Psychoactive drugs: occurrence in aquatic environment, analytical methods, and ecotoxicity-a review.
Abstract This review focused on seven psychoactive drugs being six benzodiazepines (alprazolam, bromazepam, clonazepam, diazepam, lorazepam, and oxazepam) and one antidepressant (citalopram) widely consumed by modern society and detected in different aqueous matrices (drinking water, surface water, groundwater, seawater, estuary water, influent and effluent of wastewater treatment plants). The review included 219 selected scientific papers from which 1642 data/entries were obtained, each entry corresponding to one target compound in one aqueous matrix. Concentrations of all investigated drugs in all aqueous matric...
Source: Environmental Science and Pollution Research International - September 23, 2017 Category: Environmental Health Authors: Cunha DL, de Araujo FG, Marques M Tags: Environ Sci Pollut Res Int Source Type: research

Anticonvulsant activity, organotypic hippocampal neuroprotection assay and in-silico sodium channel blocking potential of 2-amino-6-nitrobenzothiazole derived semicarbazones.
Abstract Epilepsy is one of the dreadful neurodegenerative disorder characterized by recurrent, unprovoked seizures. Currently available antiepileptic drugs are still associated with enormous side effects resulting in search of newer, more effective and safer agents. In view of this, we have investigated anticonvulsant activity of 2-amino-6-nitrobenzothiazole derived semicarbazones (7-32) in various in-vivo animal seizure models viz. maximal electroshock (MES), subcutaneous pentylenetetrazole (scPTZ) and 6Hz psychomotor seizure model. Neurotoxicity was estimated by rotarod test. The compounds were also assessed fo...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 19, 2017 Category: Drugs & Pharmacology Authors: Prasad Tripathi RK, Ayyannan SR Tags: Biomed Pharmacother Source Type: research

The Effect of Citalopram Versus a Placebo on Central Auditory Processing in the Elderly
Conclusion: There was no clinical effect with the use of citalopram in central auditory processing tests of the subjects. (Source: Otology and Neurotology)
Source: Otology and Neurotology - September 16, 2017 Category: ENT & OMF Tags: Audiology Source Type: research

Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT1A [ 11C ] CUMI-101 PET and Functional MRI Study
Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT1A [11C]CUMI-101 PET and Functional MRI Study Neuropsychopharmacology advance online publication, September 13 2017. doi:10.1038/npp.2017.166 Authors: Sudhakar Selvaraj, Chris Walker, Danilo Arnone, Bo Cao, Paul Faulkner, Philip J Cowen, Jonathan P Roiser & Oliver Howes Keywords: (Source: Neuropsychopharmacology)
Source: Neuropsychopharmacology - September 13, 2017 Category: Neurology Authors: Sudhakar Selvaraj Chris Walker Danilo Arnone Bo Cao Paul Faulkner Philip J Cowen Jonathan P Roiser Oliver Howes Source Type: research

Study lends support to genuine efficacy of antidepressants
Findings show that the antidepressants citalopram and paroxetine have significant beneficial effects, clearly outperforming placebo. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - September 12, 2017 Category: Drugs & Pharmacology Source Type: research

A Practical Approach to Avoiding Cardiovascular Adverse Effects of Psychoactive Medications
Publication date: Available online 11 September 2017 Source:Canadian Journal of Cardiology Author(s): Judith Brouillette, Stanley Nattel Drugs that act on mental state, generally termed “psychoactive agents”, are among the most widely used medications in medicine. Psychoactive agents can affect the cardiovascular system and must be used carefully to avoid negative cardiovascular consequences. The present paper reviews the potential adverse cardiovascular consequences of psychoactive medications and provides suggestions for practical approaches to avoiding them. We consider adverse reactions in terms of 1) arrh...
Source: Canadian Journal of Cardiology - September 12, 2017 Category: Cardiology Source Type: research

126 The selective serotonin reuptake inhibitor fluoxetine exerts anti-inflammatory actions on human epidermal keratinocytes
By releasing several cytokines and mediators (e.g. endothelin 1 [ET1]), keratinocytes are key players in orchestrating cutaneous inflammation and itch. The selective serotonin reuptake inhibitor (SSRI) fluoxetine (FL), a widely applied antidepressant, has already been shown to exert anti-inflammatory actions in mice; thus, in the current study, we assessed putative anti-inflammatory effects of selected SSRIs (FL, citalopram [CP] and paroxetine [PX]) as well as serotonin (ST) on immortalized (HaCaT) and primary (NHEK) human epidermal keratinocytes. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - September 8, 2017 Category: Dermatology Authors: K.F. T óth, J. Szabó-Papp, A. Kilic, M. Soeberdt, C. Abels, T. Bíró, A. Oláh Tags: Epidermal Structure and Function Source Type: research

Prediction of human efficacious antidepressant doses using the mouse forced swim test
Publication date: Available online 6 September 2017 Source:Pharmacology Biochemistry and Behavior Author(s): Eunice Yuen, Steven Swanson, Jeffrey M. Witkin The forced swim test (FST) is a commonly used preclinical animal behavioural model for prediction of antidepressant activity in humans. While the FST may qualitatively predict efficacy, less is known about the quantitative translation of FST data to human efficacious doses. Assessing quantitative translation allows better predictions of human efficacious doses and a higher chance of success in the drug development process. Dose-response and time-course FST experiments ...
Source: Pharmacology Biochemistry and Behavior - September 7, 2017 Category: Biochemistry Source Type: research

Drugs for Cognitive Loss and Dementia
Date: September 25, 2017 Issue #:  1530Summary:  Alzheimer's disease (AD) is the most common cause of dementia, but cognitive loss is also associated with other neurological conditions such as Parkinson's disease, dementia with Lewy bodies, vascular dementia, and frontotemporal dementia. (Source: The Medical Letter)
Source: The Medical Letter - September 6, 2017 Category: Drugs & Pharmacology Authors: admin Tags: Alzheimer ' s disease Antidepressants Antipsychotics Aricept Benadryl Celexa Citalopram dextromethrophan diphenhydramine Ditropan Donepezil Ebixa Exelon Galantamine Herbals Imipramine Memantine Namenda Namzaric Nu Source Type: research

Quality of Life, Functioning, and Depressive Symptom Severity in Older Adults With Major Depressive Disorder Treated With Citalopram in the STAR*D Study.
This study examines these outcomes before and after SSRI treatment. On the basis of prior research, we hypothesized that older adults would have worse treatment outcomes in QOL, functioning, and depressive symptom severity and that nonremitters would have worse outcomes. METHODS: A retrospective secondary data analysis was conducted from the National Institute of Mental Health-funded Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study (July 2001-September 2006). We analyzed data for 2,280 nonpsychotic adults with DSM-IV-TR-defined MDD who received citalopram monotherapy. Older adults were classified a...
Source: Journal of Clinical Psychiatry - September 2, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research

Major Depressive Disorder in Patients With Doctoral Degrees: Patient-reported Depressive Symptom Severity, Functioning, and Quality of Life Before and After Initial Treatment in the STAR*D Study
Conclusions: Findings from this study indicated that, following citalopram monotherapy, the participants in the DOCS group achieved greater reductions in depressive symptom severity (based on effect sizes) than the participants in the non-DOCS group. For both treatment groups, the findings also showed the positive effect that remission status from MDD can have on QOL and functioning. (Source: Journal of Psychiatric Practice)
Source: Journal of Psychiatric Practice - September 1, 2017 Category: Psychiatry Tags: Articles Source Type: research

Acute Change in Anterior Cingulate Cortex GABA, but not Glutamine/Glutamate, Mediates Antidepressant Response to Citalopram
Little is known about the acute effects of antidepressant treatments on brain glutamate and gamma-amino-butyric acid (GABA) levels, and their association with clinical response. Using proton magnetic resonance spectroscopy (1H-MRS) we examined longitudinally the effects of citalopram on glutamine/glutamate ratios and GABA levels in the pregenual anterior cingulate cortex (pgACC) of individuals with major depressive disorder (MDD). We acquired 1H-MRS scans at baseline and at days 3, 7, and 42 of citalopram treatment in nineteen unmedicated individuals with MDD. (Source: Psychiatry Research: Neuroimaging)
Source: Psychiatry Research: Neuroimaging - September 1, 2017 Category: Psychiatry Authors: Brian P. Brennan, Roee Admon, Chris Perriello, Erin M. LaFlamme, Alison J. Athey, Diego A. Pizzagalli, James I. Hudson, Harrison G. Pope, J. Eric Jensen Source Type: research

Incidence of early anxiety aggravation in trials of selective serotonin reuptake inhibitors in depression
ConclusionWhereas an anxiety‐reducing effect of SSRIs is notable already during the first week of treatment, these drugs may also elicit an early increase in anxiety in susceptible subjects that however does not predict a poor subsequent response to treatment. (Source: Acta Psychiatrica Scandinavica)
Source: Acta Psychiatrica Scandinavica - September 1, 2017 Category: Psychiatry Authors: J. N äslund, F. Hieronymus, J. F. Emilsson, A. Lisinski, S. Nilsson, E. Eriksson Tags: Original Article Source Type: research

Epileptic Seizures Under Antidepressive Drug Treatment: Systematic Review
Conclusions Antidepressive treatment is rather safe in terms of risk of seizures and also can be generally recommended in the treatment of patients with epilepsy. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - August 29, 2017 Category: Psychiatry Authors: Steinert, Tilman Fr öscher, Walter Tags: Review Source Type: research

Stable Remission of Multiple Chemical Sensitivity Syndrome and Major Depression With Citalopram and 1-Month Deep Transcranial Magnetic Stimulation: A Case Report
No abstract available (Source: The Journal of ECT)
Source: The Journal of ECT - August 24, 2017 Category: Psychiatry Tags: Letters to the Editor Source Type: research

Inhibitory Effect of Citalopram on the Pharmacokinetics of Carvedilol in Rats and in vitro Models
Conclusion: Citalopram co-administration led to a significant alteration of carvedilol's PK profile in rats; it also demonstrated, in vitro, these effects could be explained by the existence of a drug-drug interaction mediated by CYP2D6 inhibition.Pharmacology 2017;100:301-307 (Source: Pharmacology)
Source: Pharmacology - August 18, 2017 Category: Drugs & Pharmacology Source Type: research

Use of antidepressants and risk of epithelial ovarian cancer
In conclusion, use of selective serotonin reuptake inhibitors was associated with a decreased risk of epithelial ovarian cancer; thereby implying potential chemopreventive properties of these drugs. This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - August 9, 2017 Category: Cancer & Oncology Authors: Lina S. M ørch, Christian Dehlendorff, Louise Baandrup, Søren Friis, Susanne K. Kjær Tags: Research Article Source Type: research

Association of QT-Prolonging Medication Use in CKD with Electrocardiographic Manifestations.
CONCLUSIONS: Use of medications associated with QT prolongation is common in CKD; the safety implications of these findings should be considered in these high-risk patients. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2017_08_09_CJASNPodcast_17_09_b.mp3. PMID: 28793999 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 9, 2017 Category: Urology & Nephrology Authors: Snitker S, Doerfler RM, Soliman EZ, Deo R, St Peter WL, Kramlik S, Fischer MJ, Navaneethan S, Delafontaine P, Jaar BG, Ojo A, Makos GK, Slaven A, Weir MR, Zhan M, Fink JC, for CRIC Study Investigators Tags: Clin J Am Soc Nephrol Source Type: research

Antidepressants for chronic non-cancer pain in children and adolescents.
CONCLUSIONS: We identified only a small number of studies with small numbers of participants and insufficient data for analysis.As we could undertake no meta-analysis, we are unable to comment about efficacy or harm from the use of antidepressants to treat chronic non-cancer pain in children and adolescents. Similarly, we cannot comment on our remaining secondary outcomes: Carer Global Impression of Change; requirement for rescue analgesia; sleep duration and quality; acceptability of treatment; physical functioning; and quality of life.There is evidence from adult randomised controlled trials that some antidepressants, su...
Source: Cochrane Database of Systematic Reviews - August 5, 2017 Category: General Medicine Authors: Cooper TE, Heathcote LC, Clinch J, Gold JI, Howard R, Lord SM, Schechter N, Wood C, Wiffen PJ Tags: Cochrane Database Syst Rev Source Type: research

A comparative study of QT prolongation with serotonin reuptake inhibitors
ConclusionThis study, performed in real conditions of life, shows a clear signal of QT prolongation with only two SRIs, citalopram and escitalopram, indicating that QT prolongation is not a SRI class effect. (Source: Psychopharmacology)
Source: Psychopharmacology - August 3, 2017 Category: Psychiatry Source Type: research

Antidepressant-Induced Acute Liver Injury: A Case –Control Study in an Italian Inpatient Population
ConclusionThe use of antidepressants is not as safe in terms of liver injury as expected; instead, the risk of antidepressant-induced liver injury is likely underestimated. The lack of significance does not reflect the absence of risk, but rather suggests the need to evaluate it in a wider setting of antidepressant users. (Source: Drug Safety)
Source: Drug Safety - August 2, 2017 Category: Drugs & Pharmacology Source Type: research

Effects of Central Nervous System Drugs on Recovery After Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
ConclusionsAdministration of SSRIs may improve gross motor function, reduce disability and enhance QOL for patients recovering from stroke. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - July 29, 2017 Category: Drugs & Pharmacology Source Type: research

Proton pump inhibitor and selective serotonin reuptake inhibitor therapy for the management of noncardiac chest pain
Conclusion: Combined impedance-pH monitoring identifies different subtypes of NCCP patients who can receive tailored management. Targeted therapy with PPIs and/or citalopram offers complete symptom relief in the great majority of them. (Source: European Journal of Gastroenterology and Hepatology)
Source: European Journal of Gastroenterology and Hepatology - July 27, 2017 Category: Gastroenterology Tags: Original Articles: Gastro-esophageal Disorders Source Type: research

Neonatal fluoxetine exposure modulates serotonergic neurotransmission and disturb inhibitory action of serotonin on food intake.
za SL Abstract The neurotransmitter serotonin (5-HT) acts as an important regulator of the critical neurodevelopmental processes and thus alterations in 5-HT signaling early promotes permanent structural and functional changes in brain. The selective serotonin reuptake inhibitors (SSRIs), as fluoxetine and citalopram, blocking serotonin transporter (SERT) at the presynaptic neuron, which regulates extracellular 5-HT levels. Evidence suggests that the exposure to SSRIs in the neurodevelopmental period may alters 5-HT signaling sensitivity on food intake control. The aim of the present study was to evaluate the effe...
Source: Behavioural Brain Research - July 26, 2017 Category: Neurology Authors: Pinheiro IL, da Silva AI, Reginato A, da Silva Filho RC, Galindo LCM, Matos RJB, de Souza Ferraz Junior JC, Toscano Meneses da Silva AE, Milanski Ferreira M, Manhães de Castro R, de Souza SL Tags: Behav Brain Res Source Type: research

Efficacy of selective serotonin reuptake inhibitors in the absence of side effects: a mega-analysis of citalopram and paroxetine in adult depression
riksson (Source: Molecular Psychiatry)
Source: Molecular Psychiatry - July 25, 2017 Category: Psychiatry Authors: F Hieronymus A Lisinski S Nilsson E Eriksson Source Type: research

Efficacy and Safety of Citalopram Compared to Atypical Antipsychotics on Agitation in Nursing Home Residents With Alzheimer Dementia
To assess efficacy and safety of citalopram compared to quetiapine and olanzapine for the treatment of agitation in patients with Alzheimer disease (AD). (Source: Journal of the American Medical Directors Association)
Source: Journal of the American Medical Directors Association - July 21, 2017 Category: Health Management Authors: Giovanni Viscogliosi, Iulia Maria Chiriac, Evaristo Ettorre Tags: Brief Report Source Type: research

Biological effects of citalopram in a suspended sediment-water system on Daphnia magna.
Abstract Suspended sediment (SPS) plays an important role in the aquatic ecosystems. Selective serotonin uptake inhibitors (SSRIs) are commonly used antidepressants and are frequently detected in aquatic environments. However, the biological effects of SSRIs in the presence of SPS are not well understood. To fill this gap, an SPS-water system was constructed to investigate the effects of citalopram (CIT) on Daphnia magna in the presence of SPS with different concentrations (0.1, 0.5, 1 g l(-1)) and organic carbon contents (0.5, 1, 1.5, 2%). A dialysis bag was applied in the exposure system to control the...
Source: Environmental Science and Pollution Research International - July 21, 2017 Category: Environmental Health Authors: Yang H, Lu G, Yan Z, Liu J, Ma B, Dong H Tags: Environ Sci Pollut Res Int Source Type: research

Impact of safety warnings on domperidone prescribing in Ireland
ConclusionsSafety warnings concerning domperidone appeared to have had little effect on prescribing patterns in Ireland. Of concern is the continuing co-prescription with drugs known to increase the risk of QT prolongation, in all ages, including the 60+ year age group. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - July 20, 2017 Category: General Medicine Source Type: research

The Diagnosis and Treatment of Behavioral Disorders in Dementia.
CONCLUSION: Because of an improved evidence base, the latest version of the German S3 guideline on the diagnosis and treatment of dementia places greater emphasis on non-pharmacological treatments for behavioral disorders in dementia than it did in the past. The global efficacy of such treatments against behavioral disorders is well documented. Nonetheless, because of the heterogeneity of interventions and varying standards of assessment, the evidence for the utility of certain specific methods in the treatment of specific behavioral disorders is still limited. More research is needed in this area. PMID: 28705297 [PubM...
Source: Deutsches Arzteblatt International - July 16, 2017 Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research

Detached mindfulness reduced both depression and anxiety in elderly women with major depressive disorders
We investigated the influence of detached mindfulness (DM) in treating symptoms of depression and anxiety among elderly women. Thirty-four elderly females (mean age: 69.23 years) suffering from moderate major depressive disorders (MDD) and treated with a standard medication (citalopram) at therapeutic doses were randomly assigned either to an intervention condition (DM; group treatment, twice weekly) or to a control condition (with leisure activities, twice weekly). At baseline (BL), four weeks later at study completion (SC), and four weeks after that at follow-up (FU), participants completed ratings for symptoms of depres...
Source: Psychiatry Research - July 15, 2017 Category: Psychiatry Authors: Mohammad Ahmadpanah, Tayebe Akbari, Amineh Akhondi, Mohammad Haghighi, Leila Jahangard, Dena Sadeghi Bahmani, Hafez Bajoghli, Edith Holsboer-Trachsler, Serge Brand Source Type: research

Pregnancy exposure to citalopram – Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood
Conclusions Citalopram concentrations in amniotic fluid and cord blood give evidence that maternally administered citalopram is constantly accessible to the fetus via amniotic fluid. A high correlation between maternal serum concentrations of citalopram and umbilical cord blood concentrations highlights a predictive role of quantifying drug concentrations in maternal serum for assessing drug concentrations in the fetal circulation. Findings support the important role of therapeutic drug monitoring in maintaining the safety of pregnant women and exposed infants. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - July 7, 2017 Category: Psychiatry Source Type: research

Response of Htr3a knockout mice to antidepressant treatment and chronic stress
Conclusions and ImplicationsTaken together, these data show that Htr3a deletion promotes SSRI efficacy and prevents the occurrence of stress‐induced deleterious effects, suggesting that the 5‐HT3 receptor may represent an interesting target for the treatment of stress‐related disorders. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - July 5, 2017 Category: Drugs & Pharmacology Authors: Vincent Martin, Armance Riffaud, Tevrasamy Marday, Charly Brouillard, Bernard Franc, Jean ‐Pol Tassin, Caroline Sevoz‐Couche, Raymond Mongeau, Laurence Lanfumey Tags: RESEARCH PAPER Source Type: research

Enantiomeric profiling of a chemically diverse mixture of chiral pharmaceuticals in urban water.
Abstract Due to concerns regarding the release of pharmaceuticals into the environment and the understudied impact of stereochemistry of pharmaceuticals on their fate and biological potency, we focussed in this paper on stereoselective transformation pathways of selected chiral pharmaceuticals (16 pairs) at both microcosm (receiving waters and activated sludge wastewater treatment simulating microcosms) and macrocosm (wastewater treatment plant (WWTP) utilising activated sludge technology and receiving waters) scales in order to test the hypothesis that biodegradation of chiral drugs is stereoselective. Our monito...
Source: Environmental Pollution - June 30, 2017 Category: Environmental Health Authors: Evans S, Bagnall J, Kasprzyk-Hordern B Tags: Environ Pollut Source Type: research

Body Composition in Adolescents During Treatment With Selective Serotonin Reuptake Inhibitors
CONCLUSIONS: Depression severity was associated with a decrease in measures of body composition in older adolescents over a mean of 1.5 years, whereas SSRI treatment was positively associated with these outcomes, with differential effects across treatment groups. (Source: PEDIATRICS)
Source: PEDIATRICS - June 30, 2017 Category: Pediatrics Authors: Calarge, C. A., Mills, J. A., Janz, K. F., Burns, T. L., Coryell, W. H., Zemel, B. S. Tags: Psychiatry/Psychology Article Source Type: research

Whole-body hyperthermia and a subthreshold dose of citalopram act synergistically to induce antidepressant-like behavioral responses in adolescent rats
Conclusions Preclinical data support use of infrared whole-body hyperthermia in the treatment of MDD. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - June 27, 2017 Category: Psychiatry Source Type: research

Comparative evaluation of vortioxetine as a switch therapy in patients with major depressive disorder
Switching antidepressant therapy is a recommended strategy for depressed patients who neither respond to nor tolerate an initial pharmacotherapy course. This paper reviews the efficacy and tolerability of switching to vortioxetine. All three published studies of patients with major depressive disorder (MDD) switched from SSRI/SNRI therapy to vortioxetine due to lack of efficacy or tolerability were selected. Vortioxetine was evaluated versus agomelatine directly (REVIVE) and versus sertraline, venlafaxine, bupropion, and citalopram in an indirect treatment comparison (ITC) from switch studies retrieved in a literature revi...
Source: European Neuropsychopharmacology - June 27, 2017 Category: Psychiatry & Psychology Authors: Michael E. Thase, Natalya Danchenko, Melanie Brignone, Ioana Florea, Francoise Diamand, Paula L. Jacobsen, Eduard Vieta Source Type: research

The involvement of monoaminergic neurotransmission in the antidepressant-like action of scopolamine in the tail suspension test
Publication date: 3 October 2017 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 79, Part B Author(s): Agnieszka Pałucha-Poniewiera, Karolina Podkowa, Tomasz Lenda, Andrzej Pilc Some clinical studies indicate that scopolamine may induce a rapid antidepressant effect. Although scopolamine is a muscarinic antagonist, it seems that not only cholinergic but also glutamatergic and GABAergic systems might be involved in the mechanism of its antidepressant activity in animal models of depression. Here, we present a set of behavioral data aimed at investigating the role of monoaminergic system activ...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - June 24, 2017 Category: Psychiatry Source Type: research

Differential effects of perinatal exposure to antidepressants on learning and memory, acoustic startle, anxiety, and open-field activity in Sprague-Dawley rats.
Abstract Most antidepressants inhibit monoamine reuptake. Selective serotonin (5-HT) reuptake inhibitors (SSRIs) act on the 5-HT transporter (SERT) whereas norepinephrine-dopamine reuptake inhibitors (NDRIs) act on the norepinephrine and dopamine transporters. Epidemiological reports link SSRI use during pregnancy to an increased prevalence of autism spectrum disorder (ASD). We previously showed that perinatal exposure to the SSRI citalopram (CIT) results in rodent offspring that exhibit a number of behaviors consistent with an ASD-like phenotype. The present study examined the effect of perinatal exposure to CIT ...
Source: International Journal of Developmental Neuroscience - June 24, 2017 Category: Neuroscience Authors: Sprowles JLN, Hufgard JR, Gutierrez A, Bailey RA, Jablonski SA, Williams MT, Vorhees CV Tags: Int J Dev Neurosci Source Type: research

Serotonergic 5HTTLPR/rs25531 s ‐allele homozygosity associates with violent suicides in male citalopram users
In this study, we tested the hypothesis that the genetic variants associated with decreased citalopram efficiency, 5HTTLPR/rs25531, and increased impulsive behavior, MAOA‐uVNTR and HTR2B Q20*, are more frequent among citalopram users committing suicide than among the citalopram users in general. Also the effect of alcohol was evaluated. The study population comprised 349 suicide victims (184 males and 165 females). Based on the suicide method used, cases were divided into two groups; violent (88 males and 49 females) and non‐violent (96 males and 116 females). The control group (284; 159 males and 125 females) consiste...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - June 1, 2017 Category: Genetics & Stem Cells Authors: Anna ‐Liina Rahikainen, Salla Majaharju, Jari Haukka, Jukka U. Palo, Antti Sajantila Tags: RESEARCH ARTICLE Source Type: research

SSRIs Associated with Decreased Risk of Hepatocellular Carcinoma: A Population ‐based Case‐control Study
Abstract BackgroundHepatocellular carcinoma (HCC) is the second leading cancer‐related cause of mortality worldwide. Antidepressants, especially selective serotonin re‐uptake inhibitors (SSRIs), are commonly used worldwide. Available evidence investigating the association between SSRIs use and HCC risk is limited. Objectivehe present study aimed to investigate if the effect of all kinds of SSRIs on HCC was the same or not using population‐based study. MethodsThe nationwide population‐based study herein using Taiwan's National Health Insurance Research Database included a total of 59,859 cases with HCC and 285,124 m...
Source: Psycho-Oncology - June 1, 2017 Category: Cancer & Oncology Authors: Hsiang ‐Lin Chan, Wei‐Che Chiu, Vincent Chin‐Hung Chen, Kuo‐You Huang, Tsu‐Nai Wang, Yena Lee, Roger S. McIntyre, Tsai‐Ching Hsu, Charles Tzu‐Chi Lee, Bor‐Show Tzang Tags: PAPER Source Type: research

Involvement of serotonin in the ventral tegmental area in thermoregulation of freely moving rats
Publication date: 13 July 2017 Source:Neuroscience Letters, Volume 653 Author(s): Takayuki Ishiwata, Hiroshi Hasegawa, Benjamin N. Greenwood We have recently reported that the serotonin (5-HT) projections from the midbrain’s raphe nuclei that contains 5-HT cell bodies may play a role both in heat production and in heat loss. The purpose of the present study was to clarify the involvement of 5-HT in the ventral tegmental area (VTA), where 5-HT is suggested to participate in thermoregulation, using the combined methods of telemetry, microdialysis, and high performance liquid chromatography, with a special emphasis on ...
Source: Neuroscience Letters - May 26, 2017 Category: Neuroscience Source Type: research

Granulomatosis with polyangiitis (GPA) presenting as thick-walled cavitary lung lesion
A 58-year-old female with a history of psoriatic arthritis on immunosuppressive therapy presented to the clinic with flu-like symptoms, cough, and blood-tinged sputum for one week. She denied chills, night sweats, wheezing, chest pain, weight loss, joint pain, or muscle aches. She had smoked for 31 pack-years and quit 1  year earlier. She was born and lived in upstate New York with no previous exposure to tuberculosis (TB). She had no exposure to chemicals or bird or bat droppings. There was no recent history of travel to any fungal endemic areas. Her home medications included albuterol, fluticasone-salmeterol, m on...
Source: QJM - May 26, 2017 Category: Internal Medicine Source Type: research

Autism risk following antidepressant medication during pregnancy.
CONCLUSION: Medication with antidepressants during pregnancy does not appear to be causally associated with an increased risk of ASD in the offspring. Instead, the results suggest that the association is explained by factors related to the underlying susceptibility to psychiatric disorders. Based on these findings, the risk of ASD in the offspring should not be a consideration to withhold treatment with commonly used antidepressant drugs from pregnant women. PMID: 28528584 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - May 22, 2017 Category: Psychiatry Authors: Viktorin A, Uher R, Reichenberg A, Levine SZ, Sandin S Tags: Psychol Med Source Type: research

Cellulose Acetate/Poly Lactic Acid Coaxial Wet-Electrospun Scaffold Containing Citalopram-Loaded Gelatin Nanocarriers for Neural Tissue Engineering Applications.
Abstract The current study aimed to develop a biodegradable three-dimensional drug-loaded scaffold with the core-shell structured fibrils using coaxial wet-electrospinning for neural tissue engineering application. Poly lactic acid was wet-electrospun as the core, whereas cellulose acetate was fabricated into the fibril's shell. The scaffold then was coated with citalopram-loaded gelatin nanocarriers (CGNs) produced by nanoprecipitation. Scanning electron microscope observation revealed that the fibrils formed a nonwoven structure with the average diameter of ∼950nm. The particle size measurement by a dynamic ...
Source: International Journal of Biological Macromolecules - May 15, 2017 Category: Biochemistry Authors: Naseri-Nosar M, Salehi M, Hojjati-Emami S Tags: Int J Biol Macromol Source Type: research

Response of Htr3a KO mice to antidepressant treatment and chronic stress
Conclusion and ImplicationsTaken together, these data show that Htr3a deletion promotes SSRI efficacy and prevents from stress‐induced deleterious effects, suggesting that 5‐HT3 receptor may represent an interesting target for the treatment of stress‐related disorders. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - May 10, 2017 Category: Drugs & Pharmacology Authors: Vincent Martin, Armance Riffaud, Tevrasamy Marday, Charly Brouillard, Bernard Franc, Jean ‐Pol Tassin, Caroline Sevoz‐Couche, Raymond Mongeau, Laurence Lanfumey Tags: RESEARCH PAPER Source Type: research

Ultrasound-assisted low-density solvent dispersive liquid –liquid microextraction for the simultaneous determination of 12 new antidepressants and 2 antipsychotics in whole blood by gas chromatography–mass spectrometry
In this study, a simple and rapid ultrasound-assisted low-density solvent dispersive liquid–liquid microextraction (UA-LDS-DLLME) method was developed for the simultaneous determination of 12 new antidepressants (norfluoxetine, fluoxetine, fluvoxamine, agomelatine, mirtazapine, moclobemide, melitracen, N-desmethylmirtazapine, maprotiline, sertraline, citalopram, paroxetine) and 2 antipsychotics (clozapine and haloperidol) in human whole blood by gas chromatography–mass spectrometry (GC–MS). Different parameters affecting the UA-LDS-DLLME were optimized and the optimal conditions were as follows: 100μL ...
Source: Journal of Pharmaceutical and Biomedical Analysis - May 7, 2017 Category: Drugs & Pharmacology Source Type: research

Predicting relapse with individual residual symptoms in major depressive disorder: a reanalysis of the STAR*D data
ConclusionsSome residual symptoms, including restlessness, insomnia, and weight change, may help better identify patients with MDD vulnerable to relapse. Contribution of individual residual symptoms to subsequent relapse was similar between self-report and clinician-rated symptoms. (Source: Psychopharmacology)
Source: Psychopharmacology - May 3, 2017 Category: Psychiatry Source Type: research

Citalopram Discontinuation More Harmful Than Gradual Dosage Reduction?
American Journal of Psychiatry,Volume 174, Issue 5, Page 485-485, May 01, 2017. (Source: American Journal of Psychiatry)
Source: American Journal of Psychiatry - May 1, 2017 Category: Psychiatry Source Type: research

Clarifying Methods in a Study of Outcomes of Citalopram Dosage Risk Mitigation in a Veteran Population: Response to Krijnsen et al.
American Journal of Psychiatry,Volume 174, Issue 5, Page 485-486, May 01, 2017. (Source: American Journal of Psychiatry)
Source: American Journal of Psychiatry - May 1, 2017 Category: Psychiatry Source Type: research

Clarifying Methods in a Study of Outcomes of Citalopram Dosage Risk Mitigation in a Veteran Population: Response to Krijnsen et al.
PMID: 28457161 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - May 1, 2017 Category: Psychiatry Authors: Rector TS Tags: Am J Psychiatry Source Type: research