Elucidating hepatoprotective potential of Cichorium intybus through multimodal assessment and molecular docking analysis with hepatic protective enzymes
This study employed a comprehensive approach to validate the hepatoprotective potential of phytoconstituents from Cichorium intybus leaves. In vitro, in vivo and in silico techniques were used to confirm the protective effects on liver enzymes. In vitro antioxidant assessment revealed the highest potential in the hydroethanolic leaf extract compared to aqueous and methanolic extracts. The study further investigated the ameliorative efficacy of the hydro-ethanolic extract (HECL) in male Wistar rats exposed to lead (50 mg/kg b wt.) and nickel (4.0 mg/kg b wt.) individually and in combination for 90 days. HECL at 250 mg/kg b ...
Source: Food and Chemical Toxicology - March 30, 2024 Category: Food Science Authors: Abhishek Pathak Satya Pal Singh Apoorv Tiwari Source Type: research
Attenuated neuronal differentiation caused by acrylamide is not related to oxidative stress in differentiated human neuroblastoma SH-SY5Y cells
Food Chem Toxicol. 2024 Mar 28:114623. doi: 10.1016/j.fct.2024.114623. Online ahead of print.ABSTRACTAcrylamide (ACR) is a known neurotoxicant and developmental neurotoxicant. As a soft electrophile, ACR reacts with thiol groups in cysteine. One hypothesis of ACR induced neurotoxicity and developmental neurotoxicity (DNT) is conjugation with reduced glutathione (GSH) leading to GSH depletion, increased reactive oxygen species (ROS) production and further oxidative stress and cellular damage. In this regard, we have investigated the effect of ACR on neuronal differentiation, glutathione levels and ROS production in the huma...
Source: Food and Chemical Toxicology - March 30, 2024 Category: Food Science Authors: Ylva Johansson Mathilda Andreassen Muriel Hartsch Stella Wagner Anna Forsby Source Type: research
On the universality of viscosity in supersaturated binary aqueous sugar solutions: Cryopreservation by vitrification
We present the construction of the Supplemented Phase Diagram and the non-equilibrium nature of the undersaturated-supersaturated kinetic transition. The description of its thermodynamic nature is achieved through the study of behavior of their viscosity as temperature is lowered and concentration increased. In this work, we find a universal character for the viscosities of several sugar water solutions.PMID:38555011 | DOI:10.1016/j.cryobiol.2024.104886 (Source: Cryobiology)
Source: Cryobiology - March 30, 2024 Category: Biology Authors: Soledad Ruiz-Matus Patricia Goldstein Source Type: research
Featured Cover
The cover image is based on the Review ArticleBuilding forests for the future by A. Robert MacKenzie et al.,https://doi.org/10.1002/fes3.518. Image Credit: Ian Crompton. (Source: Food and Energy Security)
Source: Food and Energy Security - March 30, 2024 Category: Food Science Authors: A. Robert MacKenzie,
Sami Ullah,
Christine H. Foyer Tags: FEATURED COVER Source Type: research
Update to RIFM fragrance ingredient safety assessment, 2-methylvaleric acid, CAS Registry Number 97-61-0
Food Chem Toxicol. 2024 Mar 27:114617. doi: 10.1016/j.fct.2024.114617. Online ahead of print.NO ABSTRACTPMID:38552941 | DOI:10.1016/j.fct.2024.114617 (Source: Food and Chemical Toxicology)
Source: Food and Chemical Toxicology - March 29, 2024 Category: Food Science Authors: A M Api A Bartlett D Belsito D Botelho M Bruze A Bryant-Freidrich G A Burton M A Cancellieri H Chon M L Dagli W Dekant C Deodhar K Farrell A D Fryer L Jones K Joshi A Lapczynski M Lavelle I Lee H Moustakas J Muldoon T M Penning G Ritacco N Sadekar I Schem Source Type: research
