ASCO: Low - Dose Chemo Benefits Advanced Gastroesophageal Cancer
Elderly, frail receiving 60 percent of oxaliplatin/capecitabine dose have noninferior PFS, less toxicity (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 3, 2019 Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pharmacy, Geriatrics, Conference News, Source Type: news
Does Oxaliplatin Improve Survival Over Cisplatin in Advanced Gastric Cancer?
Researchers tested the novel oral fluoropyrimidine derivative S-1 plus oxaliplatin vs S-1 plus cisplatin in patients with diffuse-type or mixed-type advanced gastric adenocarcinoma. (Source: CancerNetwork)
Source: CancerNetwork - June 3, 2019 Category: Cancer & Oncology Authors: Lauren M. Dembeck Source Type: news
Sucking Ice Chips Cuts Oral Side Effects of Oxaliplatin Chemo
Benefits include less trouble eating and fewer symptom - related negative effects on quality of life (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - April 24, 2019 Category: Cancer & Oncology Tags: Gastroenterology, Oncology, Pharmacy, Journal, Source Type: news
Sucking Ice Chips Cuts Oral Side Effects of Oxaliplatin Chemo
WEDNESDAY, April 24, 2019 -- Chemotherapy patients who suck on ice chips during treatment with oxaliplatin infusion have less trouble with eating and drinking cold things, fewer negative effects on quality of life due to oral symptoms, and a shorter... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 24, 2019 Category: Pharmaceuticals Source Type: news
Active ingredient of aconite root against peripheral neuropathic pain is identified as neoline
(Nagoya City University) Aconite root is used in East Asian traditional medicines to treat pain. Since its toxicity, it is used after heat-processing for detoxifying. The present study revealed that processed aconite root could relief neuropathic pain in murine peripheral neuropathy model induced by oxaliplatin, paclitaxel, or partial ligation of the sciatic nerve (Seltzer model), and identified that its active ingredient is not benzoylmesaconine, a degraded compound of toxic mesaconitine, but neoline, a stable compound by detoxifying heat-processing. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 10, 2019 Category: Biology Source Type: news
Science Saturday: Fruit flies rise to the occasion
Fishing them out of a drink, you may not see the benefit of fruit flies. But they are a vital scientific model, and at Mayo Clinic, they are helping researchers investigate a debilitating chemotherapy side effect: nerve damage called "peripheral neuropathy." "The platinum drugs -- cisplatin, carboplatin, oxaliplatin -- are the [most common] drugs used [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - April 5, 2019 Category: Databases & Libraries Source Type: news
Modified-FOLFIRINOX Beneficial in Resected Pancreatic Cancer
WEDNESDAY, Dec. 19, 2018 -- For patients with resected pancreatic cancer, adjuvant therapy with a modified regimen of chemotherapy with fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX), compared with gemcitabine, results in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 19, 2018 Category: Pharmaceuticals Source Type: news
Neuromics FBS at 259 USD/500 ml.
Only 2 Weeks LeftWe wanted to get ourFBS in the hands of more cell culturing experts. Our low pricing has accelerated purchasing of this culture supplement.More importantly, we are pleased with the positive feedback. Here are some recentreviews.Linda S.on BirdEye ★★★★★9 days agoMy experience with Neuromics was very positive. I asked for a sample of FBS and after to use the FBS I received. Peter T.on BirdEye ★★★★★month agoI purchased FBS from Neuromics. It was shipped to Canada without any problems. It arrived safely and still frozen. Cells grow well in the product. Customer ser...
Source: Neuromics - December 15, 2018 Category: Neuroscience Tags: FBS Fetal Bovine Serum Source Type: news
The Adjuvant Treatment of Stage III Colon Cancer: Might Less Be More?
In this article, we review the findings of the IDEA study and discuss the optimal duration of oxaliplatin-based adjuvant chemotherapy using patient-based risk factors. (Source: CancerNetwork)
Source: CancerNetwork - September 18, 2018 Category: Cancer & Oncology Authors: James J. Lee, MD, PhD, Edward Chu, MD Source Type: news
Second-Line Irinotecan/Cetuximab/Ramucirumab Combo Ups PFS in Advanced CRC
John SchieszerJun 6, 2018A combination of irinotecan, cetuximab, and ramucirumab may boost PFS in advanced CRC, when given after failure of oxaliplatin-and-bevacizumab –based therapy. (Source: CancerNetwork)
Source: CancerNetwork - June 7, 2018 Category: Cancer & Oncology Authors: A Source Type: news
ASCO: mFOLFIRINOX Improves Survival in Pancreatic Cancer
MONDAY, June 4, 2018 -- The oxaliplatin, leucovorin, irinotecan, and 5-fluorouracil (mFOLFIRINOX) regimen is associated with longer median disease-free and overall survival in pancreatic ductal adenocarcinoma; and, receiving chemotherapy before... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 4, 2018 Category: Pharmaceuticals Source Type: news
A3AR Agonists May Help Prevent Chemotherapy-Induced Neuropathic Pain
A highly selective small molecule A3AR agonist blocked development of oxaliplatin-induced neuropathic pain without interfering with anticancer effects. (Source: CancerNetwork)
Source: CancerNetwork - April 13, 2018 Category: Cancer & Oncology Authors: John Schieszer Tags: Colorectal Cancer Gastrointestinal Cancer News Source Type: news
'I'm so lucky my cancer was spotted after budget cuts hit screening' says LORD LANSLEY
LAST Monday, I sat in a chair in a medical day unit while chemotherapy medication went into my vein. A drug called oxaliplatin which, with daily tablets of capecitabine to follow, are my ongoing treatment for bowel cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - April 3, 2018 Category: Consumer Health News Source Type: news
3, 6 Month Adjuvant CAPOX Equally Effective for Colon Cancer
THURSDAY, March 29, 2018 -- For patients with stage III colon cancer, three months of capecitabine and oxaliplatin (CAPOX) therapy is not noninferior to six months of therapy overall, according to a study published in the March 20 issue the New... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - March 30, 2018 Category: Pharmaceuticals Source Type: news
Palmitoylation of {delta}-catenin promotes kinesin-mediated membrane trafficking of Nav1.6 in sensory neurons to promote neuropathic pain
Palmitoylation of -catenin is critical to synapse plasticity and memory formation. We found that -catenin palmitoylation is also instrumental in the development of neuropathic pain. The abundances of palmitoylated -catenin and the palmitoyl acyltransferase DHHC3 were increased in dorsal root ganglion (DRG) sensory neurons in rat models of neuropathic pain. Inhibiting palmitoyl acyltransferases or decreasing -catenin abundance in the DRG by intrathecal injection of 2-bromopalmitate or shRNA, respectively, alleviated oxaliplatin or nerve injury–induced neuropathic pain in the rats. The palmitoylation of -catenin, which...
Source: Signal Transduction Knowledge Environment - March 27, 2018 Category: Science Authors: Zhang, X.-L., Ding, H.-H., Xu, T., Liu, M., Ma, C., Wu, S.-L., Wei, J.-Y., Liu, C.-C., Zhang, S.-B., Xin, W.-J. Tags: STKE Research Articles Source Type: news
