GSE209589 Human blastocysts uptake extracellular vesicles secreted by endometrial cells containing miRNAs related to implantation.
Conclusion: Data suggest that extracellular vesicles secreted by human endometrial epithelial cells are internalized by human blastocysts, and transport miRNAs to modulate biological processes related to implantation events and early embryo development. Knowledge of the communication system between human endometrium and embryo via miRNA cargo of these vesicles could describe new biomarkers of implantation success and embryo competence. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 1, 2022 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research

Case report: Spontaneous remission of synchronous endometrial and ovarian cancers following pregnancy
ConclusionThis unique case demonstrates a natural phenomenon, in which the complete, natural remission of endometrial and ovarian cancers occurred following pregnancy and childbirth. The aetiology may be related to the high progesterone levels occurring in pregnancy. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 29, 2022 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 14, Pages 5892: Point-of-Care Diagnosis of Endometrial Cancer Using the Surgical Intelligent Knife (iKnife) & mdash;A Prospective Pilot Study of Diagnostic Accuracy
Conclusions: This study is the first to use the iKnife to identify cancer in endometrial Pipelle biopsy samples. These results are highly encouraging and suggest that the iKnife could be used in the clinic to provide a POC diagnosis. (Source: Cancers)
Source: Cancers - November 29, 2022 Category: Cancer & Oncology Authors: Diana Marcus David L. Phelps Adele Savage Julia Balog Hiromi Kudo Roberto Dina Zsolt Bodai Francesca Rosini Jacey Ip Ala Amgheib Julia Abda Eftychios Manoli James McKenzie Joseph Yazbek Zoltan Takats Sadaf Ghaem-Maghami Tags: Article Source Type: research

Diagnostic accuracy of mutational analysis along the M üllerian tract to detect ovarian cancer
CONCLUSIONS: Mutational analysis in cervicovaginal and endometrial samples has limited accuracy in the detection of ovarian cancer. Future research with cytologic samples analyzed on methylation status or the vaginal microbiome may be relevant.PMID:36384753 | DOI:10.1136/ijgc-2022-003911 (Source: Cancer Control)
Source: Cancer Control - November 17, 2022 Category: Cancer & Oncology Authors: Majke H D van Bommel Johanna M A Pijnenborg Louis J M van der Putten Johan Bulten Marc P L M Snijders Heidi V N K üsters-Vandevelde Sanne Sweegers M Caroline Vos Marjolein J L Ligtenberg Astrid Eijkelenboom Joanne A de Hullu Casper Reijnen Source Type: research

Low plasma progesterone concentration during the early luteal phase delays endometrial development and the beginning of placentation in mares
Anim Reprod Sci. 2022 Nov 8;247:107149. doi: 10.1016/j.anireprosci.2022.107149. Online ahead of print.ABSTRACTWhile detrimental effects of reduced plasma progesterone concentration in the early luteal phase on conceptus development in horses have recently been demonstrated, there is no information on associated effects on the endometrium, allantochorion (AC), and chorionic girdle (CG) in this species. We hypothesised that reduced early postovulatory progesterone concentration in pregnant horses is detrimental to endometrial function and development of the embryonic membranes and is an underlying cause of delayed conceptus ...
Source: Animal Reproduction Science - November 14, 2022 Category: Zoology Authors: Carolina T C Okada Martim Kaps Ursula Reichart Ingrid Walter Camille Gautier J örg Aurich Christine Aurich Source Type: research

Low plasma progesterone concentration during the early luteal phase delays endometrial development and the beginning of placentation in mares
Anim Reprod Sci. 2022 Nov 8;247:107149. doi: 10.1016/j.anireprosci.2022.107149. Online ahead of print.ABSTRACTWhile detrimental effects of reduced plasma progesterone concentration in the early luteal phase on conceptus development in horses have recently been demonstrated, there is no information on associated effects on the endometrium, allantochorion (AC), and chorionic girdle (CG) in this species. We hypothesised that reduced early postovulatory progesterone concentration in pregnant horses is detrimental to endometrial function and development of the embryonic membranes and is an underlying cause of delayed conceptus ...
Source: Animal Reproduction Science - November 14, 2022 Category: Zoology Authors: Carolina T C Okada Martim Kaps Ursula Reichart Ingrid Walter Camille Gautier J örg Aurich Christine Aurich Source Type: research

Sentinel lymph node mapping in patients with endometrial hyperplasia: A practice to preserve or abandon?
CONCLUSIONS: SLN assessment appears safe, detects a small number of occult nodal metastases for those upstaged, and provides additional staging information that can guide adjuvant treatment. SLN mapping should be discussed in preoperative counseling and offered using a shared decision-making approach.PMID:36334496 | DOI:10.1016/j.ygyno.2022.10.017 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 5, 2022 Category: Cancer & Oncology Authors: Jennifer J Mueller Eric Rios-Doria Kay J Park Vance A Broach Kaled M Alektiar Elizabeth L Jewell Oliver Zivanovic Yukio Sonoda Nadeem R Abu-Rustum Mario M Leitao Ginger J Gardner Source Type: research

Sentinel lymph node mapping in patients with endometrial hyperplasia: A practice to preserve or abandon?
CONCLUSIONS: SLN assessment appears safe, detects a small number of occult nodal metastases for those upstaged, and provides additional staging information that can guide adjuvant treatment. SLN mapping should be discussed in preoperative counseling and offered using a shared decision-making approach.PMID:36334496 | DOI:10.1016/j.ygyno.2022.10.017 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 5, 2022 Category: Cancer & Oncology Authors: Jennifer J Mueller Eric Rios-Doria Kay J Park Vance A Broach Kaled M Alektiar Elizabeth L Jewell Oliver Zivanovic Yukio Sonoda Nadeem R Abu-Rustum Mario M Leitao Ginger J Gardner Source Type: research

Sentinel lymph node mapping in patients with endometrial hyperplasia: A practice to preserve or abandon?
CONCLUSIONS: SLN assessment appears safe, detects a small number of occult nodal metastases for those upstaged, and provides additional staging information that can guide adjuvant treatment. SLN mapping should be discussed in preoperative counseling and offered using a shared decision-making approach.PMID:36334496 | DOI:10.1016/j.ygyno.2022.10.017 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - November 5, 2022 Category: Cancer & Oncology Authors: Jennifer J Mueller Eric Rios-Doria Kay J Park Vance A Broach Kaled M Alektiar Elizabeth L Jewell Oliver Zivanovic Yukio Sonoda Nadeem R Abu-Rustum Mario M Leitao Ginger J Gardner Source Type: research

IJERPH, Vol. 19, Pages 14451: Mesonephric-Like Adenocarcinomas a Rare Tumor: The Importance of Diagnosis
cambia Giuseppe Vizzielli Mesonephric-like adenocarcinomas (MLA) are rare neoplasms that arise in the uterine body and ovary and have been added to the World Health Organisation’s recent 2020 classification of female genital cancers. The pathogenesis of MLA is unknown and it remains debated whether they represent mesonephric carcinomas (Wolffian) arising in the endometrium/ovary or endometrioid carcinomas (Müllerian) closely mimicking mesonephric carcinomas. Here we report the case of a 57-year-old woman with an initial misdiagnosis of endometrioid adenocarcinoma on diagnostic biopsy. The p...
Source: International Journal of Environmental Research and Public Health - November 4, 2022 Category: Environmental Health Authors: Stefano Restaino Giulia Pellecchia Angelica Tulisso Chiara Paglietti Maria Orsaria Claudia Andreetta Elena Poletto Martina Arcieri Monica della Martina Anna Biasioli Laura Mariuzzi Lorenza Driul Giovanni Scambia Giuseppe Vizzielli Tags: Case Report Source Type: research

Consistency of era and histological dating of spatially distinct endometrial samplings: a prospective, blinded study
The ERA is intended to provide information on the timing of embryo transfer based on transcriptional analysis of a single endometrial biopsy. However, multiple sources describe histological asynchrony between different locations in the secretory endometrium (1,2). Endometrial biopsies are not typically performed under ultrasound guidance, and therefore the exact location of the tissue retrieved from biopsy is unknown. No study to date has questioned whether ERA results are consistent between multiple, spatially distinct tissue samples from the same biopsy. (Source: Fertility and Sterility)
Source: Fertility and Sterility - November 1, 2022 Category: Reproduction Medicine Authors: Trenton Place, Parisa Najafzadeh, Saloni Walia, Lynda McGinnis, Priya Kohli, Juna Felix, Richard Paulson Source Type: research

8847 Office Operative Hysteroscopy Using the LiNA Operascope Lasso and Biopsy Forceps
To evaluate the LiNA OperaScope Lasso and Biopsy Forceps for office hysteroscopy with polypectomy and targeted endometrial biopsy. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - November 1, 2022 Category: OBGYN Authors: N.L. Hafner, N. Hammoud Source Type: research

The management of perimenopausal abnormal uterine bleeding
Abnormal uterine bleeding in the perimenopause is a common gynaecological disorder and may affect 20 –50 % of all women. It may be the first sign of premalignant or malignant disease. All women require assessment by means of pelvic ultrasound and an endometrial biopsy to exclude sinister pathology, identify other causes, and plan appropriate treatment. Pharmacological treatment includes antifibri nolytics, non-steroidal anti-inflammatories, combined hormonal contraception, cyclical progestogens and the levonorgestrel intrauterine system (LNG – IUS). (Source: Obstetrics, Gynaecology and Reproductive Medicine)
Source: Obstetrics, Gynaecology and Reproductive Medicine - October 25, 2022 Category: OBGYN Authors: Chloe Manley, Theofanis Manias Tags: Review Source Type: research

Preoperative sampling in endometrial cancer: evaluation of the histopathological agreement with definitive surgical specimen
ConclusionsAccording to this study, the use of pipelle sampling could become an adequate diagnostic method in endometrial cancer due to its similar agreement to HSC, ease of use and affordability. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - October 21, 2022 Category: Cancer & Oncology Source Type: research

Accuracy of office hysteroscopy in diagnosis of endometrial pathologies compared to ultrasound and histopathology in Baghdad Teaching Hospital
CONCLUSION: Although a transvaginal ultrasound was considered an integral part in the diagnosis of endometrial pathologies, it can be used for initial investigation, however, when suspecting endometrial pathology, hysteroscopy can be more advanced for evaluation, immediate treatment of endometrial masses, and obtaining targeted biopsies. Hysteroscopy showed high sensitivity in detecting endometrial polyps.PMID:36196944 | DOI:10.47750/jptcp.2022.954 (Source: Journal of Population Therapeutics and Clinical Pharmacology)
Source: Journal of Population Therapeutics and Clinical Pharmacology - October 5, 2022 Category: Drugs & Pharmacology Authors: Farah Abdul Hussein Salih Al-Asadi Shaymaa Kadhim Jasim Source Type: research