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Incidence of Acanthamoeba Keratitis in the United Kingdom in 2015: A Prospective National Survey
CONCLUSIONS: This study provides the first published data on the nationwide incidence of AK in the United Kingdom. The findings confirm an increasing incidence of AK, particularly among contact lens wearers since 1997/8 to 1998/9. PRSCLs were identified as a significant risk factor compared with DDSCLs. Misdiagnosis and treatment delays remain an ongoing problem for patients with AK.PMID:38097200 | DOI:10.1097/ICO.0000000000003445 (Source: Herpes)
Source: Herpes - December 14, 2023 Category: Infectious Diseases Authors: Haneen Jasim Mariusz Grzeda Barny Foot Derek Tole Jeremy J Hoffman Source Type: research

Proteases of Acanthamoeba
Parasitol Res. 2023 Dec 8;123(1):19. doi: 10.1007/s00436-023-08059-z.ABSTRACTThe members of genus Acanthamoeba are the etiological agent of uncommon but severe or even fatal opportunistic infections in human beings. The presence of different classes of intracellular and extracellular proteases including serine proteases, cysteine proteases, and metalloproteases has been well documented in environmental and clinical isolates of Acanthamoeba spp. However, the role of the proteolytic enzymes in physiological, biological, and pathological mechanisms of the amoeba remains partially investigated. Some attempts have been conducte...
Source: Cell Research - December 8, 2023 Category: Cytology Authors: Behroz Mahdavi Poor Jalil Rashedi Vahid Asgharzadeh Amirali Mirmazhary Nazila Gheitarani Source Type: research

The First Case of Cutaneous Acanthamoebiasis Caused by < em > Acanthamoeba triangularis < /em > in Korea
Ann Dermatol. 2023 Nov;35(Suppl 2):S275-S280. doi: 10.5021/ad.21.293.ABSTRACTA 62-year-old man with multiple myeloma visited our clinic with multiple painful erythematous to purpuric nodules on his whole body. He received a skin biopsy which showed septal and lobular inflammation with vasculitis, and multiple amoebic organisms were found. Polymerase chain reaction and culture were performed and an Acanthamoeba triangularis infection was diagnosed. This is the first report on cutaneous acanthamoebiasis caused by A. triangularis, suggesting that A. triangularis should be regarded as a clinical pathogen that can cause ocular ...
Source: Annals of Dermatology - December 7, 2023 Category: Dermatology Authors: Mi Soo Choi Na Hye Myong Min Seo Sukbin Jang Dae Kwan Yun Kyujin Yeom Dong-Il Chung Byung Cheol Park Yeonchul Hong Myung Hwa Kim Source Type: research

Cell death of Acanthamoeba castellanii following exposure to antimicrobial agents commonly included in contact lens disinfecting solutions
Parasitol Res. 2023 Dec 7;123(1):16. doi: 10.1007/s00436-023-08061-5.ABSTRACTSeveral antimicrobial agents are commonly included in contact lens disinfectant solutions including chlorhexidine diacetate (CHX), polyhexamethylene biguanide (PHMB) or myristamidopropyl dimethylamine (MAPD); however, their mode of action, i.e. necrosis versus apoptosis is incompletely understood. Here, we determined whether a mechanism of cell death resembling that of apoptosis was present in Acanthamoeba castellanii of the T4 genotype (NEFF) following exposure to the aforementioned antimicrobials using the anticoagulant annexin V that undergoes ...
Source: Cell Research - December 7, 2023 Category: Cytology Authors: Louise Thomas Naveed Ahmed Khan Ruqaiyyah Siddiqui Bader S Alawfi David Lloyd Source Type: research

Discovery of the first unconventional myosin: < em > Acanthamoeba < /em > myosin-I
Front Physiol. 2023 Nov 17;14:1324623. doi: 10.3389/fphys.2023.1324623. eCollection 2023.ABSTRACTHaving characterized actin from Acanthamoeba castellanii (Weihing and Korn, Biochemistry, 1971, 10, 590-600) and knowing that myosin had been isolated from the slime mold Physarum (Hatano and Tazawa, Biochim. Biophys. Acta, 1968, 154, 507-519; Adelman and Taylor, Biochemistry, 1969, 8, 4976-4988), we set out in 1969 to find myosin in Acanthamoeba. We used K-EDTA-ATPase activity to assay myosin, because it is a unique feature of muscle myosins. After slightly less than 3 years, we purified a K-EDTA ATPase that interacted with ac...
Source: Biochimica et Biophysica Acta - December 4, 2023 Category: Biochemistry Authors: Thomas D Pollard Edward D Korn Source Type: research

The role of apoptosis and oxidative stress in the pathophysiology of Acanthamoeba spp. infection in the kidneys of hosts with different immunological status
Acanthamoeba spp. are opportunistic pathogens that cause inflammation, mostly in the brain, lungs and cornea. Recent reports indicate kidney dysfunction in hosts with systemic acanthamoebiasis. The aim of the stu... (Source: Parasites and Vectors)
Source: Parasites and Vectors - December 1, 2023 Category: Microbiology Authors: Karolina Kot, Patrycja Kupnicka, Maciej Tarnowski, Patrycja Tomasiak, Danuta Kosik-Bogacka and Natalia Łanocha-Arendarczyk Tags: Research Source Type: research

SA59 Clinical Evidence on Acanthamoeba Keratitis Treatments: Systematic Literature Review
Acanthamoeba keratitis (AK) is a rare, severe, progressive corneal infection with no approved medicinal treatments. To understand the existing evidence-base on AK treatments, we conducted a systematic literature review (CRD42022345288). (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: L. Tofani, D. Bodicoat, A. Alves, A. Arteaga, V. Papa Source Type: research

CO144 A Trial-Based Health Utility Analysis in Patients with Acanthamoeba Keratitis
To estimate the health-related quality of life (HRQoL) of patients with Acanthamoeba keratitis (AK) and to explore the impact of Acanthamoeba infection, treatment and visual acuity on HRQoL. (Source: Value in Health)
Source: Value in Health - December 1, 2023 Category: International Medicine & Public Health Authors: A. Alves, E. Spaepen, M. De Francesco, F. Gissara, L. Tofani Source Type: research

Kratosvirus quantuckense: the history and novelty of an algal bloom disrupting virus and a model for giant virus research
Since the discovery of the first “giant virus,” particular attention has been paid toward isolating and culturing these large DNA viruses through Acanthamoeba spp. bait systems. While this method has allowed for the discovery of plenty novel viruses in the Nucleocytoviricota, environmental -omics-based analyses have shown that there is a wealth of diversity among this phylum, particularly in marine datasets. The prevalence of these viruses in metatranscriptomes points toward their ecological importance in nutrient turnover in our oceans and as such, in depth study into non-amoebal Nucleocytoviricota should be considere...
Source: Frontiers in Microbiology - November 30, 2023 Category: Microbiology Source Type: research