Separating host and microbiome contributions to drug pharmacokinetics and toxicity
The gut microbiota is implicated in the metabolism of many medical drugs, with consequences for interpersonal variation in drug efficacy and toxicity. However, quantifying microbial contributions to drug metabolism is challenging, particularly in cases where host and microbiome perform the same metabolic transformation. We combined gut commensal genetics with gnotobiotics to measure brivudine drug metabolism across tissues in mice that vary in a single microbiome-encoded enzyme. Informed by these measurements, we built a pharmacokinetic model that quantitatively predicts microbiome contributions to systemic drug and metabo...
Source: ScienceNOW - February 7, 2019 Category: Science Authors: Zimmermann, M., Zimmermann-Kogadeeva, M., Wegmann, R., Goodman, A. L. Tags: Medicine, Diseases, Microbiology, Online Only r-articles Source Type: news
Lyrica (pregabalin) vs. Klonopin (clonazepam)
Title: Lyrica (pregabalin) vs. Klonopin (clonazepam)Category: MedicationsCreated: 12/18/2018 12:00:00 AMLast Editorial Review: 12/18/2018 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 18, 2018 Category: Drugs & Pharmacology Source Type: news
Medical News Today: What is the difference between clonazepam and Xanax?
Clonazepam and Xanax both belong to a class of drugs called benzodiazepines. As a result, they are quite similar, but doctors may prescribe them for different reasons. Learn more about the differences in their uses, effects, and dosages here. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 12, 2018 Category: Consumer Health News Tags: Anxiety / Stress Source Type: news
What We Know About the Effect of Psychotropic Drugs on Migrant Kids
A federal judge on Monday ruled that the government must obtain parental or guardian consent before administering psychotropic drugs—those that can affect the brain or behavior—to migrant children in its care. But plenty of questions still remain about what these drugs do to young brains in the first place.
“The benefits or risks of psychotropic medications to brain development are only beginning to be evaluated,” says Dr. Manpreet Singh, director of the Pediatric Mood Disorders Program at Stanford University. “We haven’t actually looked, directly and in systematic ways, at the effects o...
Source: TIME: Health - July 31, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Drugs healthytime onetime Source Type: news
May 7, 2018: Abingdon Nurse Practitioner Pleads Guilty to Conspiring to Illegally Prescribe Buprenorphine, Clonazepam, and Gabapentin at Substance Abuse Treatment Program
(Source: Office of Criminal Investigations (OCI) Press Releases)
Source: Office of Criminal Investigations (OCI) Press Releases - May 15, 2018 Category: Medical Law Source Type: news
Clonazepam Tablets (New - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - May 8, 2018 Category: Drugs & Pharmacology Source Type: news
The Drugs That Changed Our Minds by Lauren Slater – review
Twenty years after hailing antidepressants in her memoir Prozac Diary, a now jaded, sceptical Lauren Slater revisits the psychopharmacological industry – with uneven resultsInProzac Diary (1998), Lauren Slater wrote powerfully of the way fluoxetine had transformed her previously chaotic life. While the author recorded a handful of negative side-effects – a profound loss of libido, for instance – the reader was left with the sense that Prozac had pieced back together the shards of Slater’s existence. In some ways,The Drugs That Changed Our Minds is a sequel to that book. Slater is now in her mid-50s, recently divorc...
Source: Guardian Unlimited Science - April 1, 2018 Category: Science Authors: Alex Preston Tags: Autobiography and memoir Science and nature Books Medical research Depression Society Culture Source Type: news
REM sleep behavior disorder causing subdural hematoma - Ramos-Campoy O, Gaig C, Villas M, Iranzo A, Santamaria J.
Highlights
•Subdural hematoma can complicate REM sleep behavior disorder.
•Abrupt discontinuation of clonazepam may cause a rebound of RBD symptomatology and increase the risk for injuries.
•Clonazepam or melatonin and safety measures in the ... (Source: SafetyLit)
Source: SafetyLit - February 24, 2017 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
Just Like Millions of Americans, I Cling to My Emergency Klonopin Prescription
Klonopin is a brand name of the drug, Clonazepam, used to treat seizures, panic disorder, and anxiety. It is a controlled substance and can cause paranoid or suicidal thoughts and impair memory, judgment, and coordination. Combining this pharmaceutical with other substances, particularly alcohol, can slow breathing and possibly lead to death.
Therapists and my primary care physician have prescribed this for me to ease panic attacks. The prescription is for 30 pills with two refills available in the next six months. Instructions indicate to take it once or twice daily, "as needed," which incidentally is the least scientifi...
Source: Healthy Living - The Huffington Post - September 20, 2016 Category: Consumer Health News Source Type: news
clonazepam (Klonopin)
Title: clonazepam (Klonopin)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 9/8/2016 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - September 8, 2016 Category: Drugs & Pharmacology Source Type: news
School Test Results Lower in Kids Exposed Prenatally to AEDSchool Test Results Lower in Kids Exposed Prenatally to AED
Sixth-graders exposed to an antiepileptic drug, particularly valproate or clonazepam, performed significantly worse than unexposed kids on math and reading tests, new results show. Medscape Medical News (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - May 31, 2016 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Combat Dreams Haunting Veterans Could Be A New Disorder
This report contains a case series of just four individuals, all of whom are men and all of whom are on the younger side," said Dr. Raj Dasgupta, a USC professor and Fellow of the American Academy of Sleep Medicine. "We definitely need a broader study." He pointed out that several of the patients in the cases were on prescription medications and one had a history of alcoholism -- all of which complicates their diagnoses.
Still, Dasgupta thinks that further study may confirm the idea of a veteran-specific sleep disorder. "We already know that war can literally change the brain, so I would not be surprised if active com...
Source: Science - The Huffington Post - May 26, 2016 Category: Science Source Type: news
Klonopin (Clonazepam) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 2, 2016 Category: Drugs & Pharmacology Source Type: news
Medications May Cause Dementia, But It Could Be Untreated Sleep Apnea
By Brandon R. Peters, M.D. The news was enough to give you indigestion: Some of the over-the-counter and prescription medications most widely used to treat heartburn and acid reflux are linked to the development of dementia. The research suggesting a possible association is the latest in a string of implicated drugs over the past few years, including medications taken to treat anxiety, seizures, insomnia, and allergies. What is going on? Before emptying out the medicine cabinet, take a moment to consider the role of untreated obstructive sleep apnea. Scientific research can be difficulty to contextualize, especially when...
Source: Healthy Living - The Huffington Post - February 27, 2016 Category: Consumer Health News Source Type: news
Electronic health records can help catch undiagnosed cases of Type 2 diabetes, UCLA researchers find
In 2012, a group of UCLA researchers set out to mine thousands of electronic health records for a more accurate and less expensive way to identify people who have undiagnosed Type 2 diabetes. The researchers got much more than they bargained for.
Not only did they develop an algorithm with the potential to vastly increase the number of correct diagnoses of the disease by refining the pool of candidates who are put forward for screening; they also uncovered several previously unknown risk factors for diabetes, including a history of sexual and gender identity disorders, intestinal infections and a category of illnesses tha...
Source: UCLA Newsroom: Health Sciences - February 16, 2016 Category: Universities & Medical Training Source Type: news
