Roche and Alnylam report positive topline results from the Phase II KARDIA-2 study in people with hypertension, demonstrating clinically significant blood pressure reductions with zilebesiran when added to standard of care
KARDIA-2 study met its primary endpoint, demonstrating clinically significant systolic blood pressure reductions in each treatment arm at month threeZilebesiran added to a standard of care hypertension medication demonstrated an encouraging safety and tolerability profile in adults with mild to moderate uncontrolled hypertension, and results support the potential for twice-yearly dosingRoche and Alnylam have initiated the Phase II KARDIA-3 study in adults with uncontrolled hypertension at high cardiovascular riskKARDIA-2 study results will be presented as a late-breaking abstract in April at the 2024 American College of Ca...
Source: Roche Investor Update - March 5, 2024 Category: Pharmaceuticals Source Type: news
Roche and Alnylam report positive topline results from the Phase II KARDIA-2 study in people with hypertension, demonstrating clinically significant blood pressure reductions with zilebesiran when added to standard of care
KARDIA-2 study met its primary endpoint, demonstrating clinically significant systolic blood pressure reductions in each treatment arm at month threeZilebesiran added to a standard of care hypertension medication demonstrated an encouraging safety and tolerability profile in adults with mild to moderate uncontrolled hypertension, and results support the potential for twice-yearly dosingRoche and Alnylam have initiated the Phase II KARDIA-3 study in adults with uncontrolled hypertension at high cardiovascular riskKARDIA-2 study results will be presented as a late-breaking abstract in April at the 2024 American College of Ca...
Source: Roche Media News - March 5, 2024 Category: Pharmaceuticals Source Type: news
Accessing special educational needs and disabilities (SEND) provision for Black and mixed Black heritage children: lived experiences from parents and professionals living in South London
Impact on Urban Health - Global Black Maternal Health were commissioned to lead a research project to better understand the experiences of Black and mixed heritage children and families (including the impact on mental health) when a child has special educational needs or disabilities (SEND). This research provides clear recommendations for policy makers to improve families ’ experiences of navigating the support system for children with SEND.ReportMore detail (Source: The Kings Fund - Health Management Specialist Collection)
Source: The Kings Fund - Health Management Specialist Collection - March 5, 2024 Category: Health Management Authors: The King ' s Fund Library Tags: Mental health Source Type: news
QuickStats: Percentage* of children and adolescents aged 5-17 years who had chronic school absenteeism due to illness, injury, or disability during the past 12 months,( †) by age group and year - National Health Interview Survey,(§) United States, 2019 and 2022 - Black LI, Elgaddal N.
The percentage of children and adolescents aged 5-17 years who had chronic school absenteeism during the past 12 months was higher in 2022 (5.8%) than in 2019 (3.3%). From 2019 to 2022, the percentage of children who had chronic school absenteeism increase... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
A public health approach to reducing violence within the CARICOM region - Maharaj S, Seepersad R, Sooknanan J, Anderson S, Franco D, Ramdass A, Seemungal T.
[SafetyLit note: CARICOM = Caribbean Community]
Widespread crime has become a worldwide problem so much so that violence is now ranked fourth globally in its contribution to disability-adjusted life years in the 10 to 24 age group. Homicides, a surrogat... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Prevalence and related factors of dizziness among older adults: a cross-sectional study in Ardakan City, Iran - Morowatisharifabad MA, Sharifabad MH, Aboutorabi-Zarchi M.
BACKGROUND: Dizziness and balance disorders are directly related to aging in humans- Dizziness is one of the most important factors causing the burden of disability after the age of 65. Bearing in mind the increase in the elderly population in Iran and the... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Current state of neuroprotective therapy using antibiotics in human traumatic brain injury and animal models - Ritter K, Somnuke P, Hu L, Griemert EV, Sch äfer MKE.
TBI is a leading cause of death and disability in young people and older adults worldwide. There is no gold standard treatment for TBI besides surgical interventions and symptomatic relief. Post-injury infections, such as lower respiratory tract and surgic... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Availability and usability of transportation for people with disabilities depending on what the user is expected to do - Venkataram PS, Flynn JA, Bhuiya MMR, Barajas JM, Handy S.
We comprehensively review typical problems that people with disabilities face when using local transportation modes. We show how specific problems with each mode can affect many different disability subgroups at once and can affect or be affected by proble... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Tertiary trauma survey on emergency department observational units: a systematic literature review - Pervez T, Malik M.
In today's competitive world with a fast-paced lifestyle, trauma is on the rise and is globally recognized as the leading cause of mortality, morbidity, and disability. Despite the development of major trauma centers and the introduction of advanced trauma... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Rank order impedimentsto first responder care on road traffic accident victims among the auto rickshaw drivers of a selected district of Karnataka - Vinish V, Chakrabarty J, Vijayan S, Shashidhara YN, Nayak BS, Kulkarni M, Noronha JA.
BACKGROUND: The mortality rate of road traffic accidents (RTAs) is high in India. RTAs lead to disability and mortality in young adults in the country. It is a global problem as approximately 1.24 million deaths occur annually worldwide because of RTAs. In... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Economic burden of accidents and injuries In india: what does 75(th) round of National Sample Survey imply? - Thomas MB, Pandey AK, Gautam D, Gopinathan S, Panolan S.
BACKGROUND: Accidents and injuries constitute a sizable share of mortality and morbidity in low- and middle-income countries. This affects the most productive age group and increases disability-adjusted life years (DALYs). It results in a substantial finan... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Risky driving behavior among public transport vehicle drivers in Ethiopia using the health belief model - Mazengia EM, Kassie A, Zewdie A, Tesfa H, Aschale A, Debalkie Demissie G.
Introduction
Every year, road traffic accidents cause 1.35 million deaths and up to 50 million disabilities worldwide. Low and middle-income countries account for 93% of all fatalities, despite owning 60% of the world's vehicles. Road traffic accidents co... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
Validity and reliability International Classification of Diseases-10 codes for all forms of injury: a systematic review - Paleczny S, Osagie N, Sethi J.
BACKGROUND: Intentional and unintentional injuries are a leading cause of death and disability globally. International Classification of Diseases (ICD), Tenth Revision (ICD-10) codes are used to classify injuries in administrative health data and are widel... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Research Methods, Surveillance and Codes, Models Source Type: news
Measuring the burden of disease in Korea using disability-adjusted life years (2008-2020) - Jung YS, Kim YE, Ock M, Yoon SJ.
This study aimed to examine the burden of disease in Korea for both the t... (Source: SafetyLit)
Source: SafetyLit - March 4, 2024 Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news
Paid Family Caregivers in Indiana Face Steep Cutbacks
Now that federal pandemic-era funds are shrinking, states like Indiana are ending or curtailing programs that finance home care by relatives of seriously ill children and adults. (Source: NYT Health)
Source: NYT Health - March 4, 2024 Category: Consumer Health News Authors: Ted Alcorn and Kaiti Sullivan Tags: Health Insurance and Managed Care Medicaid States (US) Families and Family Life Coronavirus (2019-nCoV) Disabilities Home Health Care Budgets and Budgeting United States Politics and Government State Legislatures Government Contracts a Source Type: news
