Global seroprevalence of Zika virus in asymptomatic individuals: A systematic review
Conclusions/SignificanceThe study highlights the high heterogeneity and gaps in the distribution of seroprevalence. The implementation of standardized protocols and the development of tests with high specificity are essential for ensuring a valid comparison between studies. Equally crucial are vector surveillance and control methods to reduce the risk of emerging and re-emerging ZIKV outbreaks, whether caused byAe.aegypti orAe.albopictus or by the Asian or African ZIKV. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - April 17, 2024 Category: Tropical Medicine Authors: Paola Mariela Saba Villarroel Source Type: research
Comparative examination of breast cancer burden in sub-Saharan Africa, 1990-2019: estimates from Global Burden of Disease 2019 study
Conclusion
The results show the increasing burden of breast cancer in sub-Saharan Africa and provide valuable information on the trends of breast cancer and the risk factors attributable to breast cancer across sociodemographic index, region and country. These findings may inform health policies and improve the rational allocation of health resources. (Source: BMJ Open)
Source: BMJ Open - March 29, 2024 Category: General Medicine Authors: Igbokwe, K. K. Tags: Open access, Oncology Source Type: research
Dynamics of Plasmodium species and genotype diversity in adults with asymptomatic infection in Gabon
With 249 million estimated cases and 608,000 deaths worldwide in 2022 [1], malaria remains a public health concern. In endemic areas, individuals can be infected by different Plasmodium species and distinct genotypes of the same species. In serially collected samples, alleles disappearance and reappearance over time was described in asymptomatic infections, raising the question of whether a single blood sample is sufficient to characterize parasite diversity within-host [2]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - March 16, 2024 Category: Infectious Diseases Authors: Juliana Inoue, Annika Galys, Miriam Rodi, Dorothea Ekoka Mbassi, Ghyslain Mombo-Ngoma, Ay ôla A. Adegnika, Michael Ramharter, Rella Zoleko-Manego, Peter G. Kremsner, Benjamin Mordmüller, Jana Held Source Type: research
Low diagnostic performance of thick blood smears of 50 µl in comparison with direct examination of 10 µl blood and the leukoconcentration technique of 5ml blood among loiasis-suspected patients with low microfilaremia in Gabon, Central Africa, using the STARD-BLCM guidelines
The aim of this study was to determine performance indicators of thick blood smears of 50 µl (TBS-50), following the Standards for the Reporting of Diagnostic Accuracy Studies–Bayesian Latent Class Model (STAR... (Source: Parasites and Vectors)
Source: Parasites and Vectors - March 15, 2024 Category: Microbiology Authors: No é Patrick M’Bondoukwé, Matthieu Owono-Medang, Marie Noëlle Moussavou-Boussougou, Yvan Akoue, Valentin Migueba, Dmitry Bulaev, Anouk Neven, Luice Aurtin Joel James, Sylvie Alberte Ntsame Ella, Denise Patricia Mawili-Mboumba, Julienne Atsame, Michel Tags: Research Source Type: research
Analysis of diagnostic test outcomes in a large loiasis cohort from an endemic region: Serological tests are often false negative in hyper-microfilaremic infections
ConclusionNone of the tests demonstrated high sensitivity and specificity for loiasis. Indirect diagnostic assays were characterized by low specificity. Additionally, hyper-microfilaremic individuals often tested negative by RDT and ELISA, indicating that these tests are not suitable for individual case management in endemic populations. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 14, 2024 Category: Tropical Medicine Authors: Luzia Veletzky Source Type: research
HIV protease resistance mutations in patients receiving second-line antiretroviral therapy in Libreville, Gabon
In 2022, the WHO reported that 29.8 million people around the world were living with HIV (PLHIV) and receiving antiretroviral treatment (ART), including 25 375 people in Gabon (54% of all those living with HI... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - March 14, 2024 Category: Infectious Diseases Authors: Guy Francis Nzengui-Nzengui, Ga ël Mourembou, Hervé M’boyis-Kamdem, Ayawa Claudine Kombila-Koumavor and Angélique Ndjoyi-Mbiguino Tags: Research Source Type: research
Local people enhance our understanding of Afrotropical frugivory networks
Curr Biol. 2024 Feb 23:S0960-9822(24)00166-0. doi: 10.1016/j.cub.2024.02.026. Online ahead of print.ABSTRACTAfrotropical forests are undergoing massive change caused by defaunation, i.e., the human-induced decline of animal species,1 most of which are frugivorous species.1,2,3 Frugivores' depletion and their functional disappearance are expected to cascade on tree dispersal and forest structure via interaction networks,4,5,6,7 as the majority of tree species depend on frugivores for their dispersal.8 However, frugivory networks remain largely unknown, especially in Afrotropical areas,9,10,11 which considerably limits our a...
Source: Current Biology - March 7, 2024 Category: Biology Authors: Cl émentine Durand-Bessart Etienne Fran çois Akomo-Okoue Ghislain Wilfried Ebang Ella Vincent Porcher Paul Yannick Bitome Essono Fran çois Bretagnolle Colin Fontaine Source Type: research
Local people enhance our understanding of Afrotropical frugivory networks
Curr Biol. 2024 Feb 23:S0960-9822(24)00166-0. doi: 10.1016/j.cub.2024.02.026. Online ahead of print.ABSTRACTAfrotropical forests are undergoing massive change caused by defaunation, i.e., the human-induced decline of animal species,1 most of which are frugivorous species.1,2,3 Frugivores' depletion and their functional disappearance are expected to cascade on tree dispersal and forest structure via interaction networks,4,5,6,7 as the majority of tree species depend on frugivores for their dispersal.8 However, frugivory networks remain largely unknown, especially in Afrotropical areas,9,10,11 which considerably limits our a...
Source: Current Biology - March 7, 2024 Category: Biology Authors: Cl émentine Durand-Bessart Etienne Fran çois Akomo-Okoue Ghislain Wilfried Ebang Ella Vincent Porcher Paul Yannick Bitome Essono Fran çois Bretagnolle Colin Fontaine Source Type: research
Evidence for circulation of Rift Valley fever virus in wildlife and domestic animals in a forest environment in Gabon, Central Africa
by Pierre Becquart, Linda Bohou Kombila, Telstar Ndong Mebaley, Christophe Paupy, D éborah Garcia, Nicolas Nesi, Marie-Marie Olive, Jessica Vanhomwegen, Larson Boundenga, Illich Manfred Mombo, Camille Piro-Mégy, Matthieu Fritz, Léadisaelle Hosanna Lenguiya, Meriadeg Ar Gouilh, Eric M. Leroy, Nadine N’Dilimabaka, Catherine Cêtre-Sossah, Gael Darren Maganga
Rift Valley fever (RVF) is a mosquito-borne viral zoonosis caused by the Rift Valley fever virus (RVFV) that can infect domestic and wild animals. Although the RVFV transmission cycle has been well documented across Africa in savanna ecosystems, little is known abo...
Source: PLoS Neglected Tropical Diseases - March 1, 2024 Category: Tropical Medicine Authors: Pierre Becquart Source Type: research
Validation of artificial intelligence-based digital microscopy for automated detection of < i > Schistosoma haematobium < /i > eggs in urine in Gabon
ConclusionOverall, the performance of the Schistoscope was non-inferior to conventional microscopy with a comparable sensitivity, although the specificity varied. The Schistoscope shows promising diagnostic accuracy, particularly for samples with moderate to higher infection intensities as well as for banked sample slides, highlighting the potential for retrospective analysis in resource-limited settings. Trial registrationNCT04505046 ClinicalTrials.gov. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - February 23, 2024 Category: Tropical Medicine Authors: Brice Meulah Source Type: research
Bayesian spatio-temporal analysis of malaria prevalence in children between 2 and 10 years of age in Gabon
Gabon still bears significant malaria burden despite numerous efforts. To reduce this burden, policy-makers need strategies to design effective interventions. Besides, malaria distribution is well known to be ... (Source: Malaria Journal)
Source: Malaria Journal - February 23, 2024 Category: Infectious Diseases Authors: Fabrice Mougeni, Bertrand Lell, Ngianga-Bakwin Kandala and Tobias Chirwa Tags: Research Source Type: research
Molecular characterization of Haemoproteus enucleator with emphasis on the host and geographic distribution
This study combined microscopic and molecular approaches to characterize Haemoproteus enucleator morphologically and molecularly. Blood samples were collected from the African pygmy kingfisher Ispidina picta in Cameroon, and the parasite was identified using morphological characters of gametocytes. The analysis of partial cytochrome b sequences (cytb) identified a new Haemoproteus lineage (hISPIC03), which was linked to the morphospecies H. enucleator. Illustrations of blood stages were provided and the phylogenetic analysis showed that the new lineage clustered with five other closely related lineages belonging to the sam...
Source: Acta Tropica - February 19, 2024 Category: Infectious Diseases Authors: M élanie Tchoumbou Josef Harl Aladji Souaibou Tatjana Iezhova Gediminas Valki ūnas Source Type: research
Molecular characterization of Haemoproteus enucleator with emphasis on the host and geographic distribution
This study combined microscopic and molecular approaches to characterize Haemoproteus enucleator morphologically and molecularly. Blood samples were collected from the African pygmy kingfisher Ispidina picta in Cameroon, and the parasite was identified using morphological characters of gametocytes. The analysis of partial cytochrome b sequences (cytb) identified a new Haemoproteus lineage (hISPIC03), which was linked to the morphospecies H. enucleator. Illustrations of blood stages were provided and the phylogenetic analysis showed that the new lineage clustered with five other closely related lineages belonging to the sam...
Source: Acta Tropica - February 19, 2024 Category: Infectious Diseases Authors: M élanie Tchoumbou Josef Harl Aladji Souaibou Tatjana Iezhova Gediminas Valki ūnas Source Type: research
Current Resistance of HIV-1 Strains Isolated in Volunteer Blood Donors in Gabon
AIDS Research and Human Retroviruses, Ahead of Print. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - February 19, 2024 Category: Infectious Diseases Authors: Christian Mangala Denis Maulot-Bangola Alain Moutsinga Anges Gar Wamba Serge Christian Okolongo-Mayani Joseph Fokam Source Type: research
Carbapenem-producing Enterobacteriaceae in mothers and newborns in southeast Gabon, 2022
This study, conducted at Franceville hospital's maternity and neonatology wards from February 22nd to June 20th, 2022, investigated the prevalence of CPE in 197 parturients and 203 newborns. Rectal swabs were taken from parturients before delivery and from newborns 30 minutes after birth. Blood culture samples were collected if signs of infection were observed in newborns during a 28-day follow-up. A total of 152 environmental samples were obtained, comprising 18 from sinks, 14 from incubators, 27 from cradles, 39 from maternal beds, 14 from tables and desks, four from the two baby scales and 36 from bedside furniture.Resu...
Source: Frontiers in cellular and infection microbiology - February 8, 2024 Category: Microbiology Source Type: research
