A series of N-of-1 trials to assess the therapeutic interchangeability of two enalapril formulations in the treatment of hypertension in Addis Ababa, Ethiopia: study protocol for a randomized controlled trial
DiscussionThe number of locally produced products, such as enalapril, being approved without proof of bioequivalence is dramatically increasing. By bridging the information gap on bioequivalence, the trial will give rigorous evidence on therapeutic equivalence of locally produced enalapril in the treatment of hypertension. If there is no difference, the hypothesized result, then patients can take the local medicine with confidence. This trial will also will determine whether aggregated N-of-1 studies are feasible to evaluate untested generic drugs in resource-limited countries where bioequivalence testing centers are unava...
Source: Trials - October 10, 2017 Category: Research Source Type: clinical trials
PROACT: Can we Prevent Chemotherapy-related Heart Damage in Patients With Breast Cancer?
Condition: Breast Cancer Intervention: Drug: Enalapril Sponsors: South Tees Hospitals NHS Foundation Trust; Newcastle University; University of Durham; Newcastle-upon-Tyne Hospitals NHS Trust Not yet recruiting - verified August 2017 (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - August 24, 2017 Category: Research Source Type: clinical trials
