Predisposition to treatment response in major depressive episode: A peripheral blood gene coexpression-network analysis
Publication date: Available online 9 July 2016 Source:Journal of Psychiatric Research Author(s): Raoul Belzeaux, Chien-Wei Lin, Ying Ding, Aurélie Bergon, El Chérif Ibrahim, Gustavo Turecki, George Tseng, Etienne Sibille Antidepressant efficacy is insufficient, unpredictable and poorly understood in major depressive episode (MDE). Gene expression studies allow for the identification of significantly dysregulated genes but can limit the exploration of biological pathways. In the present study, we proposed a gene coexpression analysis to investigate biological pathways associated with treatment respon...
Source: Journal of Psychiatric Research - July 11, 2016 Category: Psychiatry Source Type: research

Comparative efficacy and acceptability of first-generation and second-generation antidepressants in the acute treatment of major depression: protocol for a network meta-analysis
Introduction Many antidepressants are indicated for the treatment of major depression. Two network meta-analyses have provided the most comprehensive assessments to date, accounting for both direct and indirect comparisons; however, these reported conflicting interpretation of results. Here, we present a protocol for a systematic review and network meta-analysis aimed at updating the evidence base and comparing all second-generation as well as selected first-generation antidepressants in terms of efficacy and acceptability in the acute treatment of major depression. Methods and analysis We will include all randomised cont...
Source: BMJ Open - July 8, 2016 Category: Journals (General) Authors: Furukawa, T. A., Salanti, G., Atkinson, L. Z., Leucht, S., Ruhe, H. G., Turner, E. H., Chaimani, A., Ogawa, Y., Takeshima, N., Hayasaka, Y., Imai, H., Shinohara, K., Suganuma, A., Watanabe, N., Stockton, S., Geddes, J. R., Cipriani, A. Tags: Open access, Mental health, Pharmacology and therapeutics, Research methods Protocol Source Type: research

Early citalopram treatment increases mortality due to left ventricular rupture in mice after myocardial infarction
Both anxiety and depression are common and independent outcome predictors in patients after myocardial infarction (MI). However, it is unclear whether and how anti-depressants influence remodeling after MI. Thus, we studied cardiac remodeling in mice after experimental MI under treatment with citalopram, a selective serotonin reuptake inhibitor widely used as antidepressant.Methods and Results.Treatment with citalopram versus saline was applied via osmotic pump after coronary artery ligation. Two different groups were studied: early treatment during the healing phase (starting immediately after surgery), or late treatment ...
Source: Journal of Molecular and Cellular Cardiology - July 7, 2016 Category: Cytology Authors: Anna Frey, Veronica-Maria Saxon, Sandy Popp, Marc Lehmann, Denise Mathes, Christina Pachel, Ulrich Hofmann, Georg Ertl, Klaus-Peter Lesch, Stefan Frantz Source Type: research

Antidepressant drug use in England has doubled in a decade
61 million prescriptions for antidepressant drugs, including citalopram and fluoxetine, were filled in England in 2015, up from 29 million in 2005 (Source: New Scientist - Cancer)
Source: New Scientist - Cancer - July 6, 2016 Category: Cancer & Oncology Source Type: research

Antidepressants detection and quantification in whole blood samples by GC–MS/MS, for forensic purposes
Publication date: 5 September 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 128 Author(s): Liliana Truta, André L. Castro, Sónia Tarelho, Pedro Costa, M. Goreti F. Sales, Helena M. Teixeira Depression is among the most prevalent psychiatric disorders of our society, leading to an increase in antidepressant drug consumption that needs to be accurately determined in whole blood samples in Forensic Toxicology Laboratories. For this purpose, this work presents a new gas chromatography tandem mass spectrometry (GC–MS/MS) method targeting the simultaneous and rapid determinatio...
Source: Journal of Pharmaceutical and Biomedical Analysis - July 2, 2016 Category: Drugs & Pharmacology Source Type: research

Therapeutic effects of 10‐HzPulsed wave lasers in rat depression model: A comparison between near‐infrared and red wavelengths
ConclusionsThis study showed that non‐invasive tLLLT using 10‐Hz pulsed NIR laser light was as effective as Citalopram and more effective than red laser in the treatment of depressive‐like behaviors and may help improve tLLLT as an alternative non‐pharmacological treatments of psychological disorders such as depression. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)
Source: Lasers in Surgery and Medicine - July 1, 2016 Category: Laser Surgery Authors: Farzad Salehpour, Seyed Hossein Rasta, Gisou Mohaddes, Saeed Sadigh‐Eteghad, Sima Salarirad Tags: Preclinical Reports Source Type: research

Therapeutic effects of 10 ‐HzPulsed wave lasers in rat depression model: A comparison between near‐infrared and red wavelengths
ConclusionsThis study showed that non‐invasive tLLLT using 10‐Hz pulsed NIR laser light was as effective as Citalopram and more effective than red laser in the treatment of depressive‐like behaviors and may help improve tLLLT as an alternative non‐pharmacological treatments of psychological disorders such as depression. Lasers Surg. Med. © 2016 Wiley Periodicals, Inc. (Source: Lasers in Surgery and Medicine)
Source: Lasers in Surgery and Medicine - July 1, 2016 Category: Laser Surgery Authors: Farzad Salehpour, Seyed Hossein Rasta, Gisou Mohaddes, Saeed Sadigh ‐Eteghad, Sima Salarirad Tags: Preclinical Reports Source Type: research

Stereo ‐Psychopharmacology: The Case of Citalopram and Escitalopram
(Source: Clinical Pharmacology in Drug Development)
Source: Clinical Pharmacology in Drug Development - July 1, 2016 Category: Drugs & Pharmacology Authors: Isaac Ng, H. Karl Greenblatt, David J. Greenblatt Tags: Editorial Source Type: research

Research Roundup
Study in elderly identifies predictors of remission of depression Meta‐analysis finds omega‐3s effective as adjunctive treatment for depression Citalopram shows effectiveness for range of Alzheimer's disease symptoms Metoclopramide controls hypersalivation associated with clozapine treatment Augmentation therapy with memantine improves symptoms of schizophrenia Cognitive symptoms in Lyme disease fail to respond to antibiotics Psychoactive drug use adds dimension to Islamic terrorist activity (Source: The Brown University Psychopharmacology Update)
Source: The Brown University Psychopharmacology Update - June 22, 2016 Category: Psychiatry Tags: Research Roundup Source Type: research

Review Describes How Genetic Information Can Guide Antidepressant Prescribing
Although antidepressants are one of the most commonly prescribed medications in the United States, it is well known that the safety and effectiveness of antidepressants can vary greatly from one patient to the next. In a review published in Mayo Clinic Proceedings, Malik Nassan, M.B.B.S., and colleagues from the Mayo Clinic describe how using genetic tests that screen for pharmacokinetic metabolizing genes can assist with individualizing antidepressant therapy for patients.The review describes evidence to support the role of two metabolizing genes—cytochrome P450 2D6 (CYP2D6), known to metabolize fluoxetine, paroxeti...
Source: Psychiatr News - June 21, 2016 Category: Psychiatry Tags: antidepressants genetic tests Malik Nassan Mayo Clinic Proceedings personalized medicine Source Type: research

R ‐and S‐citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation
ConclusionsOur results suggest that citalopram enantiomers contributed differentially to treatment outcomes. (R)‐citalopram accounted for a greater proportion of the adverse consequences associated with racemic citalopram treatment in patients with AD including a decreased probability of treatment response as measured by the CGIC and a reduction in MMSE scores. The S‐enantiomer was associated with increased probability of response based on the CGIC. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - June 20, 2016 Category: Drugs & Pharmacology Authors: Thang Ho, Bruce G. Pollock, Benoit H. Mulsant, Oliver Schantz, Devangere P. Devanand, Jacobo E. Mintzer, Anton P. Porsteinsson, Lon S. Schneider, Daniel Weintraub, Jerome Yesavage, Lea T. Drye, Cynthia A. Munro, David M. Shade, Constantine Lyketsos, Rober Tags: Pharmacokinetic Dynamic Relationships Source Type: research

R ‐ and S‐citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation
ConclusionsOur results suggest that citalopram enantiomers contributed differentially to treatment outcomes. (R)‐citalopram accounted for a greater proportion of the adverse consequences associated with racemic citalopram treatment in patients with AD including a decreased probability of treatment response as measured by the CGIC and a reduction in MMSE scores. The S‐enantiomer was associated with increased probability of response based on the CGIC. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - June 20, 2016 Category: Drugs & Pharmacology Authors: Thang Ho, Bruce G. Pollock, Benoit H. Mulsant, Oliver Schantz, Devangere P. Devanand, Jacobo E. Mintzer, Anton P. Porsteinsson, Lon S. Schneider, Daniel Weintraub, Jerome Yesavage, Lea T. Drye, Cynthia A. Munro, David M. Shade, Constantine Lyketsos, Rober Tags: PHARMACOKINETIC DYNAMIC RELATIONSHIPS Source Type: research

Determination of some psychotropic drugs in serum and saliva samples by HPLC-DAD and HPLC MS
Publication date: 5 August 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 127 Author(s): A. Petruczynik, K. Wróblewski, M. Szultka-Młyńska, B. Buszewski, H. Karakuła-Juchnowicz, J. Gajewski, J. Morylowska-Topolska, M. Waksmundzka-Hajnos A simple, rapid and sensitive HPLC-DAD method has been developed and validated for the simultaneous determination of seven psychotropic drugs (risperidone, citalopram, clozapine,quetiapine, levomepromazine, perazine and aripiprazole) in human serum or saliva samples. The chromatographic analyses were performed on a XSELECT CSH Phenyl-Hexyl column w...
Source: Journal of Pharmaceutical and Biomedical Analysis - June 15, 2016 Category: Drugs & Pharmacology Source Type: research

Application of electromembrane extraction followed by corona discharge ion mobility spectrometry analysis as a fast and sensitive technique for determination of tricyclic antidepressants in urine samples
Publication date: November 2016 Source:Microchemical Journal, Volume 129 Author(s): Zolfaghar Aladaghlo, Ali Reza Fakhari, Kobra Sadat Hasheminasab In the paper, electromembrane extraction (EME) method coupled with corona discharge ion mobility spectrometry (CD-IMS) was introduced for determination of antidepressant drugs (desipramine, sertraline, clomipramine, citalopram) in urine samples. IMS is a well-known, comparatively inexpensive, robust and easy to operate analytical instrumentation. This combination would provide a selective and sensitive determination. In order to achieve the best extraction efficiency, opti...
Source: Microchemical Journal - June 12, 2016 Category: Chemistry Source Type: research

The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression.
Authors: Tatham EL, Hall GB, Clark D, Foster J, Ramasubbu R Abstract Symptom improvement in depression due to antidepressant treatment is highly variable and clinically unpredictable. Linking neuronal connectivity and genetic risk factors in predicting antidepressant response has clinical implications. Our investigation assessed whether indices of white matter integrity, serotonin transporter-linked polymorphism (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) val66met polymorphism predicted magnitude of depression symptom change following antidepressant treatment. Fractional anisotropy (FA) was used as an i...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 11, 2016 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

The Clinical and Cost Effectiveness of Vortioxetine for the Treatment of a Major Depressive Episode in Patients With Failed Prior Antidepressant Therapy: A Critique of the Evidence
This article provides a description of the company submission, the ERG review and the resulting NICE guidance TA367 issued in November 2015. The ERG critically reviewed the evidence presented in the manufacturer’s submission and identified areas requiring clarification, for which the manufacturer provided additional evidence. Two phase III randomised controlled trials for a second-line population involving vortioxetine were identified—REVIVE and TAK318. These two trials represent only 972 of over 7000 patients included in trials of vortioxetine. In REVIVE, there was a statistically significant difference in dep...
Source: PharmacoEconomics - June 11, 2016 Category: Health Management Source Type: research

Amitriptyline-induced cutaneous hyperpigmentation: case report and review of psychotropic drug-associated mucocutaneous hyperpigmentation.
CONCLUSIONS: Psychotropic drugs associated with cutaneous hyperpigmentation include amitriptyline, chlorpromazine, citalopram, desipramine, imipramine, mirtazapine, phenytoin, sertraline, and thioridazine. The hyperpigmentation may initially appear many years after starting the medication. Pathology typically shows melanophages and melanin in the dermis. Fontana Masson stain confirms the presence of melanin; Perl stain for hemosiderin or iron is negative. Discontinuation of the drug may result in spontaneous improvement. Further studies are needed to better understand the role of Q-switched laser in treating drug-induced h...
Source: Dermatol Online J - June 10, 2016 Category: Dermatology Authors: Eichenfield DZ, Cohen P Tags: Dermatol Online J Source Type: research

Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis
This study is registered with PROSPERO, number CRD42015016023. Findings We deemed 34 trials eligible, including 5260 participants and 14 antidepressant treatments. The quality of evidence was rated as very low in most comparisons. For efficacy, only fluoxetine was statistically significantly more effective than placebo (standardised mean difference −0·51, 95% credible interval [CrI] −0·99 to −0·03). In terms of tolerability, fluoxetine was also better than duloxetine (odds ratio [OR] 0·31, 95% CrI 0·13 to 0·95) and imipramine (0·23, 0·04 to 0·...
Source: The Lancet - June 9, 2016 Category: Journals (General) Source Type: research

Citalopram May Offer Limited Benefit for Patients Experiencing Complicated Grief
Use of citalopram alone or in combination with psychotherapy for complicated grief (CG) may do little to help patients experiencing the persistent maladaptive thoughts, dysfunctional behaviors, and poorly regulated emotionality that characterize this chronic condition, according to findings published today in JAMA Psychiatry. However, a combination of citalopram and complicated grief therapy (CGT) may lead to improvements in patients with complicated grief and co-occurring depression. Although it is common for patients with CG to experience co-occurring depressive symptoms, the primary symptoms of CG and response to t...
Source: Psychiatr News - June 8, 2016 Category: Psychiatry Tags: antidepressant citalopram complicated grief Source Type: research

Optimizing Treatment of Complicated Grief: A Randomized Clinical Trial
This randomized trial compares the efficacy of targeted complicated grief treatment, citalopram, both, or neither on the outcomes of patients with complicated grief. (Source: JAMA Psychiatry)
Source: JAMA Psychiatry - June 8, 2016 Category: Psychiatry Source Type: research

The 5-HTTLPR and BDNF polymorphisms moderate the association between uncinate fasciculus connectivity and antidepressants treatment response in major depression
Abstract Symptom improvement in depression due to antidepressant treatment is highly variable and clinically unpredictable. Linking neuronal connectivity and genetic risk factors in predicting antidepressant response has clinical implications. Our investigation assessed whether indices of white matter integrity, serotonin transporter-linked polymorphism (5-HTTLPR) and brain-derived neurotrophic factor (BDNF) val66met polymorphism predicted magnitude of depression symptom change following antidepressant treatment. Fractional anisotropy (FA) was used as an indicator of white matter integrity and was assessed in the...
Source: European Archives of Psychiatry and Clinical Neuroscience - June 8, 2016 Category: Neuroscience Source Type: research

Comparative efficacy of selective serotonin reuptake inhibitors (SSRI) in treating major depressive disorder: a protocol for network meta-analysis of randomised controlled trials
This study aims to compare the efficacy of SSRIs by conducting a Bayesian network meta-analysis, which will be the most comprehensive evaluation of evidence to resolve the inconsistency among previous studies. Methods and analyses SSRIs including citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline and vilazodone have been selected. Systematic database searching and screening will be conducted for the RCTs on drug treatment of patients with MDD according to pre-specified search strategies and selection criteria. PubMed, the Cochrane Library, EMBASE, ScienceDirect, the US Food and Drug Administration W...
Source: BMJ Open - June 7, 2016 Category: Journals (General) Authors: Jia, Y., Zhu, H., Leung, S.-w. Tags: Open access, Evidence based practice, Health informatics, Mental health Protocol Source Type: research

In vitro and in vivo evaluation of the mechanisms of citalopram-induced hepatotoxicity.
In conclusion, it is suggested that citalopram hepatotoxicity might be a result of oxidative hazard leading to mitochondrial/lysosomal toxic connection and disorders in biochemical markers which were supported by histomorphological studies. PMID: 27271269 [PubMed - as supplied by publisher] (Source: Archives of Pharmacal Research)
Source: Archives of Pharmacal Research - June 6, 2016 Category: Drugs & Pharmacology Authors: Ahmadian E, Eftekhari A, Fard JK, Babaei H, Nayebi AM, Mohammadnejad D, Eghbal MA Tags: Arch Pharm Res Source Type: research

Low-dose intravenous lipid emulsion for the treatment of severe quetiapine and citalopram poisoning.
Abstract The treatment of quetiapine and/or citalopram poisoning is mainly supportive and involves gastric lavage, activated charcoal, intubation, and mechanical ventilation. Recently, however, there were reports of successful treatment with intravenous lipid emulsion. Here we report a case of a 19-year-old Caucasian girl who ingested approximately 6000 mg of quetiapine, 400 mg of citalopram, and 45 mg of bromazepam in a suicide attempt. The patient developed ventricular tachycardia and epileptic seizures 12 h after admission to the hospital. As the patient's condition deteriorated, we combined standard therapy (i...
Source: Arhiv za Higijenu Rada i Toksikologiju - June 1, 2016 Category: Occupational Health Authors: Purg D, Markota A, Grenc D, Sinkovič A Tags: Arh Hig Rada Toksikol Source Type: research

Investigational drugs for treating agitation in persons with dementia.
Authors: Garay RP, Citrome L, Grossberg GT, Cavero I, Llorca PM Abstract INTRODUCTION: Agitation is common and distressing in persons with dementia, but safe, effective treatments remain elusive. In this review, the authors describe investigational compounds in ongoing or recently completed clinical trials for this indication and provide an opinion on how they may meet current therapeutic needs. AREAS COVERED: Phase II and phase III clinical trials for agitation in persons with dementia were searched in US and EU clinical trial registries and in the medical literature for the period January 2013-February 2016 E...
Source: Expert Opinion on Investigational Drugs - May 28, 2016 Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research

Genetic polymorphisms and the adequacy of brain stimulation: state of the art.
Authors: Saghazadeh A, Esfahani SA, Rezaei N Abstract INTRODUCTION: Heterogeneity of therapeutic response to brain stimulation techniques has inspired scientists to uncover the secrets to success or failure of these projects. Genetic polymorphisms are one of the major causes of this heterogeneity. AREAS COVERED: More than twenty genetic variants within more than ten genes (e.g. BDNF, COMT, DRD2, TRPV1, 5-HT1A, 5-HHT, P2RX7, VEGF, TPH1, TPH2, ACE, APOE, GNB3, NET, NMDA receptors, and RGS4) have been investigated, among which the BDNF gene and its polymorphism, Val66Met, is the best documented variant. We review ...
Source: Expert Review of Neurotherapeutics - May 27, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Hepatotoxicity Associated with Donepezil in an Individual Taking Citalopram
(Source: Journal of the American Geriatrics Society)
Source: Journal of the American Geriatrics Society - May 25, 2016 Category: Geriatrics Authors: Liping Ma, Cheng Wen, Can Chen, Sijing Shen, Junnan Yang Tags: Letters to the Editor Source Type: research

Antidepressants for treating depression in adults with end-stage kidney disease treated with dialysis.
Abstract BACKGROUND: Depression affects approximately one-quarter of people treated with dialysis and is considered an important research uncertainty by patients and health professionals. Treatment for depression in dialysis patients may have different benefits and harms compared to the general population due to different clearances of antidepressant medication and the severity of somatic symptoms associated with end-stage kidney disease (ESKD). Guidelines suggest treatment of depression in dialysis patients with pharmacological therapy, preferably a selective serotonin reuptake inhibitor. This is an update of a r...
Source: Cochrane Database of Systematic Reviews - May 23, 2016 Category: Journals (General) Authors: Palmer SC, Natale P, Ruospo M, Saglimbene VM, Rabindranath KS, Craig JC, Strippoli GF Tags: Cochrane Database Syst Rev Source Type: research

The citalopram CIT-MD-18 pediatric depression trial: Deconstruction of medical ghostwriting, data mischaracterisation and academic malfeasance.
CONCLUSION: Deconstruction of court documents revealed that protocol-specified outcome measures showed no statistically significant difference between citalopram and placebo. However, the published article concluded that citalopram was safe and significantly more efficacious than placebo for children and adolescents, with possible adverse effects on patient safety. PMID: 27176755 [PubMed - in process] (Source: International Journal of Risk and Safety in Medicine)
Source: International Journal of Risk and Safety in Medicine - May 18, 2016 Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research

Antidepressants and the risk of hyponatremia: a Danish register-based population study
Conclusions All antidepressants except mianserin are associated with hyponatremia. The association is strongest with citalopram and lowest with duloxetine, venlafaxine and mirtazapine. (Source: BMJ Open)
Source: BMJ Open - May 18, 2016 Category: Journals (General) Authors: Leth-Moller, K. B., Hansen, A. H., Torstensson, M., Andersen, S. E., Odum, L., Gislasson, G., Torp-Pedersen, C., Holm, E. A. Tags: Open access, Geriatric medicine, Mental health, Pharmacology and therapeutics, Renal medicine Research Source Type: research

Synthesis of Citalopram
Synfacts 2016; 12: 0556-0556DOI: 10.1055/s-0035-1562127© Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Full text (Source: Synfacts)
Source: Synfacts - May 17, 2016 Category: Chemistry Tags: Synthesis of Natural Products and Potential Drugs Source Type: research

Clinical Reasoning: Heart to swallow
A 55-year-old woman was admitted to our intensive care department after intoxication with lithium. Her medical history was relevant for bipolar disorder for which she received medical treatment with lithium, haloperidol, and citalopram. In the week before admission, she had developed a clinical picture of gastroenteritis with diarrhea and vomiting, which resulted in dehydration and a marked deterioration in kidney function. During the last days before admission, she had become progressively lethargic and had developed dysarthria as well as postural tremors of the extremities. The tremors were coarse and irregular, most cle...
Source: Neurology - May 16, 2016 Category: Neurology Authors: van Westerloo, D. J., Barge-Schaapveld, D. Q., Bikker, H., van Noorden, M. S., Tannemaat, M. R. Tags: All Clinical Neurology, All Psychiatric disorders, Cardiac; see Cerebrovascular Disease/Cardiac, Syncope RESIDENT AND FELLOW SECTION Source Type: research

Identification and Management of Peripartum Depression.
Abstract Peripartum depression affects up to one in seven women and is associated with significant maternal and neonatal morbidity if untreated. A history of depression is the strongest risk factor for developing peripartum depression. The U.S. Preventive Services Task Force recommends screening pregnant and postpartum women for depression. Both two-step and one-step screening strategies are effective in identifying peripartum depression. Peripartum depression should be distinguished from the baby blues, which is characterized by short duration, mild symptoms, and minimal impact on functioning. Women with peripart...
Source: American Family Physician - May 15, 2016 Category: Primary Care Authors: Langan R, Goodbred AJ Tags: Am Fam Physician Source Type: research

Protein Kinases Alter the Allosteric Modulation of the Serotonin Transporter In Vivo and In Vitro.
CONCLUSION: Taken together, these results highlight for the first time an involvement of protein kinases in the allosteric modulation of SERT function. PMID: 27171685 [PubMed - as supplied by publisher] (Source: CNS Neuroscience and Therapeutics)
Source: CNS Neuroscience and Therapeutics - May 12, 2016 Category: Neuroscience Authors: Mnie-Filali O, Lau T, Matthaeus F, Abrial E, Delcourte S, El Mansari M, Pershon A, Schloss P, Sánchez C, Haddjeri N Tags: CNS Neurosci Ther Source Type: research

Hospitalizations Among Veterans Increase After Reductions in Citalopram, Study Shows
All-cause hospitalizations and deaths among veterans significantly increased following reductions in prescribed doses of the antidepressant citalopram in response to an FDA safety bulletin that warned against prescribing citalopram at doses higher than 40 mg/day, according to a report appearing online today in AJP in Advance.The August 2011 FDA communication stated that doses of citalopram above 40 mg/day may be associated with risk for arrhythmia related to QT prolongation. But today’s AJP study appears to indicate serious unintended consequences in the form of increased hospitalization for mental disorders.“R...
Source: Psychiatr News - May 10, 2016 Category: Psychiatry Tags: ajp in advance arrhythmias citalopram depression FDA QT prolongation veterans Source Type: research

Outcomes of Citalopram Dosage Risk Mitigation in a Veteran Population.
CONCLUSIONS: Reduction of prescribed citalopram dosages to a new safety limit was associated with a higher rate of hospitalization in a large patient population who had been treated with substantially higher dosages. Stipulating a safety limit for citalopram dosages before the benefits and risks of doing so were firmly established appears to have had unintended clinical consequences. PMID: 27166093 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 10, 2016 Category: Psychiatry Authors: Rector TS, Adabag S, Cunningham F, Nelson D, Dieperink E Tags: Am J Psychiatry Source Type: research

Depression and anxiety in cardiovascular disease.
Abstract Cardiovascular disease (CVD) and mental disorders often coexist. Mood and anxiety disorders are common in patients treated by general practitioners, where the prevalence of those disorders may be two times higher than in the general population (35%). Moreover, the prevalence rises up to 40% in patients suffering from cardiovascular disease. Observational studies revealed that depression caused an increased incidence of cardiovascular disease (CVD), and also increased the risk (1.2 to 2.7 fold) of incidents that led to cardiac-related, and all-cause death in patients with a history of CVD. There is not cle...
Source: Kardiologia Polska - May 10, 2016 Category: Cardiology Authors: Małyszczak KM, Rymaszewska J Tags: Kardiol Pol Source Type: research

Outcomes of Citalopram Dosage Risk Mitigation in a Veteran Population
American Journal of Psychiatry, Ahead of Print. (Source: American Journal of Psychiatry)
Source: American Journal of Psychiatry - May 10, 2016 Category: Psychiatry Authors: Thomas S. RectorSelcuk AdabagFrancesca CunninghamDavid NelsonEric Dieperink Source Type: research

Outcomes of Citalopram Dosage Risk Mitigation in a Veteran Population
American Journal of Psychiatry, Ahead of Print. (Source: American Journal of Psychiatry)
Source: American Journal of Psychiatry - May 10, 2016 Category: Psychiatry Authors: Thomas S. Rector Selcuk Adabag Francesca Cunningham David Nelson Eric Dieperink Source Type: research

Optimization of ultrasound-assisted dispersive liquid-liquid microextraction based on solidification of floating organic droplets by experimental design methodologies for determination of three anti-anxiety drugs in human serum and urine samples by high performance liquid chromatography
Publication date: September 2016 Source:Microchemical Journal, Volume 128 Author(s): Sahar Farsimadan, Nasser Goudarzi, Mansour Arab Chamjangali, Ghadamali Bagherian A novel coupling of ultrasound-assisted dispersive liquid–liquid microextraction based on solidification of floating organic droplets (UA-DLLME-SFODs) with high performance liquid chromatography (HPLC) was developed for the simultaneous preconcentration and determination of citalopram (CIT), diazepam (DIZ), and sertraline (SER) in their tablets and in the human serum and urine samples. In this proposed procedure, 1-undecanol and ethanol were used a...
Source: Microchemical Journal - May 9, 2016 Category: Chemistry Source Type: research

Serotonin transporter polymorphism alters citalopram effects on human pain responses to physical pain
Publication date: 15 July 2016 Source:NeuroImage, Volume 135 Author(s): Yina Ma, Chenbo Wang, Siyang Luo, Bingfeng Li, Tor D. Wager, Wenxia Zhang, Yi Rao, Shihui Han Humans exhibit substantial inter-individual differences in pain perception, which contributes to variability in analgesic efficacy. Individual differences in pain sensitivity have been linked with variation in the serotonin transporter gene (5-HTTLPR), and selective serotonin reuptake inhibitors (SSRIs) such as citalopram have been increasingly used as treatments for multiple pain conditions. We combined genotyping, pharmacological challenge, and neu...
Source: NeuroImage - May 8, 2016 Category: Neuroscience Source Type: research

Principal components analysis of agitation outcomes in Alzheimer's disease
Conclusions Results suggest that a composite measure of change in agitation might be more sensitive than change in a single primary agitation measure. (Source: Journal of Psychiatric Research)
Source: Journal of Psychiatric Research - May 6, 2016 Category: Psychiatry Source Type: research

Prevalence, impact, and management of depression and anxiety in patients with HIV: a review
Suprakash Chaudhury,1 Ajay Kumar Bakhla,2 Rajiv Saini,3 1Department of Psychiatry, Pravara Institute of Medical Sciences (Deemed University), Loni, Maharashtra, 2Department of Psychiatry, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, 3Department of Psychiatry, Armed Forces Medical College (AFMC), Pune, Maharashtra, India Abstract: The prevalence of depression and anxiety in people living with HIV/AIDS (PLWHA) ranges from 7.2% to 71.9% and 4.5% to 82.3%, respectively. This wide variation is attributed to differences in sample size and characteristics, and methodology for assessment of anxiety and depression. Mo...
Source: Neurobehavioral HIV Medicine - May 5, 2016 Category: Psychiatry Tags: Neurobehavioral HIV Medicine Source Type: research

R‐and S‐citalopram concentrations have differential effects on neuropsychiatric scores in elders with dementia and agitation
CONCLUSIONSOur results suggest that citalopram enantiomers contributed differentially to treatment outcomes. (R)‐citalopram accounted for a greater proportion of the adverse consequences associated with racemic citalopram treatment in patients with AD including a decreased probability of treatment response as measured by the CGIC and a reduction in MMSE scores. The S‐enantiomer was associated with increased probability of response based on the CGIC. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - May 4, 2016 Category: Drugs & Pharmacology Authors: T. Ho, B. G. Pollock, B. H. Mulsant, O. Schantz, D. P. Devanand, J. E. Mintzer, A. P. Porsteinsson, L. S. Schneider, D. Weintraub, J. Yesavage, L. T. Drye, C. A. Munro, D. M. Shade, C. Lyketsos, R. Bies Tags: Pharmacokinetic Dynamic Relationships Source Type: research

REM sleep homeostasis in the absence of REM sleep: Effects of antidepressants.
This study investigated the impact of antidepressants with different mechanisms of action, such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCA), on the regulation of REM sleep in rats. REM sleep was first demonstrated to be homeostatically regulated using 5, 8 and 10 h of REM-sleep specific restriction through EEG-triggered arousals, with an average of 91 ± 10% of lost REM sleep recovered following a 26-29 -hour recovery period. Acute treatment with the antidepressants paroxetine, citalopram and imipramine inhibited REM sleep by 84 ± 8, 84 &...
Source: Neuropharmacology - May 2, 2016 Category: Drugs & Pharmacology Authors: McCarthy A, Wafford K, Shanks E, Ligocki M, Edgar DM, Dijk DJ Tags: Neuropharmacology Source Type: research

Citalopram
(Source: Reactions Weekly)
Source: Reactions Weekly - May 1, 2016 Category: Drugs & Pharmacology Source Type: research

Persistence And Concomitant Drug Use On Branded Desvenlafaxine Compared With Other Antidepressants In Patients With Major Depressive Disorder
To compare medication persistence and concomitant MDD drug use in patients prescribed i) branded desvenlafaxine, ii) other branded selective serotonin re-uptake inhibitors (SSRIs) and selective serotonin-norepinephrine re-uptake inhibitors (SNRIs), and iii) generic SSRIs/SNRIs (escitalopram, venlafaxine, citalopram, fluvoxamine, sertraline, fluoxetine and paroxetine). (Source: Value in Health)
Source: Value in Health - May 1, 2016 Category: Global & Universal Authors: A Shelbaya, C Deshpande, E Pappadopulos, J Alvir, V Chirikov, JM Stephens Source Type: research

Citalopram pulse-loading for treatment-resitant obsessive-compulsive disorder: preliminary data from an open-label trial
Treatment resistance is a frequent situation in Obsessive Compulsive Disorder (OCD), occurring in 40–60% of patients. However, in the current literature there are only a few evidence-based options for treatment resistant patients. Pulse-loading treatment consists in a rapid titration of the pharmacological agent in the first days of treatment. A few studies suggested that this kind of titration with intravenous clomipramine could result in a greater and faster response than with a standard titration in OCD resistant patients (Koran et al., 2006; Grassi et al., 2013). (Source: European Neuropsychopharmacology)
Source: European Neuropsychopharmacology - May 1, 2016 Category: Psychiatry & Psychology Authors: Giacomo Grassi, Stefano Pallanti Source Type: research

Psychotherapy versus Pharmacotherapy for Posttraumatic Stress Disorder: Systemic Review and Meta‐Analyses to Determine First‐Line Treatments
ConclusionsStudy findings support use of TFPs over nontrauma‐focused psychotherapy or medication as first‐line interventions. Second‐line interventions include SIT, and potentially sertraline or venlafaxine, rather than entire classes of medication, such as SSRIs. Future revisions of CPGs should prioritize studies that utilize active controls over waitlist or treatment‐as‐usual conditions. Direct head‐to‐head trials of TFPs versus sertraline or venlafaxine are needed. (Source: Depression and Anxiety)
Source: Depression and Anxiety - April 30, 2016 Category: Psychiatry Authors: Daniel J. Lee, Carla W. Schnitzlein, Jonathan P. Wolf, Meena Vythilingam, Ann M. Rasmusson, Charles W. Hoge Tags: Research Article Source Type: research

Simultaneous determination of ambroxol and salbutamol in human plasma by ultra performance liquid chromatography - tandem mass spectrometry and its application to a pharmacokinetic study.
Abstract A rapid, selective and sensitive liquid chromatography-tandem mass spectrometry assay method was developed for simultaneous determination of ambroxol and salbutamol in human plasma using citalopram hydrobromide as internal standard (IS). Sample was alkalinized with ammonia water (33:67, v/v) and extracted by single liquid-liquid extraction with ethyl acetate. Separation was achieved on Waters ACQUITY UPLC BEH C18 column using gradient program at a flow rate of 0.2 mL/min. Detection was performed using electrospray ionization in positive ion multiple reaction monitoring (MRM) mode by monitoring the ...
Source: Biomedical Chromatography : BMC - April 30, 2016 Category: Biomedical Science Authors: Guo Z, Chen Y, Ding X, Huang C, Miao L Tags: Biomed Chromatogr Source Type: research