Poly(I:C)/c-GAMP/Alum ternary adjuvant system synergistically enhances the immunogenicity of glycopeptide antigen
(Source: Journal of Carbohydrate Chemistry)
Source: Journal of Carbohydrate Chemistry - April 24, 2024 Category: Chemistry Authors: Zhou, Shi-Hao Zou, Yong-Ke Liu, Yan-Ling Zhang, Ru-Yan Wen, Yu Ding, Dong Guo, Jun Source Type: research
Cyclopropylmethylidene as a versatile protecting group for carbohydrate synthesis
(Source: Journal of Carbohydrate Chemistry)
Source: Journal of Carbohydrate Chemistry - April 24, 2024 Category: Chemistry Authors: Li, Xiaohua Ibrahim, Nasma Jaber, Zahraa Ali, Sara Masood, Isha Source Type: research
GSE242103 Cationic amphiphilic drug induced phospholipidosis and lysosomal dysgenesis during in vitro adipogenesis
Contributors : Deniz Bozdag ; Hande G Orhan ; Jeroen van Voorthuizen ; Jorke H Kamstra ; Sander LentzSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSelective Serotonin Reuptake Inhibitors (SSRIs) are widely used medications for the treatment of major depressive disorder. However, long-term SSRI use has been associated with weight gain and altered lipid profiles. These findings suggest that SSRIs may have negative effects on metabolism. Exposure to certain chemicals called 'obesogens' are known to promote lipid accumulation and obesity by modulating adipogenesis. Here, we investiga...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE256464 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability (ChIP-Seq)
Series Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensSOX10 plays important roles in development of neural crest lineages and melanocyte lineages. SOX10 binding sites on chromatin have been characterized in glial lineages, but fewer focused on melanoma. To examine chromatin occupancy of SOX10 and chromatin landscape in melanoma, we performed ChIP-seq analysis of SOX10 and H3K27ac in SOX10-dependent melanoma SKMEL5. We confirmed SOX10 binding in genes previously reported as direct targets of SOX10, including ERBB3 and IL16. Importantly, SOX10 chemical probe (SH-0029) treatment ...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE256466 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability (RNA-Seq)
Series Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensSOX10 is a lineage-restricted transcription factor important for melanoma proliferation and survival. Our data demonstrate that SOX10 genetic depletion by CRISPR/Cas9 significantly impaired melanoma proliferation. We chose 7 different melanoma, all of which exhibited growth dependency on SOX10 with different levels. To define the SOX10 transcriptional signature shared with different SOX10-dependent melanoma, we performed bulk RNA-seq on 7 melanoma transfected with siSOX10 or siControl. Each melanoma cell line was plated and transfected w...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE253657 Chemical manipulation of m1A mediates its detection in human tRNA
In this study, we introduce a reduction-based m1A sequencing (red-m1A-seq). We report that NaBH4 reduction of m1A can improve the mutation and readthrough rates using commercially available RT enzymes to give better positive signature, while alkaline-catalyzed Dimroth rearrangement can efficiently convert m1A to m6A to provide good controls, allowing the detection of m1A with higher sensitivity and accuracy. We applied red ‑m1A-seq to sequence human small RNA and we not only detected all the previously reported tRNA m1A sites, but also new m1A sites in mt-tRNAAsn-ATT and 5.8S rRNA. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
GSE238255 Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [scRNA-seq]
Contributors : Spyridon Palikyras ; Konstantinos Sofiadis ; Athanasia Stavropoulou ; Vassiliki Varamogianni-Mamatsi ; Adi Danieli-Mackay ; Yajie Zhu ; Natasa JosipovicSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCellular senescence is now acknowledged as a key contributor to organismal ageing and late-life disease. Although popular, the study of senescence in vitro can be complicated by the prolonged and asynchronous timing of cells committing to it and its paracrine effects. To address these issues, we repurposed the small molecule inhibitor inflachromene (ICM) to induce se...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE238256 Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor
Series Type : Expression profiling by high throughput sequencing ; Genome binding/occupancy profiling by high throughput sequencing ; OtherOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Genome binding/occupancy profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE238253 Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [CUT & TAG]
Contributors : Spyridon Palikyras ; Konstantinos Sofiadis ; Athanasia Stavropoulou ; Vassiliki Varamogianni-Mamatsi ; Adi Danieli-Mackay ; Yajie Zhu ; Natasa JosipovicSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensCellular senescence is now acknowledged as a key contributor to organismal ageing and late-life disease. Although popular, the study of senescence in vitro can be complicated by the prolonged and asynchronous timing of cells committing to it and its paracrine effects. To address these issues, we repurposed the small molecule inhibitor inflachromene (ICM...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research
GSE238254 Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [factory RNA-seq]
Contributors : Spyridon Palikyras ; Konstantinos Sofiadis ; Athanasia Stavropoulou ; Vassiliki Varamogianni-Mamatsi ; Adi Danieli-Mackay ; Yajie Zhu ; Natasa JosipovicSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCellular senescence is now acknowledged as a key contributor to organismal ageing and late-life disease. Although popular, the study of senescence in vitro can be complicated by the prolonged and asynchronous timing of cells committing to it and its paracrine effects. To address these issues, we repurposed the small molecule inhibitor inflachromene (ICM) to induce se...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE238250 Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [microC]
Contributors : Spyridon Palikyras ; Konstantinos Sofiadis ; Athanasia Stavropoulou ; Vassiliki Varamogianni-Mamatsi ; Adi Danieli-Mackay ; Yajie Zhu ; Natasa JosipovicSeries Type : OtherOrganism : Homo sapiensCellular senescence is now acknowledged as a key contributor to organismal ageing and late-life disease. Although popular, the study of senescence in vitro can be complicated by the prolonged and asynchronous timing of cells committing to it and its paracrine effects. To address these issues, we repurposed the small molecule inhibitor inflachromene (ICM) to induce senescence to human primary cells. Within six d...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
GSE238251 Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [Ribo-seq]
Contributors : Spyridon Palikyras ; Konstantinos Sofiadis ; Athanasia Stavropoulou ; Vassiliki Varamogianni-Mamatsi ; Adi Danieli-Mackay ; Yajie Zhu ; Natasa JosipovicSeries Type : Expression profiling by high throughput sequencing ; OtherOrganism : Homo sapiensCellular senescence is now acknowledged as a key contributor to organismal ageing and late-life disease. Although popular, the study of senescence in vitro can be complicated by the prolonged and asynchronous timing of cells committing to it and its paracrine effects. To address these issues, we repurposed the small molecule inhibitor inflachromene (ICM) to i...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Other Homo sapiens Source Type: research
GSE238252 Rapid and synchronous chemical induction of replicative-like senescence via a small molecule inhibitor [bulk RNA-seq]
Contributors : Spyridon Palikyras ; Konstantinos Sofiadis ; Athanasia Stavropoulou ; Vassiliki Varamogianni-Mamatsi ; Adi Danieli-Mackay ; Yajie Zhu ; Natasa JosipovicSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCellular senescence is now acknowledged as a key contributor to organismal ageing and late-life disease. Although popular, the study of senescence in vitro can be complicated by the prolonged and asynchronous timing of cells committing to it and its paracrine effects. To address these issues, we repurposed the small molecule inhibitor inflachromene (ICM) to induce se...
Source: GEO: Gene Expression Omnibus - April 24, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Sea creatures began to glow half a billion years ago
When a shaggy bamboo coral (
Isidella tentaculum
) gets jostled by the arm of a remotely operated submersible, its limbs begin to sparkle with bluish light. The gleam penetrates the blackness of the deep sea, where many octocorals—an ancient, diverse group of marine invertebrates that includes quill-shaped sea pens, bamboo corals, and other soft corals and waving sea fans—form lush underwater gardens.
Some
three-quarters of all undersea animals can generate their own light
, but the origin of this ability has been shrouded in mystery. Now, research reported today in the
Proceedings...
Source: Science of Aging Knowledge Environment - April 24, 2024 Category: Geriatrics Source Type: research
Molecules, Vol. 29, Pages 1955: Ensemble-Based Virtual Screening Led to the Discovery of Novel Lead Molecules as Potential NMBAs
nhui Wu
Neuromuscular blocking agents (NMBAs) are routinely used during anesthesia to relax skeletal muscle. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels; NMBAs can induce muscle paralysis by preventing the neurotransmitter acetylcholine (ACh) from binding to nAChRs situated on the postsynaptic membranes. Despite widespread efforts, it is still a great challenge to find new NMBAs since the introduction of cisatracurium in 1995. In this work, an effective ensemble-based virtual screening method, including molecular property filters, 3D pharmacophore model, and molecular docking, was applied t...
Source: Molecules - April 24, 2024 Category: Chemistry Authors: Yi Zhang Gonghui Ge Xiangyang Xu Jinhui Wu Tags: Article Source Type: research
