Comparison of microbial profiles and viral status along the vagina-cervix-endometrium continuum of infertile patients
Syst Biol Reprod Med. 2023 Apr 27:1-10. doi: 10.1080/19396368.2023.2195040. Online ahead of print.ABSTRACTFor decades, the endometrium was considered to be a sterile environment. However, now this concept is disputed, and there is growing evidence that microbiota composition might affect endometrial receptivity. Routine clinical management of infertility is still limited to a microbiological assessment of the lower reproductive tract. The purpose of this study was to compare the abundance of various bacterial, fungal, and viral species, qualitatively and quantitatively, in vaginal, cervical, and endometrial biomaterial of ...
Source: Systems Biology in Reproductive Medicine - April 27, 2023 Category: Reproduction Medicine Authors: Mark Jain Elena Mladova Anna Dobychina Karina Kirillova Anna Shichanina Daniil Anokhin Liya Scherbakova Larisa Samokhodskaya Olga Panina Source Type: research
Comparison of microbial profiles and viral status along the vagina-cervix-endometrium continuum of infertile patients
Syst Biol Reprod Med. 2023 Apr 27:1-10. doi: 10.1080/19396368.2023.2195040. Online ahead of print.ABSTRACTFor decades, the endometrium was considered to be a sterile environment. However, now this concept is disputed, and there is growing evidence that microbiota composition might affect endometrial receptivity. Routine clinical management of infertility is still limited to a microbiological assessment of the lower reproductive tract. The purpose of this study was to compare the abundance of various bacterial, fungal, and viral species, qualitatively and quantitatively, in vaginal, cervical, and endometrial biomaterial of ...
Source: Systems Biology in Reproductive Medicine - April 27, 2023 Category: Reproduction Medicine Authors: Mark Jain Elena Mladova Anna Dobychina Karina Kirillova Anna Shichanina Daniil Anokhin Liya Scherbakova Larisa Samokhodskaya Olga Panina Source Type: research
Comparison of microbial profiles and viral status along the vagina-cervix-endometrium continuum of infertile patients
Syst Biol Reprod Med. 2023 Apr 27:1-10. doi: 10.1080/19396368.2023.2195040. Online ahead of print.ABSTRACTFor decades, the endometrium was considered to be a sterile environment. However, now this concept is disputed, and there is growing evidence that microbiota composition might affect endometrial receptivity. Routine clinical management of infertility is still limited to a microbiological assessment of the lower reproductive tract. The purpose of this study was to compare the abundance of various bacterial, fungal, and viral species, qualitatively and quantitatively, in vaginal, cervical, and endometrial biomaterial of ...
Source: Systems Biology in Reproductive Medicine - April 27, 2023 Category: Reproduction Medicine Authors: Mark Jain Elena Mladova Anna Dobychina Karina Kirillova Anna Shichanina Daniil Anokhin Liya Scherbakova Larisa Samokhodskaya Olga Panina Source Type: research
Comparison of microbial profiles and viral status along the vagina-cervix-endometrium continuum of infertile patients
Syst Biol Reprod Med. 2023 Apr 27:1-10. doi: 10.1080/19396368.2023.2195040. Online ahead of print.ABSTRACTFor decades, the endometrium was considered to be a sterile environment. However, now this concept is disputed, and there is growing evidence that microbiota composition might affect endometrial receptivity. Routine clinical management of infertility is still limited to a microbiological assessment of the lower reproductive tract. The purpose of this study was to compare the abundance of various bacterial, fungal, and viral species, qualitatively and quantitatively, in vaginal, cervical, and endometrial biomaterial of ...
Source: Systems Biology in Reproductive Medicine - April 27, 2023 Category: Reproduction Medicine Authors: Mark Jain Elena Mladova Anna Dobychina Karina Kirillova Anna Shichanina Daniil Anokhin Liya Scherbakova Larisa Samokhodskaya Olga Panina Source Type: research
Comparison of microbial profiles and viral status along the vagina-cervix-endometrium continuum of infertile patients
Syst Biol Reprod Med. 2023 Apr 27:1-10. doi: 10.1080/19396368.2023.2195040. Online ahead of print.ABSTRACTFor decades, the endometrium was considered to be a sterile environment. However, now this concept is disputed, and there is growing evidence that microbiota composition might affect endometrial receptivity. Routine clinical management of infertility is still limited to a microbiological assessment of the lower reproductive tract. The purpose of this study was to compare the abundance of various bacterial, fungal, and viral species, qualitatively and quantitatively, in vaginal, cervical, and endometrial biomaterial of ...
Source: Systems Biology in Reproductive Medicine - April 27, 2023 Category: Reproduction Medicine Authors: Mark Jain Elena Mladova Anna Dobychina Karina Kirillova Anna Shichanina Daniil Anokhin Liya Scherbakova Larisa Samokhodskaya Olga Panina Source Type: research
Safety and acceptability of intravaginal rings releasing estradiol and progesterone
CONCLUSIONS: Both IVR1 and IVR2 were safe and well tolerated in healthy postmenopausal women. TEAE profiles were comparable to the referent oral regimen.PMID:37054722 | DOI:10.1080/13697137.2023.2194526 (Source: Climacteric)
Source: Climacteric - April 13, 2023 Category: Geriatrics Authors: M L Hull B Stuckey K Hartman N Zack A Thurman D R Friend Source Type: research
Safety and acceptability of intravaginal rings releasing estradiol and progesterone
CONCLUSIONS: Both IVR1 and IVR2 were safe and well tolerated in healthy postmenopausal women. TEAE profiles were comparable to the referent oral regimen.PMID:37054722 | DOI:10.1080/13697137.2023.2194526 (Source: Climacteric)
Source: Climacteric - April 13, 2023 Category: Geriatrics Authors: M L Hull B Stuckey K Hartman N Zack A Thurman D R Friend Source Type: research
Safety and acceptability of intravaginal rings releasing estradiol and progesterone
CONCLUSIONS: Both IVR1 and IVR2 were safe and well tolerated in healthy postmenopausal women. TEAE profiles were comparable to the referent oral regimen.PMID:37054722 | DOI:10.1080/13697137.2023.2194526 (Source: Climacteric)
Source: Climacteric - April 13, 2023 Category: Geriatrics Authors: M L Hull B Stuckey K Hartman N Zack A Thurman D R Friend Source Type: research
Safety and acceptability of intravaginal rings releasing estradiol and progesterone
CONCLUSIONS: Both IVR1 and IVR2 were safe and well tolerated in healthy postmenopausal women. TEAE profiles were comparable to the referent oral regimen.PMID:37054722 | DOI:10.1080/13697137.2023.2194526 (Source: Climacteric)
Source: Climacteric - April 13, 2023 Category: Geriatrics Authors: M L Hull B Stuckey K Hartman N Zack A Thurman D R Friend Source Type: research
Dienogest versus norethisterone acetate in management of endometrial hyperplasia without atypia
ConclusionIf used as first-line treatment, Dienogest produces a better rate of regression and a lower incidence of hysterectomy than Norethisterone Acetate does when used in EH without atypia. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - April 3, 2023 Category: OBGYN Source Type: research
Integrated microRNA and secretome analysis of human endometrial organoids reveal the miR-3194-5p/Aquaporin/S100A9 module in regulating trophoblast functions
Mol Cell Proteomics. 2023 Mar 6:100526. doi: 10.1016/j.mcpro.2023.100526. Online ahead of print.ABSTRACTSuccessful placentation requires delicate communication between the endometrium and trophoblasts. The invasion and integration of trophoblasts into the endometrium during early pregnancy is crucial to placentation. Dysregulation of these functions is associated with various pregnancy complications, such as miscarriage and preeclampsia. The endometrial microenvironment has an important influence on trophoblast cell functions. The precise effect of the endometrial gland secretome on trophoblast functions remains uncertain....
Source: Molecular and Cellular Proteomics : MCP - March 8, 2023 Category: Molecular Biology Authors: Yang Dong Jianlin Li Dandan Cao Jiangming Zhong Xiaofeng Liu Yong-Gang Duan Kai-Fai Lee WilliamS B Yeung Cheuk-Lun Lee PhilipC N Chiu Source Type: research
Integrated microRNA and secretome analysis of human endometrial organoids reveal the miR-3194-5p/Aquaporin/S100A9 module in regulating trophoblast functions
Mol Cell Proteomics. 2023 Mar 6:100526. doi: 10.1016/j.mcpro.2023.100526. Online ahead of print.ABSTRACTSuccessful placentation requires delicate communication between the endometrium and trophoblasts. The invasion and integration of trophoblasts into the endometrium during early pregnancy is crucial to placentation. Dysregulation of these functions is associated with various pregnancy complications, such as miscarriage and preeclampsia. The endometrial microenvironment has an important influence on trophoblast cell functions. The precise effect of the endometrial gland secretome on trophoblast functions remains uncertain....
Source: Molecular and Cellular Proteomics : MCP - March 8, 2023 Category: Molecular Biology Authors: Yang Dong Jianlin Li Dandan Cao Jiangming Zhong Xiaofeng Liu Yong-Gang Duan Kai-Fai Lee WilliamS B Yeung Cheuk-Lun Lee PhilipC N Chiu Source Type: research
Detection of malignancy in whole slide images of endometrial cancer biopsies using artificial intelligence
In this study we use artificial intelligence (AI) to categorise endometrial biopsy whole slide images (WSI) from digital pathology as either “malignant”, “other or benign” or “insufficient”. An endometrial biopsy is a key step in diagnosis of endometrial cancer, biopsies are viewed and diagnosed by pathologists. Pathology is increasingly digitised, with slides viewed as images on screens rather than through the lens of a microscope. The availability of these images is driving automation via the application of AI. A model that classifies slides in the manner proposed would allow p rioritisation of these slides f...
Source: PLoS One - March 8, 2023 Category: Biomedical Science Authors: Christina Fell Source Type: research
Comparison of Hysterosalpingography and Laparoscopy in the Evaluation of Infertility: A Prospective Study
ConclusionsHSG and laparoscopy are not alternative, but complimentary in diagnosing tubal pathologies. HSG remains as primary screening procedure, but laparoscopy is gold standard. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - March 2, 2023 Category: OBGYN Source Type: research
