Contemporary concepts of prevention and management of gastroesophageal variceal bleeding in liver cirrhosis patients
World J Hepatol. 2024 Feb 27;16(2):126-134. doi: 10.4254/wjh.v16.i2.126.ABSTRACTThis editorial describes the contemporary concepts of prevention and management of gastroesophageal variceal bleeding in liver cirrhosis (LC) patients according to the current guidelines. Gastroesophageal variceal bleeding is the most dangerous complication of portal hypertension in LC patients. Risk stratification and determination of an individual approach to the choice of therapeutic measures aimed at their prevention and management has emerged as one of the top concerns in modern hepatology. According to the current guidelines, in the absen...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Dmitry Victorovich Garbuzenko Source Type: research

Effect of Concomitant Drugs on Sodium Zirconium Cyclosilicate Hydrate in Artificial Intestinal Juice
Chem Pharm Bull (Tokyo). 2024;72(3):286-293. doi: 10.1248/cpb.c23-00687.ABSTRACTTo explore drug interactions involving sodium zirconium cyclosilicate hydrate (SZC) and concomitant drugs like calcium antagonists (amlodipine and nifedipine) and β-blockers (carvedilol and bisoprolol), we investigate how these concomitant drugs influenced the administration of SZC in an artificial intestinal juice. Initially, we assessed the potassium ion adsorption capacity, ranking it as follows: calcium polystyrene sulfonate (CPS, 54.9 mg/g) < sodium polystyrene sulfonate (SPS, 62.1 mg/g) < SZC (90.8 mg/g). However, the adsorption eq...
Source: Chemical and Pharmaceutical Bulletin - March 6, 2024 Category: Drugs & Pharmacology Authors: Yuri Mizuno Fumihiko Ogata Yugo Uematsu Naohito Kawasaki Source Type: research