Fight Aging! Newsletter, April 12th 2021
In conclusion, the MR exhibited the protective effects against age-related behavioral disorders, which could be partly explained by activating circulating FGF21 and promoting mitochondrial biogenesis, and consequently suppressing the neuroinflammation and oxidative damages. These results demonstrate that FGF21 can be used as a potential nutritional factor in dietary restriction-based strategies for improving cognition associated with neurodegeneration disorders.
Senescent T Cells Cause Changes in Fat Tissue that are Harmful to Long-Term Health
https://www.fightaging.org/archives/2021/04/senescent-t-cells-cause...
Source: Fight Aging! - April 11, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Latest Data from the Interventions Testing Program: Nicotinamide Riboside has No Effect on Mouse Life Span
The Interventions Testing Program (ITP) at the National Institute on Aging runs very rigorous, costly life span studies in large numbers of mice, picking a few interventions to test each year. The usual outcome is that a treatment with some interesting past results is found to have absolutely no effect on life span when run through the rigor of the ITP process. We should all bear this in mind whenever modest life span extension in mice is reported by researchers elsewhere in the community. Based on past ITP data, a great many such results are the result of chance or poor experimental design.
Will the ITP ever get ar...
Source: Fight Aging! - April 9, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 14th 2020
This study is the first to provide a direct link between this inflammation and plaque development - by way of IFITM3.
Scientists know that the production of IFITM3 starts in response to activation of the immune system by invading viruses and bacteria. These observations, combined with the new findings that IFITM3 directly contributes to plaque formation, suggest that viral and bacterial infections could increase the risk of Alzheimer's disease development. Indeed, researchers found that the level of IFITM3 in human brain samples correlated with levels of certain viral infections as well as with gamma-secretase activ...
Source: Fight Aging! - September 13, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Hormone Therapy in Postmenopausal Women Correlates with Lesser Senescent Cell Signaling
This study examined whether menopausal hormone therapies, in the form of oral conjugated equine estrogens (oCEE) and transdermal 17β-estradiol (tE2), altered the circulating levels of a specific set of SASP proteins in women who had undergone natural menopause.
Growth differentiation factor 15 (GDF15), tumor necrosis factor receptor 1 (TNFR1), FAS, and macrophage inflammatory protein 1α (MIP1α) were measured in serum. Results were compared among menopausal women participating in the Kronos Early Estrogen Prevention Study randomized to either placebo (n = 38), oral conjugated equine estrogen (oCEE, n = 37), or tra...
Source: Fight Aging! - September 11, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Wearable Sweat Sensor Made from Microbial Nanocellulose
Researchers in Brazil have developed a wearable sweat sensor made from microbial nanocellulose. The natural polymer provides a breathable interface with the underlying skin and allows sweat to travel through for electrochemical analysis using printed electrodes. The system can measure a wide variety of metabolites and biomarkers present in sweat, and could be useful for monitoring conditions such as diabetes.
Wearable sensors are developing apace, and hold significant promise in monitoring various biomarkers. However, developing materials that interface well with the skin is a challenge, with many sensors, including pla...
Source: Medgadget - August 18, 2020 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Sports Medicine Source Type: blogs
Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons.
Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Repetitive Element Activity is Reduced in Mice Subject to Interventions that Modestly Slow Aging
Today's open access paper is a companion piece to a recent discussion of repetitive element activity as a potential biomarker of biological aging. In today's paper, the authors note that a number of interventions that modestly slow aging in mice also reduce the activity of repetitive elements in the genome. Many forms of repetitive element are the remnants of ancient viruses, sequences that are capable of copying themselves into new locations in the genome, but are normally suppressed. A fair amount of attention has been given to retrotransposons, one category of repetitive elements, in the context of aging in recent years...
Source: Fight Aging! - July 14, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Can a daily pill lighten heavy menstrual bleeding caused by fibroids?
Fibroids are generally benign (not cancerous) tumors that form within the tissues of the uterus. They are very common in reproductive-age women: studies report that up to 70% of white women and 80% of Black women may develop fibroids by age 50. And research suggests Black women are more likely to experience severe or very severe symptoms related to fibroids, such as heavy and sometimes prolonged monthly periods.
In some cases, women seek medical care due to menstrual bleeding so heavy that they develop anemia and require iron supplements or, much more rarely, blood transfusions. The FDA recently approved new medicine, take...
Source: Harvard Health Blog - July 10, 2020 Category: Consumer Health News Authors: Huma Farid, MD Tags: Fertility Health Health care disparities Women's Health Source Type: blogs
Fight Aging! Newsletter, October 14th 2019
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health.
Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice
https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/
Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought that the...
Source: Fight Aging! - October 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lipid Metabolism in Aging and Age-Related Disease
Lipids are everywhere in our biochemistry. Where they are present in cell structures and molecular mechanisms that are important to any specific age-related disease, or are among the underlying root causes of aging, it will tend to be the case that differences between species (and possibly individuals) can lead to changes in the pace of aging and disease. For example, lipid composition determines resistance to oxidative damage to cell membranes. A range of evidence supports the membrane pacemaker hypothesis of aging, in that longer-lived species tend to have more resilient cell membranes, based on their lipid composition.
...
Source: Fight Aging! - October 10, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 2nd 2019
In conclusion, in the absence of obesity, visceral adipose tissue possesses a pronounced anti-inflammatory phenotype during aging which is further enhanced by exercise.
Methods of Inducing Cellular Damage are Rarely Relevant to Aging, and the Details Matter
https://www.fightaging.org/archives/2019/08/methods-of-inducing-cellular-damage-are-rarely-relevant-to-aging-and-the-details-matter/
One of the major challenges in aging research is determining whether or not models of cellular or organismal damage and its consequences are in any way relevant to the natural processes of aging. One can hit a brick wit...
Source: Fight Aging! - September 1, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Estradiol Accelerates Liver Regeneration in Mice
The liver is the most regenerative organ in mammals, capable of regrowing lost sections, albeit imperfectly in comparison to the capabilities of highly regenerative species such as salamanders. Researchers here demonstrate that the sex hormone estradiol is involved in the regulation of liver regeneration, and that regeneration can be accelerated via artificially increased levels of estradiol. This is particularly interesting in the context of recent work showing that loss of estradiol with aging is involved in loss of muscle mass, due to effects on stem cell activity. One might wonder if this sort of mechanism will show up...
Source: Fight Aging! - August 26, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications.
Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression
https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/
Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vesse...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Diminished Estradiol Explains Faster Muscle Loss Following Menopause
In this study, we use rigorous and unbiased approaches to demonstrate the in vivo necessity of estradiol to maintain the satellite cell number in females. Further, we use mouse genetics to show that the molecular mechanism of estradiol action is cell-autonomous signaling through estrogen receptor α (ERα). Specifically, we show the functional consequence of estradiol-ERα ablated signaling in satellite cells including impaired self-renewal, engraftment, and muscle regeneration, and the activation of satellite cell mitochondrial caspase-dependent apoptosis. Together, these results demonstrate an important role for estrogen...
Source: Fight Aging! - July 19, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 15th 2019
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - April 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
