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Crimean-Congo hemorrhagic fever
Uirusu. 2022;72(1):19-30. doi: 10.2222/jsv.72.19.ABSTRACTCrimean-Congo hemorrhagic fever (CCHF) is an acute febrile illness with a high case fatality rate caused by the infection with Crimean-Congo hemorrhagic fever virus (CCHFV). The disease is endemic to a wide regions from the African continent to Asia through Europe. CCHFV is maintained in nature between Hyalomma species ticks and some species of animals. Humans are infected with CCHFV from CCHFV-positive tick bite or through a close contact with viremic animals in clucling hum am patients with CCHF. The CCHF-endemic regions depend on the distribution of the species of...
Source: Uirusu. Journal of Virology - October 29, 2023 Category: Virology Authors: Keita Matsuno Masayuki Saijo Source Type: research

BSL-4 facility and New virus research in Japan
Uirusu. 2022;72(1):1-6. doi: 10.2222/jsv.72.1.ABSTRACTViral hemorrhagic fevers such as Ebola virus disease, Marburg disease, Lassa fever, and Crimean-Congo hemorrhagic fever are infectious diseases that can cause severe, life-threatening illness. At present, there are only few licensed vaccines and antiviral drugs for these viral hemorrhagic fevers. The viruses which cause these viral hemorrhagic fevers are classified as BSL-4 pathogens and can be handled only in BSL-4 containment laboratories. Therefore, to develop the vaccines and treatments for these diseases, BSL-4 facility is essential. However, the BSL-4 facility ava...
Source: Uirusu. Journal of Virology - October 29, 2023 Category: Virology Authors: Jiro Yasuda Source Type: research

A New Score for Predicting Mortality in Crimean-Congo Hemorrhagic Fever Associating CURB-65 with Bleeding: CURB-65+B
This study was conducted as a retrospective, single-center study in patients diagnosed with CCHF in a tertiary care hospital in a region where CCHF is endemic between April 2016 and October 2022. Five hundred patients with verified polymerase chain reaction (PCR) and/or IgM positive for CCHF were included in the study. In the CURB-65+B score, variables believed to be related with mortality; such as confusion, elevated urea, tachypnea, hypotension, age 65 or older, and the presence of bleeding, were assessed. The CURB-65+B scores of the patients were calculated and evaluated at the time of admission to the hospital. The med...
Source: Mikrobiyoloji Bulteni - October 27, 2023 Category: Microbiology Authors: Rukiye İnan Sarıkaya Ömer Karaşahin Source Type: research