The Interventions Testing Program Finds Glycine Supplementation has a Tiny Effect on Mouse Life Span
The NIA Interventions Testing Program (ITP) is a very conservative organization. The organizers take compounds that cannot possibly do more than slightly slow aging, largely those that upregulate stress response mechanisms in a similar way to calorie restriction, and rigorously test them in large mouse studies. The results are of the best quality, and tend to demonstrate that most earlier, less rigorous studies overestimated the effects of compounds on life span. This is an expensive business, but I would say one of dubious practical value.
The practice of calorie restriction shows us the likely bounds of the possib...
Source: Fight Aging! - April 10, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
LH as the villain in IVF protocols.
The purpose of an IVF superovulation protocol is to help you grow lots of follicles, which is why we use gonadotropin injections which contain 2 hormones - FSH and LH.One of the problems is that the LH hormone can sometimes play the role of a rogue.If there is an early LH surge, the follicles can rupture too early , and we may not be able to pick up an egg at all.This used to be a major problem in the past, which has now been solved by using either GnRH agonists, or GnRH antagonists, which prevent these LH surges.Sometimes the LH surge may not be enough to cause premature follicular rupture, which means we can still c...
Source: Dr.Malpani's Blog - February 25, 2019 Category: Reproduction Medicine Source Type: blogs
Hormone therapy for depression: Are the risks worth the benefits?
When you think of menopause, you might think of hot flashes and night sweats. But many women also experience symptoms of depression. The risk of depression doubles or even quadruples during the menopausal transition, which has researchers looking for ways to address — or even prevent — the problem.
One study published in JAMA Psychiatry found that hormone therapy may help ward off symptoms of peri- and postmenopausal depression in some women. Researchers found that perimenopausal and early postmenopausal women who were treated with hormones were less likely to experience symptoms of depression than women in the study w...
Source: Harvard Health Blog - November 16, 2018 Category: Consumer Health News Authors: Kelly Bilodeau Tags: Anxiety and Depression Health Menopause Source Type: blogs
Orgasms during an IVF cycle
It's not uncommon for IVF patients to have an orgasm during their IVF cycle ; and during the two-week wait after the embryo transfer. This is often involuntary , and happens during their sleep. They wake up , and many start to panic , because they are worried that the orgasm is going to harm their embryo. Their fear is that the uterine cramping will cause the uterus to expel the embryo.This can be quite embarrassing, and they are ashamed to discuss this with their doctor.The reason for the orgasm is because of the increased blood flow to the clitoris during this time. Your hormonal levels of estradiol and progesterone...
Source: Dr.Malpani's Blog - September 17, 2018 Category: Reproduction Medicine Source Type: blogs
How doctors take advantage of IVF patient's ignorance
A patient sent me this email.-----Original Message-----From:To: Aniruddha MalpaniSubject: Re: Two ivf cycles failedSir,Can U pls suggest ivf success supplements?Next month I m going for third cycleCan I use mothers Horlicks?How to get good eggs and embryos?Any diet chart before, during and after embryo transfer?Sir, pls kindly suggest meLifelong I will be really thankful to youNow I m taking1. apcod sachets2. Metformin3. Normoz4. Ultra CoQ105. Folic acidMy previous ivf failure reasons are poor quality eggs and embryos, implantation failure and may be unexplained infertility reason Actually, the most likely reason for ...
Source: Dr.Malpani's Blog - July 21, 2018 Category: Reproduction Medicine Source Type: blogs
Might Depression Be Linked to One of These Popular Medications?
If you’re taking beta blockers, certain kinds of anxiety drugs, certain types of painkillers (including ibuprofen), proton pump inhibitors (PPIs) (used to treat acid reflux), ACE inhibitors (used to treat high blood pressure), or anti-convulsant drugs, you may be at greater risk for depression. That’s according to a new, large-scale study published earlier this week in JAMA.
However, this was a correlational study, so it can’t say that these medications actually cause depression or not. It may be that people with greater health problems are more likely to take one of these medications and be depressed abo...
Source: World of Psychology - June 15, 2018 Category: Psychiatry & Psychology Authors: John M. Grohol, Psy.D. Tags: Depression General Medications Psychiatry Research Drugs cause depression popular medications Source Type: blogs
Will L. reuteri yogurt EXTEND life?
Among the many powerful and life-changing effects of Lactobacillus reuteri ATCC PTA 6475 yogurt that increases oxytocin levels is a reduction in appetite, the so-called anorexigenic effect. If you experience this effect, you know that you have provoked oxytocin. And it can be quite profound. Food still tastes good, but you have far less interest in it.
Follow this reasoning: We know that, in numerous experimental models such as dogs and mice, reduction in calorie intake considerably lengthens life. Unfortunately, the same sorts of experiments have not been conducted in humans for obvious logistical reasons: length of time ...
Source: Wheat Belly Blog - June 4, 2018 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle anti-aging antiaging oxytocin reuteri yogurt youthfulness Source Type: blogs
How to prevent errors in IVF - what every patient needs to know !
The biggest nightmare for any IVF patient is that the lab may mix up their eggs and sperms with another patients. This has happened in many clinics, and IVF is as prone to errors as any other treatment because it is provided by a host of people working together – doctors, nurses, receptionist, ultrasonographers, lab technicians and embryologists. It requires lots of coordination, and there are few treatment processes for which a team approach is more important than for assisted reproduction. Close, continuous communication is required at many levels to e nsure everything goes as planned.Communication mattersAll of these ...
Source: Dr.Malpani's Blog - May 15, 2018 Category: Reproduction Medicine Tags: IVF error IVF mistakes Source Type: blogs
The 7 steps of IVF
IVF seems to be an extremely complicated procedure, and sometimes IVF doctors take perverse pleasure in mystifying it, because they like showing off their expertise. This is why IVF patients are often completely confused about what to expect. Actually , it's very straightforward and logical, and if you understand this simple framework , you will be able to make sure your doctor's doing the right stuff for you. Remember that all we are doing in an IVF cycle is replicating what should have happened normally in the fallopian tubes - the only difference is that we are doing this in the test tube ! 1. First is t...
Source: Dr.Malpani's Blog - March 26, 2018 Category: Reproduction Medicine Source Type: blogs
Mr. and Mrs. Wheat Belly
Men and women follow the Wheat Belly lifestyle and can undergo important and sometime startling hormonal changes. Though results vary with stage of life—young adults, middle-aged, older—there are a variety of hormonal changes that women and men typically experience, some in concert, others independently. Such hormonal shifts can be powerful and part of the health-restoring menu of changes that develop with this lifestyle. They can even improve a relationship in a number of ways, both physically and emotionally, especially if we weave in some of the newer Wheat Belly/Undoctored concepts and practices such as oxy...
Source: Wheat Belly Blog - March 13, 2018 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle estradiol estrogen hormonal hormones Inflammation low-carb oxytocin testosterone Thyroid Weight Loss Source Type: blogs
Why it's a pleasure treating well informed patients !
A patient sent me this emailWe are considering embarking upon IVF to have our 4th living child . We have a history of successful pregnancies (births 2008, 2010, 2012) mixed with miscarriages (3 in 2007, one in 2017). We want to expedite conception rather than trying for years more on our own. My AMH appears reasonable (21.6 pmol/l) and my CD3 FSH was 8.3; LH and estradiol, prolactin etc. were in normal range). We have approached two fertility clinics (one in Greece, one in the Czech republic, both well known) who have both recommended a hysteroscopy before proceeding. I do not feel that this is evidence-based practice. I h...
Source: Dr.Malpani's Blog - February 20, 2018 Category: Reproduction Medicine Source Type: blogs
Making sense of your IVF blood results
A patient sent me this emailI am doing an IVF cycle, and my Day 6 results are as follows: E2- 1776 (great result) PO- 0.6 nmol/l LH 1.6 mIU/mL I am wondering if LH or Progesterone can be too low and should the cycle be cancelled. I am on Puregon- 300iu Menopur- 1 vial Orgalutran- 1 syringe ThanksI am very pleased when patients are well-informed, and take an active and intelligent interest in their treatment !Yes, the medical jargon can be quite confusing, and doctors don't make it easier, because they rarely bother to explain what's happening.This is why the internet can be such a valuable resource for infertile women, who...
Source: Dr.Malpani's Blog - February 14, 2018 Category: Reproduction Medicine Source Type: blogs
Is “man flu” really a thing?
Follow me on Twitter @RobShmerling
This one got by me. I’d never heard of “man flu” but according to a new study of the topic, the term is “so ubiquitous that it has been included in the Oxford and Cambridge dictionaries. Oxford defines it as ‘a cold or similar minor ailment as experienced by a man who is regarded as exaggerating the severity of the symptoms.’”
Another reference called it “wimpy man” syndrome. Wow. I’d heard it said (mostly in jest) that if men had to carry and deliver babies, humankind would have long ago gone extinct. But wimpy man syndrome? I just had to learn more.
What is man flu?
...
Source: Harvard Health Blog - January 4, 2018 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Cold and Flu Health Infectious diseases Men's Health Source Type: blogs
Poor quality IVF treatment
I received this tearful email from a patient.I have a very sad medical history . I used to get extremely painful periods (I got my first periods at the age of around 14-15 years) where medical help was always required by me. The doctors in my home town could not understand the problem and we were completely relying on the best doctors of our city. I was treated for depression, epilepsy, abdominal TB, hormones, etc. etc. because they believed that my symptoms were similar to any of these ailments.After years of treatment but no relief (around 11 years of treatment with no solid diagnosis, no reports nothing), I got ma...
Source: Dr.Malpani's Blog - December 1, 2017 Category: Reproduction Medicine Source Type: blogs
