Food as Medicine: Food Insecurity and HIV-related Comorbidities, Coinfections, and Complications within the Mission of the NIDDK (R01 Clinical Trial Optional)
This funding opportunity announcement (FOA) seeks US domestic research projects that address how food insecurity effects HIV comorbidities, coinfections, and complications (CCCs) within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The approaches may address the pathways linking food insecurity and the development or exacerbation of CCCs; or they may evaluate the mechanisms whereby interventions that alleviate food insecurity improve CCCs. These mechanisms could be related to nutritional inadequacies or patient health-related behaviors.RFA-DK-19-019 (Source: NIDDK Funding Opportunities)
Source: NIDDK Funding Opportunities - August 30, 2019 Category: Endocrinology Source Type: funding
Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UG3/UH3 Clinical Trial Required)
The National Institutes of Health (NIH) participating Institutes and Centers, in coordination with the U.S. Food and Drug Administration (FDA), seeks highly meritorious clinical trial applications proposing to explore and enable the development of safe and effective regenerative medicine (RM) interventions using adult stem cells. This Funding Opportunity Announcement (FOA), issued as part of the Regenerative Medicine Innovation Project (RMIP), represents one step in fulfilling a statutory provision set forth in the 21st Century Cures Act. Applications submitted in response to this bi-phasic, milestone-driven cooperative ag...
Source: NIDDK Funding Opportunities - August 14, 2019 Category: Endocrinology Source Type: funding
SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance (SB1, R44) Clinical Trial Not Allowed
The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from small business concerns (SBCs) to the newly re-authorized Commercialization Readiness Pilot (CRP) program. The FOA aims to facilitate the transition of previously funded SBIR and STTR Phase II and Phase IIB projects to the commercialization stage by providing additional support for technical assistance not typically supported through Phase II or Phase IIB grants or contracts. This may include preparation of documents for a Food and Drug Administration (FDA) submission, development of an intellectual property strategy, and/or planni...
Source: NIDDK Funding Opportunities - August 5, 2019 Category: Endocrinology Source Type: funding
SBIR/STTR Commercialization Readiness Pilot (CRP) Program Technical Assistance and Late Stage Development (SB1, R44) Clinical Trial Not Allowed
The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications from small business concerns (SBCs) to the newly re-authorized Commercialization Readiness Pilot (CRP) program. The FOA aims to facilitate the transition of previously or currently funded SBIR and STTR Phase II and Phase IIB projects to the commercialization stage by providing additional support for technical assistance and later stage research and development (R and D) not typically supported through Phase II or Phase IIB grants or contracts. This may include independent replication of key studies, Investigational New Drug (IND)-enabli...
Source: NIDDK Funding Opportunities - August 5, 2019 Category: Endocrinology Source Type: funding
Catalyst Award In Diabetes, Endocrinology and Metabolic Diseases (DP1 Clinical Trial Not Allowed)
The Catalyst Award in Diabetes, Endocrinology and Metabolic Diseases (Catalyst-DEMD) is designed to complement NIDDK's traditional, investigator-initiated grant programs by supporting individual scientists who propose pioneering andtransformational studies in DEMD topic areas. Applications should be focused on major scientific challenges, and have the potential to produce an unusually high impact on diseases and conditions that are central to the mission of NIDDK's Division of Diabetes, Endocrinology and Metabolic Diseases. To be considered responsive to this initiative, the proposed research should reflect new and novel s...
Source: NIDDK Funding Opportunities - July 31, 2019 Category: Endocrinology Source Type: funding
Request for Information (RFI): Precision Nutrition Tools for Continuous Monitoring of Nutrients and Metabolites in Humans
The purpose of this Request for Information (RFI) is to solicit public input to advance precision nutrition research, specifically related to the availability of tools for continuous monitoring of nutrients and metabolites. The information respondents provide will help characterize what monitoring technologies are currently available for precision nutrition research approaches as well as identify key priorities and recommendations for future research efforts.Christopher Lynch, Ph.D. | NOT-DK-19-021 (Source: NIDDK Funding Opportunities)
Source: NIDDK Funding Opportunities - July 29, 2019 Category: Endocrinology Source Type: funding
NIDDK Central Repositories Non-renewable Sample Access (X01 Clinical Trial Not Allowed)
The NIDDK Central Repositories house valuable biological samples and data from numerous major clinical studies. This initiative allows investigators to apply for access to non-renewable samples from one or more of these studies. Information about the samples available can be found at https://repository.niddk.nih.gov. Applicants must provide a report from the NIDDK Central Repositories documenting sample availability.PAR-19-319 (Source: NIDDK Funding Opportunities)
Source: NIDDK Funding Opportunities - July 29, 2019 Category: Endocrinology Source Type: funding
Central Coordinating Site for the Polycystic Kidney Disease Research and Translation Core Centers (U24 Clinical Trial Not Allowed)
This Funding Opportunity Announcement (FOA) requests applications for the Central Coordinating Site (CCS) for the Polycystic Kidney Disease (PKD) Research and Translation Core Centers (RTCC). The CCS is expected to work collaboratively with four RTCCs as part of the PKD Research Consortium and serve as a national resource for the larger research community. The CCS will provide central administrative and communications support for the Consortium. All activities within the Consortium are expected to address the overall goal of improving our understanding of the pathogenesis, progression, prevention and clinical management of...
Source: NIDDK Funding Opportunities - July 26, 2019 Category: Endocrinology Source Type: funding
Polycystic Kidney Disease Research and Translation Core Centers (U54 Clinical Trial Not Allowed)
This Funding Opportunity Announcement (FOA) requests applications for Polycystic Kidney Disease (PKD) Research and Translation Core Centers (RTCC). The RTCCs are expected to work collaboratively with the Central Coordinating Site (CCS) as part of a PKD Research Consortium and serve as a national resource for the larger research community. The RTCCs should develop and share research resources (e.g. reagents, tools etc.), services and expertise that would be difficult or impractical to support in individual labs. The FOA is open to new applications, not renewals. Previously funded PKD Centers may apply as new centers.Christi...
Source: NIDDK Funding Opportunities - July 26, 2019 Category: Endocrinology Source Type: funding
Request for Information (RFI): Swallowable Smart Pills or Devices to Enable Precision Nutrition, Microbiome and Gastroenterological Research
The purpose of this Request for Information (RFI) is to solicit public input to inform efforts aimed at advancing the development of and accessibility to devices that enable clinical gastroenterological procedures on awake individuals and research on dietary components-host interactions and gut microbiota ecology in discrete gastrointestinal (GI) regions, with the focus on advancing host-diet microbial interactions. The information respondents provide will help characterize what technologies are currently available to facilitate the study of discrete regions of the human GI tract as well as identify key priorities and reco...
Source: NIDDK Funding Opportunities - July 25, 2019 Category: Endocrinology Source Type: funding
(Re)Building a Kidney (UC2 Clinical Trial Not Allowed)
This FOA invites new applications for the (Re)Building a Kidney (RBK) Consortium. The goal of the RBK is to improve or restore failing kidney function after injury or disease. This FOA invites teams of investigators with complementary expertise to develop and test novel ways to either (1) stimulate productive kidney repair/regeneration in vivo, or (2) generate functional kidney tissue ex vivo for transplantation.RFA-DK-19-007 (Source: NIDDK Funding Opportunities)
Source: NIDDK Funding Opportunities - July 22, 2019 Category: Endocrinology Source Type: funding
Early-Stage Preclinical Validation of Therapeutic Leads for Diseases of Interest to the NIDDK (R01 Clinical Trial Not Allowed)
The goal of this Funding Opportunity Announcement (FOA) is to support translational research that provides strong justification for later-phase therapeutics discovery and development efforts in health-related outcomes relevant to the National Institute of Diabetes and Digestive and Kidney Diseases. This includes outcomes relevant to obesity, diabetes and related aspects of endocrinology and metabolism, digestive diseases, liver diseases, nutrition, kidney and urological diseases, and hematology. Additional information concerning programmatic areas at NIDDK is available a www.niddk.nih.gov/research-funding/research-programs...
Source: NIDDK Funding Opportunities - June 6, 2019 Category: Endocrinology Source Type: funding
Adipogenesis, Adipocyte Function and Obesity Following HIV Infection, Antiretroviral Therapy, or Pre-Exposure Prophylaxis (R01 Clinical Trial Optional)
The prevalence of obesity is increasing in people with HIV (PWH), contributing to multiple complications associated with this condition. There is mounting evidence that there are unique mechanisms contributing to the development of obesity in PWH versus people without HIV. Furthermore, the biology of the adipocytes might be altered in overweight or obese PWH versus overweight or obese people without HIV. This FOA seeks applications to elucidate the underlying mechanisms of how HIV and antiretroviral drugs used for therapy or pre-exposure prophylaxis contribute to the development of obesity and alter adipocyte and adipose t...
Source: NIDDK Funding Opportunities - May 29, 2019 Category: Endocrinology Source Type: funding
Methods to Improve Reproducibility of Human iPSC Derivation, Growth and Differentiation (SBIR) (R44 Clinical Trial Not Allowed)
Human induced pluripotent stem cells (iPSCs) have been used with great success to mimic the differentiation of a variety of tissues, understand early development and study human diseases. Despite approaches that have made the derivation, growth and differentiation of iPSCs more efficient, there remains significant variability in reprogramming efficacy, genomic integrity and developmental potential of iPSCs derived from a single fibroblast or tissue sample. Thus, iPSCs derived from the same sample may differ in their in vitro growth characteristics and their ability to re-differentiate into the desired tissue type. A variet...
Source: NIDDK Funding Opportunities - May 21, 2019 Category: Endocrinology Source Type: funding
Methods to Improve Reproducibility of Human iPSC Derivation, Growth and Differentiation (SBIR) (R44 Clinical Trial Not Allowed)
Human induced pluripotent stem cells (iPSCs) have been used with great success to mimic the differentiation of a variety of tissues, understand early development and study human diseases. Despite approaches that have made the derivation, growth and differentiation of iPSCs more efficient, there remains significant variability in reprogramming efficacy, genomic integrity and developmental potential of iPSCs derived from a single fibroblast or tissue sample. Thus, iPSCs derived from the same sample may differ in their in vitro growth characteristics and their ability to re-differentiate into the desired tissue type. A variet...
Source: NIDDK Funding Opportunities - May 21, 2019 Category: Endocrinology Source Type: funding
