Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Neuroscience Trend Forecasters
As 2022 draws to a close, the SNL Trend Forecasters have agreed to divulge their predictions for the most — and the least— exciting research fads for the New Year.The Neurocritic: How do you guys predict today ' s most popular neuroscience trends? Trend Forecasters: Oh, well we have 4,000 computers, they ' re all big they all make charts and they beep LOUD.TN: Let ' s get started!In:posterior cingulate cortexHey Posterior Cingulate — we see you! You ' re fresh, you ' re mysterious, you ' re misunderstood. But we know you exist far beyond the default fashion mode. Thenew tripartite view proposes......that the bro...
Source: The Neurocritic - December 31, 2022 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
A Look Back at 2022: Progress Towards the Treatment of Aging as a Medical Condition
At the end of 2022, we can reflect on the fact that we are steadily entering a new era of medicine, one in which mechanisms of aging are targeted rather than ignored. It is a profound change, one that will change the shape of a human life and ultimately the human condition by eliminating the greatest sources of suffering and death in the world. Year after year, we see increased funding, ongoing progress towards therapies capable of slowing aging or reversing aspects of aging, and a growing taxonomy of such potential therapies and their target mechanisms.
The view of aging in the medical community and public at large...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
A Popular Science View of the Development of Senolytic Therapies
Over the last decade, an increasing diversity of research groups and companies are working towards the clinical use of senolytic therapies to reverse aspects of aging in older patients by clearing harmful senescent cells. Of the early senolytic therapies, the dasatinib and quercetin combination is the only one with published data in human clinical trials showing clearance of senescent cells. This treatment is in fact easily accessible to self-experimenters, and even being prescribed off-label by more adventurous physicians. The biotech industry is working to produce a next generation of (probably) better approaches, and ob...
Source: Fight Aging! - December 29, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Weekly Roundup – December 24, 2022
Welcome to our Healthcare IT Today Weekly Roundup. Each week, we’ll be providing a look back at the articles we posted and why they’re important to the healthcare IT community. We hope this gives you a chance to catch up on anything you may have missed during the week.
Tytocare’s Mission to Make Home Medical Care Easier and More Accurate. Demand for care at home is rising, but traditional telehealth and remote monitoring doesn’t support examination and diagnosis in the patient’s home. Colin Hung talked to TytoCare at HLTH about the company’s new Home Smart Clinic and its efforts to bring primary...
Source: EMR and HIPAA - December 24, 2022 Category: Information Technology Authors: Brian Eastwood Tags: Healthcare IT Healthcare IT Today Weekly Roundup Source Type: blogs
Former US Sec. of Veterans Affairs & Daughter Launch Chronic Pain Care Startup, Override, Raise $3.5M, Acquire Leading Pain Coaching Company
A non-opioid solution utilizing a team-based approach to care & the latest in pain neuroscience
Emerging from stealth, Override, a new multi-specialty, virtual chronic pain solution, announces seed funding of $3.5 million. Founded by former US Secretary of Veterans Affairs, David Shulkin MD, and his daughter, Jennie Shulkin JD, Override’s funding round was led by 7wireVentures and Martin Ventures, with SignalFire and Confluent Health joining the round. Shortly after fundraising, Override acquired the country’s leading pain management coaching business: Take Courage Coaching.
Today, 50 million adults (1 in 5) in th...
Source: EMR and HIPAA - December 22, 2022 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Telemedicine and Remote Monitoring 7wireVentures behavioral health Chronic Conditions Chronic Pain Chronic Pain Treatment Chronic Patient Confluent Health David Shulkin MD Health IT Funding Health IT Source Type: blogs
Bad Backs & Deductibles
It’s time again for me to use my bad back as a case study in why American health care has such crazy incentives.
About a month ago at the HLTH conference in Vegas, over the course of a few hours I developed debilitating leg pain. To quote from my earlier twitter thread on my time in Vegas, “After 3 days of excruciating pain, my wife insisted I went to the ER. The public policy person in me was horrified but we had already spent our deductible, so the cost was actually lower than paying cash for an MRI”
What actually happened was that after 3 days of dreadful pain & inability to wal...
Source: The Health Care Blog - December 19, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Matthew Holt Chronic Back Pain health deductible health plans (HDHP) Insurers Surgery Source Type: blogs
Persistent pain and movement practices
Here I go, stepping into “the bio” to write about movement. Oh dear, what am I doing?
Movement practices of various kinds are part and parcel of pain management. In fact, to read some of the material in social media-land, exercise is the be-all and end-all of pain management, maybe with a dash of psychology. Can we please stop doing this?
I’ve said it often, for many forms of persistent pain, especially the most common forms – nonspecific chronic low back pain, fibromyalgia, and osteoarthritic pain – movement is a good thing, but the effect sizes are small for both pain intensity and d...
Source: HealthSkills Weblog - December 18, 2022 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Chronic pain Clinical reasoning Low back pain Occupational therapy Physiotherapy Psychology Resilience/Health Science in practice movement optimism movement practices pain management Research Therapeutic approaches Source Type: blogs
Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Struggle to Deal with the Presently Incurable Issues of Aging
The struggles and sufferings of the old are largely conducted behind the curtain, not talked about all that much in the public sphere. How does one manage the last phase of life for a failing, complex machine that cannot be repaired, only coaxed into a slightly slower decline? As it turns out, a fair amount of not thinking about it is involved: on the part of younger people, and particularly on the part of research and development institutions that do not wish to be burdened with the very complex, interacting nature of late life age-related diseases. New treatments and adjustments to the standard of care are rarely formall...
Source: Fight Aging! - December 16, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fecal Microbiota Transplant Treatment Approved by the FDA
The balance of microbial populations making up the gut microbiome changes with age in ways that produce harm, such as loss of beneficial metabolites, and generation of chronic inflammation. This form of aging is only loosely connected to age-related damage in our tissues, in that animal studies appear to show that a readjustment of the balance of populations in the gut microbiome of an aged animal, making it more youthful, will persist even as aging progresses in the body. In killifish, the result is improved health and extended life span; in mice, similar studies have demonstrated improved health, with lifespan studies ye...
Source: Fight Aging! - December 13, 2022 Category: Research Authors: Reason Tags: Politics and Legislation Source Type: blogs
AMA Touts Apples ‐to‐Oranges Study in its Fight to Preserve the Medical Cartel
This study supports the evidence that use of NPs can improve access to primary care with similar quality and cost of care.The VHA emergency medicine study that the AMA is touting makes no case against NPs and FNPs independently providing primary care. However, its findings do suggest that hospitals should prefer board ‐certified ENPs to FNPs when staffing their emergency departments with non‐physicians.Spencer Pratt is a Research Associate in the Department of Health Policy Studies (Source: Cato-at-liberty)
Source: Cato-at-liberty - December 13, 2022 Category: American Health Authors: Jeffrey A. Singer, Spencer Pratt Source Type: blogs
Reimagining Pain in the Wake of the Opioid Epidemic
The following is a guest article by Vijay Yanamadala, MD, Chief Medical Officer at Sword Health and System Medical Director of Spine Quality at Hartford Healthcare.
In 2017, after years of over prescribing opioids to treat pain, leading to opioid addiction for millions of Americans, opioid dependency was declared a public health emergency.
Since then, the opioid epidemic has only worsened. The COVID-19 pandemic, and its impact on people’s mental and physical health, has greatly contributed to a rise in opioid-related deaths.
When I was a medical student in the early 2000s, pain was viewed as a vital sign, like heart rate...
Source: EMR and HIPAA - December 13, 2022 Category: Information Technology Authors: Guest Author Tags: Communication and Patient Experience Healthcare IT Chronic Pain Hartford HealthCare MSK Musculoskeletal Care opioid crisis Opioid Epidemic Pain Management Patient Care Patient Compliance Physical Therapy PT Reimagining Pain Swo Source Type: blogs
The joy of having many data points
Researchers and clinicians are drawn to studies with many participants. Especially randomised controlled trials, where two groups are randomly divided and one gets “the real thing” while the other does not. The joy comes from knowing that results from these kinds of studies suggest that, all things being equal, the differences between the groups is “real” and not just by chance.
When we come to analyse the graphs from these kinds of studies, what we hope to see are two nice bell-shaped curves, with distinct peaks (the arithmetic mean) and long tails either side – and a clear separation betw...
Source: HealthSkills Weblog - December 11, 2022 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Assessment Occupational therapy Physiotherapy Professional topics Psychology Research Science in practice Uncategorized Chronic pain Clinical reasoning Health pain management Therapeutic approaches Source Type: blogs
What ’ s Happening In Your Stomach? – Gastric Alimetry Review
Conclusion
The Gastric Alimetry device is a first-of-a-kind solution, fully fitting all principles of digital health. It is making patients the point of care and it targets a niche area with massive demand. I am eager to see where Body Surface Gastric Mapping develops in the coming years.
The total time requirement of such a test is significant, patients need to dedicate a total of 10.5 hours to it. The discomfort of the prolonged process is tolerable, many gastric diagnostic methods are much more demanding. If you have chronic NVS and would like to find a way to detect its causes, it is well worth the effort.
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Source: The Medical Futurist - December 8, 2022 Category: Information Technology Authors: Andrea Koncz Tags: Health Sensors & Trackers review Gastric alimetry gastric sencor Body Surface Gastric Mapping gut sensor stomach sensor Source Type: blogs
