Effect of a chronic treatment with an mGlu5 receptor antagonist on brain serotonin markers in parkinsonian monkeys
In conclusion, reduction of development of LID with MPEP was associated with lower striatal and pallidal 5-HT2A receptors showing that glutamate activity also affects serotoninergic markers. (Source: Progress in Neuro Psychopharmacology and Biological Psychiatry)
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - November 6, 2014 Category: Psychiatry Source Type: research

The use of citalopram for the treatment of cataplexy
In this study, we report a series of cases with patients with narcolepsy and cataplexy, treated with citalopram for the control of cataplexy. (Source: Sleep Science)
Source: Sleep Science - November 6, 2014 Category: Sleep Medicine Source Type: research

Influence of Concomitant Medications on the Total Clearance and the Risk for Supra-therapeutic Plasma Concentrations of Citalopram. A Population-Based Cohort Study
Discussion: Due to pharmacokinetic interactions, citalopram plasma concentrations are often higher than expected with a given dose. Especially in geriatric and often multimorbid patients who are usually prescribed high numbers of concomitant drugs and are at higher risk for adverse drug reactions (ADR), restriction of the maximal dose of citalopram is not sufficient to prevent supra-therapeutic plasma concentrations.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Pharmacopsychiatry)
Source: Pharmacopsychiatry - November 5, 2014 Category: Psychiatry Authors: Wenzel-Seifert, K.Brandl, R.Hiemke, C.Haen, E. Tags: Original Paper Source Type: research

Happy pills in nursing homes in Belgium: A cohort study to determine prescribing patterns and relation to fall risk
Conclusion Despite recommendations against chronic use and a growing body of evidence showing the risk of side effects, the use of psychotropic drugs currently is still alarmingly high in Flemish nursing home residents without dementia. Strategies to optimize prescribing are discussed. (Source: Journal of Clinical Gerontology and Geriatrics)
Source: Journal of Clinical Gerontology and Geriatrics - November 3, 2014 Category: Geriatrics Source Type: research

Investigation of the mechanisms mediating MDMA “Ecstasy”-induced increases in cerebro-cortical perfusion determined by btASL MRI
Conclusions Cortical 5-HT depletion is associated with increases in perfusion although this mechanism alone does not account for MDMA-related changes. A role for NO, a key regulator of cerebrovascular perfusion, is implicated in MDMA-induced increases in cortical perfusion. (Source: Psychopharmacology)
Source: Psychopharmacology - November 1, 2014 Category: Psychiatry Source Type: research

Are antidepressants equally effective in the long‐term treatment of major depressive disorder?
ConclusionsBupropion and fluvoxamine appear less effective in long‐term treatment of MDD. These results should be confirmed by randomized placebo‐controlled prospective studies with larger samples. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Human Psychopharmacology: Clinical and Experimental)
Source: Human Psychopharmacology: Clinical and Experimental - November 1, 2014 Category: Psychiatry Authors: Massimiliano Buoli, Claudia Cumerlato Melter, Alice Caldiroli, A. Carlo Altamura Tags: Research Article Source Type: research

Metabolic Kinetics of 5-Hydroxytryptamine and the Research Targets of Functional Gastrointestinal Disorders
Abstract 5-Hydroxytryptamine (5-HT) is an important neurotransmitter in both the central and enteric nervous systems. It has diverse functions in regulating gastrointestinal motility and visceral sensitivity, emotion, appetite, pain and sensory perception, cognition, sexual activity and sleep. These functions are mainly associated with the metabolic kinetics of 5-HT in different tissues. Tryptophan hydroxylase is the rate-limiting enzyme and modulates serotonin synthesis. Vesicular monoamine transporter 1 plays a role in 5-HT storage and release. Degradation of 5-HT is mediated by monoamine oxidase-A. All these f...
Source: Digestive Diseases and Sciences - October 28, 2014 Category: Gastroenterology Source Type: research

Citalopram Overdose: a Fatal Case.
CONCLUSIONS: Although most patients recover from citalopram overdose, high-dose ingestions can produce severe effects and fatalities may occur. In this case, it is likely that the patient's delayed presentation also contributed significantly to her death. The clinician must be aware of the potential for large ingestions of citalopram to produce life-threatening effects and monitor closely for the neurologic, cardiovascular, and other manifestations that, in rare cases, can be fatal. PMID: 25326372 [PubMed - as supplied by publisher] (Source: Journal of Medical Toxicology)
Source: Journal of Medical Toxicology - October 18, 2014 Category: Toxicology Authors: Kraai EP, Seifert SA Tags: J Med Toxicol Source Type: research

GABAB receptor-mediated tonic inhibition regulates the spontaneous firing of locus coeruleus neurons in developing rats and in citalopram-treated rats.
In conclusion, our results show that GABABR-mediated tonic inhibition has a direct impact on the spontaneous activity of LC neurons and that the extent of the effect varies with ambient GABA levels and functionality of GABABR signaling. This article is protected by copyright. All rights reserved. PMID: 25326452 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - October 17, 2014 Category: Physiology Authors: Wang HY, Kuo ZC, Fu YS, Chen RF, Min MY, Yang HW Tags: J Physiol Source Type: research

New Drug Candidates for Metastatic Colorectal Cancer
This study proposes citalopram as a potential therapeutic option for patients with colorectal cancer, illustrating the potential of systems pharmacology. Cancer Res; 74(20); 5690–9. ©2014 AACR. (Source: Cancer Research)
Source: Cancer Research - October 14, 2014 Category: Cancer & Oncology Authors: van Noort, V., Scholch, S., Iskar, M., Zeller, G., Ostertag, K., Schweitzer, C., Werner, K., Weitz, J., Koch, M., Bork, P. Tags: Early Detection, Early Detection: Biomarkers: Discovery, Methodology, Validation Integrated Systems and Technologies Source Type: research

A New Screen-printed Ion Selective Electrode for Determination of Citalopram Hydrobromide in Pharmaceutical Formulation
Publication date: April 2014 Source:Chinese Journal of Analytical Chemistry, Volume 42, Issue 4 Author(s): Tamer Awad Ali , Gehad G. Mohamed , A.M. Al-Sabagh , M.A. Migahed Abstract Novel citalopram screen-printed ion selective electrodes were fabricated, characterized and used for the determination of citalopram in pharmaceutical formulations. The proposed sensors incorporated potassium tetrakis(p-chlorophenyl) borate (KTpClPB) ionophore (electrode V) and citalopram-phosphotungstate (CP-PT) ion pair complex (electrode X) as electroactive materials in screen-printed electrodes and tricresylphosphate (TCP) as solvent medi...
Source: Chinese Journal of Analytical Chemistry - October 12, 2014 Category: Chemistry Source Type: research

Citalopram, escitalopram and prolonged QT: Warning or alarm?
Publication date: July–September 2014 Source:Revista de Psiquiatría y Salud Mental (English Edition), Volume 7, Issue 3 Author(s): Enric Álvarez , Sara Vieira , Xavier Garcia-Moll The alerts issued by Regulatory Agencies on the potential cardiac toxicity of citalopram and escitalopram have caused alarm among clinicians. A review of the data concerning this topic shows that the alarm should be limited to patients with a history of syncope or poisoning. As a precautionary measure, an electrocardiogram should be performed on elderly patients. (Source: Revista de Psiquiatria y Salud Mental)
Source: Revista de Psiquiatria y Salud Mental - October 12, 2014 Category: Psychiatry Source Type: research

5-HT depletion, but not 5-HT1A antagonist, prevents the anxiolytic-like effect of citalopram in rat contextual conditioned fear stress model.
CONCLUSION: The anxiolytic-like effect of citalopram in contextual CFS model depends on 5-HT availability. In addition, contextual CFS model is suggested to be completely different from conventional anxiety models in neural mechanism or manners of serotonergic involvement. However, further studies are needed to identify the pharmacological mechanisms responsible for the anxiolytic-like effect of citalopram. PMID: 25287308 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - October 9, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Memantine may affect pseudobulbar affect in patients with Alzheimer's disease.
CONCLUSION: Surprisingly, our research showed the opposite action of memantine on neuropsychiatric symptoms as expected. In a limited number of AD patients with PBA, memantine had a beneficial effect on involuntary emotional expression, but it potentiated agitation/aggression, irritability and caused a crucial drop of the platelet 5-HT concentration. PMID: 25287877 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - October 9, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Use of Selective Serotonin-Reuptake Inhibitors During Pregnancy and the Risk of Clubfoot
Conclusion:Our data suggest an increased risk of clubfoot occurrence in relation to SSRI use. Drug-specific risks varied widely, and some estimates were unstable. (Source: Epidemiology)
Source: Epidemiology - October 3, 2014 Category: Epidemiology Tags: Pharmacoepidemiology Source Type: research

Augmentation of Citalopram with Aspirin for Treating Major Depressive Disorder, a Double Blind Randomized Placebo Controlled Clinical Trial
(Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry)
Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry - October 2, 2014 Category: Allergy & Immunology Authors: Ghanizadeh, AhmadHedayati, Arvin Tags: Articles Source Type: research

Testing the Predictive Value of Peripheral Gene Expression for Nonremission Following Citalopram Treatment for Major Depression
p; Etienne Sibille Keywords: (Source: Neuropsychopharmacology)
Source: Neuropsychopharmacology - October 1, 2014 Category: Neurology Authors: Jean-Philippe GuillouxSabrina BassiYing DingChris WalshGustavo TureckiGeorge TsengJill M CyranowskiEtienne Sibille Source Type: research

B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomised, double-blind, placebo-controlled trial.
Conclusions B vitamins did not increase the 12-week efficacy of antidepressant treatment, but enhanced and sustained antidepressant response over 1 year. Replication of these findings would mandate that treatment guidelines adopt the adjunctive use of B vitamins as a safe and inexpensive strategy to manage major depression in middle-aged and older adults. PMID: 25257064 [PubMed - as supplied by publisher] (Source: The British Journal of Psychiatry for Mental Science)
Source: The British Journal of Psychiatry for Mental Science - September 27, 2014 Category: Psychiatry Tags: Br J Psychiatry Source Type: research

MDMA modulates spontaneous firing of subthalamic nucleus neurons in vitro.
Abstract 3,4-Methylene-dioxy-N-methylamphetamine (MDMA, 'ecstasy') has a broad spectrum of molecular targets in the brain, among them receptors and transporters of the serotonergic (5-hydroxytryptamine, 5-HT) and noradrenergic systems. Its action on the serotonergic system modulates motor systems in rodents and humans. Although parts of the basal ganglia could be identified as mediators of the motor effects of MDMA, very little is known about the role of the subthalamic nucleus (STN). Therefore, this study investigated the modulation of spontaneous action potential activity of the STN by MDMA (2.5-20 µM...
Source: Experimental Brain Research - September 19, 2014 Category: Neuroscience Authors: Liebig L, von Ameln-Mayerhofer A, Hentschke H Tags: Exp Brain Res Source Type: research

Treating Compulsive Buying Disorder
Opinion statement Based on the available evidence, we would offer a Compulsive Buying Disorder (CBD) patient the choice of a 12-session trial of Cognitive Behavioral Therapy (CBT) targeting CBD, or a seven-week trial of pharmacotherapy with citalopram. We would treat any co-morbid psychiatric disorder with appropriate psychotherapy or pharmacotherapy, and evaluate the need for couples or family therapy, and for inpatient treatment of suicidality, or comorbid conditions. We would also encourage the use of educational self-help materials. Patients preferring pharmacotherapy would be encouraged to take steps to help ...
Source: Current Treatment Options in Psychiatry - September 18, 2014 Category: Psychiatry Source Type: research

Citalopram decreases agitation in the context of Alzheimer's disease, but at doses higher than those commonly prescribed and at the expense of side effects
Commentary on: Porsteinsson AP, Drye LT, Pollock BG, et al.. Effect of citalopram on agitation in Alzheimer disease. The CitAD randomised clinical trial. JAMA 2014;311:682–91. Context By 2050, an estimated 135 million people will suffer from dementia globally.1 Caring for those with Alzheimer's disease (AD)—by far the most common form of dementia—is expensive, costing an estimated £23 billion per annum in the UK. As the disease progresses, neuropsychiatric symptoms such as depression, agitation and behavioural disturbance appear. The incidence of these symptoms, which predict institutionalisation an...
Source: Evidence-Based Medicine - September 15, 2014 Category: Internal Medicine Authors: Underwood, B. R., Fox, C. Tags: Neurogastroenterology, Geriatric medicine, Dementia, Drugs: CNS (not psychiatric), Sleep disorders (neurology), Stroke, Drugs: psychiatry, Eating disorders, Memory disorders (psychiatry), Psychiatry of old age, Psychotic disorders (incl schizophrenia), Sl Source Type: research

Citalopram, QTc Prolongation and Torsades de Pointes
The aim of this systematic review is to identify case reports of citalopram use resulting in QTc prolongation and/or Torsades de Pointes (TdP) in the medical literature. (Source: Psychosomatics)
Source: Psychosomatics - September 6, 2014 Category: Psychiatry & Psychology Authors: Rajesh R. Tampi, Michael Balderas, Kathleen V. Carter, Deena J. Tampi, Marian Moca, Amy Knudsen, Jacquelyn May Source Type: research

Citalopram, QTc Prolongation, and Torsades de Pointes
The aim of this systematic review is to identify case reports of citalopram use resulting in QTc prolongation, torsades de pointes, or both, in the medical literature. (Source: Psychosomatics)
Source: Psychosomatics - September 6, 2014 Category: Psychiatry & Psychology Authors: Rajesh R. Tampi, Michael Balderas, Kathleen V. Carter, Deena J. Tampi, Marian Moca, Amy Knudsen, Jacquelyn May Tags: Review Articles Source Type: research

Psychotropic drugs in mixture alter swimming behaviour of Japanese medaka (Oryzias latipes) larvae above environmental concentrations.
This study aims to analyse the effects of six psychotropic drugs, valproate, cyamemazine, citalopram, sertraline, fluoxetine and oxazepam, on the survival and locomotion of Japanese medaka Oryzias latipes larvae. Newly hatched Japanese medaka were exposed to individual compounds for 72 h, at concentrations ranging from 10 μg L(-1) to 10 mg L(-1). Lethal concentrations 50 % (LC50) were estimated at 840, 841 and 9,136 μg L(-1) for fluoxetine, sertraline and citalopram, respectively, while other compounds did not induce any significant increase in mortality. Analysis of the swimmi...
Source: Environmental Science and Pollution Research International - September 2, 2014 Category: Environmental Health Authors: Chiffre A, Clérandeau C, Dwoinikoff C, Le Bihanic F, Budzinski H, Geret F, Cachot J Tags: Environ Sci Pollut Res Int Source Type: research

Side‐Effect Profile of Serotoninergic Treatments for Parkinson's Disease and L‐DOPA‐induced Dyskinesia in Rats
Conclusions and ImplicationsResults suggest that compounds that indirectly facilitate 5‐HT1A activation, such as citalopram, may be more effective therapeutics than direct 5‐HT1A receptor agonists because they exhibit similar anti‐dyskinesia efficacy, while possessing a lesser side‐effect profile. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - September 1, 2014 Category: Drugs & Pharmacology Authors: D. Lindenbach, N. Palumbo, C. Y. Ostock, N. Vilceus, M. M. Conti, C. Bishop Tags: Research Paper Source Type: research

Citalopram for pediatric functional abdominal pain: a randomized, placebo‐controlled trial
Conclusions & InferencesOverall, we found a trend toward the effectiveness of citalopram in the treatment of children with FAP. Trials with longer treatment duration in larger samples of patients are required in this regard. In a randomized, placebo‐controlled trial, children with functional abdominal pain received either citalopram 20 mg/day or placebo for 4 weeks and were followed up for 8 weeks after medication period. Citalopram, when taken as prescribed, achieves a higher treatment response rate over placebo based on self‐rated pain severity scale and also achieves more reduction in physician...
Source: Neurogastroenterology and Motility - September 1, 2014 Category: Gastroenterology Authors: H. Roohafza, Z. Pourmoghaddas, H. Saneian, A. Gholamrezaei Tags: Original Article Source Type: research

Treatment of Obsessive-Compulsive and Related Disorders
Opinion statement Pharmacotherapy and cognitive-behavioural therapy (CBT) have been studied in many of the obsessive-compulsive and related disorders (OCRDs). Serotonin reuptake inhibitors (SRIs) and cognitive-behavioural therapies (CBT) are first-line considerations in many, but not all, of these conditions. There are fewer data available on the combination of these treatment modalities in OCRDs. In obsessive-compulsive disorder (OCD), the SRIs and CBT – which include exposure and response prevention (ERP) – are well-established safe and efficacious first-line treatments in adult and paediatric popul...
Source: Current Treatment Options in Psychiatry - September 1, 2014 Category: Psychiatry Source Type: research

Selective serotonin reuptake inhibitor exposure alters osteoblast gene expression and craniofacial development in mice
ConclusionOur results provide confirmatory evidence that citalopram exposure is associated with cellular and morphological alterations of the craniofacial complex, which may have important implications for use during pregnancy. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 1, 2014 Category: Perinatology & Neonatology Authors: James J. Cray, Seth M. Weinberg, Trish E. Parsons, R. Nicole Howie, Mohammed Elsalanty, Jack C. Yu Tags: Original Research Article Source Type: research

QTc Interval Prolongation and Torsade de Pointes Associated with Second-Generation Antipsychotics and Antidepressants: A Comprehensive Review
Abstract We comprehensively reviewed published literature to determine whether it supported the link between corrected QT (QTc) interval prolongation and torsade de pointes (TdP) for the 11 second-generation antipsychotics and seven second-generation antidepressants commonly implicated in these complications. Using PubMed and EMBASE, we identified four thorough QT studies (one each for iloperidone, ziprasidone, citalopram, and escitalopram), 40 studies specifically designed to assess QTc interval prolongation or TdP, 58 publications based on data from efficacy and safety trials, 18 toxicology studies, and 102 case...
Source: CNS Drugs - August 29, 2014 Category: Neurology Source Type: research

A systematic review of Chinese randomized clinical trials of SSRI treatment of depression
Conclusions: In light of the low trial quality, the findings of a significant advantage of SSRI over TCA in terms of response rate and remission rate should be replicated by large high-quality Chinese studies. (Source: BMC Psychiatry - Latest articles)
Source: BMC Psychiatry - Latest articles - August 27, 2014 Category: Psychiatry Authors: Ying ZhangThomas BeckerYongchun MaMarkus Koesters Source Type: research

Do Serotonin Reuptake Inhibitors worsen Outcome of Patients referred to the Emergency Department for Deliberate Multidrug Exposure?
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 22, 2014 Category: Drugs & Pharmacology Authors: Sébastien Beaune, Emmanuel Curis, Enrique Casalino, Philippe Juvin, Bruno Mégarbane Tags: Original Article Source Type: research

Citalopram for the Prevention of Depression and Its Consequences in HIV-Hepatitis C Coinfected Individuals Initiating Pegylated Interferon/Ribavirin Therapy: A Multicenter Randomized Double-Blind Placebo-Controlled Trial
Conclusions: A strategy of prophylactic citalopram compared to treatment of emergent depression was not associated with higher adherence or a reduction in treatment-limiting depression nor did it significantly reduce depressive symptoms among HIV-HCV coinfected persons during treatment for HCV. Content Type Journal ArticleCategory Original ArticlePages 161-175DOI 10.1310/hct1504-161Authors Marina B. Klein, Division of Infectious Diseases/Chronic Viral Illness Service, Department of Medicine, Royal Victoria Hospital, McGill University Health Centre, Montréal, Québec, CanadaTerry Lee, Canadian HIV Trials Net...
Source: HIV Clinical Trials - August 20, 2014 Category: Infectious Diseases Tags: HIV Clinical Trials Source Type: research

Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: Effect of antidepressant treatment.
F, Meana JJ Abstract Several studies have demonstrated alterations in serotonin 5-HT2A (5-HT2AR) and glutamate metabotropic mGlu2 (mGlu2R) receptors in depression, but never in the same sample population. Recently it has been shown that both receptors form a functional receptor heterocomplex that is altered in schizophrenia. The present study evaluates the gene expression and protein density of 5-HT2AR and mGlu2/3R in the postmortem prefrontal cortex of subjects with major depressive disorder (n=14) compared with control subjects (n=14) in a paired design. No significant differences between subjects with depressio...
Source: Neuropharmacology - August 20, 2014 Category: Drugs & Pharmacology Authors: Muguruza C, Miranda-Azpiazu P, Díez-Alarcia R, Morentin B, González-Maeso J, Callado LF, Meana JJ Tags: Neuropharmacology Source Type: research

Systematic review of pharmacological treatments for depressive symptoms in Huntington's disease
ConclusionsInadequate evidence exists to guide antidepressant treatment in HD. Further research is needed to assess antidepressant efficacy and to examine whether treatment of depression represents a modifiable target for the high suicide rate in HD. © 2014 International Parkinson and Movement Disorder Society (Source: Movement Disorders)
Source: Movement Disorders - August 11, 2014 Category: Neurology Authors: Calum D. Moulton, C. W. P. Hopkins, W. Richard Bevan‐Jones Tags: Brief Report Source Type: research

Serotonin neurones have anticonvulsant effects and reduce seizure-induced mortality.
This article is protected by copyright. All rights reserved. PMID: 25107926 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 8, 2014 Category: Physiology Authors: Buchanan GF, Murray NM, Hajek MA, Richerson GB Tags: J Physiol Source Type: research

Serotonin modulates fast ripple activity in rats with spontaneous recurrent seizures.
án A Abstract Fast ripples (FRs) are pathological high frequency oscillations that occur in patients with temporal lobe epilepsy (TLE), as well as in animal models of epilepsy in which seizures are induced with kainic acid or pilocarpine. These oscillations have been considered potential biomarkers of epileptogenesis in the hippocampus. Indeed, experimental evidence suggests an important role of serotonin in epilepsy and an increased frequency of FRs have been demonstrated in slow wave sleep, a period during which serotonin levels decrease. Accordingly, we investigated the role of serotonin in FRs modulatio...
Source: Brain Research - August 6, 2014 Category: Neurology Authors: Pardo-Peña K, Medina-Ceja L, Morales-Villagrán A Tags: Brain Res Source Type: research

Desipramine and citalopram attenuate pretest swim-induced increases in prodynorphin immunoreactivity in the dorsal bed nucleus of the stria terminalis and the lateral division of the central nucleus of the amygdala in the forced swimming test
The forced swimming test (FST) has been widely used as an effective behavioral test for screening of antidepressant efficacy (Cryan et al., 2005; Lucki, 1997). Rodents previously subjected to a 15-min pretest swim tended to show prodepressive behavior as evidenced by increased immobility in a 5-min test swim conducted 24 h later. However, antidepressant treatments administered during the 24 h after the pretest swim reduce immobility during the test swim (Detke et al., 1995). These results suggest that some neuroplastic changes occur between the pretest swim and test swim, and that antidepressant treatment after the pretest...
Source: Neuropeptides - August 1, 2014 Category: Neuroscience Authors: Sung Chung, Hee Jeong Kim, Hyun Ju Kim, Sun Hye Choi, Jin Hee Cho, Yun Ha Cho, Dong-Hoon Kim, Kyung Ho Shin Source Type: research

Desipramine and citalopram attenuate pretest swim-induced increases in prodynorphin immunoreactivity in the dorsal bed nucleus of the stria terminalis and the lateral division of the central nucleus of the amygdala in the forced swimming test
The forced swimming test (FST) has been widely used as an effective behavioral test for screening of antidepressant efficacy (Cryan et al., 2005; Lucki, 1997). Rodents previously subjected to a 15-min pretest swim tended to show prodepressive behavior as evidenced by increased immobility in a 5-min test swim conducted 24h later. However, antidepressant treatments administered during the 24h after the pretest swim reduce immobility during the test swim (Detke et al., 1995). These results suggest that some neuroplastic changes occur between the pretest swim and test swim, and that antidepressant treatment after the pretest s...
Source: Neuropeptides - August 1, 2014 Category: Neuroscience Authors: Sung Chung, Hee Jeong Kim, Hyun Ju Kim, Sun Hye Choi, Jin Hee Cho, Yun Ha Cho, Dong-Hoon Kim, Kyung Ho Shin Source Type: research

The Development and Validation of a Turbulent Flow-Liquid Chromatographic-Tandem Mass Spectrometric Method for the Simultaneous Quantification of Citalopram, Sertraline, Bupropion and Hydroxybupropion in Serum.
CONCLUSIONS: The development and validation of this TFC-MS/MS method allows for the robust and high-throughput quantification of commonly prescribed antidepressants. PMID: 25087976 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - July 31, 2014 Category: Biochemistry Authors: Petrides AK, Moskowitz J, Johnson-Davis KL, Jannetto PJ, Langman LJ, Clarke W, Marzinke MA Tags: Clin Biochem Source Type: research

A Systematic Review of Treatments for Anxiety in Youth with Autism Spectrum Disorders.
This study systematically examined the efficacy and safety of psychopharmacological and non-psychopharmacological treatments for anxiety in youth with autism spectrum disorders (ASD). Four psychopharmacological, nine cognitive behavioral therapy (CBT), and two alternative treatment studies met inclusion criteria. Psychopharmacological studies were descriptive or open label, sometimes did not specify the anxiety phenotype, and reported behavioral activation. Citalopram and buspirone yielded some improvement, whereas fluvoxamine did not. Non-psychopharmacological studies were mainly randomized controlled trials (RCTs) with C...
Source: Journal of Autism and Developmental Disorders - July 29, 2014 Category: Psychiatry Authors: Vasa RA, Carroll LM, Nozzolillo AA, Mahajan R, Mazurek MO, Bennett AE, Wink LK, Bernal MP Tags: J Autism Dev Disord Source Type: research

Antidepressant dose and the risk of deliberate self-harm.
Authors: Barbui C, Patten SB Abstract Although the mechanism by which antidepressants (ADs) may increase the risk of suicide-related outcomes is unknown, it has been hypothesised that some adverse effects, including akathisia, insomnia and panic attacks, as well as an early energising effect that might allow patients with depression to act on suicidal impulses, may have a key role. Considering that these adverse effects are dose-related, it might be hypothesised that the risk of suicidal behaviour is similarly related to the AD dose. This research question has recently been addressed by a propensity score-matched o...
Source: Epidemiology and Psychiatric Sciences - July 17, 2014 Category: Psychiatry Tags: Epidemiol Psychiatr Sci Source Type: research

The role of adenosine receptors and endogenous adenosine in citalopram-induced cardiovascular toxicity
Conclusions: Citalopram may lead to QT prolongation by stimulating adenosine A 1 receptors without affecting the release of adenosine. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 4, 2014 Category: Drugs & Pharmacology Authors: Kubilay OransayNil HocaogluMujgan BuyukdeligozYesim TuncokSule Kalkan Source Type: research

DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy
(Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - July 4, 2014 Category: Neurology Authors: Bárbara Arias, Chiara Fabbri, Alessandro Serretti, Antonio Drago, Marina Mitjans, Cristóbal Gastó, Rosa Catalán, Lourdes Fañanás Source Type: research

Interaction of injectable neurotropic drugs with the red cell membrane.
i T Abstract The normal red blood cell (RBC) shape is a biconcave discocyte. An intercalation of a drug in the outer half of the membrane lipid bilayer leads to echinocytosis, an intercalation in the inner half to stomatocytosis. We have used the shape transforming capacity of RBCs as a model to analyse the membrane interaction potential of various neurotropic drugs. Chlorpromazine, clomipramine, citalopram, clonazepam, and diazepam induced a reversible stomatocytosis, phenytoin induced echinocytosis, while the anticonvulsants levetirazetam, valproic acid and phenobarbital had no effect. This diversity of RBC shap...
Source: Toxicology in Vitro - July 2, 2014 Category: Toxicology Authors: Reinhart WH, Lubszky S, Thöny S, Schulzki T Tags: Toxicol In Vitro Source Type: research

Neurodegenerative disease: Citalopram drives down amyloid-β
Nature Reviews Drug Discovery 13, 496 (2014). doi:10.1038/nrd4378 Author: Charlotte Harrison Serotonin signalling suppresses the production of amyloid-β (Aβ) in animal models of Alzheimer's disease. Sheline et al. showed that the antidepressant citalopram — a selective serotonin reuptake inhibitor — prevented the growth of pre-existing Aβ plaques and reduced the appearance of new plaques in (Source: Nature Reviews Drug Discovery)
Source: Nature Reviews Drug Discovery - July 1, 2014 Category: Drugs & Pharmacology Authors: Charlotte Harrison Tags: Research Highlight Source Type: research

Current Pharmacological Interventions in Panic Disorder.
di AE Abstract The aim of this review was to summarize the recent evidences regarding the pharmacological treatment of panic disorder (PD). The authors performed a review of the literature regarding the pharmacological treatment of PD since the year 2000. The research done in the last decade brought strong evidences of effectiveness for paroxetine, venlafaxine, sertraline, fluvoxamine, citalopram, fluoxetine, clonazepam, and the relatively novel agent escitalopram. There are evidences indicating that the other new compounds inositol, duloxetine, mirtazapine, milnacipran, and nefazodone have antipanic properties an...
Source: CNS and Neurological Disorders Drug Targets - June 12, 2014 Category: Drugs & Pharmacology Authors: Freire RC, Machado S, Arias-Carrión O, Nardi AE Tags: CNS Neurol Disord Drug Targets Source Type: research

Effectiveness and safety of Wuling capsule for post stroke depression: A systematic review.
Abstract OBJECTIVE: To review the effectiveness and safety of Wuling capsule for post stroke depression (PSD) systematically. METHODS: We searched electronic databases for randomized controlled trials (RCTs) that compared either Wuling capsule with placebo, no treatment or Wuling capsule plus conventional treatment with conventional treatment alone in adults with post stroke depression. Relevant resources were also retrieved. Two reviewers screened the citations, assessed the risk of bias and extracted data independently. RESULTS: A total of 16 studies involving 1378 patients were identified for this rev...
Source: Complementary Therapies in Medicine - June 1, 2014 Category: Complementary Medicine Authors: Peng L, Zhang X, Kang DY, Liu XT, Hong Q Tags: Complement Ther Med Source Type: research

The efficacy and tolerability of SSRI/SNRIs in the treatment of vasomotor symptoms in menopausal women: A systematic review
ConclusionsResults from these trials indicate that paroxetine, citalopram, escitalopram, venlafaxine, and desvenlafaxine are effective in reducing the frequency and severity of hot flashes. Fluoxetine and sertraline appear to be less effective and should be considered second‐line options for treatment. Implications for practiceThe SSRIs and SNRIs can reduce hot flashes by 65% and begin working within the first week. Patient response is variable and if one drug does not improve hot flashes, another can be tried after a 1‐ to 2‐week drug trial. Paroxetine, citalopram, and escitalopram appear to have the fewest adverse ...
Source: Journal of the American Academy of Nurse Practitioners - June 1, 2014 Category: Nursing Authors: Amy P. Handley, Mary Williams Tags: REVIEW Source Type: research

Treatment with citalopram, but not with agomelatine, adversely affects sperm parameters: a case report and translational review.
CONCLUSIONS: SSRI treatment can be associated with impaired semen quality. Potential underlying mechanisms include changes in sperm DNA integrity, activation of IDO and shifting tryptophan metabolism. Further studies of the effects of antidepressants on spermatogenesis might benefit from including investigation of changes in IDO activity during antidepressant administration. PMID: 24855891 [PubMed - in process] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - May 27, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Monoamine reuptake site occupancy of sibutramine: relationship to antidepressant-like and thermogenic effects in rats.
Abstract Sibutramine was formerly marketed as an anti-obesity agent. The current study investigated the relationships between monoamine reuptake site occupancy for sibutramine and both its antidepressant-like efficacy and thermogenic effects. Sibutramine's effects on locomotor activity (LMA) and food intake were also evaluated. Sibutramine occupied monoamine reuptake binding sites with the rank order of potency of NET>SERT>DAT; at 10mg/kg, po, occupancy was 95% NET, 81% SERT and 73% DAT. Sibutramine produced antidepressant-like behavior in the forced swim test; at the lowest effective dose (3mg/kg, po) occup...
Source: European Journal of Pharmacology - May 9, 2014 Category: Drugs & Pharmacology Authors: Li YW, Langdon S, Pieschl R, Strong T, Wright RN, Rohrbach K, Lelas S, Lodge NJ Tags: Eur J Pharmacol Source Type: research