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216 TGF- β1 reduces expression of the RNA-binding protein PCBP1 to decrease levels of CFTR and LRRC26 transcripts in airway epithelial cells, an effect reversed by losartan
(Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - October 1, 2023 Category: Respiratory Medicine Authors: N. Silswal, N. Baumlin, M. Kim, M. Salathe Tags: AIRWAYS PHYSIOLOGY, PATHOPHYSIOLOGY & AIRWAYS DEFENSE Source Type: research

Comparing Cardiovascular Outcomes and Costs of Perindopril-, Enalapril- or Losartan-Based Antihypertensive Regimens in South Africa: Real-World Medical Claims Database Analysis
CONCLUSION: In South African individuals with private health insurance, a perindopril-based antihypertensive regimen provided better clinical and cost outcomes compared with other regimens.PMID:37730949 | DOI:10.1007/s12325-023-02641-8 (Source: Adv Data)
Source: Adv Data - September 21, 2023 Category: Epidemiology Authors: Jacques R Snyman Freedom Gumedze Erika S W Jones Olufunke A Alaba Nqoba Tsabedze Alykhan Vira Ntobeko A B Ntusi Source Type: research

Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes
Vortioxetine is a novel anti-major depression disorder drug with a high safety profile compared with other similar drugs. However, little research has been done on drug-drug interactions (DDI) about vortioxetine. In this paper, the inhibitory effect of vortioxetine on cytochrome P450 (CYP450) and the type of inhibitory mechanism were investigated in human and rat liver microsomes. We set up an in vitro incubation system of 200 μL to measure the metabolism of probe substrates at the present of vortioxetine at 37°C. The concentrations of the metabolites of probe substrates were all measured by ultra-performance liquid chr...
Source: Frontiers in Pharmacology - September 18, 2023 Category: Drugs & Pharmacology Source Type: research

Impact of Concomitant Cardiovascular Therapies on Efficacy and Safety of Relugolix vs Leuprolide: Subgroup Analysis from HERO Study in Advanced Prostate Cancer
CONCLUSION: Relugolix suppressed testosterone and was generally well tolerated when given with concomitant CV agents.TRIAL REGISTRATION: Clinical Trial ID NCT03085095.PRIOR PRESENTATION: Data presented at 15th Annual Genitourinary Cancers Symposium; February 17-19, 2022, San Francisco, CA, USA [Abstract 101, Poster board E11]. The published abstract from this presentation can be found at https://ascopubs.org/doi/10.1200/JCO.2022.40.6_suppl.101 .PMID:37713020 | DOI:10.1007/s12325-023-02634-7 (Source: Adv Data)
Source: Adv Data - September 15, 2023 Category: Epidemiology Authors: Neal D Shore Bryan A Mehlhaff Michael S Cookson Daniel R Saltzstein Ronald Tutrone Bruce Brown Sophia Lu Mark Fallick Sarah Hanson Fred Saad Source Type: research

Angiotensinergic and GABAergic transmission in the medial preoptic area: role in urinary bladder and cardiovascular control in female rats
This study aimed to investigate whether angiotensin II (Ang II) and GABA could act or not in the mPOA to mediate the cardiovascular and micturition control pathways.Methods: Female Wistar rats were submitted to stereotaxic surgery for implantation of a guide cannula into the mPOA 7 days prior to the experiments. Afterwards, the animals were isoflurane- anesthetized and submitted to the catheterization of the femoral artery and vein and urinary bladder cannulation for mean arterial pressure (MAP), heart rate (HR), and intravesical pressure (IP) recordings, respectively. After the baseline MAP, HR, and IP recordings for 15�...
Source: Frontiers in Physiology - September 13, 2023 Category: Physiology Source Type: research

The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell
Transl Res. 2023 Sep 9:S1931-5244(23)00145-7. doi: 10.1016/j.trsl.2023.09.005. Online ahead of print.ABSTRACTGlomeruli stand at the center of nephrons to accomplish filtration and albumin interception. Podocytes and mesangial cells are the major constituents in the glomeruli. However, their interdependency in glomerular injury has rarely been reported. Herein, we investigated the role of C-X-C chemokine receptor type 4 (CXCR4) in mediating the crosstalk between podocytes and mesangial cells. We found CXCR4 and angiotensin II (AngII) increased primarily in injured podocytes. However, type-1 receptor of angiotensin II (AT1) ...
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Qinyu Wu Shan Zhou Dan Xu Ping Meng Qiurong Chen Xiaoxu Wang Xiaolong Li Shuangqin Chen Huiyun Ye Wenting Ye Yabing Xiong Jiemei Li Jinhua Miao Weiwei Shen Xu Lin Fan Fan Hou Youhua Liu Yunfang Zhang Lili Zhou Source Type: research

The CXCR4-AT1 axis plays a vital role in glomerular injury via mediating the crosstalk between podocyte and mesangial cell
Transl Res. 2023 Sep 9:S1931-5244(23)00145-7. doi: 10.1016/j.trsl.2023.09.005. Online ahead of print.ABSTRACTGlomeruli stand at the center of nephrons to accomplish filtration and albumin interception. Podocytes and mesangial cells are the major constituents in the glomeruli. However, their interdependency in glomerular injury has rarely been reported. Herein, we investigated the role of C-X-C chemokine receptor type 4 (CXCR4) in mediating the crosstalk between podocytes and mesangial cells. We found CXCR4 and angiotensin II (AngII) increased primarily in injured podocytes. However, type-1 receptor of angiotensin II (AT1) ...
Source: Translational Research : the journal of laboratory and clinical medicine - September 11, 2023 Category: Laboratory Medicine Authors: Qinyu Wu Shan Zhou Dan Xu Ping Meng Qiurong Chen Xiaoxu Wang Xiaolong Li Shuangqin Chen Huiyun Ye Wenting Ye Yabing Xiong Jiemei Li Jinhua Miao Weiwei Shen Xu Lin Fan Fan Hou Youhua Liu Yunfang Zhang Lili Zhou Source Type: research

Perindopril and losartan attenuate pro-coagulation factors in human adipocytes exposed to SARS-CoV-2 spike protein
This study use adipose tissue harvested from an obese male donor was isolated and exposed to perindopril, losartan, and ACE2 recombinant as binding assay, following exposure with 10 nm of SARS-CoV-2 S1 spike protein. After 48 hours, tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) as pro-coagulation factors as well as ACE2 levels and binding evaluated. The results shows TF level was significantly reduced in Perindopril group compared to control (4.834; p=0.005), while a non-significant reduction was observed in Losartan group (5.624; p=0.111). However, Losartan group showed a better reduction of PAI-1 level...
Source: Journal of Physiology and Pharmacology - September 3, 2023 Category: Drugs & Pharmacology Authors: M Ardiana I G R Suryawan H O Hermawan P M Harsoyo I M Sufiyah A R Muhammad B S I Zaini Source Type: research