The Efficacy of Recombinant Human Type III Collagen in the Treatment of Atrophic Scars and Its Impact on p38 MAPK Signaling Pathway Proteins
CONCLUSION: Recombinant human type III collagen significantly improves the treatment of atrophic scars, effectively ameliorating scar conditions and skin physiology. It also regulates the p38MAPK signaling pathway and reduces inflammation.PMID:38743896 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 14, 2024 Category: Complementary Medicine Authors: Ruobing Zhang Wenhui Shao Qianyue Zhang Jun Yan Genyan Xu Chen Ke Changhan Chen Youhui Ke Source Type: research

The Efficacy of Recombinant Human Type III Collagen in the Treatment of Atrophic Scars and Its Impact on p38 MAPK Signaling Pathway Proteins
CONCLUSION: Recombinant human type III collagen significantly improves the treatment of atrophic scars, effectively ameliorating scar conditions and skin physiology. It also regulates the p38MAPK signaling pathway and reduces inflammation.PMID:38743896 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - May 14, 2024 Category: Complementary Medicine Authors: Ruobing Zhang Wenhui Shao Qianyue Zhang Jun Yan Genyan Xu Chen Ke Changhan Chen Youhui Ke Source Type: research

The effect of combined red, blue, and near-infrared light-emitting diode (LED) photobiomodulation therapy on speed of wound healing after superficial ablative fractional resurfacing
In conclusion, PBM therapy has the potential to improve wound healing. In this study, a three wavelength PBM device resulted in some subjects achieving faster healing after AFL but the results were not statistically significant. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - March 27, 2024 Category: Laser Surgery Source Type: research

Comparison of the 1064-nm picosecond laser with fractionated microlens array and 1565-nm non-ablative fractional laser for the treatment of enlarged pores: a randomized, split-face, controlled trial
ConclusionBoth the 1064-nm picosecond laser with MLA and the 1565-nm nonablative fractional laser are viable options for treating enlarged pores, and showed comparable respective efficacies; however, the former was less likely to cause hyperpigmentation and was better tolerated. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - February 24, 2024 Category: Laser Surgery Source Type: research

Early intervention of carbon dioxide fractional laser in hypertrophic scar through TGF β-1/ Smad3 signaling pathway
AbstractHypertrophic scars are usually the result of surgical trauma or burn,and more common in individuals with a darker skin color. They appear as red and raised lesions around the wound that continually expand over a period of weeks or months, causing itching, pain, burning sensation and discomfort. Severe scarring affects interpersonal and social relationships, and decreases the quality of life of the patients.The aim of this study was to evaluate the effect of carbon dioxide fractional laser as an early intervention against hypertrophic scars using a rabbit ear scar model, and explore the role of the TGF β-1/ Smad3 s...
Source: Lasers in Medical Science - February 23, 2024 Category: Laser Surgery Source Type: research

Efficacy and Safety of  Ablative Fractional Laser in Melasma: A Meta-analysis and Systematic Review
This study aimed to evaluate the efficacy and safety of ablative fractional lasers in the treatment of melasma. A comprehensive systematic search of literature published before June 20, 2023, was conducted on online databases, including PubMed, Embase, Cochrane Library, and Web of Science. The data obtained were analyzed using Review Manager 5.4 software. Fourteen randomized controlled trials, comprising 527 patients, were included. Compared to the drug alone, the combination of AFL and the drug showed improved therapeutic efficacy in the melasma area and severity index (MASI) (MD = 1.54, 95% CI [0.16, 2.92], P = 0.03) and...
Source: Herpes - February 21, 2024 Category: Infectious Diseases Authors: Shasha Zhao Meng Wang Xiaodong Lai Yan Yan Source Type: research

Efficacy and Safety of  Ablative Fractional Laser in Melasma: A Meta-analysis and Systematic Review
This study aimed to evaluate the efficacy and safety of ablative fractional lasers in the treatment of melasma. A comprehensive systematic search of literature published before June 20, 2023, was conducted on online databases, including PubMed, Embase, Cochrane Library, and Web of Science. The data obtained were analyzed using Review Manager 5.4 software. Fourteen randomized controlled trials, comprising 527 patients, were included. Compared to the drug alone, the combination of AFL and the drug showed improved therapeutic efficacy in the melasma area and severity index (MASI) (MD = 1.54, 95% CI [0.16, 2.92],P = 0.03) and ...
Source: Lasers in Medical Science - February 21, 2024 Category: Laser Surgery Source Type: research

The efficacy, satisfaction, and safety of carbon dioxide (CO2) fractional laser in combination with pulsed dye laser (PDL) versus each one alone in the treatment of hypertrophic burn scars: a single-blinded randomized controlled trial
AbstractThe tendency to use less-invasive laser-based methods with far more obvious effectiveness has been taken into consideration today for improvement of burning scars. The present study thus aimed to assess the efficacy of two laser-based techniques including pulsed dye laser (PDL) and ablative fractional CO2 laser (AFCL) and its combination on improving different aspects of burning scars regardless of the types of scar as hypertrophic or keloid scars. This randomized single-blinded clinical trial was performed on patients suffering hypertrophic or keloid burning scars. The patients were randomly assigned into three gr...
Source: Lasers in Medical Science - February 20, 2024 Category: Laser Surgery Source Type: research

Ablative fractional laser treatment reduces hedgehog pathway gene expression in murine basal cell carcinomas
In conclusion, a single AFL treatment significantly reduced hedgehog gene expression in murine BCCs mimicking the effects of eight topical applications of vismodegib. Further studies are needed to assess whether AFL can be utilized for BCC treatment, either as monotherapy or in combination with other drugs. (Source: Lasers in Medical Science)
Source: Lasers in Medical Science - February 3, 2024 Category: Laser Surgery Source Type: research

A Comparison of 1550-nm Fractional Photothermolysis Versus Intense Focused Ultrasound for Treatment of Periorbital Wrinkles: A Randomized Control Trial
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - January 8, 2024 Category: Dermatology Authors: Eric Koza, Melissa Ma, Areeba Ahmed, Misha Haq, Victoria J. Shi, Dennis Whiting, Kapila Paghdal, Alexandra Weil, Nataya Voravutinon, Wanjarus Roongpisuthipong, Emily Poon, Murad Alam Source Type: research

Carbon Dioxide Fractional Laser Treatment Induces Lgr5+ Stem Cell Activation and Hair Regrowth Through the Canonical Wnt/ β-Catenin Pathway
ConclusionsThe results of this study suggest that CO2FL treatment can promote hair regrowth by activating Lgr5+ HFSCs and upregulating the Wnt/ β-catenin pathway. Clinical trial results demonstrated that CO2FL treatment will be a promising therapeutic regimen for alopecia.No Level AssignedThis journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medic...
Source: Aesthetic Plastic Surgery - December 28, 2023 Category: Cosmetic Surgery Source Type: research

Delayed collagen production without myofibroblast formation contributes to reduced scarring in adult skin micro-wounds
In adult mammals, wound healing predominantly follows a fibrotic pathway, culminating in scar formation. However, cutaneous micro-wounds generated via fractional photothermolysis, a modality that produces a constellation of microthermal zones (MTZs), exhibit a markedly different healing trajectory. Our study delineates the cellular attributes of these MTZs, underscoring a temporally limited, subclinical inflammatory milieu concomitant with rapid re-epithelialization within 24 hours. This wound closure is facilitated by the activation of genes associated with keratinocyte migration and differentiation. (Source: Journal of I...
Source: Journal of Investigative Dermatology - November 28, 2023 Category: Dermatology Authors: Chen-Hsiang Kuan, Kang-Yu Tai, Shao-Chi Lu, Yueh-Feng Wu, Pei-Shan Wu, Nellie Kwang, Wei-Hung Wang, Sabrina Mai-Yi Fan, Shiou-Han Wang, Hsiung-Fei Chien, Hong-Shiee Lai, Miao-Hsia Lin, Maksim V. Plikus, Sung-Jan Lin Tags: Original Article Source Type: research

Combination of Fractional Microneedling Radiofrequency and Ablative Fractional Laser versus Ablative Fractional Laser Alone for Acne and Acne Scars
CONCLUSION: FMR combined with AFL is a well-tolerated and effective treatment modality for inflammatory acne and acne scarring.PMID:37992744 | PMC:PMC10681823 | DOI:10.3349/ymj.2023.0234 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 22, 2023 Category: Universities & Medical Training Authors: Jemin Kim Sang Gyu Lee Sooyeon Choi Joohee Lee Young In Lee Jihee Kim Ju Hee Lee Source Type: research

Combination of Fractional Microneedling Radiofrequency and Ablative Fractional Laser versus Ablative Fractional Laser Alone for Acne and Acne Scars
CONCLUSION: FMR combined with AFL is a well-tolerated and effective treatment modality for inflammatory acne and acne scarring.PMID:37992744 | PMC:PMC10681823 | DOI:10.3349/ymj.2023.0234 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 22, 2023 Category: Universities & Medical Training Authors: Jemin Kim Sang Gyu Lee Sooyeon Choi Joohee Lee Young In Lee Jihee Kim Ju Hee Lee Source Type: research

Combination of Fractional Microneedling Radiofrequency and Ablative Fractional Laser versus Ablative Fractional Laser Alone for Acne and Acne Scars
CONCLUSION: FMR combined with AFL is a well-tolerated and effective treatment modality for inflammatory acne and acne scarring.PMID:37992744 | PMC:PMC10681823 | DOI:10.3349/ymj.2023.0234 (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - November 22, 2023 Category: Universities & Medical Training Authors: Jemin Kim Sang Gyu Lee Sooyeon Choi Joohee Lee Young In Lee Jihee Kim Ju Hee Lee Source Type: research