Pot Economy in the Total Synthesis of Estradiol Methyl Ether by Using an Organocatalyst
AngewchemPot Economy in the Total Synthesis of Estradiol Methyl Ether by Using an Organocatalyst: Enantioselective total synthesis of estradiol methyl ether has been accomplished in a pot ‐economical manner using five reaction vessels and four purifications. The key reaction is a diphenylprolinol silyl... (Source: Organometallic Current)
Source: Organometallic Current - August 22, 2017 Category: Chemistry Tags: organocatalysis Total synthesis Source Type: blogs
Horse Urine … Really?
An excerpt from my new book Undoctored.
This one little tale about hormonal health of human females, pregnant horses, and drug patents paints a microcosm of the bigger healthcare picture. It is an example of how when money becomes the primary goal, health may not be served.
For years, physicians prescribed estrogen hormone replacement for women experiencing menopause, believing that drugs like Premarin, manufactured by harvesting estrogens from the urine of pregnant horses, prevented osteoporosis, improved cholesterol values, and reduced cardiovascular risk, since preliminary epidemiological studies, not real clinical stud...
Source: Wheat Belly Blog - April 27, 2017 Category: Cardiology Authors: Dr. Davis Tags: Hormone Replacement Drugs Undoctored Source Type: blogs
Why IVF patients feel helpless
One of the most worrisome aspects of an IVF cycle is the uncertainty involved. The patient never knows whether the next cycle is going to work or not - and neither does the doctor ! The problem is compounded by the fact that they know very little about what happens during IVF treatment. This is because most doctors don't bother to explain anything to them . Either they don't have any time , or they use so much jargon that the "explanation" is clear as mud for the poor patient, who is too scared to ask for clarification .While patients do go on the Internet to do their homework for themselves, they still find it hard to get...
Source: Dr.Malpani's Blog - February 25, 2017 Category: Reproduction Medicine Source Type: blogs
A Summary of the NIA Interventions Testing Program
The NIA Interventions Testing Program (ITP) is a fairly old-school effort to rigorously test all the plausible claims of modestly slowed aging in mice via pharmaceuticals, dietary supplements, and environmental factors like calorie restriction. For those of us more interested in outright rejuvenation through damage repair after the SENS model, rather than merely slowing aging a little, I think there still a number of things worth learning from the ITP results to date. For example, firstly, that almost all claims of slowed aging in mice due to supplements and drugs made in past years were artifacts or otherwise erroneous re...
Source: Fight Aging! - December 13, 2016 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MKSAP: 64-year-old woman with an incidental pituitary adenoma
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 64-year-old woman is seen for follow-up evaluation. Two weeks ago, she was in a car accident, and an incidental pituitary adenoma was found on a cervical spine CT scan. She has no residual injuries from the car accident.
She is otherwise healthy and takes no medications. She went through menopause at age 51. She has night sweats two to three times per month and occasional hot flushes. These have improved over the past decade and are not bothersome. She is not sexually active. She has never taken hormone replac...
Source: Kevin, M.D. - Medical Weblog - September 17, 2016 Category: Journals (General) Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Endocrinology Source Type: blogs
MIT Unveils Portable Biopharmaceutical Production Plant for Point of Care
Biopharmaceuticals are typically manufactured on a large scale because they require culturing of uniquely developed cell lines in massive quantities. This limits how quickly drugs can be produced and delivered in specific situations and particularly to remote locations. MIT researchers have now developed a portable microfluidic system that can produce two different proteins from a single strain of a genetically engineered yeast.
The principal component of the microbioreactor is a plastic chip with microfluidic circuits (green), optical sensors (red and blue circles) for monitoring oxygen and acidity, and a filter to ret...
Source: Medgadget - August 3, 2016 Category: Medical Equipment Authors: Editors Tags: Genetics News Source Type: blogs
A herpesvirus associated with female infertility
Viruses that replicate in the male or female reproductive tract are considered to be potential causes of human infertility. Several herpesviruses have been implicated in male infertility, and now human herpesvirus 6A (HHV-6A) has been found in endometrial cells of women with unexplained fertility (paper link).
HHV-6 was only recently discovered (1986) and is now known to occur as two variants, HHV-6A and HHV-6B. The latter is a major cause of exanthem subitum, a rash of infants, but no disease has been clearly associated with HHV-6A. These viruses are transmitted to infants early in life via saliva, from mother to child, ...
Source: virology blog - July 21, 2016 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information cytokine endometrium estradiol herpesvirus HHV-6A human herpesvirus 6A infertility uterus viral viruses Source Type: blogs
That Er+/Pr+ Thing
So I haven always known (well since my diagnosis - before my diagnosis what I knew about breast cancer wouldn't fill a post-it) that have a hormone receptor positive breast cancer had a lot of impact on your treatment protocol. But I didn't know that much about how that worked.Now I am learning more. In the past, estrogen was considered to be the indicator of breast cancer diagnosis. When estrogen was detector at a biopsy, it was considered an indicator of breast cancer. Now it has been determined that progesterone has a big impact as well."Previous studies have demonstrated that estrogen receptors react to the primary fem...
Source: Caroline's Breast Cancer Blog - June 28, 2016 Category: Cancer & Oncology Tags: breast cancer breast cancer treatment hormone receptor status Source Type: blogs
Treating Menopausal Vaginal Dryness
Sex is supposed to be fun, and it’s definitely not supposed to hurt.
But one of the consequences of menopause is vaginal dryness, which for many women means painful sex.
With the loss of ovarian estrogen, vaginal walls that were once elastic, expandable, supple and sturdy can, over time, become tightened and fragile. The vaginal walls can become as thin as tissue paper, unable to withstand the manipulation that occurs with sexual activity, and can tear and even bleed with intercourse.
“Use it or lose it”
When sex becomes painful, the natural response is to begin to avoid intercourse. But without continued sexual acti...
Source: The Blog That Ate Manhattan - August 2, 2015 Category: Primary Care Authors: Margaret Polaneczky, MD Tags: Menopause painful sex sex hurts vaginal atrophy vaginal dryness Source Type: blogs
Lifespan of Mice and Primates Correlates with Immunoproteasome Expression
It is known that cellular repair processes are important in the determination of life span. Many of the methods of modestly slowing aging in laboratory species are accompanied by increased rates of cellular housekeeping, the recycling of damaged proteins and cell components. One set of these processes is centered around the proteasome, responsible for breaking down unneeded or damaged proteins, and here researchers demonstrate a correlation between proteasomal activity and species longevity in mammals:
Within the animal kingdom there is extraordinary variation in lifespan. Members of some species only live a few days or w...
Source: Fight Aging! - April 14, 2015 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Estrogen in beauty products – The Beauty Brains Show episode 39
What are xenohormones and should we be worried about them in cosmetics? This week we talk about the alleged dangers of estrogen and other endocrine disruptors in beauty products.
Click below to play Episode 39 or click “download” to save the MP3 file to your computer.
Show notes
Beauty Science News – The case of the stolen body parts
Stolen hair and skin – who would have thought that beauty body parts would be the target of theft?
Question of the week: Are endocrine disrupting hormones dangerous in cosmetics?
Melissa asks…I’m interested in your take on the Suzanne Somers organic skincare ...
Source: thebeautybrains.com - July 15, 2014 Category: Consumer Health News Authors: Perry RomanowskiThe Beauty Brains Tags: Podcast Safety Source Type: blogs
Not tonight dear, I had zymosan A injected into my hind paw
This study was published in the Journal of Neuroscience, and the strongly worded quote above is how the authors chose to conclude their abstract. They go to great lengths to “prove” that the loss of libido was due to lack of sexual motivation in the female mice, rather than a direct consequence of pain. The authors also stretch the clinical applicability (and evolutionary validity) of their work a bit beyond belief, in my view. Why? Perhaps because promoting a viable animal model of low sexual motivation in women will ultimately serve drug development purposes (Farmer et al., 2014):The link between pain and sexual moti...
Source: The Neurocritic - May 4, 2014 Category: Psychiatrists and Psychologists Authors: The Neurocritic Source Type: blogs
How do I interpret my ovarian reserve test results ?
Modern IVF technology is very effective, and we are every good at making embryos , no matter how poor the sperm quality . The biggest challenge we encounter today is treating patients with poor ovarian reserve, because poor quality eggs result in poor quality embryos.However, there’s a lot of confusion about testing ovarian reserve and egg quality. Just because a woman has poor ovarian reserve does not mean she will necessarily be infertile. After all, all testing has its limitations and flaws. Just like men with low sperm counts can father a pregnancy if their spouse is super-fertile , similarly young women with p...
Source: The Patient's Doctor - February 20, 2014 Category: Obstetricians and Gynecologists Source Type: blogs
MKSAP: 38-year-old woman with increasing fatigue and weight gain
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 38-year-old woman reports a 3-month history of increasing fatigue and weight gain. She underwent transsphenoidal surgery 4 years ago to remove a nonfunctioning pituitary macroadenoma, followed 4 months later by radiation therapy because of residual tumor. She started taking hydrocortisone 14 months ago after adrenal insufficiency was diagnosed. The patient developed amenorrhea 1 year ago and began taking an oral contraceptive. Medications are hydrocortisone, norethindrone with ethinyl estradiol, and a multivita...
Source: Kevin, M.D. - Medical Weblog - November 2, 2013 Category: Family Physicians Tags: Conditions Endocrinology Source Type: blogs
Eggs are not follicles
IVF patients often don’t understand the difference between
follicles ( which are affectionately called
“follies” ) and eggs . Doctors are sometimes
responsible for this confusion , because we usually loosely refer to the
follicles we see on your ultrasound scan as eggs. This is especially true
during IUI cycles; or when the scans are being done by a sonographer or
technician. When she sees that your ovaries have responded well to the
superovulation, she will often say – Good, your eggs are growing well.
In reality, eggs are microscopic structures which cannot be
seen on ultrasound scans. They are only 100...
Source: The Patient's Doctor - October 29, 2013 Category: Obstetricians and Gynecologists Source Type: blogs
