27.11.18: Not intended for U.S. and UK Media
U.S. FDA approves Larotrectinib, the first TRK inhibitor, for patients with advanced solid tumors harboring an NTRK gene fusionFirst treatment with a tumor-agnostic indication at the time of initial FDA approval / Larotrectinib approved under the brand name Vitrakvi® / 75% overall response rate (ORR) (95% CI, 61%, 85%) [22% complete response (CR) and 53% partial response (PR)] across various solid tumors in adults and children / Adverse events (AEs) of any grade observed in more than 20 percent of patients, regardless of attribution, included increased ALT (45%), increased AST (45%), anemia (42%), fatigue (37%), nausea...
Source: Bayer IR Newsfeed: Events - November 27, 2018 Category: Pharmaceuticals Source Type: news

U.S. FDA approves Larotrectinib, the first TRK inhibitor, for patients with advanced solid tumors harboring an NTRK gene fusion (for specialized target groups only)
First treatment with a tumor-agnostic indication at the time of initial FDA approval / Larotrectinib approved under the brand name Vitrakvi ® / 75% overall response rate (ORR) (95% CI, 61%, 85%) [22% complete response (CR) and 53% partial response (PR)] across various solid tumors in adults and children / Adverse events (AEs) of any grade observed in more than 20 percent of patients, regardless of attribution, included increased ALT (4 5%), increased AST (45%), anemia (42%), fatigue (37%), nausea (29%), dizziness (28%), cough (26%), vomiting (26%), constipation (23%), and diarrhea (22%) (Source: Bayer Company News)
Source: Bayer Company News - November 27, 2018 Category: Pharmaceuticals Source Type: news

Lung cancer symptoms: Three signs your cough is linked to the deadly disease
LUNG cancer symptoms usually become apparent in the later stages when the tumour has grown, but recognising the disease as soon as possible can significantly improve your outlook. A cough is commonly associated with this type of cancer, but there are three signs in particular to look for in your cough. (Source: Daily Express - Health)
Source: Daily Express - Health - November 25, 2018 Category: Consumer Health News Source Type: news

Health Tip: Caring for Bronchitis
-- Bronchitis is inflammation of the bronchial tubes that carry air into your lungs. When these tubes become infected, they swell and become lined with mucus, making it more difficult to breathe. Symptoms may include cough, sore throat, fever,... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 21, 2018 Category: General Medicine Source Type: news

Grand Island Man Has Plenty of Reasons to be Grateful
A year ago, Neil Wolfe ’s heart was three times the size that it should be. He had no idea it was one of the reasons he needed to buy new shirts, twice. That didn’t bother him as much as a lingering cough, his lack of energy and severe swelling in his legs and feet. They were all signs that his enlarged heart wasn’t strong enough to pump blood through his body. (Source: University of Rochester Medical Center Press Releases)
Source: University of Rochester Medical Center Press Releases - November 21, 2018 Category: Universities & Medical Training Authors: University of Rochester Medical Center Source Type: news

A 44-Year-Old Woman With a Neck Mass
A 44-year-old woman presents with a mass in the right side of the neck. The patient complains of general malaise and a cough. What is your diagnosis? (Source: CancerNetwork)
Source: CancerNetwork - November 21, 2018 Category: Cancer & Oncology Authors: Cesar A. Moran, MD Source Type: news

Camphor poisoning: a rare cause of acute symptomatic seizures in children - Mathen PG, Sreekrishnan TP, Kumar KPG, Mohan N.
Camphor is a toxic compound easily available over the counter, which can cause fatal seizures in children when ingested. It is available in several forms and is commonly used in Indian households, especially for religious rituals and for its cough-suppress... (Source: SafetyLit)
Source: SafetyLit - November 17, 2018 Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news

Africa: It's Time to Go Back to Basics in the Fight Against Childhood Pneumonia
[The Conversation Africa] Pneumonia is a respiratory infection that affects the lungs. The viruses and bacteria that cause the disease are spread through airborne droplets from a cough or sneeze. An infection can cause the lungs to fill with pus and fluid, making breathing and oxygen intake difficult. And while anyone can get pneumonia, children with weakened immune systems or underlying illnesses are more susceptible. That's why, pneumonia kills more than a million children every year across the world. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 14, 2018 Category: African Health Source Type: news

Trends in opioid prescriptions in children, adolescents
(JAMA Network) Prescription opioids dispensed to children and adolescents have steadily decreased since 2012 in an analysis of data from a large commercial insurance provider. The analysis include all oral opioids used for pain, excluding cough suppressants, and individuals with a health care claim associated with a cancer diagnosis were excluded. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 12, 2018 Category: International Medicine & Public Health Source Type: news

Nigeria: Fight Pneumonia With Good Hygiene, Strong Immunity
[Guardian] World Pneumonia Day comes up on November 12. Health experts describe the condition as an infection that inflames the air sacs in one or both lungs. The air sacs may be filled with fluid or pus, purulent material, causing cough with phlegm, fever, chills, and difficulty in breathing. A variety of organisms, including bacteria, viruses and fungi, can cause pneumonia. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - November 11, 2018 Category: African Health Source Type: news

Vaccination Strategy Can Prevent a Deadly Childhood Infection
The sound of pertussis, or whooping cough, is terrifying. It is the sound of someone coughing violently, and then gasping for air; the gasp is the “whoop” sound. Whooping cough is a highly contagious, potentially fatal respiratory disease, and a big problem in Texas. (Source: TMA News Room)
Source: TMA News Room - November 8, 2018 Category: Consumer Health News Source Type: news

The Critical Role EMS Plays in Fighting the Flu
Influenza has been impacting public health on a global scale since the beginning of recorded history. Influenza, also known as the “flu,” has numerous organizations committed to public health research, developing vaccines, and educating best practices preparing for the upcoming flu season. By gaining an understanding of the flu through history, virology, and how it impacts our society, we can have a better appreciation for the commitment that’s involved with combating the flu. What Is Influenza (and What’s Not)? The eyes of an epidemiologist can twitch for a variety of reasons, one of them being whe...
Source: JEMS Operations - November 8, 2018 Category: Emergency Medicine Authors: Morgan K. Anderson, MPH Tags: Exclusive Articles Operations Source Type: news

The Critical Role EMS Plays in Fighting the Flu
Influenza has been impacting public health on a global scale since the beginning of recorded history. Influenza, also known as the “flu,” has numerous organizations committed to public health research, developing vaccines, and educating on best practices to prepare for the upcoming flu season. By gaining an understanding of the flu through history, virology, and how it impacts our society, we can have a better appreciation for the commitment that’s involved with combating the flu. What Is Influenza (and What’s Not)? The eyes of an epidemiologist can twitch for a variety of reasons, one of them being...
Source: JEMS Special Topics - November 8, 2018 Category: Emergency Medicine Authors: Morgan K. Anderson, MPH Tags: Exclusive Articles Operations Source Type: news

Dry Cough, Rash on Legs
Patient is 54 y/o man; the cough has been present for 2 weeks, the rash on the lower extremities for 2 months; the rash is getting worse. What's your dx? (Source: ConsultantLive)
Source: ConsultantLive - November 7, 2018 Category: Internal Medicine Authors: Brady Pregerson, MD Tags: Skin Diseases Source Type: news

Lung cancer symptoms: Five signs the disease has advanced and spread within the body
LUNG cancer symptoms usually develop once the tumour has grown, and when this happens, a cough is the most common sign to look out for. When the disease spread within the body, which is recognised as advanced lung cancer, other symptoms may begin to show. (Source: Daily Express - Health)
Source: Daily Express - Health - November 5, 2018 Category: Consumer Health News Source Type: news

Health Tip: What Causes a Chronic Cough
(Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - November 5, 2018 Category: Respiratory Medicine Tags: Pulmonology, FYI, Source Type: news

The Checkup: For a Child ’ s Cough, the Best Medicine Is No Medicine
Instead of over-the-counter products, pediatricians recommend comfort measures like fluids and honey. (Source: NYT Health)
Source: NYT Health - November 5, 2018 Category: Consumer Health News Authors: PERRI KLASS, M.D. Tags: Children and Childhood Coughs Colds Parenting Fever Babies and Infants Honey Source Type: news

Health Tip: What Causes a Chronic Cough
-- Coughing serves an important purpose -- to help you expel mucus, microbes and other foreign particles from your respiratory tract. This helps protect the lungs from infection and inflammation, Harvard Medical School says. A cough becomes chronic... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 5, 2018 Category: General Medicine Source Type: news

Health Tip: What Causes a Chronic Cough
Title: Health Tip: What Causes a Chronic CoughCategory: Health NewsCreated: 11/5/2018 12:00:00 AMLast Editorial Review: 11/5/2018 12:00:00 AM (Source: MedicineNet Lungs General)
Source: MedicineNet Lungs General - November 5, 2018 Category: Respiratory Medicine Source Type: news

Infectious Diseases A-Z: Pertussis infections on the rise
Reported cases of pertussis, also known as whooping cough, have been on the rise since the 1980s, according to the Centers for Disease Control and Prevention.?"Whooping cough is becoming more common, unfortunately, for a variety of reasons???maybe declining vaccination rates or waning immunity from our previous vaccines," says Dr. Tina Ardon, a family medicine specialist [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - November 5, 2018 Category: Databases & Libraries Source Type: news

Ask Dr Ellie: How to cure coughs that won't go away 
DR ELLIE CANNON answers your questions about how to get rid of a cough that has not got better for the past five years. (Source: the Mail online | Health)
Source: the Mail online | Health - November 4, 2018 Category: Consumer Health News Source Type: news

A 65-Year-Old With Chest Pain and Fever: USMLE Question A 65-Year-Old With Chest Pain and Fever: USMLE Question
A 65-year-old man presents with chest pain, chronic cough, and intermittent fevers. What's the best treatment option?Osmosis (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 2, 2018 Category: Consumer Health News Tags: Med Students Interactive Quiz Source Type: news

Fatal measles case highlights importance of herd immunity in protecting the vulnerable
(Infectious Diseases Society of America) Last year, a 26-year-old man receiving treatment for leukemia went to a Swiss hospital's emergency room with a fever, a sore throat, and a cough, and was admitted. His condition worsened, and 17 days later, he died from severe complications of measles. The man's weakened immune system was unable to fight off the disease, even though he was vaccinated against measles as a child. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 1, 2018 Category: International Medicine & Public Health Source Type: news

Fake drugs: The global industry putting your life at risk
In late 2012, 60 people died in two cities in Pakistan after drinking cough syrup to get high. Tests in Pakistan revealed that the medicines seemed to contain the correct amount of active ingredient, but further tests revealed something that was not supposed to be there. Levomethorphan, a chemical five times stronger than morphine, was the contaminant that had caused the deaths. (Source: CNN.com - Health)
Source: CNN.com - Health - October 30, 2018 Category: Consumer Health News Source Type: news

She Fights TB and HIV Door-to-Door on this Tanzanian Island
October 25, 2018Community health workers like Nanzula link their neighbors to the essential primary health services they need.In 2003, Nanzula Jagaja ’s husband died and left her as the sole provider for their four children.“A few years after his death, a Lutheran church mission came here educating widows on HIV and tuberculosis,” she says. “Only then did I realize my husband had died from TB.”Today Nanzula is certified as a community home-based care provider on HIV and TB and goes house-to-house, making sure those in her village know about the risks and symptoms and linking them to formal hea...
Source: IntraHealth International - October 25, 2018 Category: International Medicine & Public Health Authors: mnathe Source Type: news

Lung cancer symptoms: How do you know if your cough is a sign? When to seek treatment
LUNG CANCER symptoms develop as the condition progresses, and one symptom is having a persistent cough. But how do you know if your cough is a sign of the disease? Here ’s when to seek treatment. (Source: Daily Express - Health)
Source: Daily Express - Health - October 25, 2018 Category: Consumer Health News Source Type: news

Lung cancer: Could your cough be a symptom? When to seek treatment
LUNG CANCER symptoms develop as the condition progresses, and one symptom is having a persistent cough. But how do you know if your cough is a sign of the disease? Here ’s when to seek treatment. (Source: Daily Express - Health)
Source: Daily Express - Health - October 25, 2018 Category: Consumer Health News Source Type: news

Ditch the Machine to Improve Accuracy in Blood Pressure Measurement and Diagnostics
“Medic 14, respond to an unconscious subject.” On arrival, two paramedics find a 45-year-old male sitting on a chair under a shade umbrella outside a car wash. The time is approximately 4:00 p.m., and the temperature is 94 degrees F. The patient presents with pale skin and his breathing appears slightly labored. After the paramedics introduce themselves, the patient reports that he’s feeling faint and says he almost passed out while working in the hot sun. He’s willing to submit to an assessment, but reluctant to accept transport, stating, “I just got this job, and I need to get back to work.&...
Source: JEMS Patient Care - October 24, 2018 Category: Emergency Medicine Authors: Mark Rock, NRP Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

Ditch the Machine to Improve Accuracy in Blood Pressure Measurement and Diagnostics
Conclusion For the patient in this case, the decision to forego the convenience of a machine in favor of the skills of a knowledgeable paramedic was lifesaving. Much like the comparison often drawn between the old-fashioned barbell and more sophisticated exercise machines, newer, more complex, and more expensive might make a process more comfortable, but doesn’t always equate to superior results. As we surrender more and more of our hands-on skills to the ease of automated technology, we risk more than the loss of the aptitudes that form the foundation of sound patient assessment—we place our patients in jeopar...
Source: JEMS Special Topics - October 24, 2018 Category: Emergency Medicine Authors: Mark Rock, NRP Tags: Exclusive Articles Cardiac & Resuscitation Source Type: news

Topical Ropivacaine and Endotracheal Tube Extubation Topical Ropivacaine and Endotracheal Tube Extubation
Might topical ropivacaine before intubation reduce the incidence of postoperative throat pain and cough during extubation?BMC Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 24, 2018 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Mucus, cough and chronic lung disease: New discoveries
(University of Gothenburg) As a cold ends, a severe mucus cough starts. Sound familiar? Two studies now give explanations: First, crucial mechanisms of the mucus in both diseased and healthy airways; second, what happens in such chronic lung diseases as cystic fibrosis and chronic obstructive pulmonary disease (COPD). (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 24, 2018 Category: International Medicine & Public Health Source Type: news

Mesothelioma Early Detection Getting Closer with Blood Test
German scientists are advancing a new, more reliable blood test that could lead to earlier detection and better prognosis for malignant mesothelioma. Instead of the typically lengthy and invasive process, the simple blood test could identify early stage disease almost a year before symptoms appear, making it much more treatable. The advancement stems from a study analyzing a combination of calretinin and mesothelin, two blood-based proteins that are overexpressed when mesothelioma tumors start growing. “This is a real breakthrough,” biochemist Dr. Georg Johnen, lead study researcher and head of Molecular Medici...
Source: Asbestos and Mesothelioma News - October 23, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news

They tackled chronic cough. Now with $54.5 million, this duo is targeting Alzheimer's and more
The team behind CuraSen sold their previous drug development company for up to $1.25 billion. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - October 19, 2018 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news

They tackled chronic cough. Now with $54.5 million, this duo is targeting Alzheimer's and more
The team behind CuraSen sold their previous drug development company for up to $1.25 billion. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 19, 2018 Category: Biotechnology Authors: Ron Leuty Source Type: news

They tackled chronic cough. Now with $54.5 million, this duo is targeting Alzheimer's and more
The team behind CuraSen sold their previous drug development company for up to $1.25 billion. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - October 19, 2018 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news

They tackled chronic cough. Now with $54.5 million, this duo is targeting Alzheimer's and more
The team behind CuraSen sold their previous drug development company for up to $1.25 billion. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 19, 2018 Category: Biotechnology Authors: Ron Leuty Source Type: news

Medicines marketed as being for 'tickly' or 'dry' coughs have the same ingredients
EXCLUSIVE Strepsils Sore Throat & Cough Lozenges has the same product licence number as its Sore Throat & Blocked Nose Lozenges. British pharmacy chain Boots is also guilty. (Source: the Mail online | Health)
Source: the Mail online | Health - October 19, 2018 Category: Consumer Health News Source Type: news

They tackled chronic cough. Now with $54.5 million, this duo is targeting Alzheimer's and more
The team behind CuraSen sold their previous drug development company for up to $1.25 billion. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 17, 2018 Category: Biotechnology Authors: Ron Leuty Source Type: news

They tackled chronic cough. Now with $54.5 million, this duo is targeting Alzheimer's and more
The team behind CuraSen sold their previous drug development company for up to $1.25 billion. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - October 17, 2018 Category: Pharmaceuticals Authors: Ron Leuty Source Type: news

Your Gut May Be to Blame for Your Bloodstream Infection
MONDAY, Oct. 15, 2018 -- Bloodstream infections contracted during a hospital stay are usually caused by a patient's own digestive tract, not a doctor's dirty hands or another patient's cough, a small new study suggests. Stanford University... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 15, 2018 Category: General Medicine Source Type: news

Young survivor of rare polio-like illness now thriving
Lydia Pilarowski had a fever and cough that developed into intense pain, she had unusual weakness, and she couldn't move her left arm. (Source: CNN.com - Health)
Source: CNN.com - Health - October 15, 2018 Category: Consumer Health News Source Type: news

Stanford study traces hospital-acquired bloodstream infections to patients' own bodies
(Stanford Medicine) The most common source of a bloodstream infection acquired during a hospital stay is not a nurse's or doctor's dirty hands, or another patient's sneeze or visitor's cough, but the patient's own gut, Stanford University School of Medicine investigators have found. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - October 15, 2018 Category: Infectious Diseases Source Type: news

Here ’s How to Tell if You Have a Cold or the Flu
Your nose is dripping like a leaky faucet, your throat is sore and you can’t stop sneezing. You don’t have a fever, but you feel wiped out—like you could curl up on the floor and fall asleep. Do you have a cold or the flu? If you guessed cold, you’re probably right. But experts say that differentiating the common cold (an upper respiratory infection) from the flu (influenza) can be trickier than most people assume. “There is huge overlap among non-influenza viruses and the symptoms produced by influenza and other bugs,” says Dr. Bruce Barrett, a professor of family medicine and community...
Source: TIME: Health - October 11, 2018 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized public health Source Type: news

Skip the Cold Meds for Kids Under 6, Experts Say
THURSDAY, Oct. 11, 2018 -- School is in full swing, and with it comes a plethora of colds passed back and forth among kids. But parents who want to alleviate a sick child's misery would do best to avoid over-the-counter cough and cold... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - October 11, 2018 Category: General Medicine Source Type: news

How to get rid of a cold: Relieve symptoms with this £3.50 high street remedy
HOW TO get rid of a cold: Winter illness season is fast approaching, and whether it ’s a blocked or runny nose, sore throat, cough or headache, symptoms can be difficult to handle. Alongside rest and keeping hydrated, experts recommend one high street remedy in particular. (Source: Daily Express - Health)
Source: Daily Express - Health - October 9, 2018 Category: Consumer Health News Source Type: news

Lung cancer symptoms: A cough that won’t go away could be a sign of the deadly disease
LUNG CANCER symptoms usually don ’t appear in the early stages of the disease, but will often develop as the cancer progresses. A persistent cough that won’t go away is one sign. (Source: Daily Express - Health)
Source: Daily Express - Health - October 9, 2018 Category: Consumer Health News Source Type: news

Peninsula biotech coughs up 40 percent of its value on failed clinical trial
A Peninsula drug developer's only drug failed a mid-stage clinical trial in chronic cough — its second thumbs down in the clinic since going public eight months ago — sending the company's stock down 40 percent in trading Monday. In a 185-patient study, Menlo Therapeutics Inc.'s (NASDAQ: MNLO) once-daily serlopitant, a drug licensed six years ago from Merck& Co. Inc. (NYSE: MRK), failed to even match a placebo in a study designed to see if the drug would reduce the frequency of chronic coughs. In… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - October 9, 2018 Category: American Health Authors: Ron Leuty Source Type: news

Peninsula biotech coughs up 40 percent of its value on failed clinical trial
A Peninsula drug developer's only drug failed a mid-stage clinical trial in chronic cough — its second thumbs down in the clinic since going public eight months ago — sending the company's stock down 40 percent in trading Monday. In a 185-patient study, Menlo Therapeutics Inc.'s (NASDAQ: MNLO) once-daily serlopitant, a drug licensed six years ago from Merck& Co. Inc. (NYSE: MRK), failed to even match a placebo in a study designed to see if the drug would reduce the frequency of chronic coughs. In… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - October 8, 2018 Category: Biotechnology Authors: Ron Leuty Source Type: news

Man's lips turn BLACK because of ulcers triggered by a lung infection
An unnamed 26-year-old went to hospital in Hong Kong with a fever, cough and a rash but within three days blisters started to develop on his lips, his eyes and his urethra. (Source: the Mail online | Health)
Source: the Mail online | Health - October 8, 2018 Category: Consumer Health News Source Type: news