Cancers, Vol. 16, Pages 1537: Recent Advances in Pathology of Intrahepatic Cholangiocarcinoma
This article provides an updated overview of ICCA pathology, focusing particularly on molecular features, histological subtypes, and diagnostic approaches. (Source: Cancers)
Source: Cancers - April 17, 2024 Category: Cancer & Oncology Authors: Choi Thung Tags: Review Source Type: research
Identification and validation of a lactate metabolism-related six-gene prognostic signature in intrahepatic cholangiocarcinoma
CONCLUSION: Our study revealed the biological roles of LDHA in iCCA and developed a reliable lactate metabolism-related prognostic signature for iCCA, offering promising therapeutic targets for iCCA in the clinic.PMID:38627278 | DOI:10.1007/s00432-024-05723-4 (Source: Cell Research)
Source: Cell Research - April 16, 2024 Category: Cytology Authors: Chen Sang Li Yan Jian Lin Youpei Lin Qiang Gao Xia Shen Source Type: research
Identification and validation of a lactate metabolism-related six-gene prognostic signature in intrahepatic cholangiocarcinoma
ConclusionOur study revealed the biological roles ofLDHA in iCCA and developed a reliable lactate metabolism-related prognostic signature for iCCA, offering promising therapeutic targets for iCCA in the clinic. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 16, 2024 Category: Cancer & Oncology Source Type: research
Comparison of Machine Learning Models Using Diffusion-Weighted Images for Pathological Grade of Intrahepatic Mass-Forming Cholangiocarcinoma
The objective of our study is to develop DWI radiomic models based on different machine learning algorithms and identify the optimal prediction model. We undertook a retrospective analysis of the DWI data of 77 patients with IMCC confirmed by pathological testing. Fifty-seven patients initially included in the study were randomly assigned to either the training set or the validation set in a ratio of 7:3. We established four different classifier models, namely random forest (RF), support vector machines (SVM), logistic regression (LR), and gradient boosting decision tree (GBDT), by manually contouring the region of interes...
Source: Journal of Digital Imaging - April 16, 2024 Category: Radiology Source Type: research
Impact of temperature-controlled endobiliary radiofrequency ablation for inoperable hilar cholangiocarcinoma: A propensity score –matched analysis
Conclusions Temperature-controlled endobiliary RFA resulted in favorable stent patency without increasing the rate of AEs but it did not significantly increase OS in patients with inoperable hilar CCA (Clinical trial registration number: KCT0008576). [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - April 15, 2024 Category: Gastroenterology Authors: Shin, Il Sang Moon, Jong Ho Lee, Yun Nah Myeong, Jun Ho Lee, Tae Hoon Yang, Jae Kook Cho, Young Deok Park, Sang-Heum Tags: Original article Source Type: research
Identification of Novel Cuproptosis-Related Genes Mediating the Prognosis and Immune Microenvironment in Cholangiocarcinoma
CONCLUSIONS: Collectively, we established and verified an effective prognostic model that could separate cholangiocarcinoma patients into 2 heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of 10 cuproptosis-related genes. These findings may provide potential benefits for unveiling molecular characteristics and defining subgroups could improve the early diagnosis and individualized treatment of cholangiocarcinoma patients.PMID:38613350 | DOI:10.1177/15330338241239139 (Source: Cell Research)
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Qiang Liu Jianpeng Zhu Zhicheng Huang Xiaofeng Zhang Jianfeng Yang Source Type: research
Identification of Novel Cuproptosis-Related Genes Mediating the Prognosis and Immune Microenvironment in Cholangiocarcinoma
CONCLUSIONS: Collectively, we established and verified an effective prognostic model that could separate cholangiocarcinoma patients into 2 heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of 10 cuproptosis-related genes. These findings may provide potential benefits for unveiling molecular characteristics and defining subgroups could improve the early diagnosis and individualized treatment of cholangiocarcinoma patients.PMID:38613350 | DOI:10.1177/15330338241239139 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Qiang Liu Jianpeng Zhu Zhicheng Huang Xiaofeng Zhang Jianfeng Yang Source Type: research
Identification of Novel Cuproptosis-Related Genes Mediating the Prognosis and Immune Microenvironment in Cholangiocarcinoma
CONCLUSIONS: Collectively, we established and verified an effective prognostic model that could separate cholangiocarcinoma patients into 2 heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of 10 cuproptosis-related genes. These findings may provide potential benefits for unveiling molecular characteristics and defining subgroups could improve the early diagnosis and individualized treatment of cholangiocarcinoma patients.PMID:38613350 | PMC:PMC11015765 | DOI:10.1177/15330338241239139 (Source: Cell Research)
Source: Cell Research - April 13, 2024 Category: Cytology Authors: Qiang Liu Jianpeng Zhu Zhicheng Huang Xiaofeng Zhang Jianfeng Yang Source Type: research
Identification of Novel Cuproptosis-Related Genes Mediating the Prognosis and Immune Microenvironment in Cholangiocarcinoma
CONCLUSIONS: Collectively, we established and verified an effective prognostic model that could separate cholangiocarcinoma patients into 2 heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of 10 cuproptosis-related genes. These findings may provide potential benefits for unveiling molecular characteristics and defining subgroups could improve the early diagnosis and individualized treatment of cholangiocarcinoma patients.PMID:38613350 | PMC:PMC11015765 | DOI:10.1177/15330338241239139 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Qiang Liu Jianpeng Zhu Zhicheng Huang Xiaofeng Zhang Jianfeng Yang Source Type: research
Identification of Novel Cuproptosis-Related Genes Mediating the Prognosis and Immune Microenvironment in Cholangiocarcinoma
CONCLUSIONS: Collectively, we established and verified an effective prognostic model that could separate cholangiocarcinoma patients into 2 heterogeneous cuproptosis subtypes based on the molecular or protein characteristics of 10 cuproptosis-related genes. These findings may provide potential benefits for unveiling molecular characteristics and defining subgroups could improve the early diagnosis and individualized treatment of cholangiocarcinoma patients.PMID:38613350 | PMC:PMC11015765 | DOI:10.1177/15330338241239139 (Source: Technology in Cancer Research and Treatment)
Source: Technology in Cancer Research and Treatment - April 13, 2024 Category: Cancer & Oncology Authors: Qiang Liu Jianpeng Zhu Zhicheng Huang Xiaofeng Zhang Jianfeng Yang Source Type: research
Identification of clinically relevant subsets CD39 < sup > + < /sup > PD-1 < sup > + < /sup > CD8 < sup > + < /sup > T cells and CD39 < sup > + < /sup > regulatory T cells in intrahepatic cholangiocarcinoma using single-cell CyTOF
This study utilized mass cytometry by time of flight (CyTOF) to comprehensively analyze immune cell populations in fresh iCCA tumor samples and adjacent peritumor liver tissues. Notably, NK cell percentages significantly decreased in iCCA lesions compared to peritumor liver tissues. Conversely, an enrichment of immunosuppressive CD39+Foxp3+CD4+ regulatory T cells (CD39+T-regs) and exhausted-like CD8+T cells (with pronounced CD39 and PD-1 expression) within TIME was identified and confirmed by multiplex immunofluorescence staining in an independent patient cohort (n = 140). Crucially, tumor-infiltrating CD39+T-regs and CD39...
Source: Translational Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Qi-Wei Zhang Meng-Xuan Zhu Wen-Feng Liu Wei-Wei Rui Yong Chen Xiao-Yi Ding Yong-Sheng Jiang Zhi-Yuan Wu Bin-Bin Liu Source Type: research
Identification of clinically relevant subsets CD39 < sup > + < /sup > PD-1 < sup > + < /sup > CD8 < sup > + < /sup > T cells and CD39 < sup > + < /sup > regulatory T cells in intrahepatic cholangiocarcinoma using single-cell CyTOF
This study utilized mass cytometry by time of flight (CyTOF) to comprehensively analyze immune cell populations in fresh iCCA tumor samples and adjacent peritumor liver tissues. Notably, NK cell percentages significantly decreased in iCCA lesions compared to peritumor liver tissues. Conversely, an enrichment of immunosuppressive CD39+Foxp3+CD4+ regulatory T cells (CD39+T-regs) and exhausted-like CD8+T cells (with pronounced CD39 and PD-1 expression) within TIME was identified and confirmed by multiplex immunofluorescence staining in an independent patient cohort (n = 140). Crucially, tumor-infiltrating CD39+T-regs and CD39...
Source: Translational Oncology - April 12, 2024 Category: Cancer & Oncology Authors: Qi-Wei Zhang Meng-Xuan Zhu Wen-Feng Liu Wei-Wei Rui Yong Chen Xiao-Yi Ding Yong-Sheng Jiang Zhi-Yuan Wu Bin-Bin Liu Source Type: research
False-negative factors of percutaneous transluminal clamp biopsy for suspected malignant biliary stricture: 194 cases analyzed from a single center
ConclusionPTCB is an effective minimally invasive interventional technique for BS diagnosis. Non-cholangiocarcinoma BS is an independent risk factor for FNV.Critical relevance statementIdentifying factors that are predictive of false-negative results by percutaneous transluminal clamp biopsy in the setting of biliary stricture may have a guiding effect on clinical practice.Key points• Factors predictive of false negatives in the diagnosis of biliary stricture etiology by PTCB may aid in the interpretation of results.• Non-cholangiocarcinoma BS is an independent risk factor for FNV on PTCB.• PTCB is an effective minim...
Source: Insights into Imaging - April 12, 2024 Category: Radiology Source Type: research
ASO Author Reflections: ICC PRS Score: Clinically Useful Tool to Predict Post-recurrence Survival and Guide Management of Recurrent Intrahepatic Cholangiocarcinoma
Ann Surg Oncol. 2024 Apr 11. doi: 10.1245/s10434-024-15269-x. Online ahead of print.NO ABSTRACTPMID:38602579 | DOI:10.1245/s10434-024-15269-x (Source: Ann Oncol)
Source: Ann Oncol - April 11, 2024 Category: Cancer & Oncology Authors: Diamantis I Tsilimigras Timothy M Pawlik Source Type: research
Differences in Lymph Node Metastases Patterns Among Non-pancreatic Periampullary Cancers and Histologic Subtypes: An International Multicenter Retrospective Cohort Study and Systematic Review
CONCLUSION: This study is the first to comprehensively demonstrate the differences and similarities in lymph node metastases spread among NPPCs, to identify the existing research gaps, and to underscore the importance of standardized lymphadenectomy and pathologic assessment for AAC, dCCA, and DAC.PMID:38602578 | DOI:10.1245/s10434-024-15213-z (Source: Ann Oncol)
Source: Ann Oncol - April 11, 2024 Category: Cancer & Oncology Authors: Bas A Uijterwijk Dani ël H Lemmers Giuseppe Kito Fusai Alessandro Zerbi Roberto Salvia Ernesto Sparrelid Steven White Bergthor Bj örnsson Vasileios K Mavroeidis Keith J Roberts Michele Mazzola Santiago S ánchez Cabús Zahir Soonawalla Dimitris Korkolis Source Type: research
