Isolation of Herpes Simplex Virus Nucleocapsid DNA
As an inanimate virus, herpes simplex virus type 1 (HSV-1) necessarily encodes all of its functions in its DNA. Isolation of pure viral DNA allows multiple downstream applications, including the creation of recombinant HSV strains, cloning of selected regions, and sequencing of viral DNA. The term nucleocapsid refers to the combination of the viral genome with the enclosing capsid; these viral genomes are necessarily linear and have been packaged for egress, even if they are not yet released from the cell. In contrast, viral DNA that is not associated with capsids may include episomal or concatenated forms and may have mod...
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

HSV-1 Protein Expression Using Recombinant Baculoviruses
The baculovirus expression system is an invaluable method for the expression of Herpes Simplex Virus 1 (HSV-1) proteins. The use of insect cells provides a eukaryotic system for the robust expression of heterologous proteins under control of the baculovirus polyhedrin gene promoter that naturally drives the high expression of the polyhedrin protein. Additionally, insect cells often initiate the necessary posttranslational modifications and/or disulfide-bond formation important for the proper folding of the protein. We and others have successfully expressed and purified several HSV-1 proteins including the polymerase, helic...
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

HSV-1 Biology and Life Cycle
Herpes simplex virus type 1 (HSV-1) is a common and important human pathogen that has been studied in a wide variety of contexts for several decades. This book presents chapters on protocols on many strands of HSV-1 research that are currently in use in leading laboratories. This chapter gives a brief overview of HSV-1 biology and life cycle, covering basic aspects of the virus and its replication in cultured cells, the diseases caused by the virus, viral latency, antiviral defenses, and the mechanisms that the virus uses to counteract these defenses. (Source: Springer protocols feed by Infectious Diseases)
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

Cryo-EM Techniques to Resolve the Structure of HSV-1 Capsid-Associated Components
Electron cryo-microscopy has become a routine technique to determine the structure of biochemically purified herpes simplex virus capsid particles. This chapter describes the procedures of specimen preparation by cryopreservation; low dose and low temperature imaging in an electron cryo-microscope; and data processing for reconstruction. This methodology has yielded subnanometer resolution structures of the icosahedral capsid shell where α-helices and β-sheets of individual subunits can be recognized. A relaxation of the symmetry in the reconstruction steps allows us to resolve the DNA packaging protein located ...
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

In Vivo HSV-1 DNA Transport Studies Using Murine Retinal Ganglion Cells
We present a method for studying the axonal transport of Herpes simplex virus in mature neurons in situ. Using genetically identical mice and carefully controlling the delivery of virus, an investigator can obtain insight into the transport of virus to and from the neuron cell body within the cellular environment of an intact animal. (Source: Springer protocols feed by Infectious Diseases)
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

Multifluorescence Live Analysis of Herpes Simplex Virus Type-1 Replication
The possibility to label specific viral and cellular structures with live cell markers such as autofluorescent proteins has greatly contributed to our understanding of diverse steps of the virus life cycle, as it allows monitoring virus replication in a spatial and temporal fashion. Here, we describe the multi-fluorescent analysis of the multi-compartment herpes simplex virus type-1 by live-cell confocal laser scanning microscopy. (Source: Springer protocols feed by Infectious Diseases)
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

Preparation of Herpes Simplex Virus-Infected Primary Neurons for Transmission Electron Microscopy
Transmission electron microscopy (TEM) provides the resolution necessary to identify both viruses and subcellular components of cells infected with many types of viruses, including herpes simplex virus. Recognized as a powerful tool in both diagnostic and research-based virology laboratories, TEM has made possible the identification of new viruses and has contributed to the elucidation of virus life cycle and virus–host cell interaction. (Source: Springer protocols feed by Infectious Diseases)
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

Affinity Purification Combined with Mass Spectrometry to Identify Herpes Simplex Virus Protein–Protein Interactions
The identification and characterization of herpes simplex virus protein interaction complexes are fundamental to understanding the molecular mechanisms governing the replication and pathogenesis of the virus. Recent advances in affinity-based methods, mass spectrometry configurations, and bioinformatics tools have greatly increased the quantity and quality of protein–protein interaction datasets. In this chapter, detailed and reliable methods that can easily be implemented are presented for the identification of protein–protein interactions using cryogenic cell lysis, affinity purification, trypsin digestion, a...
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

Characterization of Extracellular HSV-1 Virions by Proteomics
The analysis of herpes simplex virus type 1 mature extracellular virions by proteomics requires highly enriched samples to limit false positives and favor the detection of true components. The protocol described below involves the removal of highly contaminating serum proteins and purification of the virions by a series of differential and density centrifugation steps. In addition, L-particles, which are viral particles devoid of genome and capsid but present in the extracellular milieu, are depleted on Ficoll 400 gradients. As previously reported, the resulting viral particles are free of most contaminants and suitable fo...
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

A Precipitation-Based Assay to Analyze Interactions of Viral Particles with Cytosolic Host Factors
Since viruses are obligate intracellular parasites, viral particles, subviral structures, and viral proteins enlist the support of host proteins to foster intracellular transport, viral gene expression, replication, and evasion from antiviral host responses. We have devised a biochemical in vitro method to analyze specific interactions of cytosolic factors with capsids of herpes simplex virus and to characterize host proteins that specifically coprecipitate with different types of viral particles by immunoblotting, mass spectrometry, and immunoelectron microscopy. (Source: Springer protocols feed by Infectious Diseases)
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

Using Homogeneous Primary Neuron Cultures to Study Fundamental Aspects of HSV-1 Latency and Reactivation
We describe a primary neuronal culture system suitable for molecular characterization of herpes simplex virus type 1 (HSV-1) infection, latency, and reactivation. While several alternative models are available, including infections of live animal and explanted ganglia, these are complicated by the presence of multiple cell types, including immune cells, and difficulties in manipulating the neuronal environment. The highly pure neuron culture system described here can be readily manipulated and is ideal for molecular studies that focus exclusively on the relationship between the virus and host neuron, the fundamental unit o...
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

Phenotypic and Genotypic Testing of HSV-1 Resistance to Antivirals
Resistance testing of antivirals to herpes simplex virus type 1 can be done by phenotypic and genotypic methods. The determination of a resistant phenotype is based on the calculation of inhibitory concentrations for the antiviral drug, which should be tested. The main advantage is a clear interpretation of laboratory findings, but the method is time consuming and a considerable experience is required for handling infectious virus. Genotypic resistance testing is based on the detection of resistance-related mutations in viral genes encoding the thymidine kinase and DNA polymerase by means of amplification and sequencing. T...
Source: Springer protocols feed by Infectious Diseases - April 3, 2014 Category: Infectious Diseases Source Type: news

What Causes Ataxia?
Discussion Coordination and balance problems are caused by various problems affecting the central and peripheral nervous system. Normal development of a child or weakness of a child are commonly mistaken for true ataxia. Ataxia specifically refers to “…impairment of the coordination of movement without loss of muscle strength.” If it is purely due to abnormalities of the cerebellum then there should be no changes in mental status, sensation or weakness. Sometimes it is difficult to determine if there are abnormalities in other areas. For example, Guillian-Barre often presents with difficulty or clumsy wa...
Source: PediatricEducation.org - March 31, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

HSV-2 vaccine shows significant clinical symptoms & viral shedding reductions at 6 months
(Linnden Communications) Updated Phase 1/2a GEN-003 results, a vaccine candidate under development for the treatment of herpes simplex virus type 2 infection, showed the vaccine generated highly significant reductions in both the number of clinical lesion days and rate of viral shedding at six months after the final vaccine dose. Genocea, a company pioneering novel T cell vaccines and immunotherapies, reported the results from the ongoing trial as an oral presentation at the World Vaccine Congress. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - March 24, 2014 Category: Global & Universal Source Type: news

Shingles: Can You Get it Again?
In its latest March 2014 survey, polyDNA found that up to 78% of respondents who had a herpes zoster outbreak wanted to know if it was possible to have another. polyDNA reviews the literature on this topic, and recommends Gene-Eden-VIR to target the latent VZV. (Source: Disabled World)
Source: Disabled World - March 23, 2014 Category: Disability Tags: Herpes Simplex Virus Source Type: news

This Week in Infectious Disease: New HSV Drug
(MedPage Today) -- Clinicians and researchers were excited about the potential of a new drug for herpes simplex infection that has a novel mechanism of action, opening the door to combination therapies. (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - January 17, 2014 Category: Gastroenterology Source Type: news

Pritelivir May Be Effective and Safe Against Genital HerpesPritelivir May Be Effective and Safe Against Genital Herpes
In a proof-of-concept study, researchers have found pritelivir to be safe and effective against genital herpes simplex virus. Medscape Medical News (Source: Medscape ObGyn and Womens Health Headlines)
Source: Medscape ObGyn and Womens Health Headlines - January 16, 2014 Category: OBGYN Tags: Infectious Diseases News Source Type: news

Investigational Herpes Drug Limits Viral Shedding in Phase II Trial (FREE)
By Kelly Young Pritelivir, the first in a new class of drugs (a helicase-primase inhibitor) for herpes simplex virus, effectively suppressed viral shedding and development of genital lesions in an industry-conducted, phase II … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - January 16, 2014 Category: Primary Care Source Type: news

New Herpes Drug Blocks Viral Shedding (CME/CE)
(MedPage Today) -- An investigational drug with a novel mechanism of action reduced the rate of viral shedding in patients with genital herpes simplex-2 (HSV-2) infection, researchers reported. (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - January 16, 2014 Category: Infectious Diseases Source Type: news

This Week in Infectious Disease: New Tx for HSV?
(MedPage Today) -- The effect of a new approach to treating herpes simplex virus, as well as the risk of complications after a childhood vaccine, are likely to dominate the infectious disease news this week. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - January 13, 2014 Category: Pediatrics Source Type: news

Atopy May Double the Risk for Herpetic Eye DiseasesAtopy May Double the Risk for Herpetic Eye Diseases
Atopic disease may double the risk for herpes simplex virus ocular disease and herpes zoster ophthalmicus, according to new research. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 30, 2013 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

Cold Sores (Nongenital Herpes Simplex Infections)
Title: Cold Sores (Nongenital Herpes Simplex Infections)Category: Diseases and ConditionsCreated: 6/16/1999 7:38:00 PMLast Editorial Review: 12/9/2013 12:00:00 AM (Source: MedicineNet Skin General)
Source: MedicineNet Skin General - December 9, 2013 Category: Dermatology Source Type: news

Scientists present groundbreaking HIV prevention research
(Oak Crest Institute of Science) Researchers at the Oak Crest Institute of Science are making history by proving that it's possible to develop a drug delivery system that has the potential to protect women from sexually transmitted HIV and herpes simplex virus, while at the same time preventing unintended pregnancy. The report in the journal of Antimicrobial Agents and Chemotherapy describes in vivo results from a novel, multipurpose pod-intravaginal ring delivering three antiretroviral drugs in combination with two hormonal contraceptives. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - December 2, 2013 Category: Infectious Diseases Source Type: news

Study: Cold Sores High Risk for Genital Herpes; polyDNA Recommends...
An article published on Drugs.com on October 17 said that today's teens may be at higher risk than ever of contracting genital herpes because fewer numbers are being exposed as children to HSV-1...(PRWeb November 13, 2013)Read the full story at http://www.prweb.com/releases/2013/11/prweb11320619.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - November 14, 2013 Category: Pharmaceuticals Source Type: news

New technology combining contraception, HIV and herpes simplex virus-2 prevention
CONRAD Head of drug delivery, Meredith Clark, PhD, presented preclinical data on a new intravaginal ring that provides contraception as well as HIV-1 and HSV-2 prevention at the 2013 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in San Antonio, Texas. This multipurpose prevention technology (MPT) can remain in the vagina for up to 90 days and releases the contraceptive levonorgestrel (LNG) and tenofovir (TFV), an antiretroviral that inhibits HIV and HSV replication in susceptible cells.The CONRAD product development team, in collaboration with Dr. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 14, 2013 Category: Consumer Health News Tags: Sexual Health / STDs Source Type: news

CONRAD presents new technology combining contraception, HIV and herpes simplex virus-2 prevention
(CONRAD) CONRAD Head of drug delivery, Meredith Clark, Ph.D., today presented preclinical data on a new intravaginal ring that provides contraception as well as HIV-1 and HSV-2 prevention at the 2013 American Association of Pharmaceutical Scientists Annual Meeting and Exposition in San Antonio, Texas.CONRAD's deputy director of clinical research, Marianne Callahan, will also present information on MPTs at the International Conference on Family Planning in Addis Ababa, Ethiopia. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - November 12, 2013 Category: Global & Universal Source Type: news

Declining HSV-1 Seroprevalence Puts Adolescents at Herpes RiskDeclining HSV-1 Seroprevalence Puts Adolescents at Herpes Risk
New data on the seroprevalence of herpes simplex viruses among U.S. adolescents suggests they face a growing risk for genital infections. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 1, 2013 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Herpes Simplex Virus 1 (HSV-1)-Based Vectors
Herpes simplex virus type 1 (HSV-1) is a neurotropic virus displaying several outstanding adaptations to the nervous system, and each of them can be rationally exploited in the design of gene therapy vectors with regard to neurological applications. Replication-competent attenuated vectors are becoming a suitable and powerful tool to eradicate brain tumors, such as malignant gliomas, due to their ability to replicate and spread only within the tumor mass, and have reached Phase II clinical trials in some cases. Replication-incompetent recombinant vectors are nontoxic gene transfer tools that preserve most of the neurotropi...
Source: Springer protocols feed by Neuroscience - October 25, 2013 Category: Neuroscience Source Type: news

Genetic study confirms saga of ancient human migration
A study of the full genetic code of a common human virus offers a dramatic confirmation of the "out-of-Africa" pattern of human migration, which had previously been documented by anthropologists and studies of the human genome. The virus under study, herpes simplex virus type 1 (HSV-1), usually causes nothing more severe than cold sores around the mouth, says Curtis Brandt, a professor of medical microbiology and ophthalmology at the University of Wisconsin-Madison. Brandt is senior author of the study, now online in the journal PLOS ONE... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 23, 2013 Category: Consumer Health News Tags: Genetics Source Type: news

Increasing number of U.S. adolescents lack antibodies to herpes simplex virus type 1
A new study suggests a growing number of U.S. adolescents lack antibodies that may help protect them later in life against an increasingly important cause of genital herpes. Published in The Journal of Infectious Diseases and available online, the findings show that fewer of today's teens have been exposed in their childhood to herpes simplex virus type 1 (HSV-1), a common cause of cold sores, than U.S. adolescents in previous years... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 21, 2013 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Cold Sores: What are the Treatments? polyDNA Answers Survey Questions
In its latest October, 2013 survey, polyDNA found that up to 52% of respondents did not know what treatments are available for a herpes outbreak. polyDNA reviews the scientific literature on this...(PRWeb October 18, 2013)Read the full story at http://www.prweb.com/releases/2013/10/prweb11241932.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - October 18, 2013 Category: Pharmaceuticals Source Type: news

Today's Teens More Prone to Genital Herpes, Study Suggests
Teens today may be more susceptible to one type of genital herpes infection once they become sexually active than teens in years past, a new study suggests .In the study, adolescents ages 14 to 19 who had their blood tested between 2005 and 2010 were less likely to have antibodies against herpes simplex virus type 1(HSV-1) compared with teens who had their blood tested between 1999 and 2004. (Source: RWJF News Digest - Public Health)
Source: RWJF News Digest - Public Health - October 18, 2013 Category: American Health Source Type: news

Teens more prone to contracting herpes than before, says study
Recent rates of exposure to herpes simplex virus-1 antibodies have dwindled for adolescents, making it easier for them to get STD (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - October 17, 2013 Category: Consumer Health News Source Type: news

More US teens susceptible to HSV-1 infection, a growing cause of genital herpes
(Infectious Diseases Society of America) A new study suggests a growing number of US adolescents lack antibodies that may help protect them later in life against an increasingly important cause of genital herpes. The findings show that fewer of today's teens have been exposed in their childhood to herpes simplex virus type 1 (HSV-1), a common cause of cold sores, than US adolescents in previous years. Without these antibodies, today's teens may be more susceptible to genital infections also caused by the virus. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - October 17, 2013 Category: Global & Universal Source Type: news

Study: Herpes Outbreaks Determined by Immune Genes; polyDNA Recommends...
A study published in the medical journal PLoS Pathogens on August 8th, 2013 associates a “genetic mutation and the clinical severity of recurrent cases of HSV-1 infection (cold sores) (1).” polyDNA...(PRWeb October 12, 2013)Read the full story at http://www.prweb.com/releases/2013/10/prweb11222291.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - October 14, 2013 Category: Pharmaceuticals Source Type: news

How to Heal Cold Sores | “Cold Sore Freedom in 3 Days” Instructs...
Cold Sore Freedom In 3 Days made by Grace Melgarejo is a brand new program that teaches people how to heal cold sores effectively and quickly. A full Cold Sore Freedom In 3 Days on the site...(PRWeb October 08, 2013)Read the full story at http://www.prweb.com/releases/how-to/heal-cold-sores/prweb11200412.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - October 9, 2013 Category: Pharmaceuticals Source Type: news

What Organisms Cause Acute Epiglottitis in the Post- H. influenza Vaccination Era?
Discussion Epiglottitis is also known as supraglottitis and is caused by inflammation of the supraglottic structures and epiglottis. Usually the cause is infectious but other trauma such as thermal injuries or ingestions can also cause the disease. Before the widespread use of its conjugated immunization, Haemophilus influenza type b was the most common cause and it was usually thought of as a pediatric disease process. In the pre-immunization time period, acute epiglottitis in children was 3.47-6.0 cases per 100,000, and in the post-immunization period has declined to 0.3-0.7 cases per 100,000. However it appears that
Source: PediatricEducation.org - October 7, 2013 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: news

What Organisms Cause Acute Epiglottitis in the Post- H. influenza Vaccination Era?
Discussion Epiglottitis is also known as supraglottitis and is caused by inflammation of the supraglottic structures and epiglottis. Usually the cause is infectious but other trauma such as thermal injuries or ingestions can also cause the disease. Before the widespread use of its conjugated immunization, Haemophilus influenza type b was the most common cause and it was usually thought of as a pediatric disease process. In the pre-immunization time period, acute epiglottitis in children was 3.47-6.0 cases per 100,000, and in the post-immunization period has declined to 0.3-0.7 cases per 100,000. However it appears that
Source: PediatricEducation.org - October 7, 2013 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Nanoparticle lung vaccine protects against HIV, herpes
Scientists have created a type of nanoparticle that they say can effectively deliver vaccines to the lungs, protecting against numerous infectious diseases. This is according to a study published in Science Translational Medicine. Researchers from the Massachusetts Institute of Technology (MIT) say the nanoparticle vaccine could help protect against influenza and other respiratory diseases, as well as prevent sexually transmitted diseases such as HIV, human papilloma virus and herpes simplex virus... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 26, 2013 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news

Genetics: Research May Point to Treatment for Cold Sores
Insight about a mutated gene in people who got cold sores suggests a possible research route for both cold sores and other infections caused by herpes simplex virus type 1.     (Source: NYT Health)
Source: NYT Health - September 23, 2013 Category: Consumer Health News Authors: By DOUGLAS QUENQUA Tags: Viruses Herpes Viruses Research Source Type: news

Uganda: Propolis Has a Load of Benefits
[Observer]Propolis obtained from beehives is touted as a treatment for numerous ailments - the common cold, peptic ulcers, coughs, tuberculosis, toothaches, cold sores (those wounds that usually "grow" at mouth corners and we attribute them to malaria), genital herpes, as well as nose and throat cancer. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - September 18, 2013 Category: African Health Source Type: news

Frequent Cold Sores Tied to Genetic Mutation in Study
Title: Frequent Cold Sores Tied to Genetic Mutation in StudyCategory: Health NewsCreated: 9/17/2013 12:35:00 PMLast Editorial Review: 9/18/2013 12:00:00 AM (Source: MedicineNet Skin General)
Source: MedicineNet Skin General - September 18, 2013 Category: Dermatology Source Type: news

Frequent Cold Sores Tied to Genetic Mutation in Study
Many people carry herpes virus without developing telltale blisters (Source: WebMD Health)
Source: WebMD Health - September 17, 2013 Category: Consumer Health News Source Type: news

Frequent Cold Sores Tied to Genetic Mutation in Study
Many people carry herpes virus without developing telltale blisters Source: HealthDay Related MedlinePlus Pages: Cold Sores, Genes and Gene Therapy (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - September 17, 2013 Category: Consumer Health News Source Type: news

Cold sores linked to mutation in gene, study suggests
Why some people are troubled by cold sores while others are not has finally been explained by scientists. Cold sores affect around one in five people but, until now, no one has been sure why some are more prone to the virus that causes them. Researchers at the University of Edinburgh have found that people affected by cold sores have a mutation in a gene, which means their immune system is not able to prevent them from developing. Cold sores are caused by a strain of the herpes simplex virus - herpes simplex virus type 1 (HSV-1)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 17, 2013 Category: Consumer Health News Tags: Genetics Source Type: news

How people who suffer from cold sores lack key protein that keeps virus under control
Scientists from Edinburgh University discovered that serial cold sore sufferers lack the Interferon-lambda protein, which blocks the ailment. (Source: the Mail online | Health)
Source: the Mail online | Health - September 17, 2013 Category: Consumer Health News Source Type: news

Novel vaccine reduces shedding of genital herpes virus
Sexually transmitted infection researchers potentially have reached a milestone in vaccine treatment for genital herpes, according to a report presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy in Denver, Colo., on Sept. 12. Kenneth H. Fife, M.D., is the principal investigator for the IU School of Medicine clinical study of the vaccine for herpes simplex virus type 2 called GEN-003. According to an interim analysis, the experimental protein subunit vaccine made by Genocea Biosciences of Cambridge, Mass., effectively reduces viral shedding... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 17, 2013 Category: Consumer Health News Tags: Sexual Health / STDs Source Type: news

Cold sore linked to mutation in gene, study suggests
(University of Edinburgh) Why some people are troubled by cold sores while others are not has finally been explained by scientists.Cold sores affect around one in five people but, until now, no one has been sure why some are more prone to the virus that causes them. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 16, 2013 Category: Global & Universal Source Type: news

HSV Vaccine Linked to Lower Viral Shedding (CME/CE)
DENVER (MedPage Today) -- A therapeutic vaccine for herpes simplex type 2 (HSV-2) virus reduced viral shedding and had an acceptable safety profile, researchers reported here. (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - September 14, 2013 Category: Infectious Diseases Source Type: news

Programmed cell death activates latent herpesviruses
Researchers have found that apoptosis, a natural process of programmed cell death, can reactivate latent herpesviruses in the dying cell. The results of their research, which could have broad clinical significance since many cancer chemotherapies cause apoptosis, was published ahead of print in the Journal of Virology. Human herpesviruses (HHV) are linked to a range of childhood and adult diseases, including chickenpox, mononucleosis, cold sores, and genital sores, and are of a particular concern for patients who are immunosuppressed due cancer or AIDS... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 9, 2013 Category: Consumer Health News Tags: Biology / Biochemistry Source Type: news