Researchers discover cellular messengers communicate with bacteria in the mouth
This study establishes that there is a clear channel of communication between RNA messengers and bacteria in our mouth,” said Wong, who holds the Felix and Mildred Yip Endowed Chair in Dentistry. “Furthermore, we have shown that these messengers may play an important role in mediating interac tions between bacteria and their host.”Another significant study finding was the majority of tRNA bacteria sequences that show high sequence similarity with salivary tsRNAs came from antibiotic-resistant Gram-negative bacteria. This observation could lead to a better understanding of the mechanisms behind the growth of oral bact...
Source: UCLA Newsroom: Health Sciences - May 9, 2018 Category: Universities & Medical Training Source Type: news
UCLA researchers discover cellular messengers communicate with bacteria in the mouth
This study establishes that there is a clear channel of communication between RNA messengers and bacteria in our mouth,” said Wong, who holds the Felix and Mildred Yip Endowed Chair in Dentistry. “Furthermore, we have shown that these messengers may play an important role in mediating interac tions between bacteria and their host.”Another significant study finding was the majority of tRNA bacteria sequences that show high sequence similarity with salivary tsRNAs came from antibiotic-resistant Gram-negative bacteria. This observation could lead to a better understanding of the mechanisms behind the growth of oral bact...
Source: UCLA Newsroom: Health Sciences - May 7, 2018 Category: Universities & Medical Training Source Type: news
Inhibition of Oral Pathogens Adhesion to Human Gingival Fibroblasts by Wine Polyphenols Alone and in Combination with an Oral Probiotic
Lots of you will enjoy this research! MJ J. Agric. Food Chem., Article ASAPDOI:10.1021/acs.jafc.7b05466Publication Date (Web): February 21, 2018 AbstractSeveral benefits have been described for red wine polyphenols and probiotic strains in the promotion of colonic metabolism and health. On the contrary, knowledge about their role in the management of oral health is still scarce. In this work, the antiadhesive capacity of selected red wine polyphenols and oenological extracts against the oral pathogensPorphyromonas gingivalis,Fusobacterium nucleatum, andStreptococcus mutans in an in vitro model of human gingival f...
Source: Dental Technology Blog - February 27, 2018 Category: Dentistry Source Type: news
Influence of the oscillation frequency of different side-to-side toothbrushes on noncontact biofilm removal
ConclusionsThe oscillation frequency of the tested side-to-side toothbrushes affected the biofilm reduction in an interdental space model.Clinical relevanceWithin a toothbrush, higher oscillation frequencies may lead to beneficial effects on interdental biofilm removal by noncontact brushing. (Source: Dental Technology Blog)
Source: Dental Technology Blog - February 5, 2018 Category: Dentistry Source Type: news
Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer
Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides, Selenomonas, and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. In situ hybridization analysis revealed that Fusobacterium is predominantly associated with cancer cells in the metastatic les...
Source: ScienceNOW - December 14, 2017 Category: Science Authors: Bullman, S., Pedamallu, C. S., Sicinska, E., Clancy, T. E., Zhang, X., Cai, D., Neuberg, D., Huang, K., Guevara, F., Nelson, T., Chipashvili, O., Hagan, T., Walker, M., Ramachandran, A., Diosdado, B., Serna, G., Mulet, N., Landolfi, S., Ramon y Cajal, S., Tags: Medicine, Diseases reports Source Type: news
Why Is This Bacterium Hiding in Human Tumors?
Whether Fusobacterium nucleatum causes colon tumors is unknown. But a new study hints that it may be ‘ an integral part of the cancer. ’ (Source: NYT Health)
Source: NYT Health - November 24, 2017 Category: Consumer Health News Authors: GINA KOLATA Tags: Colon and Colorectal Cancer Bacteria Tumors Dana-Farber Cancer Institute Source Type: news
Cancer-death button gets jammed by gut bacterium
(Michigan Medicine - University of Michigan) Researchers at Michigan Medicine and in China showed that a type of bacterium is associated with the recurrence of colorectal cancer and poor outcomes. They found that Fusobacterium nucleatum in the gut can stop chemotherapy from causing a type of cancer cell death called apoptosis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 27, 2017 Category: Cancer & Oncology Source Type: news
Study suggests link between imbalanced gut microbiome and systemic sclerosis
This study is the first to examine gastrointestinal bacterial composition in two independent groups of people with systemic sclerosis. Systemic sclerosis, also known as scleroderma, is an autoimmune disease affecting the body ’s connective tissue. It is characterized by a hardening and scarring of skin and can progress to inflammation and scarring in the organs such as kidneys, heart, lungs and gastrointestinal tract. Previous UCLA-led research detailed a link between the disease and the imbalance in the gut microbiome and suggested that this imbalance contributed to scleroderma’s symptoms.METHODThe researchers stud...
Source: UCLA Newsroom: Health Sciences - May 12, 2017 Category: Universities & Medical Training Source Type: news
Oral bacterium related esophageal cancer prognosis in Japanese patients
(Kumamoto University) A type of bacterium usually found in the human mouth, Fusobacterium nucleatum (F. nucleatum), has been found to be related to the prognosis of esophageal cancer in Japanese patients by researchers from Kumamoto University, Japan. The bacteria are a causative agent of periodontal disease and though it can be found among the intestinal flora, it hasn't been the focus of much research until now. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 8, 2016 Category: Global & Universal Source Type: news
Vaccine may help diseases in animals, people meet their match
(Kansas State University) Kansas State University researchers have patented a vaccine that provides effective, antibiotic-free prevention and treatment of Fusobacterium necrophorum infection, which affects animals and people. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 4, 2016 Category: Global & Universal Source Type: news
Consider Fusobacterium in culture-negative pharyngitis
BOSTON – An underappreciated cause of bacterial pharyngitis had a similar clinical presentation to group A Streptococcus (GAS), although prevalence was low in the population of 300 pediatric... (Source: Pediatric News)
Source: Pediatric News - June 21, 2016 Category: Journals (General) Source Type: news
Your NEJM Group Today: Contagious Ecthyma Images, Fusobacterium & Pharyngitis Blog, Indiana Internal Medicine Opportunities (FREE)
By The Editors
NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today: … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - February 23, 2015 Category: Primary Care Source Type: news
When strep throat is something else: Forgotten bacterium is cause of many severe sore throats in young adults
New research suggests that Fusobacterium necrophorum more often causes severe sore throats in young adults than streptococcus — the cause of the much better known strep throat. The findings, suggest physicians should consider F. necrophorum when treating severe sore throat in young adults and adolescents that worsens. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 17, 2015 Category: Science Source Type: news
