Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions
Sorting Nexin 27 (SNX27)-retromer complex facilitates cargo recycling from endosomes to the plasma membrane. SNX27 downregulation in neurons, as the result of Trisomy 21 (T21), has been linked with cognitive d... (Source: Immunity and Aging)
Source: Immunity and Aging - January 2, 2024 Category: Geriatrics Authors: Cristina Rodriguez-Rodriguez, Natalia Gonz ález-Mancha, Ane Ochoa-Echeverría, Rosa Liébana and Isabel Merida Tags: Research Source Type: research
Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule
In this study, we employed a structure-based virtual screening (SBVS) campaign targeting DYRK1A from a database containing 1.6 million compounds. Enzymatic assays were utilized to verify inhibitory properties, confirming that Y020-3945 and Y020-3957 showed inhibitory activity towards DYRK1A. In particular, the compounds exhibited high selectivity for DYRK1A over a panel of 120 kinases, reduced the phosphorylation of tau, and reversed the tubulin polymerization for microtubule stability. Additionally, treatment with the compounds significantly reduced the secretion of inflammatory cytokines IL-6 and TNF-α activated by DYRK...
Source: International Journal of Biological Macromolecules - January 1, 2024 Category: Biochemistry Authors: Yi-Wen Wu Wei-Chun HuangFu Tony Eight Lin Chao-Hiang Peng Huang-Ju Tu Ting-Yi Sung Tzu-Ying Sung Shih-Chung Yen Shiow-Lin Pan Kai-Cheng Hsu Source Type: research
Identification of selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors and their effects on tau and microtubule
In this study, we employed a structure-based virtual screening (SBVS) campaign targeting DYRK1A from a database containing 1.6 million compounds. Enzymatic assays were utilized to verify inhibitory properties, confirming that Y020-3945 and Y020-3957 showed inhibitory activity towards DYRK1A. In particular, the compounds exhibited high selectivity for DYRK1A over a panel of 120 kinases, reduced the phosphorylation of tau, and reversed the tubulin polymerization for microtubule stability. Additionally, treatment with the compounds significantly reduced the secretion of inflammatory cytokines IL-6 and TNF-α activated by DYRK...
Source: International Journal of Biological Macromolecules - January 1, 2024 Category: Biochemistry Authors: Yi-Wen Wu Wei-Chun HuangFu Tony Eight Lin Chao-Hiang Peng Huang-Ju Tu Ting-Yi Sung Tzu-Ying Sung Shih-Chung Yen Shiow-Lin Pan Kai-Cheng Hsu Source Type: research
The circulating cells with blast-like morphology in transient abnormal myelopoiesis of Down syndrome are unique and deserve a specific name: Would the term "megakaryogones" serve this purpose?
Malays J Pathol. 2023 Dec;45(3):479-480.ABSTRACTNo abstract available.PMID:38155389 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: S B Kahwash K Nicol Source Type: research
Prosodic skills in Spanish-speaking adolescents and young adults with Down syndrome
CONCLUSIONS & IMPLICATIONS: The findings contribute to the ongoing development of the language profile of teenagers and young adults with DS and imply the need to design prosodic intervention programs based on their specific profile.WHAT THIS PAPER ADDS: What is already known on the subject Prosody is a fundamental element of language, and its mastery affects the effectiveness of communication. However, research on prosody in Down syndrome (DS) that offers a holistic view from a psycholinguistic approach is still scarce. To date, studies focused on providing a detailed profile of prosodic skills in individuals with DS have...
Source: International Journal of Language and Communication Disorders - December 28, 2023 Category: Speech-Language Pathology Authors: Elena L ópez-Riobóo Pastora Mart ínez-Castilla Source Type: research
The circulating cells with blast-like morphology in transient abnormal myelopoiesis of Down syndrome are unique and deserve a specific name: Would the term "megakaryogones" serve this purpose?
Malays J Pathol. 2023 Dec;45(3):479-480.ABSTRACTNo abstract available.PMID:38155389 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: S B Kahwash K Nicol Source Type: research
Prosodic skills in Spanish-speaking adolescents and young adults with Down syndrome
CONCLUSIONS & IMPLICATIONS: The findings contribute to the ongoing development of the language profile of teenagers and young adults with DS and imply the need to design prosodic intervention programs based on their specific profile.WHAT THIS PAPER ADDS: What is already known on the subject Prosody is a fundamental element of language, and its mastery affects the effectiveness of communication. However, research on prosody in Down syndrome (DS) that offers a holistic view from a psycholinguistic approach is still scarce. To date, studies focused on providing a detailed profile of prosodic skills in individuals with DS have...
Source: International Journal of Language and Communication Disorders - December 28, 2023 Category: Speech-Language Pathology Authors: Elena L ópez-Riobóo Pastora Mart ínez-Castilla Source Type: research
The circulating cells with blast-like morphology in transient abnormal myelopoiesis of Down syndrome are unique and deserve a specific name: Would the term "megakaryogones" serve this purpose?
Malays J Pathol. 2023 Dec;45(3):479-480.ABSTRACTNo abstract available.PMID:38155389 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: S B Kahwash K Nicol Source Type: research
Prosodic skills in Spanish-speaking adolescents and young adults with Down syndrome
CONCLUSIONS & IMPLICATIONS: The findings contribute to the ongoing development of the language profile of teenagers and young adults with DS and imply the need to design prosodic intervention programs based on their specific profile.WHAT THIS PAPER ADDS: What is already known on the subject Prosody is a fundamental element of language, and its mastery affects the effectiveness of communication. However, research on prosody in Down syndrome (DS) that offers a holistic view from a psycholinguistic approach is still scarce. To date, studies focused on providing a detailed profile of prosodic skills in individuals with DS have...
Source: International Journal of Language and Communication Disorders - December 28, 2023 Category: Speech-Language Pathology Authors: Elena L ópez-Riobóo Pastora Mart ínez-Castilla Source Type: research
The circulating cells with blast-like morphology in transient abnormal myelopoiesis of Down syndrome are unique and deserve a specific name: Would the term "megakaryogones" serve this purpose?
Malays J Pathol. 2023 Dec;45(3):479-480.ABSTRACTNo abstract available.PMID:38155389 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: S B Kahwash K Nicol Source Type: research
Prosodic skills in Spanish-speaking adolescents and young adults with Down syndrome
CONCLUSIONS & IMPLICATIONS: The findings contribute to the ongoing development of the language profile of teenagers and young adults with DS and imply the need to design prosodic intervention programs based on their specific profile.WHAT THIS PAPER ADDS: What is already known on the subject Prosody is a fundamental element of language, and its mastery affects the effectiveness of communication. However, research on prosody in Down syndrome (DS) that offers a holistic view from a psycholinguistic approach is still scarce. To date, studies focused on providing a detailed profile of prosodic skills in individuals with DS have...
Source: International Journal of Language and Communication Disorders - December 28, 2023 Category: Speech-Language Pathology Authors: Elena L ópez-Riobóo Pastora Mart ínez-Castilla Source Type: research
The circulating cells with blast-like morphology in transient abnormal myelopoiesis of Down syndrome are unique and deserve a specific name: Would the term "megakaryogones" serve this purpose?
Malays J Pathol. 2023 Dec;45(3):479-480.ABSTRACTNo abstract available.PMID:38155389 (Source: Malaysian Journal of Pathology)
Source: Malaysian Journal of Pathology - December 28, 2023 Category: Pathology Authors: S B Kahwash K Nicol Source Type: research
