Therapy using immune system cells preserves vision in mice implanted with rare eye cancer
(UNC Lineberger Comprehensive Cancer Center) A treatment that uses immune system T cells, combined with an immune-boosting drug packaged in an injectable gel, was found to preserve the vision of mice implanted with retinoblastoma tissue. The cancer, which is most commonly diagnosed in infants and young children, is treatable in early stages but can still lead to the loss of vision in about 5% of cases. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 12, 2020 Category: Cancer & Oncology Source Type: news
Morris Animal Foundation awards nearly $1M in grants for new studies for equine health
(Morris Animal Foundation) Morris Animal Foundation, a leader in advancing animal health, has awarded nearly $1 million in large animal health research grants, supporting 14 projects. The studies will help veterinary scientists improve the well-being of horses through improved prevention and treatment of numerous health challenges, including eye cancer, heart arrhythmias and risks for injury from air transport. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 17, 2020 Category: International Medicine & Public Health Source Type: news
Cell growth dilutes the cell cycle inhibitor Rb to trigger cell division
Cell size is fundamental to cell physiology. For example, cell size determines the spatial scale of organelles and intracellular transport and thereby affects biosynthesis. Although some genes that affect mammalian cell size have been identified, the molecular mechanisms through which cell growth drives cell division have remained elusive. We show that cell growth during the G1 phase of the cell division cycle dilutes the cell cycle inhibitor Retinoblastoma protein (Rb) to trigger division in human cells. RB overexpression increased cell size and G1 duration, whereas RB deletion decreased cell size and removed the inverse ...
Source: ScienceNOW - July 22, 2020 Category: Science Authors: Zatulovskiy, E., Zhang, S., Berenson, D. F., Topacio, B. R., Skotheim, J. M. Tags: Cell Biology, Engineering reports Source Type: news
Ophthalmologists Called to Catch Cancers Earlier Ophthalmologists Called to Catch Cancers Earlier
Advances in the management of common eye cancers have highlighted the need for early treatment, experts say.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 17, 2020 Category: Consumer Health News Tags: Ophthalmology News Source Type: news
Missing BAP1 gene associated with immunosuppressive molecules in uveal melanoma
(University of Turku) New study from researchers in Finland and the United Kingdom reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas (UM). The researchers also discovered that when BAP1 is lost, other molecules will be present in order to support cancer growth. Luckily, some of these molecules can be targeted with existing drugs, which can lead to the development of novel immunotherapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 9, 2020 Category: Cancer & Oncology Source Type: news
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Three brothers under the age of five have been diagnosed with a type of rare eye cancer. HLN's Lynn Smith talks to the Rush family about how the boys are doing. (Source: CNN.com - Health)
Source: CNN.com - Health - February 12, 2020 Category: Consumer Health News Source Type: news
3 Brothers Have the Same Rare Cancer
The Rush brothers, ages 5 years, 4 years, and 7 months, share something that most brothers don’t: bilateral retinoblastoma, a rare eye cancer. See how their mother, who was also born with the disease, handles treatments, daily life, and facing the unknown. (Source: WebMD Health)
Source: WebMD Health - February 11, 2020 Category: Consumer Health News Source Type: news
Combination Treatments May Improve Survival for Patients with Metastatic Uveal Melanoma
The authors indicated that prospective clinical trials investigating DTIC-based systemic chemotherapies and liver-directed treatments are necessary to validate their findings. (Source: CancerNetwork)
Source: CancerNetwork - February 6, 2020 Category: Cancer & Oncology Authors: Hannah Slater Source Type: news
Three Georgia brothers under six are all battling the same rare eye cancer
Brothers Tristan Rush, five; Caison Rush, three; and Carter Rush. six months, from Marietta, Georgia have all been diagnosed with retinoblastoma, a rare form of eye cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - February 4, 2020 Category: Consumer Health News Source Type: news
Shift in treatment modalities associated with improved outcomes in uveal melanoma patients with live
(Thomas Jefferson University) New retrospective study indicates that the shift of treatment from systemic chemotherapies to liver-directed therapies provides survival benefits. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 3, 2020 Category: Cancer & Oncology Source Type: news
p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition
The p27 protein is a canonical negative regulator of cell proliferation and acts primarily by inhibiting cyclin-dependent kinases (CDKs). Under some circumstances, p27 is associated with active CDK4, but no mechanism for activation has been described. We found that p27, when phosphorylated by tyrosine kinases, allosterically activated CDK4 in complex with cyclin D1 (CDK4-CycD1). Structural and biochemical data revealed that binding of phosphorylated p27 (phosp27) to CDK4 altered the kinase adenosine triphosphate site to promote phosphorylation of the retinoblastoma tumor suppressor protein (Rb) and other substrates. Surpri...
Source: ScienceNOW - December 11, 2019 Category: Science Authors: Guiley, K. Z., Stevenson, J. W., Lou, K., Barkovich, K. J., Kumarasamy, V., Wijeratne, T. U., Bunch, K. L., Tripathi, S., Knudsen, E. S., Witkiewicz, A. K., Shokat, K. M., Rubin, S. M. Tags: Biochemistry, Medicine, Diseases, Online Only r-articles Source Type: news
Boy's rare eye cancer spotted in photograph
Noah Blanks, aged six, had an eye removed after being diagnosed with a rare form of cancer. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - December 10, 2019 Category: Consumer Health News Source Type: news
Top Miami doctor is sued by three families of children whose eye cancer spread to their brains
Damian Creed and Salette Ruiz, patients of Dr Timothy Murray, died aged four and five in 2016 after their cancers spread. Jayden Alvarenga, six, now has brain damage after his cancer spread. (Source: the Mail online | Health)
Source: the Mail online | Health - November 27, 2019 Category: Consumer Health News Source Type: news
Markedly Elevated Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma Markedly Elevated Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma
The risk of bone and soft-tissue sarcoma is markedly elevated in long-term survivors of hereditary retinoblastoma treated with radiation, researchers report.Reuters Health Information (Source: Medscape Orthopaedics Headlines)
Source: Medscape Orthopaedics Headlines - November 26, 2019 Category: Orthopaedics Tags: Hematology-Oncology News Source Type: news
An App That Can Catch Early Signs Of Eye Disease In A Flash
After his son developed a rare eye cancer, a chemist in Texas developed a smart phone app that uses a camera and artificial intelligence to detect early signs of eye disease.(Image credit: Munson et al., Sci. Adv. 2019; 5 eaax 6363) (Source: NPR Health and Science)
Source: NPR Health and Science - October 7, 2019 Category: Consumer Health News Authors: Joe Palca Source Type: news
