024 Feb 21;30(7):614-623. doi: 10.3748/wjg.v30.i7.614.ABSTRACTSevere gallstone pancreatitis (GSP) refractory to maximum conservative therapy has wide clinical variations, and its pathophysiology remains controversial. This Editorial aimed to investigate the pathophysiology of severe disease based on Opie's theories of obstruction, the common channel, and duodenal reflux and describe its types. Severe GSP might be a hybrid disease with pathology polarized between acute cholangitis with mild pancreatitis (biliary type) and necrotizing pancreatitis uncomplicated with biliary tract disease (pancreatic t...
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Masatoshi Isogai Source Type: research
Pathophysiology of severe gallstone pancreatitis: A new paradigm
World J Gastroenterol. 2024 Feb 21;30(7):614-623. doi: 10.3748/wjg.v30.i7.614.ABSTRACTSevere gallstone pancreatitis (GSP) refractory to maximum conservative therapy has wide clinical variations, and its pathophysiology remains controversial. This Editorial aimed to investigate the pathophysiology of severe disease based on Opie's theories of obstruction, the common channel, and duodenal reflux and describe its types. Severe GSP might be a hybrid disease with pathology polarized between acute cholangitis with mild pancreatitis (biliary type) and necrotizing pancreatitis uncomplicated with biliary tract disease (pancreatic t...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Masatoshi Isogai Source Type: research
Pathophysiology of severe gallstone pancreatitis: A new paradigm
World J Gastroenterol. 2024 Feb 21;30(7):614-623. doi: 10.3748/wjg.v30.i7.614.ABSTRACTSevere gallstone pancreatitis (GSP) refractory to maximum conservative therapy has wide clinical variations, and its pathophysiology remains controversial. This Editorial aimed to investigate the pathophysiology of severe disease based on Opie's theories of obstruction, the common channel, and duodenal reflux and describe its types. Severe GSP might be a hybrid disease with pathology polarized between acute cholangitis with mild pancreatitis (biliary type) and necrotizing pancreatitis uncomplicated with biliary tract disease (pancreatic t...
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Masatoshi Isogai Source Type: research
Pathophysiology of severe gallstone pancreatitis: A new paradigm
World J Gastroenterol. 2024 Feb 21;30(7):614-623. doi: 10.3748/wjg.v30.i7.614.ABSTRACTSevere gallstone pancreatitis (GSP) refractory to maximum conservative therapy has wide clinical variations, and its pathophysiology remains controversial. This Editorial aimed to investigate the pathophysiology of severe disease based on Opie's theories of obstruction, the common channel, and duodenal reflux and describe its types. Severe GSP might be a hybrid disease with pathology polarized between acute cholangitis with mild pancreatitis (biliary type) and necrotizing pancreatitis uncomplicated with biliary tract disease (pancreatic t...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Masatoshi Isogai Source Type: research
Pathophysiology of severe gallstone pancreatitis: A new paradigm
World J Gastroenterol. 2024 Feb 21;30(7):614-623. doi: 10.3748/wjg.v30.i7.614.ABSTRACTSevere gallstone pancreatitis (GSP) refractory to maximum conservative therapy has wide clinical variations, and its pathophysiology remains controversial. This Editorial aimed to investigate the pathophysiology of severe disease based on Opie's theories of obstruction, the common channel, and duodenal reflux and describe its types. Severe GSP might be a hybrid disease with pathology polarized between acute cholangitis with mild pancreatitis (biliary type) and necrotizing pancreatitis uncomplicated with biliary tract disease (pancreatic t...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Masatoshi Isogai Source Type: research
Pathophysiology of severe gallstone pancreatitis: A new paradigm
World J Gastroenterol. 2024 Feb 21;30(7):614-623. doi: 10.3748/wjg.v30.i7.614.ABSTRACTSevere gallstone pancreatitis (GSP) refractory to maximum conservative therapy has wide clinical variations, and its pathophysiology remains controversial. This Editorial aimed to investigate the pathophysiology of severe disease based on Opie's theories of obstruction, the common channel, and duodenal reflux and describe its types. Severe GSP might be a hybrid disease with pathology polarized between acute cholangitis with mild pancreatitis (biliary type) and necrotizing pancreatitis uncomplicated with biliary tract disease (pancreatic t...
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Masatoshi Isogai Source Type: research
Pathophysiology of severe gallstone pancreatitis: A new paradigm
World J Gastroenterol. 2024 Feb 21;30(7):614-623. doi: 10.3748/wjg.v30.i7.614.ABSTRACTSevere gallstone pancreatitis (GSP) refractory to maximum conservative therapy has wide clinical variations, and its pathophysiology remains controversial. This Editorial aimed to investigate the pathophysiology of severe disease based on Opie's theories of obstruction, the common channel, and duodenal reflux and describe its types. Severe GSP might be a hybrid disease with pathology polarized between acute cholangitis with mild pancreatitis (biliary type) and necrotizing pancreatitis uncomplicated with biliary tract disease (pancreatic t...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Masatoshi Isogai Source Type: research
