Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: American Journal of Physiology. Renal Physiology - February 22, 2024 Category: Physiology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: American Journal of Physiology. Renal Physiology - February 22, 2024 Category: Physiology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: American Journal of Physiology. Renal Physiology - February 22, 2024 Category: Physiology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
Human Soluble Prorenin Receptor Expressed in Mouse Renal Collecting Duct Show Sex-Specific Effect on Cardiorenal Function
Am J Physiol Renal Physiol. 2024 Feb 22. doi: 10.1152/ajprenal.00375.2023. Online ahead of print.ABSTRACTSoluble prorenin receptor (sPRR), a component of the renin angiotensin system (RAS), has been identified as a plasma biomarker for hypertension and cardiovascular diseases in humans. Despite studies showing that sPRR in kidney is produced by renal collecting duct (CD) tubular cells, its biological actions modulating cardiorenal function remains unknown. Therefore, this study aimed to create a new murine model to investigate how expressing human sPRR (HsPRR) in CD influence the intrarenal RAS status and renal hemodynamic...
Source: Am J Physiol Renal P... - February 22, 2024 Category: Urology & Nephrology Authors: Gertrude Arthur Audrey Poupeau Katherine Biel Jeffrey L Osborn Ming Gong Terry D Hinds Volkhard Lindner Analia S Loria Source Type: research
High Dose of Estrogen Protects the Lungs from Ischemia–Reperfusion Injury by Downregulating the Angiotensin II Signaling Pathway
AbstractWe explored the sex difference in lung ischemia –reperfusion injury (LIRI) and the role and mechanism of estrogen (E2) and angiotensin II (Ang II) in LIRI. We established a model of LIRI in mice. E2, Ang II, E2 inhibitor (fulvestrant), and angiotensin II receptor blocker (losartan) were grouped for treatment. The lung wet/dry weight ratio, natu ral killer (NK) cells (by flow cytometry), neutrophils (by flow cytometry), expression of key proteins (by Western blot, immunohistochemistry, ELISA, and immunofluorescence), and expression of related protein mRNA (by qPCR) were detected. The ultrastructure of the alveolar...
Source: Inflammation - February 22, 2024 Category: Allergy & Immunology Source Type: research
Cardioprotective Effects of Losartan and Diminazene against the Ischemia/Reperfusion Injury in Hyperthyroidism Rats
Can J Physiol Pharmacol. 2024 Feb 20. doi: 10.1139/cjpp-2023-0122. Online ahead of print.ABSTRACTHyperthyroidism is a condition where the thyroid gland produces high levels of thyroid hormone. Heart diseases are one of the main complications of hyperthyroidism. Several studies have shown that losartan (LOS) and diminazene aceturate (DIZE) possess cardioprotection effects against cardiac hypertrophy, ischemic heart disease, and heart failure. The research aimed to investigate the cardioprotection of LOS, DIZE, and their combination in the case of levothyroxine-induced cardiomyopathy in rats. Hyperthyroidism was induced by l...
Source: Canadian Journal of Physiology and Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Authors: Mosayeb Pashaei Mahvash Hesari Dareuosh Shackebaei Aliashraf Godini Source Type: research
Cardioprotective Effects of Losartan and Diminazene against the Ischemia/Reperfusion Injury in Hyperthyroidism Rats
Can J Physiol Pharmacol. 2024 Feb 20. doi: 10.1139/cjpp-2023-0122. Online ahead of print.ABSTRACTHyperthyroidism is a condition where the thyroid gland produces high levels of thyroid hormone. Heart diseases are one of the main complications of hyperthyroidism. Several studies have shown that losartan (LOS) and diminazene aceturate (DIZE) possess cardioprotection effects against cardiac hypertrophy, ischemic heart disease, and heart failure. The research aimed to investigate the cardioprotection of LOS, DIZE, and their combination in the case of levothyroxine-induced cardiomyopathy in rats. Hyperthyroidism was induced by l...
Source: Canadian Journal of Physiology and Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Authors: Mosayeb Pashaei Mahvash Hesari Dareuosh Shackebaei Aliashraf Godini Source Type: research
Cardioprotective Effects of Losartan and Diminazene against the Ischemia/Reperfusion Injury in Hyperthyroidism Rats
Can J Physiol Pharmacol. 2024 Feb 20. doi: 10.1139/cjpp-2023-0122. Online ahead of print.ABSTRACTHyperthyroidism is a condition where the thyroid gland produces high levels of thyroid hormone. Heart diseases are one of the main complications of hyperthyroidism. Several studies have shown that losartan (LOS) and diminazene aceturate (DIZE) possess cardioprotection effects against cardiac hypertrophy, ischemic heart disease, and heart failure. The research aimed to investigate the cardioprotection of LOS, DIZE, and their combination in the case of levothyroxine-induced cardiomyopathy in rats. Hyperthyroidism was induced by l...
Source: Canadian Journal of Physiology and Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Authors: Mosayeb Pashaei Mahvash Hesari Dareuosh Shackebaei Aliashraf Godini Source Type: research
Cardioprotective Effects of Losartan and Diminazene against the Ischemia/Reperfusion Injury in Hyperthyroidism Rats
Can J Physiol Pharmacol. 2024 Feb 20. doi: 10.1139/cjpp-2023-0122. Online ahead of print.ABSTRACTHyperthyroidism is a condition where the thyroid gland produces high levels of thyroid hormone. Heart diseases are one of the main complications of hyperthyroidism. Several studies have shown that losartan (LOS) and diminazene aceturate (DIZE) possess cardioprotection effects against cardiac hypertrophy, ischemic heart disease, and heart failure. The research aimed to investigate the cardioprotection of LOS, DIZE, and their combination in the case of levothyroxine-induced cardiomyopathy in rats. Hyperthyroidism was induced by l...
Source: Canadian Journal of Physiology and Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Authors: Mosayeb Pashaei Mahvash Hesari Dareuosh Shackebaei Aliashraf Godini Source Type: research
Cardioprotective Effects of Losartan and Diminazene against the Ischemia/Reperfusion Injury in Hyperthyroidism Rats
Can J Physiol Pharmacol. 2024 Feb 20. doi: 10.1139/cjpp-2023-0122. Online ahead of print.ABSTRACTHyperthyroidism is a condition where the thyroid gland produces high levels of thyroid hormone. Heart diseases are one of the main complications of hyperthyroidism. Several studies have shown that losartan (LOS) and diminazene aceturate (DIZE) possess cardioprotection effects against cardiac hypertrophy, ischemic heart disease, and heart failure. The research aimed to investigate the cardioprotection of LOS, DIZE, and their combination in the case of levothyroxine-induced cardiomyopathy in rats. Hyperthyroidism was induced by l...
Source: Canadian Journal of Physiology and Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Authors: Mosayeb Pashaei Mahvash Hesari Dareuosh Shackebaei Aliashraf Godini Source Type: research
Cardioprotective Effects of Losartan and Diminazene against the Ischemia/Reperfusion Injury in Hyperthyroidism Rats
Can J Physiol Pharmacol. 2024 Feb 20. doi: 10.1139/cjpp-2023-0122. Online ahead of print.ABSTRACTHyperthyroidism is a condition where the thyroid gland produces high levels of thyroid hormone. Heart diseases are one of the main complications of hyperthyroidism. Several studies have shown that losartan (LOS) and diminazene aceturate (DIZE) possess cardioprotection effects against cardiac hypertrophy, ischemic heart disease, and heart failure. The research aimed to investigate the cardioprotection of LOS, DIZE, and their combination in the case of levothyroxine-induced cardiomyopathy in rats. Hyperthyroidism was induced by l...
Source: Canadian Journal of Physiology and Pharmacology - February 20, 2024 Category: Drugs & Pharmacology Authors: Mosayeb Pashaei Mahvash Hesari Dareuosh Shackebaei Aliashraf Godini Source Type: research
