The place of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depressive disorders in children and adolescents. Recommendations of the Main Board of the Polish Psychiatric Association. Part 1 - Clinical efficacy and areas of application
Psychiatr Pol. 2023 Oct 31;57(5):899-916. doi: 10.12740/PP/171463. Epub 2023 Oct 31.ABSTRACTIn the adult population of patients with major depression, both psychotherapeutic and pharmacological interventions are effective, but antidepressants remain the mainstay of treatment. In the case of child and adolescent psychiatry, there is still controversy over whether to use pharmacological interventions and which drug to prefer. Although psychotherapeutic treatment is still considered a first-line treatment, antidepressants are widely used to treat depression in children and adolescents, and the number of medications prescribed...
Source: Psychiatria Polska - February 12, 2024 Category: Psychiatry Authors: Ma łgorzata Honorata Janas-Kozik Agnieszka S łopień Barbara Remberk Marcin Siwek Source Type: research

Molecules, Vol. 29, Pages 767: Establishment and Validation of a Transdermal Drug Delivery System for the Anti-Depressant Drug Citalopram Hydrobromide
Yan-qiang Liu To enhance the bioavailability and antihypertensive effect of the anti-depressant drug citalopram hydrobromide (CTH) we developed a sustained-release transdermal delivery system containing CTH. A transdermal diffusion meter was first used to determine the optimal formulation of the CTH transdermal drug delivery system (TDDS). Then, based on the determined formulation, a sustained-release patch was prepared; its physical characteristics, including quality, stickiness, and appearance, were evaluated, and its pharmacokinetics and irritation to the skin were evaluated by applying it to rabbits and rats. The o...
Source: Molecules - February 7, 2024 Category: Chemistry Authors: Yi-yang Sun Ya-jing Ni Run-jia Wang Zi-cheng Qin Zhao Liu Li-hui Xiao Yan-qiang Liu Tags: Article Source Type: research

Inhibitory Actions of Antidepressants, Hypnotics, and Anxiolytics on Recombinant Human Acetylcholinesterase Activity
Biol Pharm Bull. 2024;47(1):328-333. doi: 10.1248/bpb.b23-00719.ABSTRACTAlzheimer's disease (AD) is accompanied by behavioral and psychological symptoms of dementia (BPSD), which is often alleviated by treatment with psychotropic drugs, such as antidepressants, hypnotics, and anxiolytics. If these drugs also inhibit acetylcholinesterase (AChE) activity, they may contribute to the suppression of AD progression by increasing brain acetylcholine concentrations. We tested the potential inhibitory effects of 31 antidepressants, 21 hypnotics, and 12 anxiolytics on recombinant human AChE (rhAChE) activity. At a concentration of 1...
Source: Biological and Pharmaceutical Bulletin - January 31, 2024 Category: Drugs & Pharmacology Authors: Keisuke Obara Haruka Mori Suzune Ihara Kento Yoshioka Yoshio Tanaka Source Type: research

Molecules, Vol. 29, Pages 676: Direct Immersion & ndash;Solid Phase Microextraction for Therapeutic Drug Monitoring of Patients with Mood Disorders
This article discusses a new method for monitoring drug concentrations in blood samples from patients with mood disorders. The method uses solid-phase microextraction to extract analytes directly from blood samples. It has been adapted to identify the most commonly used drugs in mood disorders, including amitriptyline, citalopram, fluoxetine, paroxetine, sertraline, trazodone, duloxetine, venlafaxine, lamotrigine, quetiapine, olanzapine, and mirtazapine. The analysis is carried out using high-performance liquid chromatography coupled with mass spectroscopy. The proposed DI-SPME/LC-MS method allows for a simple and quick sc...
Source: Molecules - January 31, 2024 Category: Chemistry Authors: Magdalena Świądro-Piętoń Dominika Dudek Renata Wietecha-Pos łuszny Tags: Article Source Type: research

Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells
In conclusion, hypericin, but not hyperforin or citalopram, is a mitochondrial toxicant at low micromolar concentrations. This mechanism may contribute to the hepatotoxicity occasionally observed in susceptible patients treated with St. John's Wort preparations.PMID:38219807 | DOI:10.1016/j.toxlet.2024.01.008 (Source: Toxicology Letters)
Source: Toxicology Letters - January 14, 2024 Category: Toxicology Authors: Vanessa Fabienne Abegg Miljenko Valentin Panajatovic Riccardo Vincenzo Mancuso Julien Arthur Allard Urs Duthaler Alex Odermatt Stephan Kr ähenbühl Jamal Bouitbir Source Type: research

Cholinesterase inhibitors-associated torsade de pointes/QT prolongation: a real-world pharmacovigilance study
Conclusion: The signals of TdP/QT prolongation related to ChEIs were strong and stable. It is necessary to be vigilant about the TdP/QT prolongation of various ChEIs, especially in elderly women, the initial stage after taking ChEIs, and when ChEIs combining with drugs that could prolong the QT interval. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 11, 2024 Category: Drugs & Pharmacology Source Type: research