WALS- George Khoury Lecture: Coronavirus Activation and Antagonism of Interferon Signaling Pathways: from MHV to SARS-CoV-2
Coronavirus interactions with the interferon signaling response are crucial for antiviral defense especially at the early stages of infection. Murine coronavirus, MHV, has taught us a lot about the basic biology of this family of viruses as well as antagonism of innate immune response, a hallmark of coronavirus infection. Building on our MHV data, we have more recently worked with human coronaviruses. We have optimized methods for comparing human coronaviruses in a primary nasal cell air liquid interface (ALI) culture system, which models the initial site of respiratory virus infection. Common cold coronaviruses as well as...
Source: Videocast - All Events - March 6, 2024 Category: General Medicine Tags: Upcoming Events Source Type: video

NIH FDA COVID-19 SIG Lecture Series- Professor Wendy Barclay
Dr. Barclay joined Imperial College in May 2007, moving with her research group from the University of Reading where she had previously been based since 1995. She had graduated in Natural Sciences from Cambridge University and had undertaken my PhD at the Common Cold Unit, Salisbury under the joint supervision of Dr David Tyrrell and Dr Fred Brown, studying the human immune response to rhinovirus. Dr. Barclay acquired molecular virology skills as a postdoctoral fellow first in the laboratories of Professor Jeff Almond at Reading and then working with Dr Peter Palese at the Mount Sinai School of Medicine, New York.Dr. Barcl...
Source: Videocast - All Events - December 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video

WALS- George Khoury Lecture: Coronavirus Activation and Antagonism of Innate Immune Pathways
Our lab studies murine and human coronavirus pathogenesis, including MHV, MERS-CoV and SARS-CoV. We use MHV infection of mice as a model system for the study of:acute viral encephalitischronic demyelinating diseases such as Multiple Sclerosisvirus-induced hepatitissevere acute respiratory diseases.We have the important tools of a well-developed animal model system and reverse genetic systems with which to manipulate the viral genome. We also investigate pathogenesis of human coronaviruses both the lethal MERS-CoV and SARS-CoV-2 as well as the common cold viruses OC43 and 229E and NL63. We are investigating these both in ep...
Source: Videocast - All Events - October 4, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video

Genetic Studies Illuminating Pathways Important for Controlling COVID Disease
We are interested in new inherited defects of innate immunity that can cause increased susceptibility to virus infections, especially those targeting the respiratory tract. One example is our discovery of human MDA5 deficiency in a patient who had recurrent severe rhinovirus and other respiratory viruses. The patient ’ s loss of MDA5 demonstrated the physiological importance of this cytosolic viral nucleic acid sensor for immunity against the common cold virus. The extent to which MDA5 physiologically contributes in humans to protect against other respiratory viruses is being studied. For more information about this rese...
Source: Videocast - All Events - October 5, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video