'Christmas berry' plant compound could fight Uveal melanoma
(Thomas Jefferson University) A molecule derived from a type of primrose could prove to be a potent inhibitor of metastatic growth for a rare and aggressive cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 3, 2019 Category: Cancer & Oncology Source Type: news

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
Molecularly targeted therapies aim to obstruct cell autonomous programs required for tumor growth. We show that mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 4/6 inhibitors act in combination to suppress the proliferation of KRAS-mutant lung cancer cells while simultaneously provoking a natural killer (NK) cell surveillance program leading to tumor cell death. The drug combination, but neither agent alone, promotes retinoblastoma (RB) protein-mediated cellular senescence and activation of the immunomodulatory senescence-associated secretory phenotype (SASP). SASP components tumor necrosis factor&ndash...
Source: ScienceNOW - December 20, 2018 Category: Science Authors: Ruscetti, M., Leibold, J., Bott, M. J., Fennell, M., Kulick, A., Salgado, N. R., Chen, C.-C., Ho, Y.-j., Sanchez-Rivera, F. J., Feucht, J., Baslan, T., Tian, S., Chen, H.-A., Romesser, P. B., Poirier, J. T., Rudin, C. M., de Stanchina, E., Manchado, E., S Tags: Immunology, Medicine, Diseases reports Source Type: news

Eye cancer symptoms: Seven warning signs you have the deadly disease in your eyes
EYE CANCER symptoms are not always obvious and they may only be picked up during a routine eye test. But it ’s important to recognise any warning signs before the disease progresses. There are seven to watch out for. (Source: Daily Express - Health)
Source: Daily Express - Health - November 18, 2018 Category: Consumer Health News Source Type: news

Spread of deadly eye cancer halted in cells and animals
(Johns Hopkins Medicine) By comparing genetic sequences in the eye tumors of children whose cancers spread with tumors that didn't spread, Johns Hopkins Medicine researchers report new evidence that a domino effect in cells is responsible for the cancer spreading. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 12, 2018 Category: International Medicine & Public Health Source Type: news

Toddler loses her eye to a rare form of cancer after her mother noticed she couldn't see
Alice Taylor, from Poole, Dorset, was diagnosed with the aggressive eye cancer retinoblastoma in May last year when she was just two years old. She had been going blind in her left eye for months. (Source: the Mail online | Health)
Source: the Mail online | Health - October 11, 2018 Category: Consumer Health News Source Type: news

CHLA team identifies developmental stage for no. 1 eye tumor in children
(Children's Hospital Los Angeles) Investigators at Children's Hospital Los Angeles have been able to pinpoint the exact stage of development of the human retina, when cells can grow out of control and form cancer-like masses. The finding could open the door for future interventions in retinoblastoma (RB), a tumor of the retina that affects children under five years of age. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 14, 2018 Category: International Medicine & Public Health Source Type: news

Eye cancer signs: Watch out for this symptom on the coloured part of your eye
EYE CANCER is not a common type of cancer but noticing certain signs as early as possible will help with your outlook. One of the symptoms to watch out for will appear on the coloured part of the eye, otherwise known as the iris. (Source: Daily Express - Health)
Source: Daily Express - Health - September 7, 2018 Category: Consumer Health News Source Type: news

Scientists identify weak point in deadly eye melanoma
(Washington University School of Medicine) A natural plant compound exploits a newly identified Achilles' heel in a cancer of the eye, uveal melanoma. In human cancer cells growing in the lab, the compound shuts down the overactive signaling that drives uveal melanoma cell growth, according to researchers at Washington University School of Medicine in St. Louis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 5, 2018 Category: Cancer & Oncology Source Type: news

Targeting nucleotide exchange to inhibit constitutively active G protein {alpha} subunits in cancer cells
Constitutively active G protein α subunits cause cancer, cholera, Sturge-Weber syndrome, and other disorders. Therapeutic intervention by targeted inhibition of constitutively active Gα subunits in these disorders has yet to be achieved. We found that constitutively active Gαq in uveal melanoma (UM) cells was inhibited by the cyclic depsipeptide FR900359 (FR). FR allosterically inhibited guanosine diphosphate–for–guanosine triphosphate (GDP/GTP) exchange to trap constitutively active Gαq in inactive, GDP-bound Gαβ heterotrimers. Allosteric inhibition of other Gα subunits...
Source: Signal Transduction Knowledge Environment - September 4, 2018 Category: Science Authors: Onken, M. D., Makepeace, C. M., Kaltenbronn, K. M., Kanai, S. M., Todd, T. D., Wang, S., Broekelmann, T. J., Rao, P. K., Cooper, J. A., Blumer, K. J. Tags: STKE Research Articles Source Type: news

Two-year-old boy battling rare cancer risks blindness as painful mass grows over his eye
Muhammad Junaid, from a small village in Mirpur Khas, Pakistan, suffers from Retinoblastoma - a type of carcinoma that usually affects children under the age of five. (Source: the Mail online | Health)
Source: the Mail online | Health - August 16, 2018 Category: Consumer Health News Source Type: news

Ocular oncologist Renelle Lim on the importance of regular eye exams
The Yale Medicine ophthalmologist says eye cancer treatments work best when the cancer is caught early. (Source: Yale Science and Health News)
Source: Yale Science and Health News - July 25, 2018 Category: Universities & Medical Training Source Type: news

Eye Cancer Intraocular Uveal Melanoma Treatment
Eye Cancer: Intraocular (Uveal) Melanoma Treatment (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - July 20, 2018 Category: General Medicine Source Type: news

International conference brings together world leaders in eye cancer
(Champalimaud Centre for the Unknown) The world's leading ocular oncology scientists and clinicians meet to discuss the latest research and treatment developments in eye cancer. The Ocular Oncogenesis and Oncology Conference (OOO) is held by the Association for Research in Vision and Ophthalmology (ARV0) in partnership with the Champalimaud Foundation, July 18-21 at the Champalimaud Centre in Lisbon, Portugal. The conference features international experts from ophthalmic and cancer centers from around the world, including the Americas, Asia and Europe. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 12, 2018 Category: Cancer & Oncology Source Type: news