HEAL Initiative: Sickle Cell Disease Pain Management Trials Utilizing the Pain Management Effectiveness Research Network Cooperative Agreement (UG3/UH3, Clinical Trial Required)
Funding Opportunity RFA-AT-22-005 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit cooperative agreement applications to support multisite effectiveness clinical trials of pharmacologic, nonpharmacologic, and/or multicomponent approaches for acute and/or chronic sickle cell disease (SCD) pain management, allowing continued opioid pain management as needed. However, opioid medication use alone should not be the only intervention studied. Trials supported under this initiative may also address the impact of these approaches on related psychological and f...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 29, 2021 Category: Research Source Type: funding

HEAL Initiative: Pragmatic and Implementation Studies for the Management of Sickle Cell Disease Pain (UG3/UH3, Clinical Trials Optional)
Funding Opportunity RFA-AT-22-004 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit cooperative agreement applications to conduct multisite embedded pragmatic or implementation trials to inform the uptake of pharmacologic, nonpharmacologic, and/or multicomponent approaches for acute and/or chronic sickle cell disease (SCD) pain management in health care systems that serve the SCD population. Trials may include or allow continuation of opioid medication as needed; however opioid medication use alone should not be the only intervention studied. Trials sup...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 29, 2021 Category: Research Source Type: funding

HEAL Initiative: Advancing Health Equity in Pain Management (R61/R33 Clinical Trial Required)
Funding Opportunity RFA-NS-22-002 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to accelerate development, testing and implementation of evidence-based interventionsthat are culturally and linguistically appropriate for NIH-designated health disparity populations[1] (HDPs)to mitigate disparities in provision of care and treatment decisions, reduce susceptibility to chronic pain and improve patient outcomes. Applications are encouraged for studies that utilize evidence-based strategies that mitigate: 1) the effects of bias, stigma and di...
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 8, 2021 Category: Research Source Type: funding

HEAL Initiative: Interdisciplinary Teams to Elucidate the Mechanisms of Device-Based Pain Relief (RM1 Clinical Trial Optional)
Funding Opportunity RFA-NS-22-016 from the NIH Guide for Grants and Contracts. More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance in the prescription of opioids for chronic pain despite their poor ability to improve function and high addiction liability. This contributed to a significant and alarming epidemic of opioid overdose deaths and addictions. Innovative scientific solutions to develop alternative pain treatment options are thus critically needed. Through targeted research...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 31, 2021 Category: Research Source Type: funding

HEAL Initiative: Notice of Special Interest (NOSI) regarding the Availability of Administrative Supplements to Support Strategies to Advance the Study of Chronic Overlapping Pain Conditions (COPCs)
Notice NOT-NS-21-068 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 25, 2021 Category: Research Source Type: funding

Notice of Change: Extension of PA-18-937 "Research on Chronic Overlapping Pain Conditions (R01 Clinical Trial Optional)"
Notice NOT-NS-22-014 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 19, 2021 Category: Research Source Type: funding

Notice of Change: Extension of PA-18-939 "Research on Chronic Overlapping Pain Conditions (R21 Clinical Trial Not Allowed)"
Notice NOT-NS-22-015 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 19, 2021 Category: Research Source Type: funding

HEAL Initiative: Analgesic Development Initial Translational Efforts [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-21-015 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) is part of a suite of FOAs to support the development of safe, effective, and non-addictive therapeutics to treat pain. The goal of this FOA is to support team-based research projects to develop assays, screening and early optimization work to develop a non-addictive therapeutic to treat pain. Discovery and validation of pharmacodynamic markers efficacy and pharmacokinetic/pharmacodynamic (PK/PD) studies are also responsive. The result of the project should be to advance a hit or lead to the point w...
Source: NIH Funding Opportunities (Notices, PA, RFA) - March 11, 2021 Category: Research Source Type: funding

HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)
Funding Opportunity RFA-DA-21-030 from the NIH Guide for Grants and Contracts. enter purposeChronic Non-Cancer Pain (CP) and Opioid Use Disorder (OUD) overlap significantly and patients with both conditions present particular clinical complexity. CP adversely impacts OUD treatment adherence and recovery, while the presence of dependence stigmatizes treatment services for chronic pain, often resulting in insufficient pain treatment. Fundamentally, the healthcare system lacks the expertise and effective interventions for managing comorbid CP and OUD, leaving patients suffering and at risk for poor outcomes. The National I...
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 11, 2021 Category: Research Source Type: funding

HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Coordination and Dissemination Center (R24 Clinical Trial Optional)
Funding Opportunity RFA-DA-21-029 from the NIH Guide for Grants and Contracts. The National Institutes of Health (NIH) intends to establish a Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) network consisting of clinical research centers, which will be supported by a single Coordination and Dissemination center. This network is intended to create multidisciplinary team science collaborations to develop effective interventions, best models of care for delivery of services, and sustainable implementation strategies for access to quality care for complex patients with chronic pain (CP) and opioid...
Source: NIH Funding Opportunities (Notices, PA, RFA) - January 11, 2021 Category: Research Source Type: funding

Limited Competition for the Continuation of the Scientific Data Research Center (SDRC) for the NIDDK Gastroparesis Consortium (U24 Clinical Trial Optional)
Funding Opportunity RFA-DK-20-505 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites an application for the Scientific Data Research Center (SDRC) of the Gastroparesis Clinical Research Consortium (GpCRC). The companion FOA, RFA-DK-20-504 will support continuation of the GpCRC Clinical Centers (CC). The Consortium forms a multi-disciplinary teams composed of members from the CCs and SDRC to undertake a comprehensive clinical, epidemiological and biological characterization of adult and children patients with GP to gain insight into the pathophysiology of GP and its sequela: ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 24, 2020 Category: Research Source Type: funding

Notice of Intent to Publish a HEAL Funding Opportunity Announcement for Consortium on Co-managing Chronic Pain and Opioid Use Disorder (C3PO) (RM1)
Notice NOT-DA-20-071 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 21, 2020 Category: Research Source Type: funding

Empowering Communities to Address Behavioral Health and Chronic Pain through Chronic Disease Self-Management Education Programs
Funding for public and private nonprofit entities to address behavioral health and/or chronic pain among older adults and adults with disabilities through the implementation of appropriate evidence-based self-management education and self-management support programs. Proposals should consider projects that reach a new population, such as rural communities, veterans, individuals with mental illness, or individuals with substance abuse/misuse issues. Geographic coverage: Nationwide -- Administration for Children and Families, U.S. Department of Health and Human Services (Source: Funding opportunities via the Rural Health Information Hub)
Source: Funding opportunities via the Rural Health Information Hub - November 22, 2019 Category: American Health Source Type: funding

Notice of Extension and Clarification for RFA-RM-19-013 Multisite Clinical Center Common Fund Acute to Chronic Pain Signatures Program: Acute Peri-operative Pain or Musculoskeletal Trauma (UM1 Clinical Trial Optional)
Notice NOT-RM-20-001 from the NIH Guide for Grants and Contracts (Source: NIH Funding Opportunities (Notices, PA, RFA))
Source: NIH Funding Opportunities (Notices, PA, RFA) - October 18, 2019 Category: Research Source Type: funding

Limited Competition: Continuation of the Consortium for the Study of Chronic Pancreatitis, Diabetes and Pancreatic Cancer Coordination and Data Management Center (CPDPC-CDMC) (U01 Clinical Trial Optional)
Funding Opportunity RFA-DK-19-504 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) is a limited invitation for U01 application for one Coordination and Data Management Center (CDMC) to continue the consortium to study Chronic Pancreatitis, Diabetes and Pancreatic Cancer (CPDPC) to conduct and complete ongoing studies on chronic pancreatitis (CP) and factors that increase the risk of pancreatic cancer in patients (children and adults) with CP, pancreatogenic (type 3c) diabetes (T3cDM) and in patients with newly diagnosed diabetes. The CPDPC is composed of several Clinical Centers (...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 26, 2019 Category: Research Source Type: funding