Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction. Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group. Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Failing Mitochondrial Quality Control in Aging and Neurodegeneration
Every one of our cells contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now fully integrated into our biochemistry. Mitochondria contain their own small remnant genome, the mitochondrial DNA, replicate like bacteria, and toil to produce adenosine triphosphate (ATP), a chemical energy store molecule used to power cell processes. Mitochondrial function declines with age, unfortunately, and our cells suffer for it. This contributes meaningfully to many age-related conditions. This decline appears to result in large part from changes in gene expression that impair the various quality control pro...
Source: Fight Aging! - January 2, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Treating a Mouse Model of Alzheimer's Disease with Hematopoietic Stem Cell Transplantation
Overly reactive, senescent, and otherwise inflammatory microglia in the brain are implicated in the development of neurodegenerative conditions. Chronic inflammation in brain tissue disrupts neural function in numerous ways. Thus why not clear or replace microglia? There are established ways to remove these cells, allowing them to regenerative over a few weeks, but these have not yet made their way to human trials for neurodegenerative conditions, despite interesting results in animal models. The replacement of microglia via transplantation of hematopoietic cells is at a similar stage, wherein there are interesting results...
Source: Fight Aging! - August 17, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Carving Up Brain Disorders
Neurology and Psychiatry are two distinct specialties within medicine, both of which treat disorders of the brain. It's completely uncontroversial to say that neurologists treat patients with brain disorders like Alzheimer's disease and Parkinson's disease. These two diseases produce distinct patterns of neurodegeneration that are visible on brain scans. For example, Parkinson's disease (PD) is a movement disorder caused by the loss of dopamine neurons in the midbrain.Fig. 3 (modified from Goldstein et al., 2007). Brain PET scans superimposed on MRI scans. Note decreased dopamine signal in the putamen and substantia nigra ...
Source: The Neurocritic - November 28, 2015 Category: Neuroscience Authors: The Neurocritic Source Type: blogs

A Brief Look at Retrotope
Today, I'll point out the early stage company Retrotope, more out of curiosity than as an example of a research and development strategy that I'd favor pursuing. They don't make it terribly easy to see exactly what they're up to, as seems to be the trend for the online presence of young biotech companies these days, but the digest is that the staff there are trying to build therapies based on substituting deuterium for hydrogen in some of the molecules employed in cellular structure and machinery. As long-time readers will no doubt recall, a slow trickle of evidence has arrived over the past decade to suggest that replaci...
Source: Fight Aging! - October 30, 2015 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, January 7th 2013
Discussion - Latest Headlines from Fight Aging!     - Dopamine Receptor Variant Associated With Longevity     - UCP1 Extends Longevity Via Hormesis?     - TFP5 Shows Promise for Treating Alzheimer's Disease     - Does Lichen Age?     - A French Interview with Aubrey de Grey     - Reduced Frataxin Expression Extends Life in Nematodes     - In Search of the Roots of Heat Shock Hormesis     - A New Record For Human Male Longevity     - Early Growth ...
Source: Fight Aging! - January 6, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Newsletters Source Type: blogs

Reduced Frataxin Expression Extends Life in Nematodes
Many of the methods of extending life in laboratory animals involve boosting levels of autophagy, the cellular housekeeping processes that remove damaged components and unwanted proteins. Here is another of them: Severe mitochondria deficiency leads to a number of devastating degenerative disorders, yet, mild mitochondrial dysfunction in different species, including the nematode Caenorhabditis elegans, can have pro-longevity effects. This apparent paradox indicates that cellular adaptation to partial mitochondrial stress can induce beneficial responses, but how this is achieved is largely unknown. Complete absence of fr...
Source: Fight Aging! - January 2, 2013 Category: Health Medicine and Bioethics Commentators Authors: Reason Tags: Daily News Source Type: blogs