The Beneficial Effects of Erbium:Yttrium-Aluminum-Garnet Laser in an Ulcer Caused by Lower Leg Arteriopathy
J Am Podiatr Med Assoc. 2021 Dec 15;111(6). doi: 10.7547/20-099.ABSTRACTAblative fractional laser is suggested to promote wound healing in diabetic and venous leg ulcers. In this article, we report the treatment outcome of a recalcitrant foot ulceration related to lower leg arteriopathy. A 43-year-old man with typical digital substraction angiographic findings of arteriopathy was admitted to our department after 30 sessions of hyperbaric oxygen therapy. There was heterotopic tissue within the ulcer consistent with osseous metaplasia and mature bone tissue. This tissue was removed with full-field erbium:yttrium-aluminum-gar...
Source: Journal of the American Podiatric Medical Association - January 21, 2022 Category: Podiatry Authors: Aysenur Botsali Ercan Caliskan Mustafa Tunca Source Type: research

Combination of Full-Field and Fractional Erbium: YAG Laser for Nonhealing Wounds
CONCLUSION Full-field erbium: YAG laser applications preserve the vascular architecture and enable delicate debridement. Ongoing maintenance fractional laser sessions promote wound healing. Similar to the previous reports of erbium: YAG laser in venous and diabetic ulcers, arterial ulcers, and ulcers of immunologic origin demonstrated an objective treatment response along with different adjuvant approaches. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - December 19, 2021 Category: Dermatology Tags: Original Article Source Type: research

Study of a 532/1064 Fractional Picosecond Laser for Facial Rejuvenation
CONCLUSION A ps 1,064/532 fractional laser achieves reduction in fine lines and pigment. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - December 19, 2021 Category: Dermatology Tags: Original Article Source Type: research

Cancers, Vol. 13, Pages 6326: Anti-PD-1 Therapy with Adjuvant Ablative Fractional Laser Improves Anti-Tumor Response in Basal Cell Carcinomas
In conclusion, local AFL shows substantial promise as an adjuvant to systemic aPD-1 therapy in a clinically relevant preclinical BCC model. (Source: Cancers)
Source: Cancers - December 16, 2021 Category: Cancer & Oncology Authors: Uffe H øgh Olesen Martin Wiinberg Catharina Margrethe Lerche Ditte Elisabeth J æhger Thomas Lars Andresen Merete Haedersdal Tags: Article Source Type: research

Topical delivery of PD-1 inhibitors with laser-assisted passive diffusion and active intradermal injection: Investigation of cutaneous pharmacokinetics and biodistribution patterns
This study aims to examine cutaneous pharmacokinetics and biodistribution of the PD-1 inhibitor nivolumab, locally delivered either by ablative fractional laser (AFL)-assisted passive diffusion or active intradermal injection, in vivo.MATERIALS AND METHODS: In vivo pig skin was either exposed to CO2 AFL (80 mJ/mb by two stacked pulses of 40 mJ/mb) at 5% or 15% density followed by topical application of nivolumab (1 mg/ml, 100 µl/10 × 10 mm) or intradermally injected with nivolumab (1 mg/ml, 100 µl). Cutaneous nivolumab delivery was evaluated at different timepoints (0, 1, 2, 4 hours and 2 days) at two tis...
Source: Cancer Control - December 3, 2021 Category: Cancer & Oncology Authors: Rikke L Christensen Kristoffer K Hendel Daniel P Persson S øren Husted Uffe H Olesen Merete Haedersdal Source Type: research

Topical delivery of PD-1 inhibitors with laser-assisted passive diffusion and active intradermal injection: Investigation of cutaneous pharmacokinetics and biodistribution patterns
This study aims to examine cutaneous pharmacokinetics and biodistribution of the PD-1 inhibitor nivolumab, locally delivered either by ablative fractional laser (AFL)-assisted passive diffusion or active intradermal injection, in vivo.MATERIALS AND METHODS: In vivo pig skin was either exposed to CO2 AFL (80 mJ/mb by two stacked pulses of 40 mJ/mb) at 5% or 15% density followed by topical application of nivolumab (1 mg/ml, 100 µl/10 × 10 mm) or intradermally injected with nivolumab (1 mg/ml, 100 µl). Cutaneous nivolumab delivery was evaluated at different timepoints (0, 1, 2, 4 hours and 2 days) at two tis...
Source: Cancer Control - December 3, 2021 Category: Cancer & Oncology Authors: Rikke L Christensen Kristoffer K Hendel Daniel P Persson S øren Husted Uffe H Olesen Merete Haedersdal Source Type: research

Efficacy Evaluation of 755-nm Long-Pulse Alexandrite Laser Combined with 0.5% Timolol Maleate Eye Drops in the Treatment of Thicker Infantile Hemangioma
Clin Cosmet Investig Dermatol. 2021 Nov 9;14:1621-1628. doi: 10.2147/CCID.S330411. eCollection 2021.ABSTRACTPURPOSE: Assessment of the clinical effectiveness and safety of 755-nm long-pulse alexandrite laser combined with 0.5% timolol maleate eye drops in treating thicker infantile hemangioma (IH).MATERIALS AND METHODS: Retrospective analysis of IH treated with 755-nm long-pulse alexandrite laser and topical timolol in the Second Affiliated Hospital of Wenzhou Medical University from October 2019 to October 2020. Seventy-eight cases were included, with a five-week laser treatment interval. Treatment status was documented d...
Source: Clinical, Cosmetic and Investigational Dermatology - November 17, 2021 Category: Dermatology Authors: Jianming Wu Fangyan Zhou Yu Gao Source Type: research

Optimizing Outcomes With the 1550/1927 nm Dual Wavelength Non-Ablative Fractional Laser: Experienced User Recommendations
CONCLUSIONS: This position paper provides practical real-world guidelines resulting from a small survey of experienced users, for new and early uses of the novel 1550 nm /1927 nm dual wavelength, non-ablative, fractional laser. J Drugs Dermatol. 2021;20(11):1150-1157. doi:10.36849/JDD.6181.PMID:34784135 | DOI:10.36849/jdd.6181 (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - November 16, 2021 Category: Dermatology Authors: Paul Friedman Anne Chapas Suzanne Kilmer Zakia Rahman Wendy Roberts E Ross Jill Waibel Jeffrey Dover Source Type: research

Comparative study of treatment for striae alba stage striae gravidarum: 1565-nm non-ablative fractional laser versus fractional microneedle radiofrequency
This study aims to compare the efficacy and safety of 1565-nm non-ablative fractional laser (NAFL) and fractional microneedle radiofrequency (MRF) for treatment of SA striae gravidarum. Fourteen Chinese women with SA striae gravidarum were included in this study. Patient abdomens were randomly divided into NAFL and MRF treatment sides, treated three times at 6-week intervals. Treatment efficacy was evaluated by subjective (clinical assessments, patient satisfaction rating, adverse effects assessment) assessments and objective (skin melanin index measurement, histological study) assessments. Clinical assessment suggested MR...
Source: Lasers in Medical Science - November 15, 2021 Category: Laser Surgery Source Type: research

Clinical and histological evaluation of a dual sequential application of fractional 10,600  nm and 1570 nm lasers, compared to single applications in a porcine model
This study aimed to assess and compare clinical effects, histological tissue damage, and wound healing after mono chromatic and sequential fractional laser treatments. In this prospective porcine model study, three adult female pigs were each irradiated using three different wavelengths: (a) monochromatic fractional ablative CO2 laser; (b) monochromatic fractional non-ablative 1570  nm laser; (c) sequential fractional 10,600 nm/CO2 followed by 1570  nm laser treatment. There were six power levels in the monochromatic 1570 nm laser, five in the 10,600 nm/CO2, and five in the sequential treatment. Th...
Source: Lasers in Medical Science - November 6, 2021 Category: Laser Surgery Source Type: research

Automated Microneedling Versus Fractional CO2 Laser in Treatment of Traumatic Scars: A Clinical and Histochemical Study
CONCLUSION In this small study, microneedling was as safe as fractional CO2 laser for rejuvenation of traumatic scars with comparable clinical effects. Fractional CO2 laser is more powerful in stimulating neocollagenesis. Automated microneedling is effective for treatment of hypertrophic scars. (Source: Dermatologic Surgery)
Source: Dermatologic Surgery - October 30, 2021 Category: Dermatology Tags: Original Article Source Type: research

Fractional carbon dioxide laser for treating hypertrophic scars: A systematic review of randomised trials
Australas J Dermatol. 2021 Oct 10. doi: 10.1111/ajd.13730. Online ahead of print.ABSTRACTHypertrophic scars present collagen deposition and an abnormal extracellular matrix that cause abnormal shape changes and limit normal movement. Although fractional carbon dioxide (CO2 ) laser therapy has provided promising evidence, the improvement of scarring has not been thoroughly reviewed. A systematic review of prospective randomised trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane and Scopus databases was conducted on 15 March 2020 in accordance with the PRISMA-P statement. Types and duration of fractional carbon ...
Source: The Australasian Journal of Dermatology - October 10, 2021 Category: Dermatology Authors: Irma Bernadette Simbolong Sitohang Sondang Aemilia P Sirait Fadhila Dea Safira Source Type: research

Q-S laser micro-drilling and multipass full-beam Q-S laser for tattoo removal — a case series
AbstractThe purpose of this study was to evaluate the safety and efficacy of a new combined method of Q-S laser-assisted tattoo removal. Ten patients with 13 professional, mostly mono-chromatic black tattoos were recruited. All tattoos received the same Q-S laser treatment sequence. An objective evaluation of tattoo clearing was assessed by careful analysis of a standardized collection of digital images taken from each tattoo, 2  months after each laser session, with the help of a custom-made pigment-fading percentage photographic ruler. The percentages of pigment clearance and side effects were evaluated by 4 indepen...
Source: Lasers in Medical Science - October 4, 2021 Category: Laser Surgery Source Type: research

246 Epidermal ablation reduces keratinocyte cancer occurrence by reducing skin mutation burden caused by chronic ultraviolet radiation
Ultra-Violet (UV) radiation from sunlight is the main carcinogen driving keratinocyte cancers of the skin. The accumulation of UV-induced mutations on sun-exposed areas leads to field cancerisation. Knowing the regenerative property of the skin, we investigated if epidermal ablation removes mutations on the epidermis and allows less mutated cells from the deeper part of the skin to repopulate the ablated surface. Patients with history of multiple epidermal cancers were subjected to epidermal ablation on their forearms with three different depths of laser (600nm, 400nm and fractional laser). (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - October 1, 2021 Category: Dermatology Authors: H. Wong, E. Roy, S. Kapadia, V. Murigneux, S. Chong, K. Khosrotehrani Source Type: research

Before-after cohort study to assess the efficacy of fractional ablative carbon dioxide laser treatment of pediatric hand scars
This study enrolled hand scar patients who received treatment in our hospital between May 2018 and April 2019. Patients were assigned to undergo AFXL surgery based on their personal intents and condition, whereas the fractional laser was used for stiffness and abnormal texture. Outcomes were as follows: hand function was evaluated using the Michigan hand outcomes questionnaire; scar condition was evaluated using the Vancouver scar scale and UNC4P scar scale. Total 30 pediatric patients (mean age, 11.4 years) were eligible for the study and laser-treated scars were significantly improved in Michigan hand outcomes questionna...
Source: Lasers in Medical Science - August 10, 2021 Category: Laser Surgery Source Type: research

Laser facilitated epicutaneous peptide immunization using dry patch technology
Vaccine. 2021 Aug 4:S0264-410X(21)00988-9. doi: 10.1016/j.vaccine.2021.07.083. Online ahead of print.ABSTRACTThe skin has been intensely investigated as a target tissue for immunization because it is populated by multiple types of antigen presenting cells. Directly addressing dendritic cells or Langerhans cells in vivo represents an attractive strategy for inducing T cell responses in cancer immunotherapy. We and others have studied fractional laser ablation as a novel method combining efficient delivery of macromolecules to the skin with an inherent adjuvant effect of laser illumination. In this proof of concept study, we...
Source: Vaccine - August 8, 2021 Category: Allergy & Immunology Authors: Sandra Scheiblhofer Stephan Drothler Werner Braun Reinhard Braun Maximilian Boesch Richard Weiss Source Type: research

Clinical efficacy of adipocyte-derived stem cells conditioned media combined with micro-injury in refractory patch of alopecia areata
This study aimed to evaluate the clinical efficacy and safety of ASC-CM combined with 10,600  nm carbon dioxide fractional laser or microneedling for the treatment of refractory patch of AA. This retrospective study was based on evaluations of 14 patients with a refractory patch of AA treated with ASC-CM, combined with a 10,600 nm carbon dioxide fractional laser, or microneedling from Mar ch 2017 to August 2020. The efficacy of treatment was assessed by extents of hair regrowth percentages of involved areas. Of the 14 enrolled patients, 9 (64.3%) showed >  50% hair regrowth and 6 patients (42.9%)...
Source: Archives of Dermatological Research - June 15, 2021 Category: Dermatology Source Type: research

Bleomycin administered by laser-assisted drug delivery or intradermal needle-injection results in distinct biodistribution patterns in skin: < em > in vivo < /em > investigations with mass spectrometry imaging
In conclusion, AFL and NI result in distinct cutaneous biodistribution patterns and pharmacokinetic profiles for BLM applied to in vivo skin. Evaluation of LSRs showed that both methods were similarly tolerable, and each method has potential for individualized approaches in a clinical setting.PMID:34121567 | DOI:10.1080/10717544.2021.1933649 (Source: Drug Delivery)
Source: Drug Delivery - June 14, 2021 Category: Drugs & Pharmacology Authors: Kristoffer Hendel Anders C N Hansen Liora Bik Charlotte Bagger Martijn B A van Doorn Christian Janfelt Uffe H Olesen Merete Haedersdal Catharina M Lerche Source Type: research

Effects of the lower energy and pulse stacking in carbon dioxide laser skin treatment: an objective analysis using second harmonic generation
CONCLUSIONS: When combined, the results obtained in this study regarding anisotropy, entropy and density tend to demonstrate that it is possible to achieve collagen remodeling with the use of lower power levels associated with stacked pulses.PMID:33978061 | PMC:PMC8112111 | DOI:10.1590/ACB360304 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - May 12, 2021 Category: Surgery Authors: Marcos Matias Motta Rafael Fantelli Stelini Davi Reis Calderoni Rovilson Gilioli Gislaine Vieira Damiani Carlos Lenz C ésar Paulo Kharmandayan Source Type: research

Effects of the lower energy and pulse stacking in carbon dioxide laser skin treatment: an objective analysis using second harmonic generation
CONCLUSIONS: When combined, the results obtained in this study regarding anisotropy, entropy and density tend to demonstrate that it is possible to achieve collagen remodeling with the use of lower power levels associated with stacked pulses.PMID:33978061 | DOI:10.1590/ACB360304 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - May 12, 2021 Category: Surgery Authors: Marcos Matias Motta Rafael Fantelli Stelini Davi Reis Calderoni Rovilson Gilioli Gislaine Vieira Damiani Carlos Lenz C ésar Paulo Kharmandayan Source Type: research

Effects of the lower energy and pulse stacking in carbon dioxide laser skin treatment: an objective analysis using second harmonic generation
CONCLUSIONS: When combined, the results obtained in this study regarding anisotropy, entropy and density tend to demonstrate that it is possible to achieve collagen remodeling with the use of lower power levels associated with stacked pulses.PMID:33978061 | PMC:PMC8112111 | DOI:10.1590/ACB360304 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - May 12, 2021 Category: Surgery Authors: Marcos Matias Motta Rafael Fantelli Stelini Davi Reis Calderoni Rovilson Gilioli Gislaine Vieira Damiani Carlos Lenz C ésar Paulo Kharmandayan Source Type: research

Effects of the lower energy and pulse stacking in carbon dioxide laser skin treatment: an objective analysis using second harmonic generation
CONCLUSIONS: When combined, the results obtained in this study regarding anisotropy, entropy and density tend to demonstrate that it is possible to achieve collagen remodeling with the use of lower power levels associated with stacked pulses.PMID:33978061 | DOI:10.1590/ACB360304 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - May 12, 2021 Category: Surgery Authors: Marcos Matias Motta Rafael Fantelli Stelini Davi Reis Calderoni Rovilson Gilioli Gislaine Vieira Damiani Carlos Lenz C ésar Paulo Kharmandayan Source Type: research

Effects of the lower energy and pulse stacking in carbon dioxide laser skin treatment: an objective analysis using second harmonic generation
CONCLUSIONS: When combined, the results obtained in this study regarding anisotropy, entropy and density tend to demonstrate that it is possible to achieve collagen remodeling with the use of lower power levels associated with stacked pulses.PMID:33978061 | DOI:10.1590/ACB360304 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - May 12, 2021 Category: Surgery Authors: Marcos Matias Motta Rafael Fantelli Stelini Davi Reis Calderoni Rovilson Gilioli Gislaine Vieira Damiani Carlos Lenz C ésar Paulo Kharmandayan Source Type: research

Effects of the lower energy and pulse stacking in carbon dioxide laser skin treatment: an objective analysis using second harmonic generation
CONCLUSIONS: When combined, the results obtained in this study regarding anisotropy, entropy and density tend to demonstrate that it is possible to achieve collagen remodeling with the use of lower power levels associated with stacked pulses.PMID:33978061 | DOI:10.1590/ACB360304 (Source: Acta Cirurgica Brasileira)
Source: Acta Cirurgica Brasileira - May 12, 2021 Category: Surgery Authors: Marcos Matias Motta Rafael Fantelli Stelini Davi Reis Calderoni Rovilson Gilioli Gislaine Vieira Damiani Carlos Lenz C ésar Paulo Kharmandayan Source Type: research

Combination Treatment of Intra/Perilesional Botulinum Toxin-A Injection and Ablative Fractional Laser for Better Clinical Outcomes of Hypertrophic Fibrotic Thyroidectomy Scars Following Fractional Ablative Laser Resurfacing
CONCLUSION: BTX-A injection combined with AFL can provide better relief for the previously treated fibrotic thyroidectomy scars. Injection of BTX-A not only into the scar itself, but also into perilesional muscles that can exert tension on the scar site may provide additional benefit in flattening scar height.PMID:33935459 | PMC:PMC8082008 | DOI:10.5021/ad.2021.33.2.170 (Source: Annals of Dermatology)
Source: Annals of Dermatology - May 3, 2021 Category: Dermatology Authors: Hyun Jeong Byun Ji-Hye Park Jong Hee Lee Source Type: research