Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics
This study investigated whether Safflower Yellow for injection (SYI) would affect the anticoagulation of warfarin in rats.Wistar male rats were divided into six groups randomly and administered with SYI (9 mg/kg, intraperitoneal injection) in single-dose and steady-dose warfarin (0.2 mg/kg, oral gavage), respectively. The pharmacodynamic parameters of PT and APTT were measured by a coagulation analyser. R/S-warfarin concentration was measured by UHPLC-MS/MS, and pharmacokinetic parameters calculated using DAS 2.0 software.The single-dose study demonstrated that SYI, alone or co-administered with warfarin, could significant...
Source: Xenobiotica - March 6, 2024 Category: Research Authors: Yan Liu Jiahui Sun Chunjuan Yang Mengnan Qin Shiwei Xu Yue Zhao Gaofeng Liu Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Safflower yellow for injection enhances anti-coagulation of warfarin in rats: implications in pharmacodynamics and pharmacokinetics
This study investigated whether Safflower Yellow for injection (SYI) would affect the anticoagulation of warfarin in rats.Wistar male rats were divided into six groups randomly and administered with SYI (9 mg/kg, intraperitoneal injection) in single-dose and steady-dose warfarin (0.2 mg/kg, oral gavage), respectively. The pharmacodynamic parameters of PT and APTT were measured by a coagulation analyser. R/S-warfarin concentration was measured by UHPLC-MS/MS, and pharmacokinetic parameters calculated using DAS 2.0 software.The single-dose study demonstrated that SYI, alone or co-administered with warfarin, could significant...
Source: Xenobiotica - March 6, 2024 Category: Research Authors: Yan Liu Jiahui Sun Chunjuan Yang Mengnan Qin Shiwei Xu Yue Zhao Gaofeng Liu Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of ...
Source: Journal of the American Podiatric Medical Association - March 6, 2024 Category: Podiatry Authors: Beth B Richardson Marc A Stees Brandon R Gumbiner Source Type: research
