Identifying atopic dermatitis risk loci in 1,094,060 individuals with sub analysis of disease severity and onset
Atopic dermatitis (AD) is a common inflammatory skin disease highly attributable to genetic factors. Here, we report results from a genome-wide meta-analysis of AD in 37,541 cases and 1,056,519 controls with data from the FinnGen project, the Estonian Biobank, the UK Biobank, the EAGLE Consortium, and the BioBank Japan. We detected 77 independent AD-associated loci of which 10 were to our knowledge previously unreported. The associated loci showed enrichment in various immune regulatory processes. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 23, 2024 Category: Dermatology Authors: Anu Pasanen, Eeva Sliz, Laura Huilaja, FinnGen, Estonian Biobank Research Team, Ene Reimann, Reedik M ägi, Triin Laisk, Kaisa Tasanen, Johannes Kettunen Tags: Original Article Source Type: research
Viruses, Vol. 16, Pages 637: Identification of New Microfoci and Genetic Characterization of Tick-Borne Encephalitis Virus Isolates from Eastern Germany and Western Poland
Conclusions: Although there are still only a few cases are reported from these areas, people spending much time outdoors should consider TBE vaccination. (Source: Viruses)
Source: Viruses - April 19, 2024 Category: Virology Authors: Nina Kr ól Lidia Chitimia-Dobler Gerhard Dobler Dorota Kiewra Aleksandra Czu łowska Anna Obiegala Joanna Zajkowska Thomas Juretzek Martin Pfeffer Tags: Article Source Type: research
The role of COVID-19 vaccines in preventing post-COVID-19 thromboembolic and cardiovascular complications
Conclusions
COVID-19 vaccination reduced the risk of post-COVID-19 cardiac and thromboembolic outcomes. These effects were more pronounced for acute COVID-19 outcomes, consistent with known reductions in disease severity following breakthrough versus unvaccinated SARS-CoV-2 infection. (Source: Heart)
Source: Heart - April 15, 2024 Category: Cardiology Authors: Mercade-Besora, N., Li, X., Kolde, R., Trinh, N. T., Sanchez-Santos, M. T., Man, W. Y., Roel, E., Reyes, C., Delmestri, A., Nordeng, H. M. E., Uusküla, A., Duarte-Salles, T., Prats, C., Prieto-Alhambra, D., Jödicke, A. M., Catala, M. Tags: Open access, Editor's choice, Press releases, COVID-19 Cardiac risk factors and prevention Source Type: research
COVID-19 Vaccination Linked With Lower Risk of Cardiac Problems
People who received a SARS-CoV-2 vaccination had a lower risk of heart failure and blood clots in their veins and arteries after COVID-19 infection than those who had not been vaccinated, a recent study involving more than 20 million participants in Estonia, Spain, and the UK found. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 12, 2024 Category: General Medicine Source Type: research
Adaptation of the Communities That Care Youth Survey for Use in Estonia: A Pilot Study
This study investigated the psychometric properties and applicability of the CTCYS in Estonia. The adaptation process involved translating and refining the US CTCYS, followed by focus group discussions with students and specialists and a pilot study in two municipalities, with data obtained from 265 students. A focus group wit h municipality members explored the measure’s feasibility. Results indicate that the original CTC framework largely captures key issues within the Estonian context. Overall, the survey showed good validity, as evidenced by its ability to predict problem outcomes through both risk and protective fa ...
Source: The Journal of Primary Prevention - April 3, 2024 Category: Sleep Medicine Source Type: research
Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: utilizing electronic health records in a Phenome-Wide Association Study
CONCLUSIONS: Overall our findings indicate that ADHD genetic liability is associated with an increased risk of a substantial number of medical conditions in undiagnosed individuals. These results highlight the need for timely detection and improved management of ADHD symptoms in adults.PMID:38563284 | DOI:10.1017/S0033291724000606 (Source: Psychological Medicine)
Source: Psychological Medicine - April 2, 2024 Category: Psychiatry Authors: Elis Haan Kristi Krebs Urmo V õsa Isabell Brikell Henrik Larsson Estonian Biobank Research Team Kelli Lehto Source Type: research
Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: utilizing electronic health records in a Phenome-Wide Association Study
CONCLUSIONS: Overall our findings indicate that ADHD genetic liability is associated with an increased risk of a substantial number of medical conditions in undiagnosed individuals. These results highlight the need for timely detection and improved management of ADHD symptoms in adults.PMID:38563284 | DOI:10.1017/S0033291724000606 (Source: Psychological Medicine)
Source: Psychological Medicine - April 2, 2024 Category: Psychiatry Authors: Elis Haan Kristi Krebs Urmo V õsa Isabell Brikell Henrik Larsson Estonian Biobank Research Team Kelli Lehto Source Type: research
First experience with nicotine products and transition to regular tobacco use: a secondary data analysis in 28 European countries
Conclusions
Although this study cannot infer causality, the findings show that odds of becoming a regular tobacco user differs widely depending on the first product used. Better understanding of the associations between first product use and regular tobacco use could be informative to tobacco control policy-makers and help tailor prevention programmes. (Source: BMJ Open)
Source: BMJ Open - March 28, 2024 Category: General Medicine Authors: Rajani, N. B., Goyal, J., Filippidis, F. T. Tags: Open access, Public health Source Type: research
Heart failure care in the Central and Eastern Europe and Baltic region: status, barriers, and routes to improvement
AbstractDespite improvements over recent years, morbidity and mortality associated with heart failure (HF) are higher in countries in the Central and Eastern Europe and Baltic region than in Western Europe. With the goal of improving the standard of HF care and patient outcomes in the Central and Eastern Europe and Baltic region, this review aimed to identify the main barriers to optimal HF care and potential areas for improvement. This information was used to suggest methods to improve HF management and decrease the burden of HF in the region that can be implemented at the national and regional levels. We performed a lite...
Source: ESC Heart Failure - March 23, 2024 Category: Cardiology Authors: Ovidiu Chioncel,
Jelena Čelutkienė,
Jan Bělohlávek,
Ginta Kamzola,
Mitja Lainscak,
Béla Merkely,
Davor Miličić,
Jadwiga Nessler,
Arsen D. Ristić,
Lidia Sawiełajc,
Izabella Uchmanowicz,
Tiina Uuetoa,
Eva Turgonyi,
Yoto Yotov,
Piotr P Tags: Review Source Type: research
Moving forward after the COVID-19 pandemic: Lessons learned in primary care from the multi-country PRICOV-19 study
CONCLUSION: Policymakers, primary care associations, and the broader healthcare system are urged to collaboratively take responsibility and increase support for GP practices to enhance their resilience, adaptability, and capacity to deliver safe and equitable healthcare during future crises.PMID:38511848 | DOI:10.1080/13814788.2024.2328716 (Source: European Journal of General Practice)
Source: European Journal of General Practice - March 21, 2024 Category: Primary Care Authors: Sara Willems Pierre Vanden Bussche Esther Van Poel Claire Collins Zalika Klemenc-Ketis Source Type: research
