Exploring the modulatory effects of sotagliflozin on dyslipidemia in mice: The role of glucagon, fibroblast growth factor 21 and glucagon-like peptide 1
In conclusion, sotagliflozin was found to have an effect on GLP-1 and also stimulate the release of glucagon and FGF21, which are important for regulating fat metabolism. Therefore, sotagliflozin might represent a potential therapeutic approach for the treatment of diabetic dyslipidemia and steatohepatitis.PMID:38527859 | DOI:10.1111/1440-1681.13854 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - March 25, 2024 Category: Drugs & Pharmacology Authors: Nitin J Deshmukh M S Kalshetti Mohan Patil Pankaj Autade Ganesh V Sangle Source Type: research

Exploring the modulatory effects of sotagliflozin on dyslipidemia in mice: The role of glucagon, fibroblast growth factor 21 and glucagon-like peptide 1
In conclusion, sotagliflozin was found to have an effect on GLP-1 and also stimulate the release of glucagon and FGF21, which are important for regulating fat metabolism. Therefore, sotagliflozin might represent a potential therapeutic approach for the treatment of diabetic dyslipidemia and steatohepatitis.PMID:38527859 | DOI:10.1111/1440-1681.13854 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - March 25, 2024 Category: Drugs & Pharmacology Authors: Nitin J Deshmukh M S Kalshetti Mohan Patil Pankaj Autade Ganesh V Sangle Source Type: research

Clinical Analysis of Atorvastatin Calcium, Fenofibrate, and Acipimox in the Treatment of Hypertriglyceridemia-induced Acute Pancreatitis
CONCLUSION: The findings of this study highlight the effectiveness of combining fenofibrate and acipimox in the treatment of HTG-AP, leading to rapid disease recovery and significant improvement in clinical symptoms. These results have important implications for clinical practice, as the combination therapy can be widely adopted as an effective treatment strategy for HTG-AP patients. Moreover, this study provides valuable insights into the management of HTG-AP and suggests that lipid-lowering agents, such as atorvastatin calcium and fenofibrate, play a crucial role in the treatment of this condition. However, further resea...
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Limin Tong Suqiong Xu Zhiyong Chen Jian Gao Qinghua Huang Xinhua Lin Sihua Lin Zhiteng Lin Yongxuan Zheng Source Type: research

Clinical Analysis of Atorvastatin Calcium, Fenofibrate, and Acipimox in the Treatment of Hypertriglyceridemia-induced Acute Pancreatitis
CONCLUSION: The findings of this study highlight the effectiveness of combining fenofibrate and acipimox in the treatment of HTG-AP, leading to rapid disease recovery and significant improvement in clinical symptoms. These results have important implications for clinical practice, as the combination therapy can be widely adopted as an effective treatment strategy for HTG-AP patients. Moreover, this study provides valuable insights into the management of HTG-AP and suggests that lipid-lowering agents, such as atorvastatin calcium and fenofibrate, play a crucial role in the treatment of this condition. However, further resea...
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Limin Tong Suqiong Xu Zhiyong Chen Jian Gao Qinghua Huang Xinhua Lin Sihua Lin Zhiteng Lin Yongxuan Zheng Source Type: research

Clinical Analysis of Atorvastatin Calcium, Fenofibrate, and Acipimox in the Treatment of Hypertriglyceridemia-induced Acute Pancreatitis
CONCLUSION: The findings of this study highlight the effectiveness of combining fenofibrate and acipimox in the treatment of HTG-AP, leading to rapid disease recovery and significant improvement in clinical symptoms. These results have important implications for clinical practice, as the combination therapy can be widely adopted as an effective treatment strategy for HTG-AP patients. Moreover, this study provides valuable insights into the management of HTG-AP and suggests that lipid-lowering agents, such as atorvastatin calcium and fenofibrate, play a crucial role in the treatment of this condition. However, further resea...
Source: Alternative Therapies in Health and Medicine - March 22, 2024 Category: Complementary Medicine Authors: Limin Tong Suqiong Xu Zhiyong Chen Jian Gao Qinghua Huang Xinhua Lin Sihua Lin Zhiteng Lin Yongxuan Zheng Source Type: research

Not enough known about fenofibrate ’s kidney effects in people with Type 2 diabetes
We report new FIELD substudy data and call for further kidney outcomes data. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - March 11, 2024 Category: Endocrinology Authors: Alicia J. Jenkins, Rachel L. O'Connell, Andrzej S. Januszewski, Angela C. Webster, Timothy M.E. Davis, Meg J. Jardine, Russell Scott, Marja-Riitta Taskinen, Anthony C. Keech, On Behalf of the FIELD Trial Study Group Source Type: research

A novel mouse model of familial combined hyperlipidemia and atherosclerosis
In this study, we constructed a novel mouse model of familial combined hyperlipidemia through inserting a human ApoC3 transgene (hApoC3-Tg) into C57BL/6 J mice and injecting a gain-of-function variant of adeno-associated virus-proprotein convertase subtilisin/kexin type 9 (AAV-PCSK9)-D377Y concurrently with high cholesterol diet (HCD) feeding for 16 weeks. In the last 10 weeks, hApoC3-Tg mice were orally treated with a combination of atorvastatin (10 mg·kg-1·d-1) and fenofibrate (100 mg·kg-1·d-1). HCD-treated hApoC3-Tg mice demonstrated elevated levels of serum TG, total cholesterol (TC) and low density lipoprotein-cho...
Source: Atherosclerosis - March 8, 2024 Category: Cardiology Authors: Mei-Jie Chen Yi-Tong Xu Lu Sun Zhi-Hua Wang Peter J Little Li Wang Xun-de Xian Jian-Ping Weng Suo-Wen Xu Source Type: research

A novel mouse model of familial combined hyperlipidemia and atherosclerosis
In this study, we constructed a novel mouse model of familial combined hyperlipidemia through inserting a human ApoC3 transgene (hApoC3-Tg) into C57BL/6 J mice and injecting a gain-of-function variant of adeno-associated virus-proprotein convertase subtilisin/kexin type 9 (AAV-PCSK9)-D377Y concurrently with high cholesterol diet (HCD) feeding for 16 weeks. In the last 10 weeks, hApoC3-Tg mice were orally treated with a combination of atorvastatin (10 mg·kg-1·d-1) and fenofibrate (100 mg·kg-1·d-1). HCD-treated hApoC3-Tg mice demonstrated elevated levels of serum TG, total cholesterol (TC) and low density lipoprotein-cho...
Source: Acta Pharmacologica Sinica - March 8, 2024 Category: Drugs & Pharmacology Authors: Mei-Jie Chen Yi-Tong Xu Lu Sun Zhi-Hua Wang Peter J Little Li Wang Xun-de Xian Jian-Ping Weng Suo-Wen Xu Source Type: research

A novel mouse model of familial combined hyperlipidemia and atherosclerosis
In this study, we constructed a novel mouse model of familial combined hyperlipidemia through inserting a human ApoC3 transgene (hApoC3-Tg) into C57BL/6 J mice and injecting a gain-of-function variant of adeno-associated virus-proprotein convertase subtilisin/kexin type 9 (AAV-PCSK9)-D377Y concurrently with high cholesterol diet (HCD) feeding for 16 weeks. In the last 10 weeks, hApoC3-Tg mice were orally treated with a combination of atorvastatin (10 mg·kg-1·d-1) and fenofibrate (100 mg·kg-1·d-1). HCD-treated hApoC3-Tg mice demonstrated elevated levels of serum TG, total cholesterol (TC) and low density lipoprotein-cho...
Source: Acta Pharmacologica Sinica - March 8, 2024 Category: Drugs & Pharmacology Authors: Mei-Jie Chen Yi-Tong Xu Lu Sun Zhi-Hua Wang Peter J Little Li Wang Xun-de Xian Jian-Ping Weng Suo-Wen Xu Source Type: research

A novel mouse model of familial combined hyperlipidemia and atherosclerosis
In this study, we constructed a novel mouse model of familial combined hyperlipidemia through inserting a human ApoC3 transgene (hApoC3-Tg) into C57BL/6 J mice and injecting a gain-of-function variant of adeno-associated virus-proprotein convertase subtilisin/kexin type 9 (AAV-PCSK9)-D377Y concurrently with high cholesterol diet (HCD) feeding for 16 weeks. In the last 10 weeks, hApoC3-Tg mice were orally treated with a combination of atorvastatin (10 mg·kg-1·d-1) and fenofibrate (100 mg·kg-1·d-1). HCD-treated hApoC3-Tg mice demonstrated elevated levels of serum TG, total cholesterol (TC) and low density lipoprotein-cho...
Source: Acta Pharmacologica Sinica - March 8, 2024 Category: Drugs & Pharmacology Authors: Mei-Jie Chen Yi-Tong Xu Lu Sun Zhi-Hua Wang Peter J Little Li Wang Xun-de Xian Jian-Ping Weng Suo-Wen Xu Source Type: research

Disturbed brain energy metabolism in a rodent model of DYT-TOR1A dystonia
Neurobiol Dis. 2024 Mar 3:106462. doi: 10.1016/j.nbd.2024.106462. Online ahead of print.ABSTRACTDYT-TOR1A (DYT1) dystonia, characterized by reduced penetrance and suspected environmental triggers, is explored using a "second hit" DYT-TOR1A rat model. We aim to investigate the biological mechanisms driving the conversion into a dystonic phenotype, focusing on the striatum's role in dystonia pathophysiology. Sciatic nerve crush injury was induced in ∆ETorA rats, lacking spontaneous motor abnormalities, and wild-type (wt) rats. Twelve weeks post-injury, unbiased RNA-sequencing was performed on the striatum to identify diffe...
Source: Neurobiology of Disease - March 5, 2024 Category: Neurology Authors: Susanne Knorr Lisa Rauschenberger Muthuraman Muthuraman Rhonda McFleder Thomas Ott Kathrin Grundmann-Hauser Takahiro Higuchi Jens Volkmann Chi Wang Ip Source Type: research

Disturbed brain energy metabolism in a rodent model of DYT-TOR1A dystonia
Neurobiol Dis. 2024 Mar 3:106462. doi: 10.1016/j.nbd.2024.106462. Online ahead of print.ABSTRACTDYT-TOR1A (DYT1) dystonia, characterized by reduced penetrance and suspected environmental triggers, is explored using a "second hit" DYT-TOR1A rat model. We aim to investigate the biological mechanisms driving the conversion into a dystonic phenotype, focusing on the striatum's role in dystonia pathophysiology. Sciatic nerve crush injury was induced in ∆ETorA rats, lacking spontaneous motor abnormalities, and wild-type (wt) rats. Twelve weeks post-injury, unbiased RNA-sequencing was performed on the striatum to identify diffe...
Source: Neurobiology of Disease - March 5, 2024 Category: Neurology Authors: Susanne Knorr Lisa Rauschenberger Muthuraman Muthuraman Rhonda McFleder Thomas Ott Kathrin Grundmann-Hauser Takahiro Higuchi Jens Volkmann Chi Wang Ip Source Type: research

Switching from Conventional Fibrates to Pemafibrate Has Beneficial Effects on the Renal Function of Diabetic Subjects with Chronic Kidney Disease
CONCLUSION: A switch to pemafibrate may be associated with an elevation in eGFR, but to a lesser extent in patients with poor renal function.PMID:38419467 | DOI:10.4093/dmj.2023.0370 (Source: Diabetes and Metabolism Journal)
Source: Diabetes and Metabolism Journal - February 29, 2024 Category: Endocrinology Authors: Rimi Izumihara Hiroshi Nomoto Kenichi Kito Yuki Yamauchi Kazuno Omori Yui Shibayama Shingo Yanagiya Aika Miya Hiraku Kameda Kyu Yong Cho So Nagai Ichiro Sakuma Akinobu Nakamura Tatsuya Atsumi PARM-T2D Study Group Source Type: research