The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell
Transl Res. 2023 Sep 9:S1931-5244(23)00145-7. doi: 10.1016/j.trsl.2023.09.005. Online ahead of print.ABSTRACTGlomeruli stand at the center of nephrons to accomplish filtration and albumin interception. Podocytes and mesangial cells are the major constituents in the glomeruli. However, their interdependency in glomerular injury has rarely been reported. Herein, we investigated the role of C-X-C chemokine receptor type 4 (CXCR4) in mediating the crosstalk between podocytes and mesangial cells. We found CXCR4 and angiotensin II (AngII) increased primarily in injured podocytes. However, type-1 receptor of angiotensin II (AT1) ...
Source: Translational Research : the journal of laboratory and clinical medicine - September 11, 2023 Category: Laboratory Medicine Authors: Qinyu Wu Shan Zhou Dan Xu Ping Meng Qiurong Chen Xiaoxu Wang Xiaolong Li Shuangqin Chen Huiyun Ye Wenting Ye Yabing Xiong Jiemei Li Jinhua Miao Weiwei Shen Xu Lin Fan Fan Hou Youhua Liu Yunfang Zhang Lili Zhou Source Type: research
The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell
Transl Res. 2023 Sep 9:S1931-5244(23)00145-7. doi: 10.1016/j.trsl.2023.09.005. Online ahead of print.ABSTRACTGlomeruli stand at the center of nephrons to accomplish filtration and albumin interception. Podocytes and mesangial cells are the major constituents in the glomeruli. However, their interdependency in glomerular injury has rarely been reported. Herein, we investigated the role of C-X-C chemokine receptor type 4 (CXCR4) in mediating the crosstalk between podocytes and mesangial cells. We found CXCR4 and angiotensin II (AngII) increased primarily in injured podocytes. However, type-1 receptor of angiotensin II (AT1) ...
Source: Translational Research : the journal of laboratory and clinical medicine - September 11, 2023 Category: Laboratory Medicine Authors: Qinyu Wu Shan Zhou Dan Xu Ping Meng Qiurong Chen Xiaoxu Wang Xiaolong Li Shuangqin Chen Huiyun Ye Wenting Ye Yabing Xiong Jiemei Li Jinhua Miao Weiwei Shen Xu Lin Fan Fan Hou Youhua Liu Yunfang Zhang Lili Zhou Source Type: research
The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell
Transl Res. 2023 Sep 9:S1931-5244(23)00145-7. doi: 10.1016/j.trsl.2023.09.005. Online ahead of print.ABSTRACTGlomeruli stand at the center of nephrons to accomplish filtration and albumin interception. Podocytes and mesangial cells are the major constituents in the glomeruli. However, their interdependency in glomerular injury has rarely been reported. Herein, we investigated the role of C-X-C chemokine receptor type 4 (CXCR4) in mediating the crosstalk between podocytes and mesangial cells. We found CXCR4 and angiotensin II (AngII) increased primarily in injured podocytes. However, type-1 receptor of angiotensin II (AT1) ...
Source: Translational Research : the journal of laboratory and clinical medicine - September 11, 2023 Category: Laboratory Medicine Authors: Qinyu Wu Shan Zhou Dan Xu Ping Meng Qiurong Chen Xiaoxu Wang Xiaolong Li Shuangqin Chen Huiyun Ye Wenting Ye Yabing Xiong Jiemei Li Jinhua Miao Weiwei Shen Xu Lin Fan Fan Hou Youhua Liu Yunfang Zhang Lili Zhou Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: Journal of Physiology and Pharmacology - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: Journal of Physiology and Pharmacology - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: Journal of Physiology and Pharmacology - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: Journal of Physiology and Pharmacology - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: Journal of Physiology and Pharmacology - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: J Physiol Pharmacol - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: Journal of Physiology and Pharmacology - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research
