Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications. Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/ Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vesse...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fibrates as a Potential Class of Senolytic Therapy to Clear Senescent Cells
Accumulation of senescent cells with age is one of the causes of aging. In recent years, the broader scientific community has become convinced of this point, and thus funding is now directed towards many varied investigations of cellular senescence and what to do about it. A young industry has emerged, made up of biotech companies focused on the selective destruction of senescent cells, mostly using small molecule drugs. Since these drugs operate through different mechanisms, tend to be tissue specific, only clear a fraction of senescent cells that varies by tissue, and will thus probably be more effective when combined to...
Source: Fight Aging! - July 18, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Reduce HIGH TRIGLYCERIDES naturally and safely . . . without scam products
High triglyceride levels are as common as muffin tops and man breasts. You will find a triglyceride level among the four values on any standard cholesterol panel. High triglycerides are either ignored by most doctors or reflexively “treated” with drugs, such as fibrates (Lopid, fenofibrate), prescription fish oil (Lovaza, Vascepa) and, of course, statins. But buried in this single triglyceride value is tremendous insight into diet, metabolic efficiencies, and cardiovascular risk, with control using natural, non-medication means easy to accomplish with absolute NO need for overpriced Big Pharma scam products. Why are ...
Source: Wheat Belly Blog - December 28, 2018 Category: Cardiology Authors: Dr. Davis Tags: News & Updates grain-free triglycerides undoctored Weight Loss wheat belly Source Type: blogs

MKSAP: 70-year-old man with a transient ischemic attack
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 70-year-old man is admitted to the hospital with a 1-hour episode of left arm and left leg weakness. He is diagnosed with a transient ischemic attack. The patient has a history of hypertension and type 2 diabetes mellitus and a 30-pack-year history of smoking. Family history is noncontributory. His medications are metformin and lisinopril. On physical examination, the patient is afebrile, and blood pressure is 148/88 mm Hg. The remainder of the examination is unremarkable. Laboratory studies show alanine amino...
Source: Kevin, M.D. - Medical Weblog - June 30, 2018 Category: General Medicine Authors: < a href="https://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Cardiology Neurology Source Type: blogs

MKSAP: 38-year-old woman with a HbA1c value of 9.1%
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 38-year-old woman is evaluated after laboratory study results show an HbA1c value of 9.1%. Her HbA1c goal is less than 7% because she has high function, long life expectancy, few comorbidities, good support, health literacy, and access to care. Medical history is significant for morbid obesity, obstructive sleep apnea, hypertension, and hyperlipidemia. Family history is notable for her mother, sister, and brother with type 2 diabetes, obesity, hypertension, and hyperlipidemia. Medications are insulin glargine ...
Source: Kevin, M.D. - Medical Weblog - September 2, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Diabetes Endocrinology Primary Care Source Type: blogs

Combination with statin – Cardiology MCQ
Which of the following should not be combined with statin? a) Fenofibrate b) Ezetimibe c) Gemfibrozil d) Aspirin Correct answer: c) Gemfibrozil   If Gemfibrozil is combined with statin, there is increased risk of muscle symptoms and rhabdomyolysis. (Source: Cardiophile MD)
Source: Cardiophile MD - December 12, 2016 Category: Cardiology Authors: Prof. Dr. Johnson Francis, MD, DM, FACC, FRCP Edin, FRCP London Tags: Cardiology Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs

Blow your HDL through the roof
The HDL cholesterol value is one of the four values on any conventional lipid/cholesterol panel, along with total cholesterol, triglycerides, and calculated LDL cholesterol (what I call “fictitious” LDL because of its incredible inaccuracy when compared to superior measures). The HDL cholesterol value has some unique characteristics not shared by the others, however, and can serve as an index of overall health. Very high HDL values, for instance, are associated with extreme longevity. Centenarians typically have values of 90 mg/dl or higher. Higher HDLs are also associated with less risk for diabetes, hypertens...
Source: Wheat Belly Blog - June 29, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle fish oil HDL longevity omega-3 saturated fat vitamin D Source Type: blogs

How NOT to have HIGH TRIGLYCERIDES
High triglyceride levels are common, as common as muffin tops and man breasts. You will find a triglyceride level among the four values on any standard cholesterol panel. High triglycerides are either ignored by most doctors or reflexively “treated” with drugs, such as fibrates (Lopid, fenofibrate) or prescription fish oil (Lovaza). But buried in this single value is tremendous insight into diet, metabolic efficiencies, and cardiovascular risk, with control using natural, non-medication means very easy to accomplish. Why are triglycerides important? Triglyceride levels of 60 mg/dl or higher will: Block insu...
Source: Wheat Belly Blog - January 24, 2015 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle carbohydrates cholesterol fats fiber prebiotic resistant starch starches triglycerides Source Type: blogs

Pharmalot... Pharmalittle... Good Morning
Hello, everyone, and how are you today? We apologize for our absence yesterday, but we were speaking on a panel at the Harvard University School of Public Health, which was hosting a conference on clinical trial data sharing and transparency. Yes, it seemed to go well, thank you. Now, though, there are the usual matters to occupy us. And so, we are quaffing a cup of needed stimulation before we leave the greater Boston environs to return to the blessed Pharmalot corporate campus for another long weekend. This explains the appearance of the weekly jobs column, which usually runs on Friday. Meanwhile, here are some tidbits. ...
Source: Pharmalot - December 5, 2013 Category: Pharma Commentators Authors: esilverman Source Type: blogs

Top stories in health and medicine, December 5, 2013
From MedPage Today: Medicare P4P to Affect More Docs in 2014. Next year will bring a number of changes to one of Medicare’s pay-for-performance programs, the physician value-based payment modifier (VPM) — changes that will show up in physicians’ paychecks a few years hence. Ecstasy Use Doubles Over 6 Years. The number of emergency department visits involving the drug ecstasy more than doubled from 2005 to 2011, according to data from the Substance Abuse and Mental Health Services Administration. Odd HDL Finding Seen in Diabetes Trial. Among patients with type 2 diabetes, treatment with both fenofibrate ...
Source: Kevin, M.D. - Medical Weblog - December 5, 2013 Category: Family Physicians Tags: News Heart Medicare OB/GYN Source Type: blogs