Cryotherapy after Topical Interferon Alpha 2b to Treat Conjunctival Primary Acquired Melanosis
When primary acquired melanosis (PAM) with atypia affects the tarsal conjunctiva, a radical surgery can be mutilating, requiring reconstructive surgery of the eyelid. Topical chemotherapy associated to local cryotherapy may be an alternative. A 64-year-old Caucasian female presented with diffuse PAM of the right eye involving the inferior tarsal conjunctiva, fornix, and inferotemporal bulbar conjunctiva. Histological study showed a PAM with atypia (C-MIN 5). Given the extent of the lesion and its location, a wide mutilating excision was ruled out. Topical interferon alpha 2b (IFN- α2b) treatment (1,000,000 IU/mL, 4 times ...
Source: Case Reports in Ophthalmology - March 22, 2023 Category: Opthalmology Source Type: research
Erratum
Dysphagia (dys) palliation in inoperable esophageal cancer (EC) continues to be a challenge. While chemotherapy and radiation help with dys, many patients require endoscopic interventions. Self-expanding metal stents have been the mainstay for endoscopic palliation but have a significant risk of adverse events (AEs), including reflux. Liquid nitrogen spray Cryotherapy (cryo) is an established modality that can be used with ST. Retrospective studies showed improvement in dys with a favorable AE profile but did not report on quality of life (QoL) in patients receiving ST. (Source: Gastrointestinal Endoscopy)
Source: Gastrointestinal Endoscopy - March 21, 2023 Category: Gastroenterology Authors: Kachaamy Toufic, R. Sharma Neil, Shaw Tilak, Mohapatra Sonmoon, G. Pollard Kimberly, M. Zelt Christina, Jewett Elaine, Gupta Saurabh, Rojas-DeLeon Mariajose, Gupta Digant, Kaul Vivek, Pannala Rahul, G. Vashi Pankaj Tags: Erratum Source Type: research
Follow-up of retinoblastoma using RetCam fluorescein angiography and correlation with clinical findings
CONCLUSION: RetCam wide-angle FA is useful to evaluate the tumor and associated vascular and retinal changes after treatment in RB. Regressed tumors demonstrate later fluorescein uptake in venous phases. Fluorescein angiographic changes in chorioretinal scars include window defects, visibility of choroidal vessels, scleral staining, and leakage from vessels. Retinal vascular leakage and peripheral non-perfusion can be seen in eyes with regressed stable tumors.PMID:36935642 | DOI:10.1177/11206721231163619 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - March 20, 2023 Category: Opthalmology Authors: Ahmet Kaan G ündüz Di ğdem Tetik Source Type: research
Follow-up of retinoblastoma using RetCam fluorescein angiography and correlation with clinical findings
CONCLUSION: RetCam wide-angle FA is useful to evaluate the tumor and associated vascular and retinal changes after treatment in RB. Regressed tumors demonstrate later fluorescein uptake in venous phases. Fluorescein angiographic changes in chorioretinal scars include window defects, visibility of choroidal vessels, scleral staining, and leakage from vessels. Retinal vascular leakage and peripheral non-perfusion can be seen in eyes with regressed stable tumors.PMID:36935642 | DOI:10.1177/11206721231163619 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - March 20, 2023 Category: Opthalmology Authors: Ahmet Kaan G ündüz Di ğdem Tetik Source Type: research
Follow-up of retinoblastoma using RetCam fluorescein angiography and correlation with clinical findings
CONCLUSION: RetCam wide-angle FA is useful to evaluate the tumor and associated vascular and retinal changes after treatment in RB. Regressed tumors demonstrate later fluorescein uptake in venous phases. Fluorescein angiographic changes in chorioretinal scars include window defects, visibility of choroidal vessels, scleral staining, and leakage from vessels. Retinal vascular leakage and peripheral non-perfusion can be seen in eyes with regressed stable tumors.PMID:36935642 | DOI:10.1177/11206721231163619 (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - March 20, 2023 Category: Opthalmology Authors: Ahmet Kaan G ündüz Di ğdem Tetik Source Type: research
Years of dermatology experience and geographic region are associated with outlier performance of excision or destruction for nonmelanoma skin cancer
CONCLUSIONS: Dermatologists with less experience or in certain geographic regions performed more malignant excision relative to destruction. As the older population of dermatologists retires, the cost of care for NMSC may increase.PMID:36932466 | DOI:10.1080/09546634.2023.2192839 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - March 18, 2023 Category: Dermatology Authors: Brad R Woodie Scott A Neltner Annabella G Pauley Alan B Fleischer Source Type: research
Contemporary patterns of local ablative therapies for prostate cancer at United States cancer centers: results from a national registry
ConclusionsLocal ablative therapy for PCa treatment is more commonly offered among older and comorbid patients. Future studies should investigate the uptake of these technologies in non-hospital-based settings and in light of recent changes in insurance coverage. (Source: World Journal of Urology)
Source: World Journal of Urology - March 17, 2023 Category: Urology & Nephrology Source Type: research
Advances in conjunctival melanoma: clinical features, diagnostic modalities, staging, genetic markers, and management
Can J Ophthalmol. 2023 Mar 12:S0008-4182(23)00043-1. doi: 10.1016/j.jcjo.2023.02.003. Online ahead of print.ABSTRACTConjunctival melanoma, a rare malignancy of the ocular surface, is increasing in incidence. When small, straightforward excision with "no touch" surgery and cryotherapy at an experienced centre can provide excellent outcomes. When advanced, management is more complex and highly individualized. The risk of metastatic disease from conjunctival melanoma is as high as 30% and depends on tumour origin, American Joint Committee on Cancer (AJCC) classification, biomarkers, and perhaps most important, management tech...
Source: Canadian Journal of Ophthalmology - March 15, 2023 Category: Opthalmology Authors: Jennifer S Zeiger Sara E Lally Lauren A Dalvin Carol L Shields Source Type: research
Advances in conjunctival melanoma: clinical features, diagnostic modalities, staging, genetic markers, and management
Can J Ophthalmol. 2023 Mar 12:S0008-4182(23)00043-1. doi: 10.1016/j.jcjo.2023.02.003. Online ahead of print.ABSTRACTConjunctival melanoma, a rare malignancy of the ocular surface, is increasing in incidence. When small, straightforward excision with "no touch" surgery and cryotherapy at an experienced centre can provide excellent outcomes. When advanced, management is more complex and highly individualized. The risk of metastatic disease from conjunctival melanoma is as high as 30% and depends on tumour origin, American Joint Committee on Cancer (AJCC) classification, biomarkers, and perhaps most important, management tech...
Source: Canadian Journal of Ophthalmology - March 15, 2023 Category: Opthalmology Authors: Jennifer S Zeiger Sara E Lally Lauren A Dalvin Carol L Shields Source Type: research
Keloid treatments: an evidence-based systematic review of recent advances
ConclusionsThis review was limited by heterogeneity of subject characteristics and study outcome measures, small sample sizes, and inconsistent study designs. Larger and more robust controlled studies are necessary to further understand the variety of existing and emerging keloid treatments, including corticosteroids, cryotherapy, intralesional injections, lasers, photodynamic therapy, excision and radiation, pressure dressings, and others. (Source: Systematic Reviews)
Source: Systematic Reviews - March 14, 2023 Category: International Medicine & Public Health Source Type: research
The relationship of apparent diffusion coefficient values of renal cell carcinoma before and after cryotherapy ablation
Implications for practice DWI is a quick addition to routine protocols, does not require intravenous gadolinium based contrast agent, and provides qualitative and quantitative data. Further research is required to establish the role of ADC for treatment monitoring. (Source: Radiography)
Source: Radiography - March 3, 2023 Category: Radiology Authors: C. Currie, S. Stewart Source Type: research
Sensors, Vol. 23, Pages 2690: A Fiber Optic Sensor for Monitoring the Spectral Alterations and Depth in Ex Vivo and In Vivo Cryosurgery
This article discusses how to monitor the freezing depth during cryotherapy using a fiber optic array sensor. The sensor was used to measure the backscattered and transmitted light from frozen and unfrozen ex vivo porcine tissue and in vivo human skin tissue (finger). The technique exploited the variations in optical diffusion properties of the frozen and unfrozen tissues to determine the extent of freezing. Ex vivo and in vivo measurements yielded comparable results, despite spectral variations attributable to the hemoglobin absorption peak in the human frozen and unfrozen tissues. However, because the spectral fingerprin...
Source: Sensors - March 1, 2023 Category: Biotechnology Authors: Aris Ikiades Ioannis D. Bassukas Nikolaos Kourkoumelis Tags: Communication Source Type: research
Acute Ankle Sprain in Elite Athletes
Despite the high frequency of ankle sprains, the ideal management is controversial, and a significant percentage of patients sustaining an ankle sprain never fully recover. There is strong evidence that residual disability of ankle joint injury is often caused by an inadequate rehabilitation and training program and early return to sports. Therefore, the athlete should start their criteria-based rehabilitation and gradually progress through the programmed activities, including cryotherapy, edema relief, optimal weight-bearing management, range of motion exercises for ankle dorsiflexion improvement, triceps surae stretching...
Source: Foot and Ankle Clinics - March 1, 2023 Category: Orthopaedics Authors: Theodorakys Mar ín Fermín, Ayyoub A. Al-Dolaymi, Pieter D'Hooghe Source Type: research
Previous therapy and the recurrence rate of basal cell carcinoma after Mohs surgery: a meta-analysis
This study aimed to examine how preoperative treatment before MMS affects the recurrence rate after surgery. We conducted a meta-analysis to compare the recurrence rates of primary BCC and previously treated BCC in patients undergoing MMS, with a 5-year follow-up. The secondary outcomes were the recurrence rate after MMS based on previous radiation therapy status, mean time to recurrence, and number of cases undergoing more than one stage of MMS. The recurrence rate in the previously treated group was 2.44 times greater than that of the primary BCC group. In the previous treatment group, the patients who underwent previous...
Source: Cell Research - February 27, 2023 Category: Cytology Authors: Apasee Sooksamran Pitchayasak Pichai Mingkwan Suphannaphong Sasathorn Singthong Source Type: research
