Exercise-induced Pulmonary Hypertension in Long-term Survivors of Congenital Diaphragmatic Hernia
To determine the prevalence of exercise-induced pulmonary hypertension (PH) among long-survivors of congenital diaphragmatic hernia (CDH) repair. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - March 27, 2024 Category: Pediatrics Authors: Paul J. Critser, Terry L. Buchmiller, Kimberlee Gauvreau, Jill M. Zalieckas, Catherine A. Sheils, Gary A. Visner, Keri M. Shafer, Ming Hui Chen, Mary P. Mullen Tags: Original Articles Source Type: research

Multicentre, randomised controlled trial of physiological-based cord clamping versus immediate cord clamping in infants with a congenital diaphragmatic hernia (PinC): statistical analysis plan
Infants born with congenital diaphragmatic hernia (CDH) are at high risk of respiratory insufficiency and pulmonary hypertension. Routine practice includes immediate clamping of the umbilical cord and endotrac... (Source: Trials)
Source: Trials - March 20, 2024 Category: General Medicine Authors: Emily J. J. Horn-Oudshoorn, Marijn J. Vermeulen, Ronny Knol, Rebekka Bout-Rebel, Arjan B. te Pas, Stuart B. Hooper, Suzan C. M. Cochius-den Otter, Rene M. H. Wijnen, Kelly J. Crossley, Neysan Rafat, Thomas Schaible, Willem P. de Boode, Anne Debeer, Berndt Tags: Methodology Source Type: research

Neurodevelopmental outcomes in children after fetoscopic endoluminal tracheal occlusion for severe congenital diaphragmatic hernia: Results from a multidisciplinary clinic
We compared early neurodevelopmental morbidity in young children with severe CDH who underwent FETO to those without fetal therapy. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - March 19, 2024 Category: Surgery Authors: Shelby R. Sferra, Annalise B. Penikis, Matthew Guo, Ahmet A. Baschat, Peter J. Mogayzel, Vera Joanna Burton, Shaun M. Kunisaki Source Type: research

Pulmonary vasculature development in congenital diaphragmatic hernia: a novel automated quantitative imaging analysis
ConclusionAccording to these findings, CDH not only reduced the amount of small order elements, but also destroyed the fractal structure of the pulmonary arterial trees. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - March 18, 2024 Category: Surgery Source Type: research

The RNA-binding protein quaking is upregulated in nitrofen-induced congenital diaphragmatic hernia lungs at the end of gestation
ConclusionsOur data show an increase in the abundance and expression of QKI at the end of gestation in nitrofen-induced CDH lungs. Therefore, a disruption in the regulation of QKI during the late stage of pregnancy could be associated with the pathogenesis of abnormal lung development in CDH. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - March 13, 2024 Category: Surgery Source Type: research

Reply to Letter to the Editor by Lohmann and Fernandes
Most patients with congenital diaphragmatic hernia (CDH) who developed pneumothorax on mechanical ventilation have an underlying pulmonary hypoplasia, in which the lung has a physiologically small volume and consequently a low compliance. The Japanese CDH Study Group (JCDHSG) conducted multicenter retrospective cohort studies of pneumothorax development in patients with CDH between 2006 and 2018 [1,2]. Pneumothorax was more likely to develop in patients with CDH associated with larger diaphragmatic defects and was associated with a fatal outcome in neonates with CDH, especially those with large diaphragmatic defects [1,2]....
Source: Journal of Pediatric Surgery - March 7, 2024 Category: Surgery Authors: Kazunori Masahata, Kouji Nagata, Keita Terui, Takuya Kondo, Ashley H. Ebanks, Matthew T. Harting, Terry L. Buchmiller, Yasunori Sato, Hiroomi Okuyama, Noriaki Usui, for the Congenital Diaphragmatic Hernia Study Group Source Type: research

Congenital Diaphragmatic Hernia
Of course death can happen at any hour. Like this: after birth, at dawn, the sun pressing through thick hospital windows, climbing peach walls of the delivery room, ending the long labor in the operating room. Cutting the baby from where she would not come. My snug gloves, warmth and wetness of birth, every single one. Except she was to die; hole at her center, bowel peristalsing her chest. Months you knew too, carrying her, she moved inside, so different from your miscarriages. Placental separation, inarched to the heart-lung machine, floors junked with effort. Luminescent skin of lanugo, newborn hirsutism; lovely photogr...
Source: JAMA - March 5, 2024 Category: General Medicine Source Type: research

Does early prostacyclin therapy decrease extracorporeal life support use in infants with congenital diaphragmatic hernia?
Journal of Perinatology, Published online: 05 March 2024; doi:10.1038/s41372-024-01920-8Does early prostacyclin therapy decrease extracorporeal life support use in infants with congenital diaphragmatic hernia? (Source: Journal of Perinatology)
Source: Journal of Perinatology - March 5, 2024 Category: Perinatology & Neonatology Authors: Jane Huang Philippe Friedlich Molly Crimmins Easterlin Source Type: research

The Association of Prenatal Diagnoses with Mortality and Long-Term Morbidity in Children with Specific Isolated Congenital Anomalies: A European Register-Based Cohort Study
ConclusionsOur findings do not show improved outcomes for prenatally diagnosed infants. For conditions where prenatal diagnoses were associated with greater mortality and morbidity, the findings might be attributed to increased detection of more severe anomalies. The increased mortality and morbidity in those diagnosed prenatally may be related to the lower mean gestational age (GA) at birth, leading to insufficient surfactant for respiratory effort. This is especially important for these four groups of children as they have to undergo anaesthesia and surgery shortly after birth. Appropriate prenatal counselling about the ...
Source: Maternal and Child Health Journal - March 4, 2024 Category: Health Management Source Type: research

Exploring new perspectives on congenital diaphragmatic hernia: A comprehensive review
Biochim Biophys Acta Mol Basis Dis. 2024 Feb 28:167105. doi: 10.1016/j.bbadis.2024.167105. Online ahead of print.ABSTRACTCongenital diaphragmatic hernia (CDH) represents a developmental anomaly that profoundly impacts the embryonic development of both the respiratory and cardiovascular systems. Understanding the influences of developmental defects, their origins, and clinical consequences is of paramount importance for further research and the advancement of therapeutic strategies for this condition. In recent years, groundbreaking studies in the fields of metabolomics and genomics have significantly expanded our knowledge...
Source: Biochimica et Biophysica Acta - March 1, 2024 Category: Biochemistry Authors: Weronika Renik-Jankowska Angelika Buczy ńska Iwona Sidorkiewicz Przemys ław Kosiński Monika Zbucka-Kr ętowska Source Type: research

Exploring new perspectives on congenital diaphragmatic hernia: A comprehensive review
Biochim Biophys Acta Mol Basis Dis. 2024 Feb 28;1870(4):167105. doi: 10.1016/j.bbadis.2024.167105. Online ahead of print.ABSTRACTCongenital diaphragmatic hernia (CDH) represents a developmental anomaly that profoundly impacts the embryonic development of both the respiratory and cardiovascular systems. Understanding the influences of developmental defects, their origins, and clinical consequences is of paramount importance for further research and the advancement of therapeutic strategies for this condition. In recent years, groundbreaking studies in the fields of metabolomics and genomics have significantly expanded our k...
Source: Biochimica et Biophysica Acta - March 1, 2024 Category: Biochemistry Authors: Weronika Renik-Jankowska Angelika Buczy ńska Iwona Sidorkiewicz Przemys ław Kosiński Monika Zbucka-Kr ętowska Source Type: research

Review of the Evaluation of Pulmonary Hypoplasia as an Important Determinant of Clinical Outcomes in Infants with Congenital Diaphragmatic Hernia
This article aims to review the evaluation of pulmonary hypoplasia or hypoplastic lung disease as an important determinant of clinical outcomes in infants with congenital diaphragmatic hernia. In this review, we emphasize the importance of early prenatal diagnosis of congenital diaphragmatic hernia and present a summary of different methods of prenatal risk assessment of lung hypoplasia in congenital diaphragmatic hernia.PMID:38419323 | DOI:10.12659/MSM.943259 (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 29, 2024 Category: Research Authors: Daria Kuchnowska Katarzyna Luterek Piotr W ęgrzyn Przemys ław Kosiński Source Type: research