Efficacy and Safety of Edoxaban in Patients With Atrial Fibrillation and Mitral Stenosis
Conditions: Mitral Valve Stenosis; Atrial Fibrillation; Stroke; Systemic Embolism Interventions: Drug: Edoxaban; Drug: Warfarin Sponsors: Sung-Hwan Kim; Daiichi Sankyo Korea Co., Ltd. Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 14, 2022 Category: Research Source Type: clinical trials
Overestimation of benefit when clinical trials stop early: a simulation study
ConclusionSimulated trials typical of those stopping early for benefit overestimate the true relative risk reduction by roughly 50% (i.e. the true RRR was 2/3 of the observed value). Overestimation was much smaller, and likely unimportant, when simulating large SPRINT-like trials stopping early. Whether trials were large or small, stopped early or not, a minimum 250 events were needed to avoid overestimating relative risk reduction by an absolute 5% or more. (Source: Trials)
Source: Trials - September 5, 2022 Category: Research Source Type: clinical trials
A Study to Examine the Effect of Daridorexant on the Way the Body Absorbs, Distributes, and Gets Rid of Midazolam and Warfarin in Healthy Male Subjects
Condition: Healthy Interventions: Drug: Midazolam; Drug: Warfarin; Drug: Daridorexant Sponsor: Idorsia Pharmaceuticals Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - July 29, 2022 Category: Research Source Type: clinical trials
