New drug could stop deadly superbug, save tens of thousands of lives
(Purdue University) A pair of Purdue University researchers from the College of Pharmacy and the College of Veterinary Medicine developed small molecules to combat deadly, drug-resistant enterococcus. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 10, 2020 Category: Biology Source Type: news

Antimicrobial activity and biocompatibility of the mixture of mineral trioxide aggregate and nitric oxide-releasing compound
ConclusionThe addition of a NO-releasing compound to the endodontic treatment using MTA root canal sealer might reduce the risk of bacterial infection and help to regenerate the dental pulp tissue. (Source: Dental Technology Blog)
Source: Dental Technology Blog - August 29, 2020 Category: Dentistry Source Type: news

Intestinal bacteriophage alters effects of cancer therapies in mice
(American Association for the Advancement of Science) Enterococcus, a genus that includes common commensal bacteria found in the gut, harbors a bacteriophage that influences the effects of various cancer immunotherapies in ways that may be clinically relevant, researchers working in mice report. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 20, 2020 Category: Cancer & Oncology Source Type: news

Cross-reactivity between tumor MHC class I-restricted antigens and an enterococcal bacteriophage
Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I–binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae. Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2Kb–restricted CD8+ T lymphocyte response upon immunotherapy with cyclophosphamide or anti–PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in ...
Source: ScienceNOW - August 19, 2020 Category: Science Authors: Fluckiger, A., Daillere, R., Sassi, M., Sixt, B. S., Liu, P., Loos, F., Richard, C., Rabu, C., Alou, M. T., Goubet, A.-G., Lemaitre, F., Ferrere, G., Derosa, L., Duong, C. P. M., Messaoudene, M., Gagne, A., Joubert, P., De Sordi, L., Debarbieux, L., Simon Tags: Immunology, Medicine, Diseases r-articles Source Type: news

Prevalence ofAntibiotic-Resistant Pathogens in Culture-Proven Sepsis and Outcomes Associated With Inadequate and Broad-Spectrum Empiric Antibiotic Use
Conclusions and Relevance: In this study, most patients with community-onset sepsis did not have resistant pathogens, yet broad-spectrum antibiotics were frequently administered. Both inadequate and unnecessarily broad empiric antibiotics were associated with higher mortality. These findings underscore the need for better tests to rapidly identify patients with resistant pathogens and for more judicious use of broad-spectrum antibiotics for empiric sepsis treatment. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2020 Category: Consumer Health News Source Type: news

Lactose drives Enterococcus expansion to promote graft-versus-host disease
We report lactose as a common nutrient that drives expansion of a commensal bacterium that exacerbates an intestinal and systemic inflammatory disease. (Source: ScienceNOW)
Source: ScienceNOW - November 27, 2019 Category: Science Authors: Stein-Thoeringer, C. K., Nichols, K. B., Lazrak, A., Docampo, M. D., Slingerland, A. E., Slingerland, J. B., Clurman, A. G., Armijo, G., Gomes, A. L. C., Shono, Y., Staffas, A., Burgos da Silva, M., Devlin, S. M., Markey, K. A., Bajic, D., Pinedo, R., Tsa Tags: Immunology, Medicine, Diseases reports Source Type: news

The anaesthetists' role in perioperative infection control: what is the action plan?
Hospitalised patients who suffer from healthcare-associated infections (HAIs) experience increased morbidity, mortality, and healthcare costs. Enterococcus, Staphylococcus aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp. (ESKAPE) are leading causative organisms of infection. Postoperative HAIs affect at least 7% of patients undergoing surgery, as proven by rigorous investigation and falling within the 1.9 –8.8% range reported by national stakeholders. Treatment of HAIs has fuelled resistance, making infections more difficult to treat when they develop. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 12, 2019 Category: Consumer Health News Source Type: news

Infective Endocarditis Prevalence 26 Percent in Patients With E. faecalis
MONDAY, July 8, 2019 -- The prevalence of infective endocarditis (IE) is about 26 percent among patients with Enterococcus faecalis bacteremia, according to a study published in the July 16 issue of the Journal of the American College of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 8, 2019 Category: Pharmaceuticals Source Type: news

What Infectious Diseases are Important to Consider in Transplantation Patients?
Discussion Transplantation is not a common problem for primary care physicians but when a child’s disease has progressed to end-stage organ failure, transplantation can be the only treatment available. While the primary care provider usually is not involved in the daily management of patients before, during and after transplantation, they can be involved in many areas. These can include providing appropriate primary and acute care, ordering and obtaining necessary medical tests, medications and equipment, assisting with medical insurance, providing medical history and records to consultants, translating medical infor...
Source: PediatricEducation.org - June 24, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
The human gut microbiota metabolizes the Parkinson’s disease medication Levodopa (l-dopa), potentially reducing drug availability and causing side effects. However, the organisms, genes, and enzymes responsible for this activity in patients and their susceptibility to inhibition by host-targeted drugs are unknown. Here, we describe an interspecies pathway for gut bacterial l-dopa metabolism. Conversion of l-dopa to dopamine by a pyridoxal phosphate-dependent tyrosine decarboxylase from Enterococcus faecalis is followed by transformation of dopamine to m-tyramine by a molybdenum-dependent dehydroxylase from Eggerthell...
Source: ScienceNOW - June 12, 2019 Category: Science Authors: Maini Rekdal, V., Bess, E. N., Bisanz, J. E., Turnbaugh, P. J., Balskus, E. P. Tags: Chemistry, Microbiology, Online Only r-articles Source Type: news

Study identifies how Enterococcus faecalis bacteria causes antibiotic resistant infection
This study examined one of the first sustained hospital outbreaks of a multidrug-resistant bacterium, Enterococcus faecalis, which occurred from the early through the mid-1980s, causing over 60 outbreak strains. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 17, 2019 Category: International Medicine & Public Health Source Type: news

Pathogenic, drug-resistant bacteria found in wastewater treatment plants
(Cold Spring Harbor Laboratory Press) Infections caused by drug-resistant bacteria are a global public health threat causing serious illness and even death. In a study published today in Genome Research, researchers conducted a survey of 20 municipal wastewater plants in England, and isolated drug-resistant Enterococcus faecium from all sites in both untreated and treated wastewater plants except three, which use ultraviolet light disinfection. A genomic comparison of E. faecium isolates from wastewater and bloodstream isolates of infected patients revealed two major lineages. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - March 21, 2019 Category: Infectious Diseases Source Type: news

External Quality Assessment of Laboratory Performance: European Antimicrobial Resistance Surveillance Network (EARS-Net), 2017
Source: European Union, European Centre for Disease Prevention and Control (ECDC). Published: 11/2018. This 25-page report provides an analysis of the external quality assessment (EQA) performance of laboratories participating in the European Antimicrobial Resistance Surveillance Network (EARS-Net) in 2017. A total of 893 laboratories participated in the EQA exercise. Six bacterial strains were used: Acinetobacter baumannii complex, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Streptococcus pneumoniae. (PDF) (Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - November 13, 2018 Category: International Medicine & Public Health Source Type: news

Manganese plays a key role in bacterial infection
(PLOS) The ability to acquire manganese during infection is essential for the virulence of Enterococcus faecalis in animals, according to a study published Sept. 20, 2018 in the open-access journal PLOS Pathogens by Jos é Lemos of the University of Florida College of Dentistry, and colleagues. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 20, 2018 Category: Biology Source Type: news

Alarming rise in superbugs tolerant of alcohol-based disinfectants
Australian researchers screened 139 samples of Enterococcus collected from two hospitals between 1997 and 2015 to see how well the bugs survived when exposed to diluted isopropyl alcohol. (Source: the Mail online | Health)
Source: the Mail online | Health - August 1, 2018 Category: Consumer Health News Source Type: news