Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols.
FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Role of Cellular Senescence in Liver Disease
Senescent cells are play a role in the onset and progression of near every age-related condition. Cells become senescent constantly throughout the body and throughout life, most because they have reached the Hayflick limit to replication. In youth, senescent cells are efficiently removed, either through programmed cell death or by the immune system. With age, the immune system declines in effectiveness. Senescent cells begin to linger and grow in number. These errant cells secrete a mix of pro-growth, pro-inflammation signals that, when present over the long term, disrupt cell and tissue function.
Today's open acce...
Source: Fight Aging! - January 20, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Uncontrollable itching – part II
As we heard the history we stopped, prior to hearing the exam and labs, and developed a differential diagnosis. With the combination of itching, probable jaundice and pale stools we assume either intrahepatic or extrahepatic obstruction. Our differential diagnosis with commentary:
Primary biliary cirrhosis – much more common in women then men – but does often present at this age with uncontrollable itching
Primary sclerosing cholangitis – no history of ulcerative colitis or diarrhea symptoms, but still possible
Gallstone – not all common duct stones cause pain
Cholangiocarcinoma – ...
Source: DB's Medical Rants - March 20, 2018 Category: Internal Medicine Authors: rcentor Tags: Medical Rants Source Type: blogs
Medmastery: Detecting malignant focal lesions
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
The team at Medmastery are providing LITFL readers with a series of FOAMed courses from across their website.
In this video, from the Abdominal Ultrasound Essentials course, Dr. Nikolaus Mayr discusses the basic principles of liver ultrasound including the differentiation of malignant pathologies such as hepatocellular carcinoma (HCC), cholangiocarcinoma and metastases.
Further reading:
LITFL Medmastery Courses
Medmastery on Facebook and Twitter
G...
Source: Life in the Fast Lane - February 20, 2018 Category: Emergency Medicine Authors: Mike Cadogan Tags: Medmastery liver malignant Ultrasound Source Type: blogs
Medmastery: Detecting malignant focal lesions.
LITFL • Life in the Fast Lane Medical Blog
LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog
The team at Medmastery are providing LITFL readers with a series of FOAMed courses from across their website.
In this video, from the Abdominal Ultrasound Essentials course, Dr. Nikolaus Mayr discusses the basic principles of liver ultrasound including the differentiation of malignant pathologies such as hepatocellular carcinoma (HCC), cholangiocarcinoma and metastases.
Further reading:
LITFL Medmastery Courses
Medmastery on Facebook and Twitter
Guest post: Nikola...
Source: Life in the Fast Lane - February 20, 2018 Category: Emergency Medicine Authors: Mike Cadogan Tags: Medmastery liver malignant Ultrasound Source Type: blogs
Precision Medicine and Public Health (from Precision Medicine and the Reinvention of Human Disease)
Excerpted fromPrecision Medicine and the Reinvention of Human DiseaseDespite having the most advanced healthcare technology on the planet, life expectancy in the United States is not particularly high. Citizens from most of the European countries and the highly industrialized Asian countries enjoy longer life expectancies than the United States. According to the World Health Organization, the United States ranks 31st among nations, trailing behind Greece, Chile, and Costa Rica, and barely edging out Cuba [42]. Similar rankings are reported by the US Central Intelligence Agency [43]. These findings lead us to infer that acc...
Source: Specified Life - February 6, 2018 Category: Information Technology Tags: cancer cancer vaccines precision medicine prevention public health Source Type: blogs
Answer to Case 305
Answer: Clonorchis sinensis, the Chinese liver fluke. As mentioned by Florida Fan and Tomáš Macháček, we can see several characteristic features of C. sinensis, including the oral sucker, esophagus, twin ceca, ova-filled uterus, lateral vitellaria, seminal receptacle and classic eggs with shouldered operculum (arrow heads). I've highlighted several of these features below:The testes and other internal structures allow Clonorchis to be differentiated from the related fluke Opsithorchis. Clonorchiasis is usually acquired through ingestion of undercooked or raw fish and long stan...
Source: Creepy Dreadful Wonderful Parasites - May 26, 2014 Category: Pathologists Source Type: blogs
Heating Effect of MRI-Possible Treatment Option
In an article by S. Nahum Goldberg, MD published in Radiology, Author discusses the potential of using undesired Heating Effects of MR Imaging as Effective Cancer Therapy. In this basic research study, Zhang et al created and report on a clever magnetic resonance (MR)-guided radiofrequency (RF) system that enables focal hyperthermic heating, targeting, and visualization for the treatment of cholangiocarcinoma. The key novelty is creating localized MR-induced heating around a metallic guidewire.From Sumer's Radiology Site http://www.sumerdoc.blogspot.com -The Top Radiology Magazine. Teleradiology Providers at www.tele...
Source: Sumer's Radiology Site - January 31, 2014 Category: Radiologists Authors: Sumer Sethi Source Type: blogs
